ID TRPA_BURM9 Reviewed; 271 AA.
AC A2S138; A2S137;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 06-MAR-2007, sequence version 1.
DT 01-MAY-2013, entry version 49.
DE RecName: Full=Tryptophan synthase alpha chain;
DE EC=4.2.1.20;
GN Name=trpA; OrderedLocusNames=BMA10229_1859;
OS Burkholderia mallei (strain NCTC 10229).
OC Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Burkholderia; pseudomallei group.
OX NCBI_TaxID=412022;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC 10229;
RA DeShazer D., Woods D.E., Nierman W.C.;
RL Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP SEQUENCE REVISION.
RA Brinkac L.M., Harkins D.M., Shrivastava S., Durkin A.S., Sutton G.;
RL Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: The alpha subunit is responsible for the aldol cleavage
CC of indoleglycerol phosphate to indole and glyceraldehyde 3-
CC phosphate (By similarity).
CC -!- CATALYTIC ACTIVITY: L-serine + 1-C-(indol-3-yl)glycerol 3-
CC phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H(2)O.
CC -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC tryptophan from chorismate: step 5/5.
CC -!- SUBUNIT: Tetramer of two alpha and two beta chains (By
CC similarity).
CC -!- SIMILARITY: Belongs to the TrpA family.
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DR EMBL; CP000545; ABN00188.2; -; Genomic_DNA.
DR RefSeq; YP_001025657.1; NC_008835.1.
DR ProteinModelPortal; A2S138; -.
DR STRING; 412022.BMA10229_1860; -.
DR EnsemblBacteria; ABN00188; ABN00188; BMA10229_1859.
DR GeneID; 4790383; -.
DR KEGG; bml:BMA10229_1860; -.
DR PATRIC; 19130169; VBIBurMal46188_1814.
DR eggNOG; COG0159; -.
DR HOGENOM; HOG000161821; -.
DR KO; K01695; -.
DR OMA; VFICPPN; -.
DR ProtClustDB; CLSK897166; -.
DR BioCyc; BMAL412022:GJI8-5266-MONOMER; -.
DR BioCyc; BMAL412022:GJI8-5267-MONOMER; -.
DR UniPathway; UPA00035; UER00044.
DR GO; GO:0004834; F:tryptophan synthase activity; IEA:HAMAP.
DR Gene3D; 3.20.20.70; -; 1.
DR HAMAP; MF_00131; Trp_synth_alpha; 1; -.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR011060; RibuloseP-bd_barrel.
DR InterPro; IPR018204; Trp_synthase_alpha_AS.
DR InterPro; IPR002028; Trp_synthase_suA.
DR Pfam; PF00290; Trp_syntA; 1.
DR SUPFAM; SSF51366; RibP_bind_barrel; 1.
DR TIGRFAMs; TIGR00262; trpA; 1.
DR PROSITE; PS00167; TRP_SYNTHASE_ALPHA; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; Aromatic amino acid biosynthesis;
KW Complete proteome; Lyase; Tryptophan biosynthesis.
FT CHAIN 1 271 Tryptophan synthase alpha chain.
FT /FTId=PRO_1000018176.
FT ACT_SITE 49 49 Proton acceptor (By similarity).
FT ACT_SITE 60 60 Proton acceptor (By similarity).
SQ SEQUENCE 271 AA; 27978 MW; AC4B83AA542695CD CRC64;
MSRIQNTFAA LAAQGRKGLI PFITAGDPDP AKTVELMHAL AEGGADVIEL GVPFSDPMAD
GPVIQRSSER ALAKGVTLHS VLDDVKRFRA RDQKTPVVLM GYANPIERMG ADAFAAAARD
AGVDGVLVVD YPPEESHDFA AKMRAAGIDP IFLLAPTSTD DRIAAVGQVA SGYVYYVSLK
GVTGAANLDV SSIAGKIPAI KSRVPLPVGV GFGIRDAATA RAVAEVADAV VIGSRLVQLL
EQAVPERAAA ELAGFVAELR AAIDGAAKPA A
//
