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Database: UniProt/SWISS-PROT
Entry: TRY1_BOVIN
LinkDB: TRY1_BOVIN
Original site: TRY1_BOVIN 
ID   TRY1_BOVIN              Reviewed;         246 AA.
AC   P00760; A6H6Y3;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 3.
DT   27-SEP-2017, entry version 189.
DE   RecName: Full=Cationic trypsin;
DE            EC=3.4.21.4;
DE   AltName: Full=Beta-trypsin;
DE   Contains:
DE     RecName: Full=Alpha-trypsin chain 1;
DE   Contains:
DE     RecName: Full=Alpha-trypsin chain 2;
DE   Flags: Precursor;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal pancreas;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 4-246.
RC   TISSUE=Pancreas;
RA   Okajima T., Maniwa M., Nagao S., Fujikawa H., Goto S.;
RL   Submitted (OCT-1994) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   PROTEIN SEQUENCE OF 18-246, AND DISULFIDE BONDS.
RX   PubMed=5967094; DOI=10.1016/0006-291X(66)90162-8;
RA   Mikes O., Holeysovsky V., Tomasek V., Sorm F.;
RT   "Covalent structure of bovine trypsinogen. The position of the
RT   remaining amides.";
RL   Biochem. Biophys. Res. Commun. 24:346-352(1966).
RN   [4]
RP   SEQUENCE REVISION.
RX   PubMed=4399051; DOI=10.1098/rstb.1970.0010;
RA   Hartley B.S.;
RT   "Homologies in serine proteinases.";
RL   Philos. Trans. R. Soc. Lond., B, Biol. Sci. 257:77-87(1970).
RN   [5]
RP   SEQUENCE REVISION.
RX   PubMed=1092332; DOI=10.1021/bi00678a003;
RA   Titani K., Ericsson L.H., Neurath H., Walsh K.A.;
RT   "Amino acid sequence of dogfish trypsin.";
RL   Biochemistry 14:1358-1366(1975).
RN   [6]
RP   ABSENCE OF SULFATED TYROSINE.
RX   PubMed=17087724; DOI=10.1111/j.1742-4658.2006.05501.x;
RA   Sahin-Toth M., Kukor Z., Nemoda Z.;
RT   "Human cationic trypsinogen is sulfated on Tyr154.";
RL   FEBS J. 273:5044-5050(2006).
RN   [7]
RP   DISULFIDE BONDS.
RX   PubMed=5892911; DOI=10.1016/S0022-2836(65)80340-0;
RA   Kauffman D.L.;
RT   "The disulphide bridges of trypsin.";
RL   J. Mol. Biol. 12:929-932(1965).
RN   [8]
RP   X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF CALCIUM-BINDING SITE.
RX   PubMed=512; DOI=10.1016/S0022-2836(75)80005-2;
RA   Bode W., Schwager P.;
RT   "The refined crystal structure of bovine beta-trypsin at 1.8-A
RT   resolution. II. Crystallographic refinement, calcium binding site,
RT   benzamidine binding site and active site at pH 7.0.";
RL   J. Mol. Biol. 98:693-717(1975).
RN   [9]
RP   X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS).
RX   PubMed=556951; DOI=10.1021/bi00623a016;
RA   Kossiakoff A.A., Chambers J.L., Kay L.M., Stroud R.M.;
RT   "Structure of bovine trypsinogen at 1.9-A resolution.";
RL   Biochemistry 16:654-664(1977).
RN   [10]
RP   X-RAY CRYSTALLOGRAPHY (1.56 ANGSTROMS) OF 24-246 IN COMPLEX WITH
RP   V.HEDERIFOLIA TRYPSIN INHIBITOR, AND DISULFIDE BONDS.
RX   PubMed=17640870; DOI=10.1074/jbc.M703871200;
RA   Conners R., Konarev A.V., Forsyth J., Lovegrove A., Marsh J.,
RA   Joseph-Horne T., Shewry P., Brady R.L.;
RT   "An unusual helix-turn-helix protease inhibitory motif in a novel
RT   trypsin inhibitor from seeds of Veronica (Veronica hederifolia L.).";
RL   J. Biol. Chem. 282:27760-27768(2007).
RN   [11]
RP   X-RAY CRYSTALLOGRAPHY (1.64 ANGSTROMS) OF 24-246 IN COMPLEX WITH THE
RP   SNAKE VENOM PROTEASE INHIBITOR TEXTILININ-1, DISULFIDE BONDS, AND
RP   METAL-BINDING SITES GLU-75; ASN-77; VAL-80 AND GLU-85.
RX   PubMed=23335990; DOI=10.1371/journal.pone.0054104;
RA   Millers E.K., Johnson L.A., Birrell G.W., Masci P.P., Lavin M.F.,
RA   de Jersey J., Guddat L.W.;
RT   "The structure of human microplasmin in complex with textilinin-1, an
RT   aprotinin-like inhibitor from the Australian brown snake.";
RL   PLoS ONE 8:E54104-E54104(2013).
CC   -!- CATALYTIC ACTIVITY: Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.
CC   -!- COFACTOR:
CC       Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC       Note=Binds 1 Ca(2+) ion per subunit.;
CC   -!- INTERACTION:
CC       P00974:-; NbExp=5; IntAct=EBI-986385, EBI-1032263;
CC       P01009:SERPINA1 (xeno); NbExp=5; IntAct=EBI-986385, EBI-986224;
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space.
CC   -!- TISSUE SPECIFICITY: Synthesized in the acinar cells of the
CC       pancreas.
CC   -!- PTM: Autocatalytic cleavage after Lys-23 leads to beta-trypsin by
CC       releasing a terminal hexapeptide. Subsequent cleavage after Lys-
CC       148 leads to alpha-trypsin. Further cleavage after Lys-193 yields
CC       pseudotrypsin. A cleavage may also occur after Arg-122.
CC   -!- PTM: Not sulfated on tyrosine residue(s).
CC   -!- SIMILARITY: Belongs to the peptidase S1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00274}.
CC   -!- WEB RESOURCE: Name=Worthington enzyme manual;
CC       URL="http://www.worthington-biochem.com/TRY/";
DR   EMBL; BC134797; AAI34798.1; -; mRNA.
DR   EMBL; BC146041; AAI46042.1; -; mRNA.
DR   EMBL; D38507; BAA07516.1; -; mRNA.
DR   PIR; A90164; TRBOTR.
DR   RefSeq; NP_001107199.1; NM_001113727.1.
DR   RefSeq; XP_002687054.3; XM_002687008.5.
DR   RefSeq; XP_871686.4; XM_866593.7.
DR   UniGene; Bt.91423; -.
DR   PDB; 1AQ7; X-ray; 2.20 A; A=24-246.
DR   PDB; 1AUJ; X-ray; 2.10 A; A=24-246.
DR   PDB; 1AZ8; X-ray; 1.80 A; A=24-246.
DR   PDB; 1BJU; X-ray; 1.80 A; A=24-246.
DR   PDB; 1BJV; X-ray; 1.80 A; A=24-246.
DR   PDB; 1BTP; X-ray; 2.20 A; A=18-246.
DR   PDB; 1BTW; X-ray; 1.70 A; A=18-246.
DR   PDB; 1BTX; X-ray; 1.70 A; A=18-246.
DR   PDB; 1BTY; X-ray; 1.50 A; A=18-246.
DR   PDB; 1BTZ; X-ray; 2.00 A; A=18-246.
DR   PDB; 1C1N; X-ray; 1.40 A; A=24-246.
DR   PDB; 1C1O; X-ray; 1.40 A; A=24-246.
DR   PDB; 1C1P; X-ray; 1.37 A; A=24-246.
DR   PDB; 1C1Q; X-ray; 1.37 A; A=24-246.
DR   PDB; 1C1R; X-ray; 1.37 A; A=24-246.
DR   PDB; 1C1S; X-ray; 1.63 A; A=24-246.
DR   PDB; 1C1T; X-ray; 1.37 A; A=24-246.
DR   PDB; 1C2D; X-ray; 1.65 A; A=24-246.
DR   PDB; 1C2E; X-ray; 1.65 A; A=24-246.
DR   PDB; 1C2F; X-ray; 1.70 A; A=24-246.
DR   PDB; 1C2G; X-ray; 1.65 A; A=24-246.
DR   PDB; 1C2H; X-ray; 1.40 A; A=24-246.
DR   PDB; 1C2I; X-ray; 1.47 A; A=24-246.
DR   PDB; 1C2J; X-ray; 1.40 A; A=24-246.
DR   PDB; 1C2K; X-ray; 1.65 A; A=24-246.
DR   PDB; 1C2L; X-ray; 1.50 A; A=24-246.
