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Database: UniProt/SWISS-PROT
Entry: UVRC_MOOTA
LinkDB: UVRC_MOOTA
Original site: UVRC_MOOTA 
ID   UVRC_MOOTA              Reviewed;         613 AA.
AC   Q2RLU8;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   14-MAY-2014, entry version 61.
DE   RecName: Full=UvrABC system protein C;
DE            Short=Protein UvrC;
DE   AltName: Full=Excinuclease ABC subunit C;
GN   Name=uvrC; OrderedLocusNames=Moth_0256;
OS   Moorella thermoacetica (strain ATCC 39073).
OC   Bacteria; Firmicutes; Clostridia; Thermoanaerobacterales;
OC   Thermoanaerobacteraceae; Moorella group; Moorella.
OX   NCBI_TaxID=264732;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 39073;
RX   PubMed=18631365; DOI=10.1111/j.1462-2920.2008.01679.x;
RA   Pierce E., Xie G., Barabote R.D., Saunders E., Han C.S., Detter J.C.,
RA   Richardson P., Brettin T.S., Das A., Ljungdahl L.G., Ragsdale S.W.;
RT   "The complete genome sequence of Moorella thermoacetica (f.
RT   Clostridium thermoaceticum).";
RL   Environ. Microbiol. 10:2550-2573(2008).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides
CC       of the lesion. The N-terminal half is responsible for the 3'
CC       incision and the C-terminal half is responsible for the 5'
CC       incision (By similarity).
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex (By
CC       similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the UvrC family.
CC   -!- SIMILARITY: Contains 1 GIY-YIG domain.
CC   -!- SIMILARITY: Contains 1 UVR domain.
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DR   EMBL; CP000232; ABC18591.1; -; Genomic_DNA.
DR   RefSeq; YP_429134.1; NC_007644.1.
DR   ProteinModelPortal; Q2RLU8; -.
DR   SMR; Q2RLU8; 3-95.
DR   STRING; 264732.Moth_0256; -.
DR   EnsemblBacteria; ABC18591; ABC18591; Moth_0256.
DR   GeneID; 3833219; -.
DR   KEGG; mta:Moth_0256; -.
DR   PATRIC; 22637543; VBIMooThe6753_0272.
DR   eggNOG; COG0322; -.
DR   HOGENOM; HOG000279960; -.
DR   KO; K03703; -.
DR   OMA; QTIASCV; -.
DR   OrthoDB; EOG6K13R9; -.
DR   BioCyc; MTHE264732:GH0A-273-MONOMER; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-HAMAP.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-HAMAP.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   Gene3D; 4.10.860.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR027299; GIY-YIG_dom.
DR   InterPro; IPR000305; GIY-YIG_SF.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_homol_region.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SMART; SM00278; HhH1; 2.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; DNA damage; DNA excision; DNA repair;
KW   Excision nuclease; Reference proteome; SOS response.
FT   CHAIN         1    613       UvrABC system protein C.
FT                                /FTId=PRO_0000264912.
FT   DOMAIN       12     89       GIY-YIG.
FT   DOMAIN      199    234       UVR.
SQ   SEQUENCE   613 AA;  68956 MW;  52BB1C8CDCDBA864 CRC64;
     MDLEEKLARL PDHPGVYIMH DANGAIIYVG KAASLRNRVR SYFRGQHQPR TQAMVSHVAD
     FEYILTDNEV EALILECNLI KQHRPRYNVS LKDDKSYPYI KITTQEDFPR IQITRSVTRD
     GSRYFGPYTS AGSLKETLKL LRGLFPIRTC RDTPLQPRSR PCLNAHIGRC LAPCAGQVDR
     ETYREAVDNV IMFLEGRHTA LVKELKEQME AAAARLEFEK AARLRDQLRA VQEVCEKQKL
     AAASGEDADA IAFAREGEAA LGLIFFSRGG KVIGRDHFFL TGSEGLSRGE VMAALLKEYY
     SRGVEIPPEI LLHDEPEDAA TIASWLSRLR GGRVNLRVPK RGTKLKLLRL VHENAVSLLQ
     EHLLTRRRQE EGSRAALLEL QEILELPRLP RRMEAYDISN FQGSSQVGAM AVFVDGRPLP
     SAYRRFQIKT VRGPNDFASL QEVLSRRFRR AAEQDPHFAD LPDFVLIDGG LGQLHAARET
     MEAMGVGYIP TFGLAKEEEL LFRVGTSEPI RLPRESKALQ ILQHLRDEVH RFAITYHRQK
     REKTAYRSVL DDIPGVGPKR KKALLRHFGS VAAISKATLE DLLAVEGMNR TVAARILAGL
     GRRSDGEDST GSP
//
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