GenomeNet

Database: UniProt/SWISS-PROT
Entry: URK_LACS1
LinkDB: URK_LACS1
Original site: URK_LACS1 
ID   URK_LACS1               Reviewed;         213 AA.
AC   Q1WTY6;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   02-MAY-2006, sequence version 1.
DT   11-JUN-2014, entry version 69.
DE   RecName: Full=Uridine kinase;
DE            EC=2.7.1.48;
DE   AltName: Full=Cytidine monophosphokinase;
DE   AltName: Full=Uridine monophosphokinase;
GN   Name=udk; OrderedLocusNames=LSL_0816;
OS   Lactobacillus salivarius (strain UCC118).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactobacillus.
OX   NCBI_TaxID=362948;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UCC118;
RX   PubMed=16617113; DOI=10.1073/pnas.0511060103;
RA   Claesson M.J., Li Y., Leahy S., Canchaya C., van Pijkeren J.P.,
RA   Cerdeno-Tarraga A.M., Parkhill J., Flynn S., O'Sullivan G.C.,
RA   Collins J.K., Higgins D., Shanahan F., Fitzgerald G.F.,
RA   van Sinderen D., O'Toole P.W.;
RT   "Multireplicon genome architecture of Lactobacillus salivarius.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:6718-6723(2006).
CC   -!- CATALYTIC ACTIVITY: ATP + uridine = ADP + UMP.
CC   -!- CATALYTIC ACTIVITY: ATP + cytidine = ADP + CMP.
CC   -!- PATHWAY: Pyrimidine metabolism; CTP biosynthesis via salvage
CC       pathway; CTP from cytidine: step 1/3.
CC   -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via salvage
CC       pathway; UMP from uridine: step 1/1.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the uridine kinase family.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; CP000233; ABD99626.1; -; Genomic_DNA.
DR   RefSeq; YP_535709.1; NC_007929.1.
DR   STRING; 362948.LSL_0816; -.
DR   EnsemblBacteria; ABD99626; ABD99626; LSL_0816.
DR   GeneID; 3977374; -.
DR   KEGG; lsl:LSL_0816; -.
DR   PATRIC; 22278535; VBILacSal43464_0890.
DR   eggNOG; COG0572; -.
DR   HOGENOM; HOG000262756; -.
DR   KO; K00876; -.
DR   OMA; RYKTNYD; -.
DR   OrthoDB; EOG6KMBCH; -.
DR   BioCyc; LSAL362948:GJDJ-891-MONOMER; -.
DR   UniPathway; UPA00574; UER00637.
DR   UniPathway; UPA00579; UER00640.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0016773; F:phosphotransferase activity, alcohol group as acceptor; IEA:InterPro.
DR   GO; GO:0004849; F:uridine kinase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0044211; P:CTP salvage; IEA:UniProtKB-UniPathway.
DR   GO; GO:0044206; P:UMP salvage; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00551; Uridine_kinase; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR006083; PRK/URK.
DR   InterPro; IPR026008; Uridine_kinase_.
DR   InterPro; IPR000764; Uridine_kinase_like.
DR   PANTHER; PTHR10285:SF6; PTHR10285:SF6; 1.
DR   Pfam; PF00485; PRK; 1.
DR   PRINTS; PR00988; URIDINKINASE.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00235; udk; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding;
KW   Transferase.
FT   CHAIN         1    213       Uridine kinase.
FT                                /FTId=PRO_1000200514.
FT   NP_BIND      15     22       ATP (Potential).
SQ   SEQUENCE   213 AA;  24743 MW;  5AF951237F61AF51 CRC64;
     MANRENKPVI IGVTGGSGSG KTTVSRAIFE QLHGHSLLML QEDSYYNDQS DMPFEERIKT
     NYDHPNAFDT ELLVKQLKDL LDWKTIEKPI YDYTEHTRSS EVEKVEPKEV IILEGILVLN
     DPALRDLMDI KIFVDTDDDI RIIRRIQRDI EERGRSLQSV IDQYKSTVKP MYHQFIEPTK
     RYADIIVPEG GENQVAIDLL VTKVRDILRK REK
//
DBGET integrated database retrieval system