ID TRMB_NOSS1 Reviewed; 219 AA.
AC Q8YVX4;
DT 16-JUN-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 01-MAY-2013, entry version 64.
DE RecName: Full=tRNA (guanine-N(7)-)-methyltransferase;
DE EC=2.1.1.33;
DE AltName: Full=tRNA (guanine(46)-N(7))-methyltransferase;
DE AltName: Full=tRNA(m7G46)-methyltransferase;
GN Name=trmB; OrderedLocusNames=alr1845;
OS Nostoc sp. (strain PCC 7120 / UTEX 2576).
OC Bacteria; Cyanobacteria; Nostocales; Nostocaceae; Nostoc.
OX NCBI_TaxID=103690;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PCC 7120 / UTEX 2576;
RX PubMed=11759840; DOI=10.1093/dnares/8.5.205;
RA Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S.,
RA Watanabe A., Iriguchi M., Ishikawa A., Kawashima K., Kimura T.,
RA Kishida Y., Kohara M., Matsumoto M., Matsuno A., Muraki A.,
RA Nakazaki N., Shimpo S., Sugimoto M., Takazawa M., Yamada M.,
RA Yasuda M., Tabata S.;
RT "Complete genomic sequence of the filamentous nitrogen-fixing
RT cyanobacterium Anabaena sp. strain PCC 7120.";
RL DNA Res. 8:205-213(2001).
CC -!- FUNCTION: Catalyzes the formation of N(7)-methylguanine at
CC position 46 (m7G46) in tRNA (By similarity).
CC -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + guanine(46) in tRNA
CC = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.
CC -!- PATHWAY: tRNA modification; N(7)-methylguanine-tRNA biosynthesis.
CC -!- SIMILARITY: Belongs to the methyltransferase superfamily. TrmB
CC family.
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DR EMBL; BA000019; BAB73544.1; -; Genomic_DNA.
DR PIR; AG2036; AG2036.
DR RefSeq; NP_485885.1; NC_003272.1.
DR ProteinModelPortal; Q8YVX4; -.
DR STRING; 103690.alr1845; -.
DR DNASU; 1105437; -.
DR EnsemblBacteria; BAB73544; BAB73544; BAB73544.
DR GeneID; 1105437; -.
DR KEGG; ana:alr1845; -.
DR PATRIC; 22773769; VBINosSp37423_2361.
DR eggNOG; COG0220; -.
DR HOGENOM; HOG000237936; -.
DR KO; K03439; -.
DR OMA; PIHLDIG; -.
DR ProtClustDB; PRK00121; -.
DR UniPathway; UPA00989; -.
DR GO; GO:0008176; F:tRNA (guanine-N7-)-methyltransferase activity; IEA:HAMAP.
DR GO; GO:0036265; P:RNA (guanine-N7)-methylation; IEA:GOC.
DR HAMAP; MF_01057; tRNA_methyltr_TrmB; 1; -.
DR InterPro; IPR003358; tRNA_(Gua-N-7)_MeTrfase.
DR Pfam; PF02390; Methyltransf_4; 1.
DR TIGRFAMs; TIGR00091; TIGR00091; 1.
PE 3: Inferred from homology;
KW Complete proteome; Methyltransferase; S-adenosyl-L-methionine;
KW Transferase; tRNA processing.
FT CHAIN 1 219 tRNA (guanine-N(7)-)-methyltransferase.
FT /FTId=PRO_0000171285.
FT BINDING 47 47 S-adenosyl-L-methionine (By similarity).
FT BINDING 72 72 S-adenosyl-L-methionine (By similarity).
FT BINDING 99 99 S-adenosyl-L-methionine (By similarity).
FT BINDING 125 125 S-adenosyl-L-methionine (By similarity).
FT BINDING 129 129 Substrate (By similarity).
FT BINDING 161 161 Substrate (Potential).
SQ SEQUENCE 219 AA; 24847 MW; 6B255C82EA25C83C CRC64;
MISGVSALPF VRVRQHVNPL AQKYLTPANP LEWEKAYSTP HQPLHLDIGC ARGRFVLQMA
QVEPNWNFLG LEIRESLVIE ANQFRSQLGL TNLHYLYCNA NNSLQPLLSS LPTGILQRVT
IQFPDPWFKT RHAKRRVVQP ELVQDIANYL AVGGVVFLQS DMEFVAVEMC DRFAANPAFK
KVGTGEWLTE NPLPVATERE TTTQNRGEPV YRALFERSS
//
