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Database: UniProt/SWISS-PROT
Entry: TRUA_RHOS5
LinkDB: TRUA_RHOS5
Original site: TRUA_RHOS5 
ID   TRUA_RHOS5              Reviewed;         257 AA.
AC   A4WPU4;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   29-MAY-2007, sequence version 1.
DT   14-MAY-2014, entry version 48.
DE   RecName: Full=tRNA pseudouridine synthase A;
DE            EC=5.4.99.12;
DE   AltName: Full=tRNA pseudouridine(38-40) synthase;
DE   AltName: Full=tRNA pseudouridylate synthase I;
DE   AltName: Full=tRNA-uridine isomerase I;
GN   Name=truA; OrderedLocusNames=Rsph17025_0502;
OS   Rhodobacter sphaeroides (strain ATCC 17025 / ATH 2.4.3).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
OC   Rhodobacteraceae; Rhodobacter.
OX   NCBI_TaxID=349102;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 17025 / ATH 2.4.3;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H.,
RA   Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Richardson P.,
RA   Mackenzie C., Choudhary M., Donohue T.J., Kaplan S.;
RT   "Complete sequence of chromosome of Rhodobacter sphaeroides ATCC
RT   17025.";
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Formation of pseudouridine at positions 38, 39 and 40 in
CC       the anticodon stem and loop of transfer RNAs (By similarity).
CC   -!- CATALYTIC ACTIVITY: tRNA uridine(38-40) = tRNA pseudouridine(38-
CC       40).
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SIMILARITY: Belongs to the tRNA pseudouridine synthase TruA
CC       family.
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DR   EMBL; CP000661; ABP69408.1; -; Genomic_DNA.
DR   RefSeq; YP_001166713.1; NC_009428.1.
DR   ProteinModelPortal; A4WPU4; -.
DR   STRING; 349102.Rsph17025_0502; -.
DR   EnsemblBacteria; ABP69408; ABP69408; Rsph17025_0502.
DR   GeneID; 5082861; -.
DR   KEGG; rsq:Rsph17025_0502; -.
DR   PATRIC; 23159136; VBIRhoSph94549_0509.
DR   eggNOG; COG0101; -.
DR   HOGENOM; HOG000248674; -.
DR   KO; K06173; -.
DR   OMA; YLTKVEY; -.
DR   OrthoDB; EOG6Z9B4R; -.
DR   BioCyc; RSPH349102:GHE1-1831-MONOMER; -.
DR   GO; GO:0009982; F:pseudouridine synthase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0031119; P:tRNA pseudouridine synthesis; IEA:UniProtKB-HAMAP.
DR   Gene3D; 3.30.70.580; -; 1.
DR   Gene3D; 3.30.70.660; -; 1.
DR   HAMAP; MF_00171; TruA; 1.
DR   InterPro; IPR020103; PsdUridine_synth_cat_dom.
DR   InterPro; IPR001406; PsdUridine_synth_TruA.
DR   InterPro; IPR020097; PsdUridine_synth_TruA_a/b_dom.
DR   InterPro; IPR020095; PsdUridine_synth_TruA_C.
DR   InterPro; IPR020094; PsdUridine_synth_TruA_N.
DR   PANTHER; PTHR11142; PTHR11142; 1.
DR   Pfam; PF01416; PseudoU_synth_1; 2.
DR   PIRSF; PIRSF001430; tRNA_psdUrid_synth; 1.
DR   SUPFAM; SSF55120; SSF55120; 1.
DR   TIGRFAMs; TIGR00071; hisT_truA; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Isomerase; tRNA processing.
FT   CHAIN         1    257       tRNA pseudouridine synthase A.
FT                                /FTId=PRO_1000017155.
FT   ACT_SITE     52     52       Nucleophile (By similarity).
FT   BINDING     111    111       Substrate (By similarity).
SQ   SEQUENCE   257 AA;  27915 MW;  919CC4274A470066 CRC64;
     MPRYALKIEY DGAPFAGWQR QAVLPSVQGA IEAALGRLEP GPHTIAAAGR TDTGVHATGQ
     VAHCDLGKDW DPFRLAGALN AHLKPLPVAV VAAARVGEDF HARFSAIERR YLFRLLARRA
     PEVHDRGRVW RVPHPLDGAA MREAAAHLVG RHDFTTFRAI GCQAASPVKT LDELTLETVE
     VPNGVEYRFR LRARSFLHNQ VRSIVGTLER VGAGAWAPDR VKEALEARDR AACGPVCPPQ
     GLYLTGVGYP ADPFAAT
//
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