ID TRUB_MYCA9 Reviewed; 298 AA.
AC B1MD72;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 29-APR-2008, sequence version 1.
DT 04-FEB-2015, entry version 51.
DE RecName: Full=tRNA pseudouridine synthase B {ECO:0000255|HAMAP-Rule:MF_01080};
DE EC=5.4.99.25 {ECO:0000255|HAMAP-Rule:MF_01080};
DE AltName: Full=tRNA pseudouridine(55) synthase {ECO:0000255|HAMAP-Rule:MF_01080};
DE Short=Psi55 synthase {ECO:0000255|HAMAP-Rule:MF_01080};
DE AltName: Full=tRNA pseudouridylate synthase {ECO:0000255|HAMAP-Rule:MF_01080};
DE AltName: Full=tRNA-uridine isomerase {ECO:0000255|HAMAP-Rule:MF_01080};
GN Name=truB {ECO:0000255|HAMAP-Rule:MF_01080};
GN OrderedLocusNames=MAB_3116c;
OS Mycobacterium abscessus (strain ATCC 19977 / DSM 44196).
OC Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC Corynebacterineae; Mycobacteriaceae; Mycobacterium;
OC Mycobacterium abscessus.
OX NCBI_TaxID=561007;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 19977 / DSM 44196;
RG Genoscope;
RA Ripoll F., Pasek S., Schenowitz C., Dossat C., Barbe V., Rottman M.,
RA Heym B., Herrmann J.L., Daffe M., Brosch R., Risler J.L.,
RA Gaillard J.L.;
RT "Acquisition of foreign virulence genes by the cystic fibrosis
RT pathogen Mycobacterium abscessus.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Responsible for synthesis of pseudouridine from uracil-
CC 55 in the psi GC loop of transfer RNAs. {ECO:0000255|HAMAP-
CC Rule:MF_01080}.
CC -!- CATALYTIC ACTIVITY: tRNA uridine(55) = tRNA pseudouridine(55).
CC {ECO:0000255|HAMAP-Rule:MF_01080}.
CC -!- SIMILARITY: Belongs to the pseudouridine synthase TruB family.
CC Type 1 subfamily. {ECO:0000255|HAMAP-Rule:MF_01080}.
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DR EMBL; CU458896; CAM63193.1; -; Genomic_DNA.
DR ProteinModelPortal; B1MD72; -.
DR SMR; B1MD72; 9-296.
DR STRING; 561007.MAB_3116c; -.
DR EnsemblBacteria; CAM63193; CAM63193; MAB_3116c.
DR KEGG; mab:MAB_3116c; -.
DR PATRIC; 17977990; VBIMycAbs55940_3168.
DR eggNOG; COG0130; -.
DR HOGENOM; HOG000231225; -.
DR KO; K03177; -.
DR OMA; HATKISG; -.
DR OrthoDB; EOG6358D3; -.
DR BioCyc; MABS36809-WGS:GSQO-3131-MONOMER; -.
DR BioCyc; MABS561007:GJTG-3131-MONOMER; -.
DR Proteomes; UP000007137; Chromosome.
DR GO; GO:0009982; F:pseudouridine synthase activity; IEA:UniProtKB-HAMAP.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0031119; P:tRNA pseudouridine synthesis; IEA:UniProtKB-HAMAP.
DR HAMAP; MF_01080; TruB_bact; 1.
DR InterPro; IPR002501; PsdUridine_synth.
DR InterPro; IPR020103; PsdUridine_synth_cat_dom.
DR InterPro; IPR015947; PUA-like_domain.
DR InterPro; IPR015225; tRNA_psdUridine_synth_fam2_C.
DR InterPro; IPR014780; tRNA_psdUridine_synth_TruB.
DR PANTHER; PTHR13767; PTHR13767; 1.
DR Pfam; PF09142; TruB_C; 1.
DR Pfam; PF01509; TruB_N; 1.
DR SUPFAM; SSF55120; SSF55120; 1.
DR SUPFAM; SSF88697; SSF88697; 1.
DR TIGRFAMs; TIGR00431; TruB; 1.
PE 3: Inferred from homology;
KW Complete proteome; Isomerase; Reference proteome; tRNA processing.
FT CHAIN 1 298 tRNA pseudouridine synthase B.
FT /FTId=PRO_1000149825.
FT ACT_SITE 44 44 Nucleophile. {ECO:0000255|HAMAP-
FT Rule:MF_01080}.
SQ SEQUENCE 298 AA; 31362 MW; EF93808A0497392D CRC64;
MTDPLSRAGL VIVDKPAGMT SHDVVSRCRR IFSTRKVGHA GTLDPMATGV LVIGIERATK
IMGLLTLTTK SYAATIRFGQ STSTDDAEGE VLQTISASHL TEVDIEAAVA GLRGDIAQVP
SSVSAIKVDG QRAYKLAREG QSVELAARPV RISRFDVLAV RGSGEDLIDV DVEIDCSSGT
YIRALARDAG AALGVGGHLT ALRRTRVGDF GLDRARTLEE LADGATLTLD LDSACRQGFP
RRDLDAAEVD AVRNGRPLAP AGIEGTYAAV DADDRVIALL ADKGSRTTSV VVLRPANL
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