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Database: UniProt/SWISS-PROT
Entry: SYFA_RHIE6
LinkDB: SYFA_RHIE6
Original site: SYFA_RHIE6 
ID   SYFA_RHIE6              Reviewed;         360 AA.
AC   B3PYE2;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 1.
DT   01-OCT-2014, entry version 42.
DE   RecName: Full=Phenylalanine--tRNA ligase alpha subunit {ECO:0000255|HAMAP-Rule:MF_00281};
DE            EC=6.1.1.20 {ECO:0000255|HAMAP-Rule:MF_00281};
DE   AltName: Full=Phenylalanyl-tRNA synthetase alpha subunit {ECO:0000255|HAMAP-Rule:MF_00281};
DE            Short=PheRS {ECO:0000255|HAMAP-Rule:MF_00281};
GN   Name=pheS {ECO:0000255|HAMAP-Rule:MF_00281};
GN   OrderedLocusNames=RHECIAT_CH0000299;
OS   Rhizobium etli (strain CIAT 652).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Rhizobium.
OX   NCBI_TaxID=491916;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CIAT 652;
RA   Gonzalez V., Acosta J.L., Santamaria R.I., Bustos P.,
RA   Hernandez-Gonzalez I.L., Fernandez J.L., Diaz R., Flores M., Mora J.,
RA   Palacios R., Davila G.;
RT   "Genome diversity and DNA divergence of Rhizobium etli.";
RL   Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: ATP + L-phenylalanine + tRNA(Phe) = AMP +
CC       diphosphate + L-phenylalanyl-tRNA(Phe). {ECO:0000255|HAMAP-
CC       Rule:MF_00281}.
CC   -!- COFACTOR: Binds 2 magnesium ions per tetramer. {ECO:0000255|HAMAP-
CC       Rule:MF_00281}.
CC   -!- SUBUNIT: Tetramer of two alpha and two beta subunits.
CC       {ECO:0000255|HAMAP-Rule:MF_00281}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00281}.
CC   -!- SIMILARITY: Belongs to the class-II aminoacyl-tRNA synthetase
CC       family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_00281}.
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DR   EMBL; CP001074; ACE89293.1; -; Genomic_DNA.
DR   RefSeq; YP_001976471.1; NC_010994.1.
DR   STRING; 491916.RHECIAT_CH0000299; -.
DR   EnsemblBacteria; ACE89293; ACE89293; RHECIAT_CH0000299.
DR   GeneID; 6398173; -.
DR   KEGG; rec:RHECIAT_CH0000299; -.
DR   PATRIC; 23094068; VBIRhiEtl120572_0301.
DR   eggNOG; COG0016; -.
DR   HOGENOM; HOG000242675; -.
DR   KO; K01889; -.
DR   OMA; QIRTMEH; -.
DR   OrthoDB; EOG6WX4QN; -.
DR   BioCyc; RETL1328306-WGS:GSTH-266-MONOMER; -.
DR   BioCyc; RETL491916:GH4T-299-MONOMER; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0004826; F:phenylalanine-tRNA ligase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0000049; F:tRNA binding; IEA:InterPro.
DR   GO; GO:0006432; P:phenylalanyl-tRNA aminoacylation; IEA:UniProtKB-HAMAP.
DR   HAMAP; MF_00281; Phe_tRNA_synth_alpha1; 1.
DR   InterPro; IPR006195; aa-tRNA-synth_II.
DR   InterPro; IPR004529; Phe-tRNA-synth_IIc_asu.
DR   InterPro; IPR004188; Phe-tRNA_ligase_II_N.
DR   InterPro; IPR022911; Phe_tRNA_ligase_alpha1_bac.
DR   InterPro; IPR002319; Phenylalanyl-tRNA_Synthase.
DR   InterPro; IPR010978; tRNA-bd_arm.
DR   Pfam; PF02912; Phe_tRNA-synt_N; 1.
DR   Pfam; PF01409; tRNA-synt_2d; 1.
DR   SUPFAM; SSF46589; SSF46589; 1.
DR   TIGRFAMs; TIGR00468; pheS; 1.
DR   PROSITE; PS50862; AA_TRNA_LIGASE_II; 1.
PE   3: Inferred from homology;
KW   Aminoacyl-tRNA synthetase; ATP-binding; Complete proteome; Cytoplasm;
KW   Ligase; Magnesium; Metal-binding; Nucleotide-binding;
KW   Protein biosynthesis.
FT   CHAIN         1    360       Phenylalanine--tRNA ligase alpha subunit.
FT                                /FTId=PRO_1000114904.
FT   METAL       260    260       Magnesium. {ECO:0000255|HAMAP-
FT                                Rule:MF_00281}.
SQ   SEQUENCE   360 AA;  40214 MW;  3129FCB6C466E775 CRC64;
     MSDIDQLNSS LLAEIAATND EPALEAVRVA ALGKKGSISE LLKTLGAMTP EERQTRGAAI
     NALKNAVTDA IAERKSVLKM AAVNARLKAE TVDVSLPVRS SPAERGRIHP ISQIVDEITA
     IFADMGFSIA EGPDIETDYY NFTALNFPEG HPAREMHDTF FFNPDENGER KVLRTHTSPV
     QVRTMEAQKP PIRIIIPGKT YRQDSDATHS PMFHQVEGLV IDKKANVANI RWVLEEFCKT
     FFEVDSVTMR FRPSFFPFTE PSFEVDIQCD RSGPIVKFGE GTDWMEILGC GMVHPNVLRY
     GGLDPDEYQG FAWGMGLDRI AMLKYGMPDL RDFFNADVRW MTHYGFRPLD MPTLFGGLSA
//
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