ID TPIS_CANFA Reviewed; 249 AA.
AC P54714;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-APR-2013, entry version 87.
DE RecName: Full=Triosephosphate isomerase;
DE Short=TIM;
DE EC=5.3.1.1;
DE AltName: Full=Triose-phosphate isomerase;
GN Name=TPI1;
OS Canis familiaris (Dog) (Canis lupus familiaris).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
OC Canis.
OX NCBI_TaxID=9615;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Beagle; TISSUE=Cornea;
RA Wistow G.;
RT "NEIBank analysis of dog cornea.";
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP PROTEIN SEQUENCE OF 8-12.
RC TISSUE=Heart;
RX PubMed=9504812; DOI=10.1002/elps.1150181514;
RA Dunn M.J., Corbett J.M., Wheeler C.H.;
RT "HSC-2DPAGE and the two-dimensional gel electrophoresis database of
RT dog heart proteins.";
RL Electrophoresis 18:2795-2802(1997).
CC -!- CATALYTIC ACTIVITY: D-glyceraldehyde 3-phosphate = glycerone
CC phosphate.
CC -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
CC -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC phosphate from glycerone phosphate: step 1/1.
CC -!- SUBUNIT: Homodimer (By similarity).
CC -!- SIMILARITY: Belongs to the triosephosphate isomerase family.
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DR EMBL; DN870474; -; NOT_ANNOTATED_CDS; mRNA.
DR RefSeq; NP_001183983.1; NM_001197054.1.
DR ProteinModelPortal; P54714; -.
DR SMR; P54714; 3-249.
DR STRING; 9615.ENSCAFP00000021462; -.
DR UCD-2DPAGE; P54714; -.
DR PaxDb; P54714; -.
DR PRIDE; P54714; -.
DR GeneID; 477711; -.
DR KEGG; cfa:477711; -.
DR CTD; 7167; -.
DR eggNOG; COG0149; -.
DR HOGENOM; HOG000226413; -.
DR HOVERGEN; HBG002599; -.
DR InParanoid; P54714; -.
DR KO; K01803; -.
DR OrthoDB; EOG40S0GF; -.
DR UniPathway; UPA00109; UER00189.
DR UniPathway; UPA00138; -.
DR NextBio; 20853140; -.
DR GO; GO:0004807; F:triose-phosphate isomerase activity; IEA:EC.
DR GO; GO:0009790; P:embryo development; IEA:Compara.
DR GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-UniPathway.
DR GO; GO:0019682; P:glyceraldehyde-3-phosphate metabolic process; IEA:Compara.
DR GO; GO:0006096; P:glycolysis; IEA:UniProtKB-UniPathway.
DR GO; GO:0006098; P:pentose-phosphate shunt; IEA:UniProtKB-KW.
DR Gene3D; 3.20.20.70; -; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR022896; TrioseP_Isoase_bac/euk.
DR InterPro; IPR000652; Triosephosphate_isomerase.
DR InterPro; IPR020861; Triosephosphate_isomerase_AS.
DR PANTHER; PTHR21139; PTHR21139; 1.
DR Pfam; PF00121; TIM; 1.
DR SUPFAM; SSF51351; Triophos_ismrse; 1.
DR TIGRFAMs; TIGR00419; tim; 1.
DR PROSITE; PS00171; TIM_1; 1.
DR PROSITE; PS51440; TIM_2; 1.
PE 1: Evidence at protein level;
KW Acetylation; Complete proteome; Direct protein sequencing;
KW Gluconeogenesis; Glycolysis; Isomerase; Pentose shunt; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1 249 Triosephosphate isomerase.
FT /FTId=PRO_0000090112.
FT ACT_SITE 96 96 Electrophile (By similarity).
FT ACT_SITE 166 166 Proton acceptor (By similarity).
FT MOD_RES 14 14 N6-acetyllysine (By similarity).
FT MOD_RES 80 80 Phosphoserine (By similarity).
FT MOD_RES 194 194 N6-acetyllysine (By similarity).
FT MOD_RES 238 238 N6-acetyllysine (By similarity).
FT CONFLICT 11 11 G -> N (in Ref. 2; AA sequence).
SQ SEQUENCE 249 AA; 26715 MW; 0EF16036CD17173A CRC64;
MAPSRKFFVG GNWKMNGRKK NLGELITTLN AAKVPADTEV VCAPPTAYID FARQKLDAKI
AVAAQNCYKV TNGAFTGEIS PGMIKDCGAT WVVLGHSERR HVFGESDELI GQKVAHALAE
GLGVIACIGE KLDEREAGIT EKVVFEQTKV IADNVKDWSK VVLAYEPVWA IGTGKTATPQ
QAQEVHEKLR GWLKSNVSDA VAQSTRIIYG GSVTGATCKE LASQPDVDGF LVGGASLKPE
FVDIINAKQ
//
