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Database: UniProt/SWISS-PROT
Entry: TRUA_BARQU
LinkDB: TRUA_BARQU
Original site: TRUA_BARQU 
ID   TRUA_BARQU              Reviewed;         247 AA.
AC   Q6G1G9;
DT   16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   14-MAY-2014, entry version 60.
DE   RecName: Full=tRNA pseudouridine synthase A;
DE            EC=5.4.99.12;
DE   AltName: Full=tRNA pseudouridine(38-40) synthase;
DE   AltName: Full=tRNA pseudouridylate synthase I;
DE   AltName: Full=tRNA-uridine isomerase I;
GN   Name=truA; OrderedLocusNames=BQ00670;
OS   Bartonella quintana (strain Toulouse) (Rochalimaea quintana).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Bartonellaceae; Bartonella.
OX   NCBI_TaxID=283165;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Toulouse;
RX   PubMed=15210978; DOI=10.1073/pnas.0305659101;
RA   Alsmark U.C.M., Frank A.C., Karlberg E.O., Legault B.-A., Ardell D.H.,
RA   Canbaeck B., Eriksson A.-S., Naeslund A.K., Handley S.A., Huvet M.,
RA   La Scola B., Holmberg M., Andersson S.G.E.;
RT   "The louse-borne human pathogen Bartonella quintana is a genomic
RT   derivative of the zoonotic agent Bartonella henselae.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:9716-9721(2004).
CC   -!- FUNCTION: Formation of pseudouridine at positions 38, 39 and 40 in
CC       the anticodon stem and loop of transfer RNAs (By similarity).
CC   -!- CATALYTIC ACTIVITY: tRNA uridine(38-40) = tRNA pseudouridine(38-
CC       40).
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SIMILARITY: Belongs to the tRNA pseudouridine synthase TruA
CC       family.
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DR   EMBL; BX897700; CAF25574.1; -; Genomic_DNA.
DR   RefSeq; YP_031792.1; NC_005955.1.
DR   ProteinModelPortal; Q6G1G9; -.
DR   STRING; 283165.BQ00670; -.
DR   EnsemblBacteria; CAF25574; CAF25574; BQ00670.
DR   GeneID; 2867384; -.
DR   KEGG; bqu:BQ00670; -.
DR   PATRIC; 31951263; VBIBarQui58630_0075.
DR   eggNOG; COG0101; -.
DR   HOGENOM; HOG000248672; -.
DR   KO; K06173; -.
DR   OMA; YLTKVEY; -.
DR   OrthoDB; EOG6Z9B4R; -.
DR   BioCyc; BQUI283165:GHZA-67-MONOMER; -.
DR   GO; GO:0009982; F:pseudouridine synthase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0031119; P:tRNA pseudouridine synthesis; IEA:UniProtKB-HAMAP.
DR   Gene3D; 3.30.70.580; -; 1.
DR   Gene3D; 3.30.70.660; -; 1.
DR   HAMAP; MF_00171; TruA; 1.
DR   InterPro; IPR020103; PsdUridine_synth_cat_dom.
DR   InterPro; IPR001406; PsdUridine_synth_TruA.
DR   InterPro; IPR020097; PsdUridine_synth_TruA_a/b_dom.
DR   InterPro; IPR020095; PsdUridine_synth_TruA_C.
DR   InterPro; IPR020094; PsdUridine_synth_TruA_N.
DR   PANTHER; PTHR11142; PTHR11142; 1.
DR   Pfam; PF01416; PseudoU_synth_1; 2.
DR   PIRSF; PIRSF001430; tRNA_psdUrid_synth; 1.
DR   SUPFAM; SSF55120; SSF55120; 1.
DR   TIGRFAMs; TIGR00071; hisT_truA; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Isomerase; tRNA processing.
FT   CHAIN         1    247       tRNA pseudouridine synthase A.
FT                                /FTId=PRO_0000057337.
FT   ACT_SITE     52     52       Nucleophile (By similarity).
FT   BINDING     113    113       Substrate (By similarity).
SQ   SEQUENCE   247 AA;  28166 MW;  EAA8FDFFD1B71039 CRC64;
     MPRFKLTLEY DGSNYAGWQR QAELHTIQSA LEQAIFHFSG QQLTTTTAGR TDAGVHATGQ
     VAHVDFIKNW QTYTVRDALN AYLQKQGEEI AVLNVQNVPD NFDARFSAIK RHYLFKILNR
     LSPPALNIKR VWWIPKPLNV DAMHQAAQKL VGQHDFTTFR SAHCQAKSPI RTLERLDVYR
     EGEEIFLYAQ ARSFLHHQIR SFAGSLMEVG IGRWTAQDLE AALHAKDRKR CGMVAPPSGL
     YLTQVDY
//
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