DR   PDB; 1C2M; X-ray; 1.40 A; A=24-246.
DR   PDB; 1C5P; X-ray; 1.43 A; A=24-246.
DR   PDB; 1C5Q; X-ray; 1.43 A; A=24-246.
DR   PDB; 1C5R; X-ray; 1.47 A; A=24-246.
DR   PDB; 1C5S; X-ray; 1.36 A; A=24-246.
DR   PDB; 1C5T; X-ray; 1.37 A; A=24-246.
DR   PDB; 1C5U; X-ray; 1.37 A; A=24-246.
DR   PDB; 1C5V; X-ray; 1.48 A; A=24-246.
DR   PDB; 1C9T; X-ray; 3.30 A; A/B/C/D/E/F=24-246.
DR   PDB; 1CE5; X-ray; 1.90 A; A=24-246.
DR   PDB; 1CU7; Model; -; A=24-246.
DR   PDB; 1CU8; Model; -; A=24-246.
DR   PDB; 1CU9; Model; -; A=24-246.
DR   PDB; 1D6R; X-ray; 2.30 A; A=24-246.
DR   PDB; 1EB2; X-ray; 2.00 A; A=24-246.
DR   PDB; 1EJM; X-ray; 1.85 A; A/C/E=24-246.
DR   PDB; 1EZX; X-ray; 2.60 A; C=4-246.
DR   PDB; 1F0T; X-ray; 1.80 A; A=4-246.
DR   PDB; 1F0U; X-ray; 1.90 A; A=4-246.
DR   PDB; 1F2S; X-ray; 1.79 A; E=24-246.
DR   PDB; 1G36; X-ray; 1.90 A; A=24-246.
DR   PDB; 1G3B; X-ray; 1.80 A; A=19-239.
DR   PDB; 1G3C; X-ray; 1.80 A; A=19-239.
DR   PDB; 1G3D; X-ray; 1.80 A; A=19-239.
DR   PDB; 1G3E; X-ray; 1.80 A; A=19-239.
DR   PDB; 1G9I; X-ray; 2.20 A; E=24-246.
DR   PDB; 1GBT; X-ray; 2.00 A; A=24-246.
DR   PDB; 1GHZ; X-ray; 1.39 A; A=24-246.
DR   PDB; 1GI0; X-ray; 1.42 A; A=24-239.
DR   PDB; 1GI1; X-ray; 1.42 A; A=24-246.
DR   PDB; 1GI2; X-ray; 1.38 A; A=24-246.
DR   PDB; 1GI3; X-ray; 1.44 A; A=24-246.
DR   PDB; 1GI4; X-ray; 1.37 A; A=24-246.
DR   PDB; 1GI5; X-ray; 1.60 A; A=24-246.
DR   PDB; 1GI6; X-ray; 1.49 A; A=24-246.
DR   PDB; 1GJ6; X-ray; 1.50 A; A=24-246.
DR   PDB; 1HJ9; X-ray; 0.95 A; A=24-246.
DR   PDB; 1J8A; X-ray; 1.21 A; A=24-246.
DR   PDB; 1JIR; X-ray; 2.00 A; A=24-246.
DR   PDB; 1JRS; X-ray; 1.80 A; A=24-246.
DR   PDB; 1JRT; X-ray; 1.70 A; A=24-246.
DR   PDB; 1K1I; X-ray; 2.20 A; A=24-246.
DR   PDB; 1K1J; X-ray; 2.20 A; A=24-246.
DR   PDB; 1K1L; X-ray; 2.50 A; A=24-246.
DR   PDB; 1K1M; X-ray; 2.20 A; A=24-246.
DR   PDB; 1K1N; X-ray; 2.00 A; A=24-246.
DR   PDB; 1K1O; X-ray; 2.00 A; A=24-246.
DR   PDB; 1K1P; X-ray; 1.90 A; A=24-246.
DR   PDB; 1LQE; X-ray; 2.20 A; A=4-246.
DR   PDB; 1MAX; X-ray; 1.80 A; A=24-246.
DR   PDB; 1MAY; X-ray; 1.80 A; A=24-246.
DR   PDB; 1MTS; X-ray; 1.90 A; A=24-246.
DR   PDB; 1MTU; X-ray; 1.90 A; A=24-246.
DR   PDB; 1MTV; X-ray; 1.90 A; A=24-246.
DR   PDB; 1MTW; X-ray; 1.90 A; A=24-246.
DR   PDB; 1N6X; X-ray; 1.40 A; A=24-246.
DR   PDB; 1N6Y; X-ray; 1.40 A; A=24-246.
DR   PDB; 1NC6; X-ray; 1.90 A; A=24-246.
DR   PDB; 1NTP; Neutron; 1.80 A; A=24-246.
DR   PDB; 1O2H; X-ray; 1.77 A; A=24-246.
DR   PDB; 1O2I; X-ray; 1.50 A; A=24-246.
DR   PDB; 1O2J; X-ray; 1.65 A; A=24-246.
DR   PDB; 1O2K; X-ray; 1.63 A; A=24-246.
DR   PDB; 1O2L; X-ray; 1.68 A; A=24-246.
DR   PDB; 1O2M; X-ray; 1.69 A; A=24-246.
DR   PDB; 1O2N; X-ray; 1.50 A; A=24-246.
DR   PDB; 1O2O; X-ray; 1.63 A; A=24-246.
DR   PDB; 1O2P; X-ray; 1.47 A; A=24-246.
DR   PDB; 1O2Q; X-ray; 1.50 A; A=24-246.
DR   PDB; 1O2R; X-ray; 1.45 A; A=24-246.
DR   PDB; 1O2S; X-ray; 1.65 A; A=24-246.
DR   PDB; 1O2T; X-ray; 1.62 A; A=24-246.
DR   PDB; 1O2U; X-ray; 1.41 A; A=24-246.
DR   PDB; 1O2V; X-ray; 1.50 A; A=24-246.
DR   PDB; 1O2W; X-ray; 1.38 A; A=24-246.
DR   PDB; 1O2X; X-ray; 1.46 A; A=24-246.
DR   PDB; 1O2Y; X-ray; 1.45 A; A=24-246.
DR   PDB; 1O2Z; X-ray; 1.65 A; A=24-246.
DR   PDB; 1O30; X-ray; 1.55 A; A=24-246.
DR   PDB; 1O31; X-ray; 1.66 A; A=24-246.
DR   PDB; 1O32; X-ray; 1.78 A; A=24-246.
DR   PDB; 1O33; X-ray; 1.46 A; A=24-246.
DR   PDB; 1O34; X-ray; 1.50 A; A=24-246.
DR   PDB; 1O35; X-ray; 1.41 A; A=24-246.
DR   PDB; 1O36; X-ray; 1.70 A; A=24-246.
DR   PDB; 1O37; X-ray; 1.45 A; A=24-246.
DR   PDB; 1O38; X-ray; 1.38 A; A=24-246.
DR   PDB; 1O39; X-ray; 1.59 A; A=24-246.
DR   PDB; 1O3A; X-ray; 2.00 A; A=24-246.
DR   PDB; 1O3B; X-ray; 1.75 A; A=24-246.
DR   PDB; 1O3C; X-ray; 1.64 A; A=24-246.
DR   PDB; 1O3D; X-ray; 1.33 A; A=24-246.
DR   PDB; 1O3E; X-ray; 1.64 A; A=24-246.
DR   PDB; 1O3F; X-ray; 1.55 A; A=24-246.
DR   PDB; 1O3G; X-ray; 1.55 A; A=24-246.
DR   PDB; 1O3H; X-ray; 1.53 A; A=24-246.
DR   PDB; 1O3I; X-ray; 1.51 A; A=24-246.
DR   PDB; 1O3J; X-ray; 1.40 A; A=24-246.
DR   PDB; 1O3K; X-ray; 1.43 A; A=24-246.
DR   PDB; 1O3L; X-ray; 1.40 A; A=24-246.
DR   PDB; 1O3M; X-ray; 1.55 A; A=24-246.
DR   PDB; 1O3N; X-ray; 1.55 A; A=24-246.
DR   PDB; 1O3O; X-ray; 1.55 A; A=24-246.
DR   PDB; 1OPH; X-ray; 2.30 A; B=4-246.
DR   PDB; 1OX1; X-ray; 2.00 A; A=24-246.
DR   PDB; 1OYQ; X-ray; 1.90 A; A=24-239.
DR   PDB; 1P2I; X-ray; 1.65 A; A=24-246.
DR   PDB; 1P2J; X-ray; 1.35 A; A=24-246.
DR   PDB; 1P2K; X-ray; 1.60 A; A=24-246.
DR   PDB; 1PPC; X-ray; 1.80 A; E=24-246.
