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Database: UniProt/SWISS-PROT
Entry: TRUA_CHLL2
LinkDB: TRUA_CHLL2
Original site: TRUA_CHLL2 
ID   TRUA_CHLL2              Reviewed;         243 AA.
AC   B3EIU9;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 1.
DT   29-OCT-2014, entry version 45.
DE   RecName: Full=tRNA pseudouridine synthase A {ECO:0000255|HAMAP-Rule:MF_00171};
DE            EC=5.4.99.12 {ECO:0000255|HAMAP-Rule:MF_00171};
DE   AltName: Full=tRNA pseudouridine(38-40) synthase {ECO:0000255|HAMAP-Rule:MF_00171};
DE   AltName: Full=tRNA pseudouridylate synthase I {ECO:0000255|HAMAP-Rule:MF_00171};
DE   AltName: Full=tRNA-uridine isomerase I {ECO:0000255|HAMAP-Rule:MF_00171};
GN   Name=truA {ECO:0000255|HAMAP-Rule:MF_00171};
GN   OrderedLocusNames=Clim_0964;
OS   Chlorobium limicola (strain DSM 245 / NBRC 103803).
OC   Bacteria; Chlorobi; Chlorobia; Chlorobiales; Chlorobiaceae;
OC   Chlorobium/Pelodictyon group; Chlorobium.
OX   NCBI_TaxID=290315;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 245 / NBRC 103803;
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E.,
RA   Tice H., Bruce D., Goodwin L., Pitluck S., Schmutz J., Larimer F.,
RA   Land M., Hauser L., Kyrpides N., Ovchinnikova G., Zhao F., Li T.,
RA   Liu Z., Overmann J., Bryant D.A., Richardson P.;
RT   "Complete sequence of Chlorobium limicola DSM 245.";
RL   Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Formation of pseudouridine at positions 38, 39 and 40 in
CC       the anticodon stem and loop of transfer RNAs. {ECO:0000255|HAMAP-
CC       Rule:MF_00171}.
CC   -!- CATALYTIC ACTIVITY: tRNA uridine(38-40) = tRNA pseudouridine(38-
CC       40). {ECO:0000255|HAMAP-Rule:MF_00171}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_00171}.
CC   -!- SIMILARITY: Belongs to the tRNA pseudouridine synthase TruA
CC       family. {ECO:0000255|HAMAP-Rule:MF_00171}.
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DR   EMBL; CP001097; ACD90040.1; -; Genomic_DNA.
DR   RefSeq; YP_001943019.1; NC_010803.1.
DR   ProteinModelPortal; B3EIU9; -.
DR   STRING; 290315.Clim_0964; -.
DR   EnsemblBacteria; ACD90040; ACD90040; Clim_0964.
DR   GeneID; 6355413; -.
DR   KEGG; cli:Clim_0964; -.
DR   PATRIC; 21373981; VBIChlLim118737_1029.
DR   eggNOG; COG0101; -.
DR   HOGENOM; HOG000248673; -.
DR   KO; K06173; -.
DR   OMA; HEKSSPR; -.
DR   OrthoDB; EOG6Z9B4R; -.
DR   BioCyc; CLIM290315:GHUH-994-MONOMER; -.
DR   GO; GO:0009982; F:pseudouridine synthase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0031119; P:tRNA pseudouridine synthesis; IEA:UniProtKB-HAMAP.
DR   Gene3D; 3.30.70.580; -; 1.
DR   Gene3D; 3.30.70.660; -; 1.
DR   HAMAP; MF_00171; TruA; 1.
DR   InterPro; IPR020103; PsdUridine_synth_cat_dom.
DR   InterPro; IPR001406; PsdUridine_synth_TruA.
DR   InterPro; IPR020097; PsdUridine_synth_TruA_a/b_dom.
DR   InterPro; IPR020095; PsdUridine_synth_TruA_C.
DR   InterPro; IPR020094; PsdUridine_synth_TruA_N.
DR   PANTHER; PTHR11142; PTHR11142; 1.
DR   Pfam; PF01416; PseudoU_synth_1; 2.
DR   PIRSF; PIRSF001430; tRNA_psdUrid_synth; 1.
DR   SUPFAM; SSF55120; SSF55120; 1.
DR   TIGRFAMs; TIGR00071; hisT_truA; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Isomerase; tRNA processing.
FT   CHAIN         1    243       tRNA pseudouridine synthase A.
FT                                /FTId=PRO_1000097729.
FT   ACT_SITE     53     53       Nucleophile. {ECO:0000255|HAMAP-
FT                                Rule:MF_00171}.
FT   BINDING     111    111       Substrate. {ECO:0000255|HAMAP-
FT                                Rule:MF_00171}.
SQ   SEQUENCE   243 AA;  27321 MW;  961AEF80B8FCD4C3 CRC64;
     MKNIRFDVEY DGTDFCGWQR QPGGIQTLQG ELEAQLGRIL QENISLTAAG RTDKGVHARL
     QVVNFMTGSA MELSKMAHAL NSLLPDTVRV SNPHVVPLDF HARFSAKERE YRYFLLEEPS
     ALRCRFTGCS KGSLHIGVMQ DAAGLLVGEH DFLLLSKEPA DKKNPVCLIK ECEWQEENGV
     FVFRIRANRF LRSMVRYLVG VMIAVGRGRA VPEDLGMLLD DGLMTFPLFP AEPNGLFLWD
     VSY
//
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