ID Y1738_MYCBO Reviewed; 254 AA.
AC P65843; O33210;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 01-MAY-2013, entry version 55.
DE RecName: Full=Uncharacterized RNA pseudouridine synthase Mb1738;
DE EC=5.4.99.-;
DE AltName: Full=RNA pseudouridylate synthase;
DE AltName: Full=RNA-uridine isomerase;
GN OrderedLocusNames=Mb1738;
OS Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC Corynebacterineae; Mycobacteriaceae; Mycobacterium;
OC Mycobacterium tuberculosis complex.
OX NCBI_TaxID=233413;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-935 / AF2122/97;
RX PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H.,
RA Pryor M., Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S.,
RA Harris B., Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R.,
RA Parkhill J., Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT "The complete genome sequence of Mycobacterium bovis.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
CC -!- CATALYTIC ACTIVITY: RNA uridine = RNA pseudouridine.
CC -!- SIMILARITY: Belongs to the pseudouridine synthase RsuA family.
CC -!- SIMILARITY: Contains 1 S4 RNA-binding domain.
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DR EMBL; BX248340; CAD94441.1; -; Genomic_DNA.
DR RefSeq; NP_855391.1; NC_002945.3.
DR ProteinModelPortal; P65843; -.
DR SMR; P65843; 14-248.
DR STRING; 233413.Mb1738; -.
DR EnsemblBacteria; CAD94441; CAD94441; Mb1738.
DR GeneID; 1092702; -.
DR KEGG; mbo:Mb1738; -.
DR PATRIC; 18005499; VBIMycBov88188_1896.
DR eggNOG; COG1187; -.
DR HOGENOM; HOG000044954; -.
DR KO; K06178; -.
DR OMA; CEDLIFR; -.
DR ProtClustDB; CLSK791343; -.
DR GO; GO:0009982; F:pseudouridine synthase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0001522; P:pseudouridine synthesis; IEA:InterPro.
DR Gene3D; 3.10.290.10; -; 1.
DR InterPro; IPR020103; PsdUridine_synth_cat_dom.
DR InterPro; IPR000748; PsdUridine_synth_RsuA/RluB/E/F.
DR InterPro; IPR018496; PsdUridine_synth_RsuA/RluB_CS.
DR InterPro; IPR006145; PsdUridine_synth_RsuA/RluD.
DR InterPro; IPR002942; S4_RNA-bd.
DR Pfam; PF00849; PseudoU_synth_2; 1.
DR Pfam; PF01479; S4; 1.
DR SMART; SM00363; S4; 1.
DR SUPFAM; SSF55120; PsdUridine_synth_cat_dom; 1.
DR TIGRFAMs; TIGR00093; TIGR00093; 1.
DR PROSITE; PS01149; PSI_RSU; 1.
DR PROSITE; PS50889; S4; 1.
PE 3: Inferred from homology;
KW Complete proteome; Isomerase; RNA-binding.
FT CHAIN 1 254 Uncharacterized RNA pseudouridine
FT synthase Mb1738.
FT /FTId=PRO_0000100030.
FT DOMAIN 14 81 S4 RNA-binding.
FT ACT_SITE 119 119 Nucleophile (By similarity).
SQ SEQUENCE 254 AA; 27597 MW; EB2D95D7CF0FDF26 CRC64;
MMAEPEESRE PRGIRLQKVL SQAGIASRRA AEKMIVDGRV EVDGHVVTEL GTRVDPQVAV
VRVDGARVVL DDSLVYLALN KPRGMHSTMS DDRGRPCIGD LIERKVRGTK KLFHVGRLDA
DTEGLMLLTN DGELAHRLMH PSHEVPKTYL ATVTGSVPRG LGRTLRAGIE LDDGPAFVDD
FAVVDAIPGK TLVRVTLHEG RNRIVRRLLA AAGFPVEALV RTDIGAVSLG KQRPGSVRAL
RSNEIGQLYQ AVGL
//