DR   PDB; 1PPE; X-ray; 2.00 A; E=24-246.
DR   PDB; 1PPH; X-ray; 1.90 A; E=24-246.
DR   PDB; 1QA0; X-ray; 1.80 A; A=24-246.
DR   PDB; 1QB1; X-ray; 1.80 A; A=24-246.
DR   PDB; 1QB6; X-ray; 1.80 A; A=24-246.
DR   PDB; 1QB9; X-ray; 1.80 A; A=24-246.
DR   PDB; 1QBN; X-ray; 1.80 A; A=24-246.
DR   PDB; 1QBO; X-ray; 1.80 A; A=24-246.
DR   PDB; 1QCP; X-ray; 1.80 A; A=24-246.
DR   PDB; 1QL7; X-ray; 2.10 A; A=24-246.
DR   PDB; 1QL8; X-ray; 3.00 A; A=24-246.
DR   PDB; 1RXP; X-ray; 1.70 A; A=24-239.
DR   PDB; 1S0Q; X-ray; 1.02 A; A=24-246.
DR   PDB; 1S0R; X-ray; 1.02 A; A=24-246.
DR   PDB; 1SBW; X-ray; 1.80 A; A=24-246.
DR   PDB; 1SFI; X-ray; 1.65 A; A=24-246.
DR   PDB; 1SMF; X-ray; 2.10 A; E=24-246.
DR   PDB; 1TAB; X-ray; 2.30 A; E=24-246.
DR   PDB; 1TAW; X-ray; 1.80 A; A=24-246.
DR   PDB; 1TGB; X-ray; 1.80 A; A=18-246.
DR   PDB; 1TGC; X-ray; 1.80 A; A=18-246.
DR   PDB; 1TGN; X-ray; 1.65 A; A=18-246.
DR   PDB; 1TGS; X-ray; 1.80 A; Z=18-246.
DR   PDB; 1TGT; X-ray; 1.70 A; A=18-246.
DR   PDB; 1TIO; X-ray; 1.93 A; A=24-246.
DR   PDB; 1TLD; X-ray; 1.50 A; A=24-246.
DR   PDB; 1TNG; X-ray; 1.80 A; A=18-246.
DR   PDB; 1TNH; X-ray; 1.80 A; A=18-246.
DR   PDB; 1TNI; X-ray; 1.90 A; A=18-246.
DR   PDB; 1TNJ; X-ray; 1.80 A; A=18-246.
DR   PDB; 1TNK; X-ray; 1.80 A; A=18-246.
DR   PDB; 1TNL; X-ray; 1.90 A; A=18-246.
DR   PDB; 1TPA; X-ray; 1.90 A; E=24-246.
DR   PDB; 1TPO; X-ray; 1.70 A; A=24-246.
DR   PDB; 1TPP; X-ray; 1.40 A; A=24-246.
DR   PDB; 1TPS; X-ray; 1.90 A; A=24-246.
DR   PDB; 1TX7; X-ray; 1.75 A; A=24-239.
DR   PDB; 1TX8; X-ray; 1.70 A; A=24-239.
DR   PDB; 1TYN; X-ray; 2.00 A; A=24-246.
DR   PDB; 1UTN; X-ray; 1.15 A; A=4-246.
DR   PDB; 1UTO; X-ray; 1.15 A; A=4-246.
DR   PDB; 1UTP; X-ray; 1.30 A; A=4-246.
DR   PDB; 1UTQ; X-ray; 1.15 A; A=4-246.
DR   PDB; 1V2J; X-ray; 1.90 A; T=24-246.
DR   PDB; 1V2K; X-ray; 2.00 A; T=24-246.
DR   PDB; 1V2L; X-ray; 1.60 A; T=24-246.
DR   PDB; 1V2M; X-ray; 1.65 A; T=24-246.
DR   PDB; 1V2N; X-ray; 1.80 A; T=24-246.
DR   PDB; 1V2O; X-ray; 1.62 A; T=24-246.
DR   PDB; 1V2P; X-ray; 1.92 A; T=24-246.
DR   PDB; 1V2Q; X-ray; 2.30 A; T=24-246.
DR   PDB; 1V2R; X-ray; 1.70 A; T=24-246.
DR   PDB; 1V2S; X-ray; 1.72 A; T=24-246.
DR   PDB; 1V2T; X-ray; 1.90 A; T=24-246.
DR   PDB; 1V2U; X-ray; 1.80 A; T=24-246.
DR   PDB; 1V2V; X-ray; 1.80 A; T=24-246.
DR   PDB; 1V2W; X-ray; 1.75 A; T=24-246.
DR   PDB; 1XUF; X-ray; 1.90 A; A=24-246.
DR   PDB; 1XUG; X-ray; 1.50 A; A=24-246.
DR   PDB; 1XUH; X-ray; 2.20 A; A=24-246.
DR   PDB; 1XUI; X-ray; 1.50 A; A=24-246.
DR   PDB; 1XUJ; X-ray; 1.92 A; A=24-246.
DR   PDB; 1XUK; X-ray; 1.80 A; A=24-246.
DR   PDB; 1Y3U; X-ray; 1.80 A; A=24-246.
DR   PDB; 1Y3V; X-ray; 1.60 A; A=24-246.
DR   PDB; 1Y3W; X-ray; 1.80 A; A=24-246.
DR   PDB; 1Y3X; X-ray; 1.70 A; A=24-239.
DR   PDB; 1Y3Y; X-ray; 1.75 A; A=24-239.
DR   PDB; 1Y59; X-ray; 1.20 A; T=24-246.
DR   PDB; 1Y5A; X-ray; 1.40 A; T=24-246.
DR   PDB; 1Y5B; X-ray; 1.65 A; T=24-246.
DR   PDB; 1Y5U; X-ray; 1.60 A; T=24-246.
DR   PDB; 1YP9; X-ray; 2.10 A; A=24-246.
DR   PDB; 1YYY; X-ray; 2.10 A; 1=24-246.
DR   PDB; 1ZR0; X-ray; 1.80 A; A/C=24-246.
DR   PDB; 1ZZZ; X-ray; 1.90 A; A=10-246.
DR   PDB; 2A7H; X-ray; 2.10 A; A=24-246.
DR   PDB; 2AGE; X-ray; 1.15 A; X=24-239.
DR   PDB; 2AGG; X-ray; 1.28 A; X=24-239.
DR   PDB; 2AGI; X-ray; 1.14 A; X=24-239.
DR   PDB; 2AH4; X-ray; 1.13 A; X=24-239.
DR   PDB; 2AYW; X-ray; 0.97 A; A=24-246.
DR   PDB; 2BLV; X-ray; 1.20 A; A=24-246.
DR   PDB; 2BLW; X-ray; 1.20 A; A=24-246.
DR   PDB; 2BTC; X-ray; 1.50 A; E=24-246.
DR   PDB; 2BY5; X-ray; 1.30 A; X=4-246.
DR   PDB; 2BY6; X-ray; 1.30 A; X=4-246.
DR   PDB; 2BY7; X-ray; 1.30 A; X=4-246.
DR   PDB; 2BY8; X-ray; 1.30 A; X=4-246.
DR   PDB; 2BY9; X-ray; 1.30 A; X=4-246.
DR   PDB; 2BYA; X-ray; 1.30 A; X=4-246.
DR   PDB; 2BZA; X-ray; 1.90 A; A=24-246.
DR   PDB; 2CMY; X-ray; 2.25 A; A=24-246.
DR   PDB; 2D8W; X-ray; 2.00 A; A=24-246.
DR   PDB; 2F3C; X-ray; 2.50 A; E=24-246.
DR   PDB; 2FI3; X-ray; 1.58 A; E=24-239.
DR   PDB; 2FI4; X-ray; 1.58 A; E=24-246.
DR   PDB; 2FI5; X-ray; 1.58 A; E=24-239.
DR   PDB; 2FTL; X-ray; 1.62 A; E=24-239.
DR   PDB; 2FTM; X-ray; 1.65 A; A=24-239.
DR   PDB; 2FX4; X-ray; 1.65 A; A=24-246.
DR   PDB; 2FX6; X-ray; 1.57 A; A=24-246.
DR   PDB; 2G55; X-ray; 1.82 A; A=24-246.
DR   PDB; 2G5N; X-ray; 1.51 A; A=24-246.
DR   PDB; 2G5V; X-ray; 1.45 A; A=24-246.
DR   PDB; 2G81; X-ray; 1.55 A; E=24-246.
DR   PDB; 2G8T; X-ray; 1.41 A; A=24-246.
DR   PDB; 2ILN; X-ray; 2.00 A; A/B=24-246.
