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Database: UniProt/SWISS-PROT
Entry: TRUB_MYCA9
LinkDB: TRUB_MYCA9
Original site: TRUB_MYCA9 
ID   TRUB_MYCA9              Reviewed;         298 AA.
AC   B1MD72;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 1.
DT   09-JUL-2014, entry version 48.
DE   RecName: Full=tRNA pseudouridine synthase B;
DE            EC=5.4.99.25;
DE   AltName: Full=tRNA pseudouridine(55) synthase;
DE            Short=Psi55 synthase;
DE   AltName: Full=tRNA pseudouridylate synthase;
DE   AltName: Full=tRNA-uridine isomerase;
GN   Name=truB; OrderedLocusNames=MAB_3116c;
OS   Mycobacterium abscessus (strain ATCC 19977 / DSM 44196).
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Corynebacterineae; Mycobacteriaceae; Mycobacterium;
OC   Mycobacterium abscessus.
OX   NCBI_TaxID=561007;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 19977 / DSM 44196;
RG   Genoscope;
RA   Ripoll F., Pasek S., Schenowitz C., Dossat C., Barbe V., Rottman M.,
RA   Heym B., Herrmann J.L., Daffe M., Brosch R., Risler J.L.,
RA   Gaillard J.L.;
RT   "Acquisition of foreign virulence genes by the cystic fibrosis
RT   pathogen Mycobacterium abscessus.";
RL   Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Responsible for synthesis of pseudouridine from uracil-
CC       55 in the psi GC loop of transfer RNAs (By similarity).
CC   -!- CATALYTIC ACTIVITY: tRNA uridine(55) = tRNA pseudouridine(55).
CC   -!- SIMILARITY: Belongs to the pseudouridine synthase TruB family.
CC       Type 1 subfamily.
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DR   EMBL; CU458896; CAM63193.1; -; Genomic_DNA.
DR   RefSeq; YP_001703847.1; NC_010397.1.
DR   ProteinModelPortal; B1MD72; -.
DR   SMR; B1MD72; 9-296.
DR   STRING; 561007.MAB_3116c; -.
DR   EnsemblBacteria; CAM63193; CAM63193; MAB_3116c.
DR   GeneID; 5965621; -.
DR   KEGG; mab:MAB_3116c; -.
DR   PATRIC; 17977990; VBIMycAbs55940_3168.
DR   eggNOG; COG0130; -.
DR   HOGENOM; HOG000231225; -.
DR   KO; K03177; -.
DR   OMA; PKNISSA; -.
DR   OrthoDB; EOG6358D3; -.
DR   BioCyc; MABS36809-WGS:GSQO-3131-MONOMER; -.
DR   BioCyc; MABS561007:GJTG-3131-MONOMER; -.
DR   GO; GO:0009982; F:pseudouridine synthase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0031119; P:tRNA pseudouridine synthesis; IEA:UniProtKB-HAMAP.
DR   HAMAP; MF_01080; TruB_bact; 1.
DR   InterPro; IPR002501; PsdUridine_synth.
DR   InterPro; IPR020103; PsdUridine_synth_cat_dom.
DR   InterPro; IPR015947; PUA-like_domain.
DR   InterPro; IPR015225; tRNA_psdUridine_synth_fam2_C.
DR   InterPro; IPR014780; tRNA_psdUridine_synth_TruB.
DR   PANTHER; PTHR13767; PTHR13767; 1.
DR   Pfam; PF09142; TruB_C; 1.
DR   Pfam; PF01509; TruB_N; 1.
DR   SUPFAM; SSF55120; SSF55120; 1.
DR   SUPFAM; SSF88697; SSF88697; 1.
DR   TIGRFAMs; TIGR00431; TruB; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Isomerase; tRNA processing.
FT   CHAIN         1    298       tRNA pseudouridine synthase B.
FT                                /FTId=PRO_1000149825.
FT   ACT_SITE     44     44       Nucleophile (By similarity).
SQ   SEQUENCE   298 AA;  31362 MW;  EF93808A0497392D CRC64;
     MTDPLSRAGL VIVDKPAGMT SHDVVSRCRR IFSTRKVGHA GTLDPMATGV LVIGIERATK
     IMGLLTLTTK SYAATIRFGQ STSTDDAEGE VLQTISASHL TEVDIEAAVA GLRGDIAQVP
     SSVSAIKVDG QRAYKLAREG QSVELAARPV RISRFDVLAV RGSGEDLIDV DVEIDCSSGT
     YIRALARDAG AALGVGGHLT ALRRTRVGDF GLDRARTLEE LADGATLTLD LDSACRQGFP
     RRDLDAAEVD AVRNGRPLAP AGIEGTYAAV DADDRVIALL ADKGSRTTSV VVLRPANL
//
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