ID Y1711_MYCTU Reviewed; 254 AA.
AC P65842; L0T7P5; O33210;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 01-MAY-2013, entry version 58.
DE RecName: Full=Uncharacterized RNA pseudouridine synthase Rv1711/MT1751.1;
DE EC=5.4.99.-;
DE AltName: Full=RNA pseudouridylate synthase;
DE AltName: Full=RNA-uridine isomerase;
GN OrderedLocusNames=Rv1711, MT1751.1; ORFNames=MTCI125.33;
OS Mycobacterium tuberculosis.
OC Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC Corynebacterineae; Mycobacteriaceae; Mycobacterium;
OC Mycobacterium tuberculosis complex.
OX NCBI_TaxID=1773;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=9634230; DOI=10.1038/31159;
RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M.,
RA Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III,
RA Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T.,
RA Connor R., Davies R.M., Devlin K., Feltwell T., Gentles S., Hamlin N.,
RA Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S.,
RA Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A.,
RA Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R.,
RA Sulston J.E., Taylor K., Whitehead S., Barrell B.G.;
RT "Deciphering the biology of Mycobacterium tuberculosis from the
RT complete genome sequence.";
RL Nature 393:537-544(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CDC 1551 / Oshkosh;
RX PubMed=12218036; DOI=10.1128/JB.184.19.5479-5490.2002;
RA Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H.,
RA Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D.,
RA Salzberg S.L., Delcher A., Utterback T.R., Weidman J.F., Khouri H.M.,
RA Gill J., Mikula A., Bishai W., Jacobs W.R. Jr., Venter J.C.,
RA Fraser C.M.;
RT "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT laboratory strains.";
RL J. Bacteriol. 184:5479-5490(2002).
RN [3]
RP IDENTIFICATION AS A DRUG TARGET [LARGE SCALE ANALYSIS].
RX PubMed=19099550; DOI=10.1186/1752-0509-2-109;
RA Raman K., Yeturu K., Chandra N.;
RT "targetTB: a target identification pipeline for Mycobacterium
RT tuberculosis through an interactome, reactome and genome-scale
RT structural analysis.";
RL BMC Syst. Biol. 2:109-109(2008).
CC -!- CATALYTIC ACTIVITY: RNA uridine = RNA pseudouridine.
CC -!- MISCELLANEOUS: Was identified as a high-confidence drug target.
CC -!- SIMILARITY: Belongs to the pseudouridine synthase RsuA family.
CC -!- SIMILARITY: Contains 1 S4 RNA-binding domain.
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DR EMBL; BX842577; CAB10968.1; -; Genomic_DNA.
DR EMBL; AE000516; AAK46022.1; -; Genomic_DNA.
DR EMBL; AL123456; CCP44477.1; -; Genomic_DNA.
DR PIR; F70504; F70504.
DR RefSeq; NP_216227.1; NC_000962.3.
DR RefSeq; NP_336208.1; NC_002755.2.
DR RefSeq; YP_006515106.1; NC_018143.1.
DR ProteinModelPortal; P65842; -.
DR SMR; P65842; 14-248.
DR STRING; 83332.Rv1711; -.
DR PRIDE; P65842; -.
DR EnsemblBacteria; AAK46022; AAK46022; MT1751.1.
DR GeneID; 13316496; -.
DR GeneID; 885122; -.
DR GeneID; 923953; -.
DR KEGG; mtc:MT1751.1; -.
DR KEGG; mtu:Rv1711; -.
DR KEGG; mtv:RVBD_1711; -.
DR PATRIC; 18125604; VBIMycTub22151_1916.
DR TubercuList; Rv1711; -.
DR eggNOG; COG1187; -.
DR HOGENOM; HOG000044954; -.
DR KO; K06178; -.
DR OMA; CEDLIFR; -.
DR ProtClustDB; CLSK791343; -.
DR GO; GO:0009982; F:pseudouridine synthase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0040007; P:growth; IMP:MTBBASE.
DR GO; GO:0001522; P:pseudouridine synthesis; IEA:InterPro.
DR Gene3D; 3.10.290.10; -; 1.
DR InterPro; IPR020103; PsdUridine_synth_cat_dom.
DR InterPro; IPR000748; PsdUridine_synth_RsuA/RluB/E/F.
DR InterPro; IPR018496; PsdUridine_synth_RsuA/RluB_CS.
DR InterPro; IPR006145; PsdUridine_synth_RsuA/RluD.
DR InterPro; IPR002942; S4_RNA-bd.
DR Pfam; PF00849; PseudoU_synth_2; 1.
DR Pfam; PF01479; S4; 1.
DR SMART; SM00363; S4; 1.
DR SUPFAM; SSF55120; PsdUridine_synth_cat_dom; 1.
DR TIGRFAMs; TIGR00093; TIGR00093; 1.
DR PROSITE; PS01149; PSI_RSU; 1.
DR PROSITE; PS50889; S4; 1.
PE 3: Inferred from homology;
KW Complete proteome; Isomerase; Reference proteome; RNA-binding.
FT CHAIN 1 254 Uncharacterized RNA pseudouridine
FT synthase Rv1711/MT1751.1.
FT /FTId=PRO_0000100029.
FT DOMAIN 14 81 S4 RNA-binding.
FT ACT_SITE 119 119 Nucleophile (By similarity).
SQ SEQUENCE 254 AA; 27597 MW; EB2D95D7CF0FDF26 CRC64;
MMAEPEESRE PRGIRLQKVL SQAGIASRRA AEKMIVDGRV EVDGHVVTEL GTRVDPQVAV
VRVDGARVVL DDSLVYLALN KPRGMHSTMS DDRGRPCIGD LIERKVRGTK KLFHVGRLDA
DTEGLMLLTN DGELAHRLMH PSHEVPKTYL ATVTGSVPRG LGRTLRAGIE LDDGPAFVDD
FAVVDAIPGK TLVRVTLHEG RNRIVRRLLA AAGFPVEALV RTDIGAVSLG KQRPGSVRAL
RSNEIGQLYQ AVGL
//
