ID ZCH18_RAT Reviewed; 947 AA.
AC Q6TQE1; Q6TQE2;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-APR-2013, entry version 43.
DE RecName: Full=Zinc finger CCCH domain-containing protein 18;
DE AltName: Full=Nuclear protein NHN1;
GN Name=Zc3h18; Synonyms=Nhn1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC Muroidea; Muridae; Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B).
RC STRAIN=Wistar;
RA Hidalgo de Quintana J., Ponnambalam S., Walker J.H.;
RT "Nhn1, a novel highly conserved nuclear protein.";
RL Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-846 AND SER-862, AND
RP MASS SPECTROMETRY.
RC STRAIN=Fischer; TISSUE=Liver;
RX PubMed=16396499; DOI=10.1021/pr0503073;
RA Moser K., White F.M.;
RT "Phosphoproteomic analysis of rat liver by high capacity IMAC and LC-
RT MS/MS.";
RL J. Proteome Res. 5:98-104(2006).
CC -!- SUBCELLULAR LOCATION: Nucleus (Probable).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=A;
CC IsoId=Q6TQE1-1; Sequence=Displayed;
CC Name=B;
CC IsoId=Q6TQE1-2; Sequence=VSP_029458;
CC -!- SIMILARITY: Contains 1 C3H1-type zinc finger.
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DR EMBL; AY389807; AAR92226.1; -; mRNA.
DR EMBL; AY389808; AAR92227.1; -; mRNA.
DR IPI; IPI00400666; -.
DR IPI; IPI00563982; -.
DR RefSeq; NP_958819.1; NM_201416.1.
DR UniGene; Rn.36848; -.
DR STRING; 10116.ENSRNOP00000048376; -.
DR PhosphoSite; Q6TQE1; -.
DR PaxDb; Q6TQE1; -.
DR PRIDE; Q6TQE1; -.
DR Ensembl; ENSRNOT00000039273; ENSRNOP00000035933; ENSRNOG00000028501.
DR Ensembl; ENSRNOT00000045657; ENSRNOP00000048376; ENSRNOG00000028501.
DR GeneID; 292067; -.
DR KEGG; rno:292067; -.
DR UCSC; RGD:1303257; rat.
DR CTD; 124245; -.
DR RGD; 1303257; Zc3h18.
DR eggNOG; NOG74292; -.
DR GeneTree; ENSGT00650000093061; -.
DR HOVERGEN; HBG103346; -.
DR KO; K13092; -.
DR NextBio; 633689; -.
DR Genevestigator; Q6TQE1; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR InterPro; IPR000571; Znf_CCCH.
DR SMART; SM00356; ZnF_C3H1; 1.
DR PROSITE; PS50103; ZF_C3H1; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Coiled coil; Complete proteome;
KW Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Zinc;
KW Zinc-finger.
FT CHAIN 1 947 Zinc finger CCCH domain-containing
FT protein 18.
FT /FTId=PRO_0000311244.
FT ZN_FING 214 240 C3H1-type.
FT COILED 915 944 Potential.
FT COMPBIAS 5 204 Glu-rich.
FT COMPBIAS 254 291 Pro-rich.
FT COMPBIAS 397 595 Arg-rich.
FT COMPBIAS 527 741 Ser-rich.
FT MOD_RES 1 1 N-acetylmethionine (By similarity).
FT MOD_RES 6 6 Phosphoserine (By similarity).
FT MOD_RES 44 44 Phosphoserine (By similarity).
FT MOD_RES 63 63 Phosphoserine (By similarity).
FT MOD_RES 70 70 Phosphoserine (By similarity).
FT MOD_RES 74 74 Phosphoserine (By similarity).
FT MOD_RES 79 79 Phosphoserine (By similarity).
FT MOD_RES 91 91 Phosphoserine (By similarity).
FT MOD_RES 104 104 Phosphothreonine (By similarity).
FT MOD_RES 105 105 Phosphoserine (By similarity).
FT MOD_RES 168 168 Phosphoserine (By similarity).
FT MOD_RES 482 482 Phosphoserine (By similarity).
FT MOD_RES 527 527 Phosphoserine (By similarity).
FT MOD_RES 529 529 Phosphoserine (By similarity).
FT MOD_RES 531 531 Phosphoserine (By similarity).
FT MOD_RES 837 837 Phosphoserine (By similarity).
FT MOD_RES 846 846 Phosphoserine.
FT MOD_RES 862 862 Phosphoserine.
FT MOD_RES 887 887 Phosphoserine (By similarity).
FT MOD_RES 890 890 Phosphoserine (By similarity).
FT VAR_SEQ 223 223 M -> MKDVVTPLSTLLPPIPNSIPLRGQV (in
FT isoform B).
FT /FTId=VSP_029458.
SQ SEQUENCE 947 AA; 105537 MW; 4A8513A205131AE4 CRC64;
MDVAESPELE PHSPDEEQPA LSDDDILRES GSEQDLDGAG ERASDLEEEE NATRVQSQEE
IHSDEEDQAS EPKSQDQDSE AHELSRGPAG SPCEEGDDAE EDGTSDLRDE ASSVTRELDE
HELDYDEEVP EEPAPAAQEE EAEKAGAEEE EEKGEGAPGE EGKPDVQSVG EKEPTEAAKE
KKKEDDDGEI DDGEIDDDDL EEGEVKDPSD RKVRPRPTCR FFMKGNCTWG MNCRFIHPGV
NDKGNYSLIT KAEPFPPNGA PPLGPHPLMP ANPWGGPVVD EILPPPPPEP PTESAWERGL
RHAKEVLKKA TIRKEQEPDF EEKRFTVTIG EDDREFDKEN EVFRDWNSRV PRDVRDTTLE
PYADPYYDYE IERFWRGGQY ENFRVQYTEA EPYHNYRDRE RERERENRQR ERERDRERDR
ERERRQRERE RERERERDKE RQRRKEEWER ERAKRDEKDR QHRDRDRDKD RDKDKEKPKP
RSPQPPSRQA EPPKKETASV GPQVKRADEW KDPWRRSKSP KKKLGVSVSP SRARRRRKTS
ASSASASNSS RSSSRSSSYS GSGSSRSRSR SSSYSSYSSR SSRRSSFSGS RSRSRSFSSS
PSPSPTPSPH RPPVRTKGEP APPPGKAGEK SIKKPAPPPA PPQATKTTAP APEPAKPGDL
REARRKERQT RTPPRRRTLS GSGSGSGSSY SGSSSRSRSL SVSSVSSVSS ATSSSSSVHS
VDSDDMYADL ASPVSSASSR SPTPAQTKKE RGKSKKEDGV REEKRKRDPS AQPPKSSKAP
AGGKASQQAA APQQAAPGQP QQGSFVAHKE IKLTLLNKAA EKGSRKRYEP SDKDRQSPPA
KKANLSPDRG SRDRKSGGRM GSPKPERQRG QNAKAPAAPA DRKRPLSPQS KSSSKVTSVP
GKATDTATAG TKSGKASTLS RREELLKQLK AVEDAIARKR AKIPGKV
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