ID URK_LACS1 Reviewed; 213 AA.
AC Q1WTY6;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 02-MAY-2006, sequence version 1.
DT 01-MAY-2013, entry version 62.
DE RecName: Full=Uridine kinase;
DE EC=2.7.1.48;
DE AltName: Full=Cytidine monophosphokinase;
DE AltName: Full=Uridine monophosphokinase;
GN Name=udk; OrderedLocusNames=LSL_0816;
OS Lactobacillus salivarius (strain UCC118).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC Lactobacillus.
OX NCBI_TaxID=362948;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UCC118;
RX PubMed=16617113; DOI=10.1073/pnas.0511060103;
RA Claesson M.J., Li Y., Leahy S., Canchaya C., van Pijkeren J.P.,
RA Cerdeno-Tarraga A.M., Parkhill J., Flynn S., O'Sullivan G.C.,
RA Collins J.K., Higgins D., Shanahan F., Fitzgerald G.F.,
RA van Sinderen D., O'Toole P.W.;
RT "Multireplicon genome architecture of Lactobacillus salivarius.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:6718-6723(2006).
CC -!- CATALYTIC ACTIVITY: ATP + uridine = ADP + UMP.
CC -!- CATALYTIC ACTIVITY: ATP + cytidine = ADP + CMP.
CC -!- PATHWAY: Pyrimidine metabolism; CTP biosynthesis via salvage
CC pathway; CTP from cytidine: step 1/3.
CC -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via salvage
CC pathway; UMP from uridine: step 1/1.
CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC -!- SIMILARITY: Belongs to the uridine kinase family.
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DR EMBL; CP000233; ABD99626.1; -; Genomic_DNA.
DR RefSeq; YP_535709.1; NC_007929.1.
DR STRING; 362948.LSL_0816; -.
DR EnsemblBacteria; ABD99626; ABD99626; LSL_0816.
DR GeneID; 3977374; -.
DR KEGG; lsl:LSL_0816; -.
DR PATRIC; 22278535; VBILacSal43464_0890.
DR eggNOG; COG0572; -.
DR HOGENOM; HOG000262756; -.
DR KO; K00876; -.
DR OMA; DICFMRR; -.
DR ProtClustDB; PRK05480; -.
DR BioCyc; LSAL362948:GJDJ-891-MONOMER; -.
DR UniPathway; UPA00574; UER00637.
DR UniPathway; UPA00579; UER00640.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR GO; GO:0016773; F:phosphotransferase activity, alcohol group as acceptor; IEA:InterPro.
DR GO; GO:0004849; F:uridine kinase activity; IEA:HAMAP.
DR GO; GO:0044211; P:CTP salvage; IEA:UniProtKB-UniPathway.
DR GO; GO:0044206; P:UMP salvage; IEA:UniProtKB-UniPathway.
DR HAMAP; MF_00551; Uridine_kinase; 1; -.
DR InterPro; IPR006083; PRK/URK.
DR InterPro; IPR000764; Uridine_kinase.
DR Pfam; PF00485; PRK; 1.
DR PRINTS; PR00988; URIDINKINASE.
DR TIGRFAMs; TIGR00235; udk; 1.
PE 3: Inferred from homology;
KW ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding;
KW Transferase.
FT CHAIN 1 213 Uridine kinase.
FT /FTId=PRO_1000200514.
FT NP_BIND 15 22 ATP (Potential).
SQ SEQUENCE 213 AA; 24743 MW; 5AF951237F61AF51 CRC64;
MANRENKPVI IGVTGGSGSG KTTVSRAIFE QLHGHSLLML QEDSYYNDQS DMPFEERIKT
NYDHPNAFDT ELLVKQLKDL LDWKTIEKPI YDYTEHTRSS EVEKVEPKEV IILEGILVLN
DPALRDLMDI KIFVDTDDDI RIIRRIQRDI EERGRSLQSV IDQYKSTVKP MYHQFIEPTK
RYADIIVPEG GENQVAIDLL VTKVRDILRK REK
//
