ID UBIE_SYMTH Reviewed; 251 AA.
AC Q67LE6;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 01-MAY-2013, entry version 57.
DE RecName: Full=Demethylmenaquinone methyltransferase;
DE EC=2.1.1.163;
DE AltName: Full=Menaquinone biosynthesis methyltransferase ubiE;
GN Name=ubiE; OrderedLocusNames=STH2515;
OS Symbiobacterium thermophilum (strain T / IAM 14863).
OC Bacteria; Firmicutes; Clostridia; Clostridiales;
OC Clostridiales Family XVIII. Incertae Sedis; Symbiobacterium.
OX NCBI_TaxID=292459;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=T / IAM 14863;
RX PubMed=15383646; DOI=10.1093/nar/gkh830;
RA Ueda K., Yamashita A., Ishikawa J., Shimada M., Watsuji T.,
RA Morimura K., Ikeda H., Hattori M., Beppu T.;
RT "Genome sequence of Symbiobacterium thermophilum, an uncultivable
RT bacterium that depends on microbial commensalism.";
RL Nucleic Acids Res. 32:4937-4944(2004).
CC -!- FUNCTION: Methyltransferase required for the conversion of
CC demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity).
CC -!- CATALYTIC ACTIVITY: A demethylmenaquinone + S-adenosyl-L-
CC methionine = a menaquinol + S-adenosyl-L-homocysteine.
CC -!- PATHWAY: Cofactor biosynthesis; menaquinone biosynthesis;
CC menaquinone-2 from chorismate: step 8/8.
CC -!- SIMILARITY: Belongs to the methyltransferase superfamily. UbiE
CC family.
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DR EMBL; AP006840; BAD41500.1; -; Genomic_DNA.
DR RefSeq; YP_076344.1; NC_006177.1.
DR ProteinModelPortal; Q67LE6; -.
DR STRING; 292459.STH2515; -.
DR EnsemblBacteria; BAD41500; BAD41500; STH2515.
DR GeneID; 2982351; -.
DR KEGG; sth:STH2515; -.
DR PATRIC; 23783202; VBISymThe116959_2509.
DR eggNOG; COG2226; -.
DR HOGENOM; HOG000249463; -.
DR KO; K03183; -.
DR OMA; DGHEETH; -.
DR UniPathway; UPA00079; UER00169.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0009234; P:menaquinone biosynthetic process; IEA:UniProtKB-UniPathway.
DR HAMAP; MF_01813; UbiE_methyltran; 1; -.
DR InterPro; IPR004033; UbiE/COQ5_MeTrFase.
DR InterPro; IPR023576; UbiE/COQ5_MeTrFase_CS.
DR PANTHER; PTHR10108:SF24; PTHR10108:SF24; 1.
DR Pfam; PF01209; Ubie_methyltran; 1.
DR TIGRFAMs; TIGR01934; MenG_MenH_UbiE; 1.
DR PROSITE; PS01183; UBIE_1; FALSE_NEG.
DR PROSITE; PS01184; UBIE_2; 1.
PE 3: Inferred from homology;
KW Complete proteome; Menaquinone biosynthesis; Methyltransferase;
KW Transferase.
FT CHAIN 1 251 Demethylmenaquinone methyltransferase.
FT /FTId=PRO_0000193339.
SQ SEQUENCE 251 AA; 28582 MW; 79E95F0D99ADA234 CRC64;
MAPGYQPPSP EEKEQYVREL FDKIAENYDA MNQVMSAGQW EKWHREFVAQ THFRPGDHIL
DVACGTGDLT LLDAAQVAPD GKVIGVDISE GMLEVGRRRV AASPYKDLIT LQLGNAMDLP
FPDNTFDGVT MGWAMRNVAS IPRTLSEIYR VLKPGGRFIC LEASKPFSRF IRFGFFVYWK
TFLPLIDWFV VKAGRQAKVR PYTYLSRSLD NYPFPDQLEE LFREAGFVET DYQLLMLGTV
AIHVGTKRRE G
//
