GenomeNet

Database: UniProt/SWISS-PROT
Entry: TRUB_TOLAT
LinkDB: TRUB_TOLAT
Original site: TRUB_TOLAT 
ID   TRUB_TOLAT              Reviewed;         324 AA.
AC   C4L8X2;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   07-JUL-2009, sequence version 1.
DT   01-OCT-2014, entry version 33.
DE   RecName: Full=tRNA pseudouridine synthase B {ECO:0000255|HAMAP-Rule:MF_01080};
DE            EC=5.4.99.25 {ECO:0000255|HAMAP-Rule:MF_01080};
DE   AltName: Full=tRNA pseudouridine(55) synthase {ECO:0000255|HAMAP-Rule:MF_01080};
DE            Short=Psi55 synthase {ECO:0000255|HAMAP-Rule:MF_01080};
DE   AltName: Full=tRNA pseudouridylate synthase {ECO:0000255|HAMAP-Rule:MF_01080};
DE   AltName: Full=tRNA-uridine isomerase {ECO:0000255|HAMAP-Rule:MF_01080};
GN   Name=truB {ECO:0000255|HAMAP-Rule:MF_01080};
GN   OrderedLocusNames=Tola_2244;
OS   Tolumonas auensis (strain DSM 9187 / TA4).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Aeromonadales;
OC   Aeromonadaceae; Tolumonas.
OX   NCBI_TaxID=595494;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 9187 / TA4;
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T.,
RA   Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Mikhailova N., Spring S., Beller H.;
RT   "Complete sequence of Tolumonas auensis DSM 9187.";
RL   Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Responsible for synthesis of pseudouridine from uracil-
CC       55 in the psi GC loop of transfer RNAs. {ECO:0000255|HAMAP-
CC       Rule:MF_01080}.
CC   -!- CATALYTIC ACTIVITY: tRNA uridine(55) = tRNA pseudouridine(55).
CC       {ECO:0000255|HAMAP-Rule:MF_01080}.
CC   -!- SIMILARITY: Belongs to the pseudouridine synthase TruB family.
CC       Type 1 subfamily. {ECO:0000255|HAMAP-Rule:MF_01080}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; CP001616; ACQ93842.1; -; Genomic_DNA.
DR   RefSeq; YP_002893428.1; NC_012691.1.
DR   ProteinModelPortal; C4L8X2; -.
DR   STRING; 595494.Tola_2244; -.
DR   EnsemblBacteria; ACQ93842; ACQ93842; Tola_2244.
DR   GeneID; 7886008; -.
DR   KEGG; tau:Tola_2244; -.
DR   PATRIC; 23981133; VBITolAue42623_2228.
DR   eggNOG; COG0130; -.
DR   HOGENOM; HOG000231223; -.
DR   KO; K03177; -.
DR   OMA; KINTANI; -.
DR   OrthoDB; EOG6358D3; -.
DR   BioCyc; TAUE595494:GHEF-2311-MONOMER; -.
DR   GO; GO:0009982; F:pseudouridine synthase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0031119; P:tRNA pseudouridine synthesis; IEA:UniProtKB-HAMAP.
DR   Gene3D; 2.30.130.10; -; 1.
DR   HAMAP; MF_01080; TruB_bact; 1.
DR   InterPro; IPR002501; PsdUridine_synth.
DR   InterPro; IPR020103; PsdUridine_synth_cat_dom.
DR   InterPro; IPR015947; PUA-like_domain.
DR   InterPro; IPR014780; tRNA_psdUridine_synth_TruB.
DR   InterPro; IPR015240; tRNA_sdUridine_synth_fam1_C.
DR   PANTHER; PTHR13767; PTHR13767; 1.
DR   Pfam; PF09157; TruB-C_2; 1.
DR   Pfam; PF01509; TruB_N; 1.
DR   SUPFAM; SSF55120; SSF55120; 1.
DR   SUPFAM; SSF88697; SSF88697; 1.
DR   TIGRFAMs; TIGR00431; TruB; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Isomerase; Reference proteome; tRNA processing.
FT   CHAIN         1    324       tRNA pseudouridine synthase B.
FT                                /FTId=PRO_1000213509.
FT   ACT_SITE     49     49       Nucleophile. {ECO:0000255|HAMAP-
FT                                Rule:MF_01080}.
SQ   SEQUENCE   324 AA;  35870 MW;  1F1745403CC12588 CRC64;
     MSRRRRFKGR DVHGIILLDK PGGITSNDAL QQVKRIYNAA KAGHTGALDP LATGMLPICF
     GEATKFSQFL LDADKRYQVT ARLGVRTDTS DSEGSVVSVR PVDVSEDQLA QALDKFRGDI
     MQVPSMFSAL KHQGRPLYEY AREGIEIERE ARPITIYSLE LKAFSGEEIS LEVHCSKGTY
     IRSLIDDLGE LLGCGAHVIQ LRRTQVACYP NDKMLNLEKL NEILDECREQ GVPPRERLDQ
     YLLPMDSAVY SLPEVNMPPV LAAYVTQGQA VMVPHAPIEG FVRMTVGPEA EFIGVGEIDD
     DGKVAPRRLV RIGGDMPDAE EQAE
//
DBGET integrated database retrieval system