ID UAP1_DICDI Reviewed; 487 AA.
AC Q54GN5;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 01-MAY-2013, entry version 52.
DE RecName: Full=Probable UDP-N-acetylglucosamine pyrophosphorylase;
DE EC=2.7.7.23;
GN Name=uap1; ORFNames=DDB_G0290055;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Mycetozoa; Dictyosteliida; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A.,
RA Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q.,
RA Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F.,
RA Bankier A.T., Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P.,
RA Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P.,
RA Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N.,
RA Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M.,
RA Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I.,
RA Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R.,
RA Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C.,
RA Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D.,
RA Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S.,
RA Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T.,
RA Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A.,
RA Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M.,
RA Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G.,
RA Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- CATALYTIC ACTIVITY: UTP + N-acetyl-alpha-D-glucosamine 1-phosphate
CC = diphosphate + UDP-N-acetyl-alpha-D-glucosamine.
CC -!- PATHWAY: Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-
CC glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-
CC acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.
CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC -!- SIMILARITY: Belongs to the UDPGP type 1 family.
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DR EMBL; AAFI02000151; EAL62433.1; -; Genomic_DNA.
DR RefSeq; XP_635927.1; XM_630835.1.
DR HSSP; Q16222; 1JVG.
DR ProteinModelPortal; Q54GN5; -.
DR STRING; 44689.DDBDRAFT_0219512; -.
DR EnsemblProtists; DDB0266385; DDB0266385; DDB_G0290055.
DR GeneID; 8627448; -.
DR KEGG; ddi:DDB_G0290055; -.
DR dictyBase; DDB_G0290055; uap1.
DR eggNOG; COG4284; -.
DR KO; K00972; -.
DR OMA; NSTICEV; -.
DR ProtClustDB; CLSZ2429709; -.
DR UniPathway; UPA00113; UER00533.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003977; F:UDP-N-acetylglucosamine diphosphorylase activity; IEA:EC.
DR GO; GO:0006048; P:UDP-N-acetylglucosamine biosynthetic process; IEA:UniProtKB-UniPathway.
DR InterPro; IPR002618; UDPGP_trans.
DR PANTHER; PTHR11952; PTHR11952; 1.
DR Pfam; PF01704; UDPGP; 1.
PE 3: Inferred from homology;
KW Complete proteome; Cytoplasm; Nucleotidyltransferase;
KW Reference proteome; Transferase.
FT CHAIN 1 487 Probable UDP-N-acetylglucosamine
FT pyrophosphorylase.
FT /FTId=PRO_0000328000.
FT MOTIF 105 108 Substrate binding (By similarity).
FT MOTIF 307 308 Substrate binding (By similarity).
FT COMPBIAS 193 196 Poly-Phe.
FT BINDING 226 226 Substrate (By similarity).
FT BINDING 412 412 Substrate (By similarity).
SQ SEQUENCE 487 AA; 55431 MW; 0E12B99059A0E87C CRC64;
MDTTNFEDIR NEWIEQGQGH VFNWFDKLSN EEKLNFENDI RKINVKEVNK DYKNVLLNKD
EQKIMKYEHF ENVMTLNKIK EQDKKKWEDI GYELISKGEV AVLLLAGGQA TRLGTTFPKG
FYDVGLPSKK SLFQLQAERI YRLQQLVSER YNGSYDQDSK PIQWYIMTSE ATHSETIKFF
ENKNYFGLKK SAFFFFSQAM IPCITPEDGK IISESGSKLS LSPNGNGGLF KALSTSGAID
DMRKKGIKYV TQYCVDNILI NMADPVFVGY MHDQSADCGA KVVSKSDPKE PVGVMALNGD
GKPFVLEYSE IDEQSKFKKD QNGQLVFNYA HICINAFSFD FLDRIAKNHL DHLKYHVAFK
KIPSAHPISG ERQSPSSPNG WKLEKFIFDV FPFSKKMVCL EIERSKEFSP LKNCGGMNLP
DSPETCLRDI SNLHKSFIEN SGGKIDSSNS TICEVSPLVS LNGENLKNFV NDKTFILPIE
INQNLNN
//