DR   PDB; 2J9N; X-ray; 1.50 A; A=24-246.
DR   PDB; 2O9Q; X-ray; 1.70 A; A=24-246.
DR   PDB; 2OTV; X-ray; 1.56 A; A=24-246.
DR   PDB; 2OXS; X-ray; 1.32 A; A=24-246.
DR   PDB; 2PLX; X-ray; 1.56 A; A=24-246.
DR   PDB; 2PTC; X-ray; 1.90 A; E=24-246.
DR   PDB; 2PTN; X-ray; 1.55 A; A=24-246.
DR   PDB; 2QN5; X-ray; 3.00 A; T=24-246.
DR   PDB; 2QYI; X-ray; 2.60 A; A/C=24-246.
DR   PDB; 2TGA; X-ray; 1.80 A; A=18-246.
DR   PDB; 2TGD; X-ray; 2.10 A; A=18-246.
DR   PDB; 2TGP; X-ray; 1.90 A; Z=18-246.
DR   PDB; 2TGT; X-ray; 1.70 A; A=18-246.
DR   PDB; 2TIO; X-ray; 1.93 A; A=24-246.
DR   PDB; 2TLD; X-ray; 2.60 A; E=24-246.
DR   PDB; 2TPI; X-ray; 2.10 A; Z=18-246.
DR   PDB; 2UUY; X-ray; 1.15 A; A=24-246.
DR   PDB; 2XTT; X-ray; 0.93 A; B=24-246.
DR   PDB; 2ZDK; X-ray; 1.67 A; A=24-246.
DR   PDB; 2ZDL; X-ray; 1.80 A; A=24-246.
DR   PDB; 2ZDM; X-ray; 1.93 A; A=24-246.
DR   PDB; 2ZDN; X-ray; 1.98 A; A=24-246.
DR   PDB; 2ZFS; X-ray; 1.51 A; A=24-246.
DR   PDB; 2ZFT; X-ray; 1.76 A; A=24-246.
DR   PDB; 2ZHD; X-ray; 1.94 A; A=24-246.
DR   PDB; 2ZQ1; X-ray; 1.68 A; A=24-246.
DR   PDB; 2ZQ2; X-ray; 1.40 A; A=24-246.
DR   PDB; 3A7T; X-ray; 1.75 A; A=24-246.
DR   PDB; 3A7V; X-ray; 1.75 A; A=24-246.
DR   PDB; 3A7W; X-ray; 1.75 A; A=24-246.
DR   PDB; 3A7X; X-ray; 1.75 A; A=24-246.
DR   PDB; 3A7Y; X-ray; 1.81 A; A=24-246.
DR   PDB; 3A7Z; X-ray; 1.80 A; A=24-246.
DR   PDB; 3A80; X-ray; 1.75 A; A=24-246.
DR   PDB; 3A81; X-ray; 1.78 A; A=24-246.
DR   PDB; 3A82; X-ray; 1.75 A; A=24-246.
DR   PDB; 3A83; X-ray; 1.78 A; A=24-246.
DR   PDB; 3A84; X-ray; 1.75 A; A=24-246.
DR   PDB; 3A85; X-ray; 1.75 A; A=24-246.
DR   PDB; 3A86; X-ray; 1.75 A; A=24-246.
DR   PDB; 3A87; X-ray; 1.75 A; A=24-246.
DR   PDB; 3A88; X-ray; 1.75 A; A=24-246.
DR   PDB; 3A89; X-ray; 1.80 A; A=24-246.
DR   PDB; 3A8A; X-ray; 1.40 A; A=24-246.
DR   PDB; 3A8B; X-ray; 1.75 A; A=24-246.
DR   PDB; 3A8C; X-ray; 1.85 A; A=24-246.
DR   PDB; 3A8D; X-ray; 1.75 A; A=24-246.
DR   PDB; 3AAS; X-ray; 1.75 A; A=24-246.
DR   PDB; 3AAU; X-ray; 1.80 A; A=24-246.
DR   PDB; 3AAV; X-ray; 1.70 A; A/B=24-246.
DR   PDB; 3ATI; X-ray; 1.71 A; A=24-246.
DR   PDB; 3ATK; X-ray; 1.74 A; A=24-246.
DR   PDB; 3ATL; X-ray; 1.74 A; A=24-246.
DR   PDB; 3ATM; X-ray; 1.72 A; A=24-246.
DR   PDB; 3BTD; X-ray; 1.90 A; E=24-246.
DR   PDB; 3BTE; X-ray; 1.85 A; E=24-246.
DR   PDB; 3BTF; X-ray; 1.80 A; E=24-246.
DR   PDB; 3BTG; X-ray; 1.90 A; E=24-246.
DR   PDB; 3BTH; X-ray; 1.75 A; E=24-246.
DR   PDB; 3BTK; X-ray; 1.85 A; E=24-246.
DR   PDB; 3BTM; X-ray; 1.80 A; E=24-246.
DR   PDB; 3BTQ; X-ray; 1.90 A; E=24-246.
DR   PDB; 3BTT; X-ray; 1.90 A; E=24-246.
DR   PDB; 3BTW; X-ray; 2.05 A; E=24-246.
DR   PDB; 3D65; X-ray; 1.64 A; E=24-246.
DR   PDB; 3E8L; X-ray; 2.48 A; A/B=24-246.
DR   PDB; 3GY2; X-ray; 1.57 A; A=24-246.
DR   PDB; 3GY3; X-ray; 1.70 A; A=24-246.
DR   PDB; 3GY4; X-ray; 1.55 A; A=24-246.
DR   PDB; 3GY5; X-ray; 1.57 A; A=24-246.
DR   PDB; 3GY6; X-ray; 1.70 A; A=24-246.
DR   PDB; 3GY7; X-ray; 1.55 A; A=24-246.
DR   PDB; 3GY8; X-ray; 1.75 A; A=24-246.
DR   PDB; 3I29; X-ray; 2.40 A; A=24-246.
DR   PDB; 3ITI; X-ray; 1.55 A; A=24-246.
DR   PDB; 3LJJ; X-ray; 1.55 A; A=24-246.
DR   PDB; 3LJO; X-ray; 1.50 A; A=24-246.
DR   PDB; 3M35; X-ray; 2.20 A; A=24-246.
DR   PDB; 3M7Q; X-ray; 1.70 A; A=24-246.
DR   PDB; 3MFJ; X-ray; 0.80 A; A=24-246.
DR   PDB; 3MI4; X-ray; 0.80 A; A=24-246.
DR   PDB; 3NK8; X-ray; 1.15 A; A=24-246.
DR   PDB; 3NKK; X-ray; 1.12 A; A=24-246.
DR   PDB; 3OTJ; Other; 2.15 A; E=24-246.
DR   PDB; 3PLB; X-ray; 1.18 A; A=24-246.
DR   PDB; 3PLK; X-ray; 1.53 A; A=24-246.
DR   PDB; 3PLP; X-ray; 1.63 A; A=24-246.
DR   PDB; 3PM3; X-ray; 1.53 A; A=24-246.
DR   PDB; 3PMJ; X-ray; 1.45 A; A=24-246.
DR   PDB; 3PTB; X-ray; 1.70 A; A=24-246.
DR   PDB; 3PTN; X-ray; 1.70 A; A=24-246.
DR   PDB; 3PWB; X-ray; 1.63 A; A=24-246.
DR   PDB; 3PWC; X-ray; 1.60 A; A=24-246.
DR   PDB; 3PYH; X-ray; 2.00 A; A=24-246.
DR   PDB; 3Q00; X-ray; 1.70 A; A=24-246.
DR   PDB; 3QK1; X-ray; 2.08 A; A=24-246.
DR   PDB; 3RDZ; X-ray; 2.26 A; A/B=24-246.
DR   PDB; 3RU4; X-ray; 1.68 A; T=24-246.
DR   PDB; 3RXA; X-ray; 1.70 A; A=24-246.
DR   PDB; 3RXB; X-ray; 1.70 A; A=24-246.
DR   PDB; 3RXC; X-ray; 1.70 A; A=24-246.
DR   PDB; 3RXD; X-ray; 1.70 A; A=24-246.
DR   PDB; 3RXE; X-ray; 1.70 A; A=24-246.
DR   PDB; 3RXF; X-ray; 1.70 A; A=24-246.
DR   PDB; 3RXG; X-ray; 1.70 A; A=24-246.
DR   PDB; 3RXH; X-ray; 1.70 A; A=24-246.
DR   PDB; 3RXI; X-ray; 1.60 A; A=24-246.
DR   PDB; 3RXJ; X-ray; 1.70 A; A=24-246.
DR   PDB; 3RXK; X-ray; 1.60 A; A=24-246.
