ID TRPC_MYCPA Reviewed; 272 AA.
AC Q740P4;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 01-MAY-2013, entry version 61.
DE RecName: Full=Indole-3-glycerol phosphate synthase;
DE Short=IGPS;
DE EC=4.1.1.48;
GN Name=trpC; OrderedLocusNames=MAP_1305;
OS Mycobacterium paratuberculosis (strain ATCC BAA-968 / K-10).
OC Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC Corynebacterineae; Mycobacteriaceae; Mycobacterium;
OC Mycobacterium avium complex (MAC).
OX NCBI_TaxID=262316;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-968 / K-10;
RX PubMed=16116077; DOI=10.1073/pnas.0505662102;
RA Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D.,
RA Banerji N., Kanjilal S., Kapur V.;
RT "The complete genome sequence of Mycobacterium avium subspecies
RT paratuberculosis.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005).
CC -!- CATALYTIC ACTIVITY: 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-
CC phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO(2) + H(2)O.
CC -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC tryptophan from chorismate: step 4/5.
CC -!- SIMILARITY: Belongs to the TrpC family.
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DR EMBL; AE016958; AAS03622.1; -; Genomic_DNA.
DR RefSeq; NP_960239.1; NC_002944.2.
DR HSSP; Q06121; 2C3Z.
DR ProteinModelPortal; Q740P4; -.
DR STRING; 262316.MAP1305; -.
DR EnsemblBacteria; AAS03622; AAS03622; MAP_1305.
DR GeneID; 2718762; -.
DR KEGG; mpa:MAP1305; -.
DR PATRIC; 17995087; VBIMycAvi108102_1374.
DR eggNOG; COG0134; -.
DR KO; K01609; -.
DR OMA; YQAGGAR; -.
DR ProtClustDB; PRK00278; -.
DR UniPathway; UPA00035; UER00043.
DR GO; GO:0004425; F:indole-3-glycerol-phosphate synthase activity; IEA:HAMAP.
DR GO; GO:0000162; P:tryptophan biosynthetic process; IEA:HAMAP.
DR Gene3D; 3.20.20.70; -; 1.
DR HAMAP; MF_00134_B; IGPS_B; 1; -.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR013798; Indole-3-glycerol_P_synth.
DR InterPro; IPR001468; Indole-3-GlycerolPSynthase_CS.
DR InterPro; IPR011060; RibuloseP-bd_barrel.
DR Pfam; PF00218; IGPS; 1.
DR SUPFAM; SSF51366; RibP_bind_barrel; 1.
DR PROSITE; PS00614; IGPS; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; Aromatic amino acid biosynthesis;
KW Complete proteome; Decarboxylase; Lyase; Tryptophan biosynthesis.
FT CHAIN 1 272 Indole-3-glycerol phosphate synthase.
FT /FTId=PRO_1000018500.
SQ SEQUENCE 272 AA; 28125 MW; B3EFE54C570ADD32 CRC64;
MSPATVLDSI LEGVRADVAA REALISLSEI KAAAAAAPPP LDVMAALREP GIGVIAEVKR
ASPSAGSLAT IADPAKLARA YEDGGARIIS VLTEERRFHG SLDDLDAVRA AVSIPVLRKD
FVVQPYQIHE ARAHGADMLL LIVAALEQSA LVSMLDRTES LGMTALVEVH TEEEADRALR
AGAKVIGVNA RDLATLEVDR DCFARIAPGL PSNVIRIAES GVRGTGDLLA YAGAGADAVL
VGEGLVKSGD PRAAVADLVT AGTHPSCPKP AR
//
