ID TRUA_BARQU Reviewed; 247 AA.
AC Q6G1G9;
DT 16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 1.
DT 01-MAY-2013, entry version 55.
DE RecName: Full=tRNA pseudouridine synthase A;
DE EC=5.4.99.12;
DE AltName: Full=tRNA pseudouridine(38-40) synthase;
DE AltName: Full=tRNA pseudouridylate synthase I;
DE AltName: Full=tRNA-uridine isomerase I;
GN Name=truA; OrderedLocusNames=BQ00670;
OS Bartonella quintana (strain Toulouse) (Rochalimaea quintana).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC Bartonellaceae; Bartonella.
OX NCBI_TaxID=283165;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Toulouse;
RX PubMed=15210978; DOI=10.1073/pnas.0305659101;
RA Alsmark U.C.M., Frank A.C., Karlberg E.O., Legault B.-A., Ardell D.H.,
RA Canbaeck B., Eriksson A.-S., Naeslund A.K., Handley S.A., Huvet M.,
RA La Scola B., Holmberg M., Andersson S.G.E.;
RT "The louse-borne human pathogen Bartonella quintana is a genomic
RT derivative of the zoonotic agent Bartonella henselae.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:9716-9721(2004).
CC -!- FUNCTION: Formation of pseudouridine at positions 38, 39 and 40 in
CC the anticodon stem and loop of transfer RNAs (By similarity).
CC -!- CATALYTIC ACTIVITY: tRNA uridine(38-40) = tRNA pseudouridine(38-
CC 40).
CC -!- SUBUNIT: Homodimer (By similarity).
CC -!- SIMILARITY: Belongs to the tRNA pseudouridine synthase TruA
CC family.
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DR EMBL; BX897700; CAF25574.1; -; Genomic_DNA.
DR RefSeq; YP_031792.1; NC_005955.1.
DR ProteinModelPortal; Q6G1G9; -.
DR STRING; 283165.BQ00670; -.
DR EnsemblBacteria; CAF25574; CAF25574; BQ00670.
DR GeneID; 2867384; -.
DR KEGG; bqu:BQ00670; -.
DR PATRIC; 31951263; VBIBarQui58630_0075.
DR eggNOG; COG0101; -.
DR HOGENOM; HOG000248672; -.
DR KO; K06173; -.
DR OMA; HHQIRSF; -.
DR ProtClustDB; PRK00021; -.
DR BioCyc; BQUI283165:GHZA-276-MONOMER; -.
DR GO; GO:0009982; F:pseudouridine synthase activity; IEA:HAMAP.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0031119; P:tRNA pseudouridine synthesis; IEA:HAMAP.
DR Gene3D; 3.30.70.580; -; 1.
DR Gene3D; 3.30.70.660; -; 1.
DR HAMAP; MF_00171; TruA; 1; -.
DR InterPro; IPR020103; PsdUridine_synth_cat_dom.
DR InterPro; IPR001406; PsdUridine_synth_TruA.
DR InterPro; IPR020097; PsdUridine_synth_TruA_a/b_dom.
DR InterPro; IPR020095; PsdUridine_synth_TruA_C.
DR InterPro; IPR020094; PsdUridine_synth_TruA_N.
DR PANTHER; PTHR11142; PTHR11142; 1.
DR Pfam; PF01416; PseudoU_synth_1; 2.
DR PIRSF; PIRSF001430; tRNA_psdUrid_synth; 1.
DR SUPFAM; SSF55120; PsdUridine_synth_cat_dom; 1.
DR TIGRFAMs; TIGR00071; hisT_truA; 1.
PE 3: Inferred from homology;
KW Complete proteome; Isomerase; tRNA processing.
FT CHAIN 1 247 tRNA pseudouridine synthase A.
FT /FTId=PRO_0000057337.
FT ACT_SITE 52 52 Nucleophile (By similarity).
FT BINDING 113 113 Substrate (By similarity).
SQ SEQUENCE 247 AA; 28166 MW; EAA8FDFFD1B71039 CRC64;
MPRFKLTLEY DGSNYAGWQR QAELHTIQSA LEQAIFHFSG QQLTTTTAGR TDAGVHATGQ
VAHVDFIKNW QTYTVRDALN AYLQKQGEEI AVLNVQNVPD NFDARFSAIK RHYLFKILNR
LSPPALNIKR VWWIPKPLNV DAMHQAAQKL VGQHDFTTFR SAHCQAKSPI RTLERLDVYR
EGEEIFLYAQ ARSFLHHQIR SFAGSLMEVG IGRWTAQDLE AALHAKDRKR CGMVAPPSGL
YLTQVDY
//