DR   PDB; 3RXL; X-ray; 1.70 A; A=24-246.
DR   PDB; 3RXM; X-ray; 1.70 A; A=24-246.
DR   PDB; 3RXO; X-ray; 1.60 A; A=24-246.
DR   PDB; 3RXP; X-ray; 1.60 A; A=24-246.
DR   PDB; 3RXQ; X-ray; 1.68 A; A=24-246.
DR   PDB; 3RXR; X-ray; 1.72 A; A=24-246.
DR   PDB; 3RXS; X-ray; 1.74 A; A=24-246.
DR   PDB; 3RXT; X-ray; 1.70 A; A=24-246.
DR   PDB; 3RXU; X-ray; 1.68 A; A=24-246.
DR   PDB; 3RXV; X-ray; 1.70 A; A=24-246.
DR   PDB; 3T25; X-ray; 1.70 A; A=24-246.
DR   PDB; 3T26; X-ray; 1.70 A; A=24-246.
DR   PDB; 3T27; X-ray; 1.95 A; A=24-246.
DR   PDB; 3T28; X-ray; 2.80 A; A=24-246.
DR   PDB; 3T29; X-ray; 1.75 A; A=24-246.
DR   PDB; 3TPI; X-ray; 1.90 A; Z=18-246.
DR   PDB; 3UNQ; X-ray; 1.62 A; A=24-246.
DR   PDB; 3UNR; X-ray; 1.20 A; A=24-246.
DR   PDB; 3UNS; X-ray; 1.80 A; A=24-246.
DR   PDB; 3UOP; X-ray; 1.69 A; A=24-246.
DR   PDB; 3UPE; X-ray; 1.54 A; A=24-246.
DR   PDB; 3UQO; X-ray; 1.80 A; A=24-246.
DR   PDB; 3UQV; X-ray; 2.40 A; A=24-246.
DR   PDB; 3UUZ; X-ray; 2.10 A; A/B=24-246.
DR   PDB; 3UWI; X-ray; 1.43 A; A=24-246.
DR   PDB; 3UY9; X-ray; 3.22 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P=24-246.
DR   PDB; 3V0X; X-ray; 1.90 A; A=24-246.
DR   PDB; 3V12; X-ray; 1.80 A; A=24-246.
DR   PDB; 3V13; X-ray; 1.63 A; A=24-246.
DR   PDB; 3VEQ; X-ray; 2.25 A; B=24-246.
DR   PDB; 3VPK; X-ray; 1.94 A; A=24-246.
DR   PDB; 4AB8; X-ray; 1.60 A; A=24-246.
DR   PDB; 4AB9; X-ray; 1.20 A; A=24-246.
DR   PDB; 4ABA; X-ray; 1.25 A; A=24-246.
DR   PDB; 4ABB; X-ray; 1.25 A; A=24-246.
DR   PDB; 4ABD; X-ray; 1.25 A; A=24-246.
DR   PDB; 4ABE; X-ray; 1.30 A; A=24-246.
DR   PDB; 4ABF; X-ray; 1.30 A; A=24-246.
DR   PDB; 4ABG; X-ray; 1.52 A; A=24-246.
DR   PDB; 4ABH; X-ray; 1.25 A; A=24-246.
DR   PDB; 4ABI; X-ray; 1.55 A; A=24-246.
DR   PDB; 4ABJ; X-ray; 1.45 A; A=24-246.
DR   PDB; 4AOQ; X-ray; 2.00 A; A/B/C=24-246.
DR   PDB; 4AOR; X-ray; 1.70 A; A/B/C=24-246.
DR   PDB; 4B1T; X-ray; 1.78 A; A/C=24-246.
DR   PDB; 4B2A; X-ray; 1.89 A; A/C=24-246.
DR   PDB; 4B2B; X-ray; 1.36 A; A/C=24-246.
DR   PDB; 4B2C; X-ray; 1.43 A; A/C=24-246.
DR   PDB; 4GUX; X-ray; 1.80 A; A/B/C=1-246.
DR   PDB; 4HGC; X-ray; 1.29 A; A=24-246.
DR   PDB; 4I8G; X-ray; 0.80 A; A=24-239.
DR   PDB; 4I8H; X-ray; 0.75 A; A=24-239.
DR   PDB; 4I8J; X-ray; 0.87 A; A=24-239.
DR   PDB; 4I8K; X-ray; 0.85 A; A=24-239.
DR   PDB; 4I8L; X-ray; 0.87 A; A=24-239.
DR   PDB; 4J2Y; X-ray; 2.00 A; B=24-246.
DR   PDB; 4KTS; X-ray; 1.30 A; A=24-246.
DR   PDB; 4KTU; X-ray; 1.35 A; A=24-246.
DR   PDB; 4MTB; X-ray; 1.22 A; A=24-246.
DR   PDB; 4NCY; X-ray; 1.42 A; A=24-246.
DR   PDB; 4NIV; X-ray; 1.00 A; A=24-246.
DR   PDB; 4NIW; X-ray; 1.31 A; A=24-246.
DR   PDB; 4NIX; X-ray; 1.30 A; A=24-246.
DR   PDB; 4NIY; X-ray; 2.84 A; A/B/C/D=24-246.
DR   PDB; 4TPI; X-ray; 2.20 A; Z=18-246.
DR   PDB; 4TPY; X-ray; 1.30 A; A=24-246.
DR   PDB; 4U2W; X-ray; 1.00 A; A=24-246.
DR   PDB; 4XOJ; X-ray; 0.91 A; A=1-246.
DR   PDB; 4Y0Y; X-ray; 1.25 A; E=24-246.
DR   PDB; 4Y0Z; X-ray; 1.37 A; E=24-246.
DR   PDB; 4Y10; X-ray; 1.37 A; E=24-246.
DR   PDB; 4Y11; X-ray; 1.30 A; E=24-246.
DR   PDB; 4YTA; X-ray; 1.20 A; A=24-246.
DR   PDB; 5EG4; X-ray; 1.32 A; A=24-246.
DR   PDB; 5F6M; X-ray; 1.10 A; A=24-246.
DR   PDB; 5FXL; X-ray; 1.78 A; A=1-246.
DR   PDB; 5GIB; X-ray; 2.70 A; A/B=24-246.
DR   PDB; 5GXP; X-ray; 2.80 A; A/B=24-246.
DR   PDB; 5JYI; X-ray; 1.91 A; A=1-246.
DR   PDB; 5K7R; EM; 1.70 A; A=24-246.
DR   PDB; 5LGO; X-ray; 1.12 A; A=24-246.
DR   PDB; 5LH8; X-ray; 1.54 A; A=24-246.
DR   PDB; 5MN1; X-ray; 0.79 A; A=24-246.
DR   PDB; 5MNA; X-ray; 1.44 A; A=24-246.
DR   PDB; 5MNB; X-ray; 0.94 A; A=24-246.
DR   PDB; 5MNC; X-ray; 0.92 A; A=24-246.
DR   PDB; 5MNX; Neutron; 1.42 A; A=24-246.
DR   PDB; 5MNY; Neutron; 1.43 A; A=24-246.
DR   PDB; 5MON; Other; 0.94 A; A=24-246.
DR   PDB; 5MOO; Other; 1.44 A; A=24-246.
DR   PDB; 5PTP; X-ray; 1.34 A; A=24-246.
DR   PDB; 5T3H; X-ray; 1.55 A; A=24-246.
DR   PDBsum; 1AQ7; -.
DR   PDBsum; 1AUJ; -.
DR   PDBsum; 1AZ8; -.
DR   PDBsum; 1BJU; -.
DR   PDBsum; 1BJV; -.
DR   PDBsum; 1BTP; -.
DR   PDBsum; 1BTW; -.
DR   PDBsum; 1BTX; -.
DR   PDBsum; 1BTY; -.
DR   PDBsum; 1BTZ; -.
DR   PDBsum; 1C1N; -.
DR   PDBsum; 1C1O; -.
DR   PDBsum; 1C1P; -.
DR   PDBsum; 1C1Q; -.
DR   PDBsum; 1C1R; -.
DR   PDBsum; 1C1S; -.
DR   PDBsum; 1C1T; -.
DR   PDBsum; 1C2D; -.
DR   PDBsum; 1C2E; -.
DR   PDBsum; 1C2F; -.
DR   PDBsum; 1C2G; -.
DR   PDBsum; 1C2H; -.
DR   PDBsum; 1C2I; -.
DR   PDBsum; 1C2J; -.
DR   PDBsum; 1C2K; -.
DR   PDBsum; 1C2L; -.
DR   PDBsum; 1C2M; -.
DR   PDBsum; 1C5P; -.
DR   PDBsum; 1C5Q; -.
