ID XPT_STRSV Reviewed; 193 AA.
AC A3CMY9;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 10-JUN-2008, sequence version 2.
DT 29-MAY-2013, entry version 39.
DE RecName: Full=Xanthine phosphoribosyltransferase;
DE Short=XPRTase;
DE EC=2.4.2.22;
GN Name=xpt; OrderedLocusNames=SSA_1134;
OS Streptococcus sanguinis (strain SK36).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=388919;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SK36;
RX PubMed=17277061; DOI=10.1128/JB.01808-06;
RA Xu P., Alves J.M., Kitten T., Brown A., Chen Z., Ozaki L.S.,
RA Manque P., Ge X., Serrano M.G., Puiu D., Hendricks S., Wang Y.,
RA Chaplin M.D., Akan D., Paik S., Peterson D.L., Macrina F.L.,
RA Buck G.A.;
RT "Genome of the opportunistic pathogen Streptococcus sanguinis.";
RL J. Bacteriol. 189:3166-3175(2007).
CC -!- FUNCTION: Converts the preformed base xanthine, a product of
CC nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so
CC it can be reused for RNA or DNA synthesis (By similarity).
CC -!- CATALYTIC ACTIVITY: XMP + diphosphate = 5-phospho-alpha-D-ribose
CC 1-diphosphate + xanthine.
CC -!- PATHWAY: Purine metabolism; XMP biosynthesis via salvage pathway;
CC XMP from xanthine: step 1/1.
CC -!- SUBUNIT: Homodimer (By similarity).
CC -!- SUBCELLULAR LOCATION: Cytoplasm (Potential).
CC -!- SIMILARITY: Belongs to the purine/pyrimidine
CC phosphoribosyltransferase family. Xpt subfamily.
CC -!- SEQUENCE CAUTION:
CC Sequence=ABN44544.1; Type=Erroneous initiation;
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DR EMBL; CP000387; ABN44544.1; ALT_INIT; Genomic_DNA.
DR RefSeq; YP_001035094.1; NC_009009.1.
DR ProteinModelPortal; A3CMY9; -.
DR SMR; A3CMY9; 1-190.
DR STRING; 388919.SSA_1134; -.
DR EnsemblBacteria; ABN44544; ABN44544; SSA_1134.
DR GeneID; 4808079; -.
DR KEGG; ssa:SSA_1134; -.
DR PATRIC; 19769234; VBIStrSan33173_1078.
DR eggNOG; COG0503; -.
DR HOGENOM; HOG000036777; -.
DR KO; K03816; -.
DR ProtClustDB; PRK09219; -.
DR BioCyc; SSAN388919:GHEN-1116-MONOMER; -.
DR UniPathway; UPA00602; UER00658.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0000310; F:xanthine phosphoribosyltransferase activity; IEA:HAMAP.
DR GO; GO:0006166; P:purine ribonucleoside salvage; IEA:HAMAP.
DR GO; GO:0046110; P:xanthine metabolic process; IEA:InterPro.
DR GO; GO:0032265; P:XMP salvage; IEA:UniProtKB-UniPathway.
DR HAMAP; MF_01184; XPRTase; 1; -.
DR InterPro; IPR000836; PRibTrfase_dom.
DR InterPro; IPR010079; Xanthine_PRibTrfase.
DR Pfam; PF00156; Pribosyltran; 1.
DR TIGRFAMs; TIGR01744; XPRTase; 1.
DR PROSITE; PS00103; PUR_PYR_PR_TRANSFER; FALSE_NEG.
PE 3: Inferred from homology;
KW Complete proteome; Cytoplasm; Glycosyltransferase; Purine salvage;
KW Transferase.
FT CHAIN 1 193 Xanthine phosphoribosyltransferase.
FT /FTId=PRO_0000339776.
FT REGION 128 132 5-phospho-alpha-D-ribose 1-diphosphate
FT binding (By similarity).
FT BINDING 20 20 Xanthine; via amide nitrogen and carbonyl
FT oxygen (By similarity).
FT BINDING 27 27 Xanthine (By similarity).
FT BINDING 156 156 Xanthine (By similarity).
SQ SEQUENCE 193 AA; 20823 MW; DBAF9B098FF8C97F CRC64;
MKKLEERILR DGQVLGENIL KVDSFLTHQV DFSLMKEIGQ VFAEAVKDAG ITKVVTIEAS
GIAPAVYVAE ALGLPMIFAK KAKNITMTEG ILTAEVYSFT KQVTSTVSIA GKFLNSDDKV
LIIDDFLANG QAAKGLITII EQAGAQIEAV GIVIEKSFQD GRQLLETAGY RVLSLARIAG
FEKGQIVFTE ADI
//
