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spo03050                    Pathway                                

Proteasome - Schizosaccharomyces pombe (fission yeast)
The proteasome is a protein-destroying apparatus involved in many essential cellular functions, such as regulation of cell cycle, cell differentiation, signal transduction pathways, antigen processing for appropriate immune responses, stress signaling, inflammatory responses, and apoptosis. It is capable of degrading a variety of cellular proteins in a rapid and timely fashion and most substrate proteins are modified by ubiquitin before their degradation by the proteasome. The proteasome is a large protein complex consisting of a proteolytic core called the 20S particle and ancillary factors that regulate its activity in various ways. The most common form is the 26S proteasome containing one 20S core particle and two 19S regulatory particles that enable the proteasome to degrade ubiquitinated proteins by an ATP-dependent mechanism. Another form is the immunoproteasome containing two 11S regulatory particles, PA28 alpha and PA28 beta, which are induced by interferon gamma under the conditions of intensified immune response. Other regulatory particles include PA28 gamma and PA200. Although PA28 gamma also belongs to a family of activators of the 20S proteasome, it is localized within the nucleus and forms a homoheptamer. PA28 gamma has been implicated in the regulation of cell cycle progression and apoptosis. PA200 has been identified as a large nuclear protein that stimulates proteasomal hydrolysis of peptides.
Genetic Information Processing; Folding, sorting and degradation
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Proteasome, 20S core particle [PATH:spo03050]
Proteasome, 19S regulatory particle (PA700) [PATH:spo03050]
Other DBs
Schizosaccharomyces pombe (fission yeast) [GN:spo]
rpn3; 19S proteasome regulatory subunit Rpn3 [KO:K03033]
rpn502; 19S proteasome regulatory subunit Rpn502 [KO:K03035]
rpn501; 19S proteasome regulatory subunit Rpn501 [KO:K03035]
rpn6; 19S proteasome regulatory subunit Rpn6 (predicted) [KO:K03036]
rpn7; 19S proteasome regulatory subunit Rpn7 [KO:K03037]
rpn8; 19S proteasome regulatory subunit Rpn8 (predicted) [KO:K03038]
rpn9; 19S proteasome regulatory subunit Rpn9 [KO:K03039]
rpn11; 19S proteasome regulatory subunit Rpn11 [KO:K03030]
rpn12; 19S proteasome regulatory subunit Rpn12 [KO:K03031]
dss1; mRNA export protein Dss1 [KO:K10881]
rpn10; 19S proteasome regulatory subunit Rpn10 [KO:K03029]
mts4; 19S proteasome regulatory subunit Mts4 [KO:K03028]
rpn2; 19S proteasome regulatory subunit Rpn2 (predicted) [KO:K03032]
rpn13; 19S proteasome regulatory subunit rpn1302 [KO:K06691]
rpn1301; hypothetical protein [KO:K06691]
rpt1; 19S proteasome regulatory subunit Rpt1 (predicted) [KO:K03061]
rpt2; 19S proteasome regulatory subunit Rpt2 [KO:K03062]
rpt6; 19S proteasome regulatory subunit Rpt6 (predicted) [KO:K03066]
rpt4; 19S proteasome regulatory subunit Rpt4 (predicted) [KO:K03064]
rpt5; 19S proteasome regulatory subunit Rpt5 (predicted) [KO:K03065]
rpt3; 19S proteasome regulatory subunit Rpt3 (predicted) [KO:K03063]
20S proteasome component alpha 1 (predicted) [KO:K02730] [EC:]
pre8; 20S proteasome component alpha 2, Pre8 (predicted) [KO:K02726] [EC:]
20S proteasome component alpha 3 (predicted) [KO:K02728] [EC:]
pre6; 20S proteasome component alpha 4 Pre6 [KO:K02731] [EC:]
pup2; 20S proteasome component alpha 5, Pup2 (predicted) [KO:K02729] [EC:]
20S proteasome component alpha 6 subunit Pre5 (predicted) [KO:K02725] [EC:]
pre10; 20S proteasome component alpha 7, Pre10 (predicted) [KO:K02727] [EC:]
pre3; 20S proteasome component beta 1 Pre3 (predicted) [KO:K02738] [EC:]
pup1; 20S proteasome component beta 2 (predicted) [KO:K02739] [EC:]
pup3; 20S proteasome component beta 3, Pup3 (predicted) [KO:K02735] [EC:]
20S proteasome component beta 4 (predicted) [KO:K02734] [EC:]
pts1; 20S proteasome component beta 5 [KO:K02737] [EC:]
pam1; 20S proteasome component beta 6 [KO:K02732] [EC:]
20S proteasome component beta 7 (predicted) [KO:K02736] [EC:]
ump1; proteasome maturation factor Ump1 (predicted) [KO:K11599]
Hirano Y, Murata S, Tanaka K
Large- and small-scale purification of mammalian 26S proteasomes.
Methods Enzymol 399:227-40 (2005)
Saeki Y, Tanaka K
Cell biology: two hands for degradation.
Nature 453:460-1 (2008)
Smith DM, Benaroudj N, Goldberg A
Proteasomes and their associated ATPases: a destructive combination.
J Struct Biol 156:72-83 (2006)
Strehl B, Seifert U, Kruger E, Heink S, Kuckelkorn U, Kloetzel PM
Interferon-gamma, the functional plasticity of the ubiquitin-proteasome system, and MHC class I antigen processing.
Immunol Rev 207:19-30 (2005)
Isono E, Toh-e A
[Biogenesis of the 26S proteasome in the yeast Saccharomyces cerevisiae]
Tanpakushitsu Kakusan Koso 51:1224-9 (2006)
Hirano Y, Murata S
[Mechanism of the assembly of mammalian 20S proteasome]
Tanpakushitsu Kakusan Koso 51:1230-5 (2006)
Saeki Y, Yashiroda H
[Diversity of proteasome activators]
Tanpakushitsu Kakusan Koso 51:1236-40 (2006)
Darwin KH
Prokaryotic ubiquitin-like protein (Pup), proteasomes and pathogenesis.
Nat Rev Microbiol 7:485-91 (2009)
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