DR   PDBsum; 1C5R; -.
DR   PDBsum; 1C5S; -.
DR   PDBsum; 1C5T; -.
DR   PDBsum; 1C5U; -.
DR   PDBsum; 1C5V; -.
DR   PDBsum; 1C9T; -.
DR   PDBsum; 1CE5; -.
DR   PDBsum; 1CU7; -.
DR   PDBsum; 1CU8; -.
DR   PDBsum; 1CU9; -.
DR   PDBsum; 1D6R; -.
DR   PDBsum; 1EB2; -.
DR   PDBsum; 1EJM; -.
DR   PDBsum; 1EZX; -.
DR   PDBsum; 1F0T; -.
DR   PDBsum; 1F0U; -.
DR   PDBsum; 1F2S; -.
DR   PDBsum; 1G36; -.
DR   PDBsum; 1G3B; -.
DR   PDBsum; 1G3C; -.
DR   PDBsum; 1G3D; -.
DR   PDBsum; 1G3E; -.
DR   PDBsum; 1G9I; -.
DR   PDBsum; 1GBT; -.
DR   PDBsum; 1GHZ; -.
DR   PDBsum; 1GI0; -.
DR   PDBsum; 1GI1; -.
DR   PDBsum; 1GI2; -.
DR   PDBsum; 1GI3; -.
DR   PDBsum; 1GI4; -.
DR   PDBsum; 1GI5; -.
DR   PDBsum; 1GI6; -.
DR   PDBsum; 1GJ6; -.
DR   PDBsum; 1HJ9; -.
DR   PDBsum; 1J8A; -.
DR   PDBsum; 1JIR; -.
DR   PDBsum; 1JRS; -.
DR   PDBsum; 1JRT; -.
DR   PDBsum; 1K1I; -.
DR   PDBsum; 1K1J; -.
DR   PDBsum; 1K1L; -.
DR   PDBsum; 1K1M; -.
DR   PDBsum; 1K1N; -.
DR   PDBsum; 1K1O; -.
DR   PDBsum; 1K1P; -.
DR   PDBsum; 1LQE; -.
DR   PDBsum; 1MAX; -.
DR   PDBsum; 1MAY; -.
DR   PDBsum; 1MTS; -.
DR   PDBsum; 1MTU; -.
DR   PDBsum; 1MTV; -.
DR   PDBsum; 1MTW; -.
DR   PDBsum; 1N6X; -.
DR   PDBsum; 1N6Y; -.
DR   PDBsum; 1NC6; -.
DR   PDBsum; 1NTP; -.
DR   PDBsum; 1O2H; -.
DR   PDBsum; 1O2I; -.
DR   PDBsum; 1O2J; -.
DR   PDBsum; 1O2K; -.
DR   PDBsum; 1O2L; -.
DR   PDBsum; 1O2M; -.
DR   PDBsum; 1O2N; -.
DR   PDBsum; 1O2O; -.
DR   PDBsum; 1O2P; -.
DR   PDBsum; 1O2Q; -.
DR   PDBsum; 1O2R; -.
DR   PDBsum; 1O2S; -.
DR   PDBsum; 1O2T; -.
DR   PDBsum; 1O2U; -.
DR   PDBsum; 1O2V; -.
DR   PDBsum; 1O2W; -.
DR   PDBsum; 1O2X; -.
DR   PDBsum; 1O2Y; -.
DR   PDBsum; 1O2Z; -.
DR   PDBsum; 1O30; -.
DR   PDBsum; 1O31; -.
DR   PDBsum; 1O32; -.
DR   PDBsum; 1O33; -.
DR   PDBsum; 1O34; -.
DR   PDBsum; 1O35; -.
DR   PDBsum; 1O36; -.
DR   PDBsum; 1O37; -.
DR   PDBsum; 1O38; -.
DR   PDBsum; 1O39; -.
DR   PDBsum; 1O3A; -.
DR   PDBsum; 1O3B; -.
DR   PDBsum; 1O3C; -.
DR   PDBsum; 1O3D; -.
DR   PDBsum; 1O3E; -.
DR   PDBsum; 1O3F; -.
DR   PDBsum; 1O3G; -.
DR   PDBsum; 1O3H; -.
DR   PDBsum; 1O3I; -.
DR   PDBsum; 1O3J; -.
DR   PDBsum; 1O3K; -.
DR   PDBsum; 1O3L; -.
DR   PDBsum; 1O3M; -.
DR   PDBsum; 1O3N; -.
DR   PDBsum; 1O3O; -.
DR   PDBsum; 1OPH; -.
DR   PDBsum; 1OX1; -.
DR   PDBsum; 1OYQ; -.
DR   PDBsum; 1P2I; -.
DR   PDBsum; 1P2J; -.
DR   PDBsum; 1P2K; -.
DR   PDBsum; 1PPC; -.
DR   PDBsum; 1PPE; -.
DR   PDBsum; 1PPH; -.
DR   PDBsum; 1QA0; -.
DR   PDBsum; 1QB1; -.
DR   PDBsum; 1QB6; -.
DR   PDBsum; 1QB9; -.
DR   PDBsum; 1QBN; -.
DR   PDBsum; 1QBO; -.
DR   PDBsum; 1QCP; -.
DR   PDBsum; 1QL7; -.
DR   PDBsum; 1QL8; -.
DR   PDBsum; 1RXP; -.
DR   PDBsum; 1S0Q; -.
DR   PDBsum; 1S0R; -.
DR   PDBsum; 1SBW; -.
DR   PDBsum; 1SFI; -.
DR   PDBsum; 1SMF; -.
DR   PDBsum; 1TAB; -.
DR   PDBsum; 1TAW; -.
DR   PDBsum; 1TGB; -.
DR   PDBsum; 1TGC; -.
DR   PDBsum; 1TGN; -.
DR   PDBsum; 1TGS; -.
DR   PDBsum; 1TGT; -.
DR   PDBsum; 1TIO; -.
DR   PDBsum; 1TLD; -.
DR   PDBsum; 1TNG; -.
DR   PDBsum; 1TNH; -.
DR   PDBsum; 1TNI; -.
DR   PDBsum; 1TNJ; -.
DR   PDBsum; 1TNK; -.
DR   PDBsum; 1TNL; -.
DR   PDBsum; 1TPA; -.
DR   PDBsum; 1TPO; -.
DR   PDBsum; 1TPP; -.
DR   PDBsum; 1TPS; -.
DR   PDBsum; 1TX7; -.
DR   PDBsum; 1TX8; -.
DR   PDBsum; 1TYN; -.
DR   PDBsum; 1UTN; -.
DR   PDBsum; 1UTO; -.
DR   PDBsum; 1UTP; -.
DR   PDBsum; 1UTQ; -.
DR   PDBsum; 1V2J; -.
DR   PDBsum; 1V2K; -.
DR   PDBsum; 1V2L; -.
DR   PDBsum; 1V2M; -.
DR   PDBsum; 1V2N; -.
DR   PDBsum; 1V2O; -.
DR   PDBsum; 1V2P; -.
DR   PDBsum; 1V2Q; -.
DR   PDBsum; 1V2R; -.
DR   PDBsum; 1V2S; -.
DR   PDBsum; 1V2T; -.
DR   PDBsum; 1V2U; -.
DR   PDBsum; 1V2V; -.
DR   PDBsum; 1V2W; -.
DR   PDBsum; 1XUF; -.
DR   PDBsum; 1XUG; -.
DR   PDBsum; 1XUH; -.
DR   PDBsum; 1XUI; -.
DR   PDBsum; 1XUJ; -.
DR   PDBsum; 1XUK; -.
DR   PDBsum; 1Y3U; -.
DR   PDBsum; 1Y3V; -.
DR   PDBsum; 1Y3W; -.
DR   PDBsum; 1Y3X; -.
DR   PDBsum; 1Y3Y; -.
DR   PDBsum; 1Y59; -.
DR   PDBsum; 1Y5A; -.
DR   PDBsum; 1Y5B; -.
DR   PDBsum; 1Y5U; -.
DR   PDBsum; 1YP9; -.
DR   PDBsum; 1YYY; -.
DR   PDBsum; 1ZR0; -.
DR   PDBsum; 1ZZZ; -.
DR   PDBsum; 2A7H; -.
DR   PDBsum; 2AGE; -.
DR   PDBsum; 2AGG; -.
DR   PDBsum; 2AGI; -.
DR   PDBsum; 2AH4; -.
DR   PDBsum; 2AYW; -.
DR   PDBsum; 2BLV; -.
DR   PDBsum; 2BLW; -.
DR   PDBsum; 2BTC; -.
DR   PDBsum; 2BY5; -.
