ID TRUA_CHLL2 Reviewed; 243 AA.
AC B3EIU9;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2008, sequence version 1.
DT 01-MAY-2013, entry version 38.
DE RecName: Full=tRNA pseudouridine synthase A;
DE EC=5.4.99.12;
DE AltName: Full=tRNA pseudouridine(38-40) synthase;
DE AltName: Full=tRNA pseudouridylate synthase I;
DE AltName: Full=tRNA-uridine isomerase I;
GN Name=truA; OrderedLocusNames=Clim_0964;
OS Chlorobium limicola (strain DSM 245 / NBRC 103803).
OC Bacteria; Chlorobi; Chlorobia; Chlorobiales; Chlorobiaceae;
OC Chlorobium/Pelodictyon group; Chlorobium.
OX NCBI_TaxID=290315;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 245 / NBRC 103803;
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E.,
RA Tice H., Bruce D., Goodwin L., Pitluck S., Schmutz J., Larimer F.,
RA Land M., Hauser L., Kyrpides N., Ovchinnikova G., Zhao F., Li T.,
RA Liu Z., Overmann J., Bryant D.A., Richardson P.;
RT "Complete sequence of Chlorobium limicola DSM 245.";
RL Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Formation of pseudouridine at positions 38, 39 and 40 in
CC the anticodon stem and loop of transfer RNAs (By similarity).
CC -!- CATALYTIC ACTIVITY: tRNA uridine(38-40) = tRNA pseudouridine(38-
CC 40).
CC -!- SUBUNIT: Homodimer (By similarity).
CC -!- SIMILARITY: Belongs to the tRNA pseudouridine synthase TruA
CC family.
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DR EMBL; CP001097; ACD90040.1; -; Genomic_DNA.
DR RefSeq; YP_001943019.1; NC_010803.1.
DR ProteinModelPortal; B3EIU9; -.
DR STRING; 290315.Clim_0964; -.
DR EnsemblBacteria; ACD90040; ACD90040; Clim_0964.
DR GeneID; 6355413; -.
DR KEGG; cli:Clim_0964; -.
DR PATRIC; 21373981; VBIChlLim118737_1029.
DR eggNOG; COG0101; -.
DR HOGENOM; HOG000248673; -.
DR KO; K06173; -.
DR OMA; GKSFLWE; -.
DR ProtClustDB; PRK00021; -.
DR BioCyc; CLIM290315:GHUH-994-MONOMER; -.
DR GO; GO:0009982; F:pseudouridine synthase activity; IEA:HAMAP.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0031119; P:tRNA pseudouridine synthesis; IEA:HAMAP.
DR Gene3D; 3.30.70.580; -; 1.
DR Gene3D; 3.30.70.660; -; 1.
DR HAMAP; MF_00171; TruA; 1; -.
DR InterPro; IPR020103; PsdUridine_synth_cat_dom.
DR InterPro; IPR001406; PsdUridine_synth_TruA.
DR InterPro; IPR020097; PsdUridine_synth_TruA_a/b_dom.
DR InterPro; IPR020095; PsdUridine_synth_TruA_C.
DR InterPro; IPR020094; PsdUridine_synth_TruA_N.
DR PANTHER; PTHR11142; PTHR11142; 1.
DR Pfam; PF01416; PseudoU_synth_1; 2.
DR PIRSF; PIRSF001430; tRNA_psdUrid_synth; 1.
DR SUPFAM; SSF55120; PsdUridine_synth_cat_dom; 1.
DR TIGRFAMs; TIGR00071; hisT_truA; 1.
PE 3: Inferred from homology;
KW Complete proteome; Isomerase; tRNA processing.
FT CHAIN 1 243 tRNA pseudouridine synthase A.
FT /FTId=PRO_1000097729.
FT ACT_SITE 53 53 Nucleophile (By similarity).
FT BINDING 111 111 Substrate (By similarity).
SQ SEQUENCE 243 AA; 27321 MW; 961AEF80B8FCD4C3 CRC64;
MKNIRFDVEY DGTDFCGWQR QPGGIQTLQG ELEAQLGRIL QENISLTAAG RTDKGVHARL
QVVNFMTGSA MELSKMAHAL NSLLPDTVRV SNPHVVPLDF HARFSAKERE YRYFLLEEPS
ALRCRFTGCS KGSLHIGVMQ DAAGLLVGEH DFLLLSKEPA DKKNPVCLIK ECEWQEENGV
FVFRIRANRF LRSMVRYLVG VMIAVGRGRA VPEDLGMLLD DGLMTFPLFP AEPNGLFLWD
VSY
//