DR   PDBsum; 2BY6; -.
DR   PDBsum; 2BY7; -.
DR   PDBsum; 2BY8; -.
DR   PDBsum; 2BY9; -.
DR   PDBsum; 2BYA; -.
DR   PDBsum; 2BZA; -.
DR   PDBsum; 2CMY; -.
DR   PDBsum; 2D8W; -.
DR   PDBsum; 2F3C; -.
DR   PDBsum; 2FI3; -.
DR   PDBsum; 2FI4; -.
DR   PDBsum; 2FI5; -.
DR   PDBsum; 2FTL; -.
DR   PDBsum; 2FTM; -.
DR   PDBsum; 2FX4; -.
DR   PDBsum; 2FX6; -.
DR   PDBsum; 2G55; -.
DR   PDBsum; 2G5N; -.
DR   PDBsum; 2G5V; -.
DR   PDBsum; 2G81; -.
DR   PDBsum; 2G8T; -.
DR   PDBsum; 2ILN; -.
DR   PDBsum; 2J9N; -.
DR   PDBsum; 2O9Q; -.
DR   PDBsum; 2OTV; -.
DR   PDBsum; 2OXS; -.
DR   PDBsum; 2PLX; -.
DR   PDBsum; 2PTC; -.
DR   PDBsum; 2PTN; -.
DR   PDBsum; 2QN5; -.
DR   PDBsum; 2QYI; -.
DR   PDBsum; 2TGA; -.
DR   PDBsum; 2TGD; -.
DR   PDBsum; 2TGP; -.
DR   PDBsum; 2TGT; -.
DR   PDBsum; 2TIO; -.
DR   PDBsum; 2TLD; -.
DR   PDBsum; 2TPI; -.
DR   PDBsum; 2UUY; -.
DR   PDBsum; 2XTT; -.
DR   PDBsum; 2ZDK; -.
DR   PDBsum; 2ZDL; -.
DR   PDBsum; 2ZDM; -.
DR   PDBsum; 2ZDN; -.
DR   PDBsum; 2ZFS; -.
DR   PDBsum; 2ZFT; -.
DR   PDBsum; 2ZHD; -.
DR   PDBsum; 2ZQ1; -.
DR   PDBsum; 2ZQ2; -.
DR   PDBsum; 3A7T; -.
DR   PDBsum; 3A7V; -.
DR   PDBsum; 3A7W; -.
DR   PDBsum; 3A7X; -.
DR   PDBsum; 3A7Y; -.
DR   PDBsum; 3A7Z; -.
DR   PDBsum; 3A80; -.
DR   PDBsum; 3A81; -.
DR   PDBsum; 3A82; -.
DR   PDBsum; 3A83; -.
DR   PDBsum; 3A84; -.
DR   PDBsum; 3A85; -.
DR   PDBsum; 3A86; -.
DR   PDBsum; 3A87; -.
DR   PDBsum; 3A88; -.
DR   PDBsum; 3A89; -.
DR   PDBsum; 3A8A; -.
DR   PDBsum; 3A8B; -.
DR   PDBsum; 3A8C; -.
DR   PDBsum; 3A8D; -.
DR   PDBsum; 3AAS; -.
DR   PDBsum; 3AAU; -.
DR   PDBsum; 3AAV; -.
DR   PDBsum; 3ATI; -.
DR   PDBsum; 3ATK; -.
DR   PDBsum; 3ATL; -.
DR   PDBsum; 3ATM; -.
DR   PDBsum; 3BTD; -.
DR   PDBsum; 3BTE; -.
DR   PDBsum; 3BTF; -.
DR   PDBsum; 3BTG; -.
DR   PDBsum; 3BTH; -.
DR   PDBsum; 3BTK; -.
DR   PDBsum; 3BTM; -.
DR   PDBsum; 3BTQ; -.
DR   PDBsum; 3BTT; -.
DR   PDBsum; 3BTW; -.
DR   PDBsum; 3D65; -.
DR   PDBsum; 3E8L; -.
DR   PDBsum; 3GY2; -.
DR   PDBsum; 3GY3; -.
DR   PDBsum; 3GY4; -.
DR   PDBsum; 3GY5; -.
DR   PDBsum; 3GY6; -.
DR   PDBsum; 3GY7; -.
DR   PDBsum; 3GY8; -.
DR   PDBsum; 3I29; -.
DR   PDBsum; 3ITI; -.
DR   PDBsum; 3LJJ; -.
DR   PDBsum; 3LJO; -.
DR   PDBsum; 3M35; -.
DR   PDBsum; 3M7Q; -.
DR   PDBsum; 3MFJ; -.
DR   PDBsum; 3MI4; -.
DR   PDBsum; 3NK8; -.
DR   PDBsum; 3NKK; -.
DR   PDBsum; 3OTJ; -.
DR   PDBsum; 3PLB; -.
DR   PDBsum; 3PLK; -.
DR   PDBsum; 3PLP; -.
DR   PDBsum; 3PM3; -.
DR   PDBsum; 3PMJ; -.
DR   PDBsum; 3PTB; -.
DR   PDBsum; 3PTN; -.
DR   PDBsum; 3PWB; -.
DR   PDBsum; 3PWC; -.
DR   PDBsum; 3PYH; -.
DR   PDBsum; 3Q00; -.
DR   PDBsum; 3QK1; -.
DR   PDBsum; 3RDZ; -.
DR   PDBsum; 3RU4; -.
DR   PDBsum; 3RXA; -.
DR   PDBsum; 3RXB; -.
DR   PDBsum; 3RXC; -.
DR   PDBsum; 3RXD; -.
DR   PDBsum; 3RXE; -.
DR   PDBsum; 3RXF; -.
DR   PDBsum; 3RXG; -.
DR   PDBsum; 3RXH; -.
DR   PDBsum; 3RXI; -.
DR   PDBsum; 3RXJ; -.
DR   PDBsum; 3RXK; -.
DR   PDBsum; 3RXL; -.
DR   PDBsum; 3RXM; -.
DR   PDBsum; 3RXO; -.
DR   PDBsum; 3RXP; -.
DR   PDBsum; 3RXQ; -.
DR   PDBsum; 3RXR; -.
DR   PDBsum; 3RXS; -.
DR   PDBsum; 3RXT; -.
DR   PDBsum; 3RXU; -.
DR   PDBsum; 3RXV; -.
DR   PDBsum; 3T25; -.
DR   PDBsum; 3T26; -.
DR   PDBsum; 3T27; -.
DR   PDBsum; 3T28; -.
DR   PDBsum; 3T29; -.
DR   PDBsum; 3TPI; -.
DR   PDBsum; 3UNQ; -.
DR   PDBsum; 3UNR; -.
DR   PDBsum; 3UNS; -.
DR   PDBsum; 3UOP; -.
DR   PDBsum; 3UPE; -.
DR   PDBsum; 3UQO; -.
DR   PDBsum; 3UQV; -.
DR   PDBsum; 3UUZ; -.
DR   PDBsum; 3UWI; -.
DR   PDBsum; 3UY9; -.
DR   PDBsum; 3V0X; -.
DR   PDBsum; 3V12; -.
DR   PDBsum; 3V13; -.
DR   PDBsum; 3VEQ; -.
DR   PDBsum; 3VPK; -.
DR   PDBsum; 4AB8; -.
DR   PDBsum; 4AB9; -.
DR   PDBsum; 4ABA; -.
DR   PDBsum; 4ABB; -.
DR   PDBsum; 4ABD; -.
DR   PDBsum; 4ABE; -.
DR   PDBsum; 4ABF; -.
DR   PDBsum; 4ABG; -.
DR   PDBsum; 4ABH; -.
DR   PDBsum; 4ABI; -.
DR   PDBsum; 4ABJ; -.
DR   PDBsum; 4AOQ; -.
DR   PDBsum; 4AOR; -.
DR   PDBsum; 4B1T; -.
DR   PDBsum; 4B2A; -.
DR   PDBsum; 4B2B; -.
DR   PDBsum; 4B2C; -.
DR   PDBsum; 4GUX; -.
DR   PDBsum; 4HGC; -.
DR   PDBsum; 4I8G; -.
DR   PDBsum; 4I8H; -.
DR   PDBsum; 4I8J; -.
DR   PDBsum; 4I8K; -.
DR   PDBsum; 4I8L; -.
DR   PDBsum; 4J2Y; -.
DR   PDBsum; 4KTS; -.
DR   PDBsum; 4KTU; -.
DR   PDBsum; 4MTB; -.
DR   PDBsum; 4NCY; -.
DR   PDBsum; 4NIV; -.
DR   PDBsum; 4NIW; -.
DR   PDBsum; 4NIX; -.
DR   PDBsum; 4NIY; -.
DR   PDBsum; 4TPI; -.
DR   PDBsum; 4TPY; -.
DR   PDBsum; 4U2W; -.
DR   PDBsum; 4XOJ; -.
DR   PDBsum; 4Y0Y; -.
DR   PDBsum; 4Y0Z; -.
DR   PDBsum; 4Y10; -.
DR   PDBsum; 4Y11; -.
DR   PDBsum; 4YTA; -.
DR   PDBsum; 5EG4; -.
DR   PDBsum; 5F6M; -.
DR   PDBsum; 5FXL; -.
DR   PDBsum; 5GIB; -.
DR   PDBsum; 5GXP; -.
DR   PDBsum; 5JYI; -.
DR   PDBsum; 5K7R; -.
DR   PDBsum; 5LGO; -.
DR   PDBsum; 5LH8; -.
DR   PDBsum; 5MN1; -.
DR   PDBsum; 5MNA; -.
DR   PDBsum; 5MNB; -.
DR   PDBsum; 5MNC; -.
DR   PDBsum; 5MNX; -.
DR   PDBsum; 5MNY; -.
DR   PDBsum; 5MON; -.
DR   PDBsum; 5MOO; -.
DR   PDBsum; 5PTP; -.
DR   PDBsum; 5T3H; -.
DR   DisProt; DP00728; -.
DR   ProteinModelPortal; P00760; -.
DR   SMR; P00760; -.
DR   IntAct; P00760; 11.
DR   MINT; MINT-87966; -.
DR   STRING; 9913.ENSBTAP00000033392; -.
DR   BindingDB; P00760; -.
DR   ChEMBL; CHEMBL3769; -.
DR   MEROPS; S01.151; -.
DR   PaxDb; P00760; -.
DR   PeptideAtlas; P00760; -.
DR   PRIDE; P00760; -.
DR   Ensembl; ENSBTAT00000004737; ENSBTAP00000004737; ENSBTAG00000003633.
DR   Ensembl; ENSBTAT00000033479; ENSBTAP00000033392; ENSBTAG00000024245.
DR   GeneID; 615026; -.
DR   GeneID; 780933; -.
DR   KEGG; bta:615026; -.
DR   KEGG; bta:780933; -.
DR   CTD; 5644; -.
DR   eggNOG; KOG3627; Eukaryota.
DR   eggNOG; COG5640; LUCA.
DR   GeneTree; ENSGT00760000118862; -.
DR   HOGENOM; HOG000251820; -.
DR   HOVERGEN; HBG013304; -.
DR   InParanoid; P00760; -.
DR   KO; K01312; -.
DR   OMA; TRAGQFC; -.
DR   OrthoDB; EOG091G0DF7; -.
DR   TreeFam; TF331065; -.
DR   BRENDA; 3.4.21.4; 908.
DR   SABIO-RK; P00760; -.
DR   EvolutionaryTrace; P00760; -.
DR   PMAP-CutDB; P00760; -.
DR   PRO; PR:P00760; -.
DR   Proteomes; UP000009136; Chromosome 4.
DR   Bgee; ENSBTAG00000003633; -.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0097180; C:serine protease inhibitor complex; IDA:CAFA.
DR   GO; GO:0004175; F:endopeptidase activity; IDA:CAFA.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0046982; F:protein heterodimerization activity; IDA:CAFA.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IDA:CAFA.
DR   GO; GO:0097655; F:serpin family protein binding; IDA:CAFA.
DR   GO; GO:0007586; P:digestion; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IDA:CAFA.
DR   CDD; cd00190; Tryp_SPc; 1.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR001314; Peptidase_S1A.
DR   InterPro; IPR001254; Trypsin_dom.
DR   InterPro; IPR018114; TRYPSIN_HIS.
DR   InterPro; IPR033116; TRYPSIN_SER.
DR   Pfam; PF00089; Trypsin; 1.
DR   PRINTS; PR00722; CHYMOTRYPSIN.
DR   SMART; SM00020; Tryp_SPc; 1.
DR   SUPFAM; SSF50494; SSF50494; 1.
DR   PROSITE; PS50240; TRYPSIN_DOM; 1.
DR   PROSITE; PS00134; TRYPSIN_HIS; 1.
DR   PROSITE; PS00135; TRYPSIN_SER; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Calcium; Complete proteome; Digestion;
KW   Direct protein sequencing; Disulfide bond; Hydrolase; Metal-binding;
KW   Protease; Reference proteome; Secreted; Serine protease; Signal;
KW   Zymogen.
FT   SIGNAL        1     17       {ECO:0000269|PubMed:5967094}.
FT   PROPEP       18     23       Activation peptide.
FT                                /FTId=PRO_0000028185.
FT   CHAIN        24    246       Cationic trypsin.
FT                                /FTId=PRO_0000028186.
FT   CHAIN        24    148       Alpha-trypsin chain 1.
FT                                /FTId=PRO_0000028187.
FT   CHAIN       149    246       Alpha-trypsin chain 2.
FT                                /FTId=PRO_0000028188.
FT   DOMAIN       24    244       Peptidase S1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00274}.
FT   REGION      194    195       Substrate binding.
FT   REGION      197    198       Substrate binding.
FT   ACT_SITE     63     63       Charge relay system.
FT   ACT_SITE    107    107       Charge relay system.
FT   ACT_SITE    200    200       Charge relay system.
FT   METAL        75     75       Calcium.
FT   METAL        77     77       Calcium; via carbonyl oxygen.
FT   METAL        80     80       Calcium; via carbonyl oxygen.
FT   METAL        85     85       Calcium.
FT   BINDING     200    200       Substrate.
FT   DISULFID     30    160
FT   DISULFID     48     64
FT   DISULFID    132    233
FT   DISULFID    139    206
FT   DISULFID    171    185
FT   DISULFID    196    220
FT   TURN         23     26       {ECO:0000244|PDB:1TGS}.
FT   TURN         32     34       {ECO:0000244|PDB:1TGS}.
FT   STRAND       38     52       {ECO:0000244|PDB:4I8H}.
FT   STRAND       54     60       {ECO:0000244|PDB:4I8H}.
FT   HELIX        62     64       {ECO:0000244|PDB:4I8H}.
FT   STRAND       70     74       {ECO:0000244|PDB:4I8H}.
FT   STRAND       76     80       {ECO:0000244|PDB:1C2D}.
FT   STRAND       81     84       {ECO:0000244|PDB:1EJM}.
FT   STRAND       86     95       {ECO:0000244|PDB:4I8H}.
FT   TURN        101    103       {ECO:0000244|PDB:4I8H}.
FT   STRAND      109    115       {ECO:0000244|PDB:4I8H}.
FT   STRAND      121    123       {ECO:0000244|PDB:1S0Q}.
FT   STRAND      138    145       {ECO:0000244|PDB:4I8H}.
FT   STRAND      149    151       {ECO:0000244|PDB:4I8H}.
FT   STRAND      159    165       {ECO:0000244|PDB:4I8H}.
FT   HELIX       168    174       {ECO:0000244|PDB:4I8H}.
FT   TURN        176    178       {ECO:0000244|PDB:4I8H}.
FT   TURN        180    182       {ECO:0000244|PDB:1V2J}.
FT   STRAND      183    187       {ECO:0000244|PDB:4I8H}.
FT   STRAND      189    192       {ECO:0000244|PDB:4XOJ}.
FT   TURN        197    201       {ECO:0000244|PDB:1C1R}.
FT   STRAND      203    206       {ECO:0000244|PDB:4I8H}.
FT   STRAND      209    216       {ECO:0000244|PDB:4I8H}.
FT   STRAND      218    221       {ECO:0000244|PDB:4I8H}.
FT   STRAND      227    231       {ECO:0000244|PDB:4I8H}.
FT   HELIX       232    235       {ECO:0000244|PDB:4I8H}.
FT   HELIX       236    244       {ECO:0000244|PDB:4I8H}.
SQ   SEQUENCE   246 AA;  25785 MW;  092E3D8ACCCCC4D3 CRC64;
     MKTFIFLALL GAAVAFPVDD DDKIVGGYTC GANTVPYQVS LNSGYHFCGG SLINSQWVVS
     AAHCYKSGIQ VRLGEDNINV VEGNEQFISA SKSIVHPSYN SNTLNNDIML IKLKSAASLN
     SRVASISLPT SCASAGTQCL ISGWGNTKSS GTSYPDVLKC LKAPILSDSS CKSAYPGQIT
     SNMFCAGYLE GGKDSCQGDS GGPVVCSGKL QGIVSWGSGC AQKNKPGVYT KVCNYVSWIK
     QTIASN
//
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