KEGG   PATHWAY: spt00010Help
Entry
spt00010                    Pathway                                

Name
Glycolysis / Gluconeogenesis - Salmonella enterica subsp. enterica serovar Paratyphi A ATCC9150
Description
Glycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabolites: six-carbon compounds of glucose-6P and fructose-6P and three-carbon compounds of glycerone-P, glyceraldehyde-3P, glycerate-3P, phosphoenolpyruvate, and pyruvate [MD:M00001]. Acetyl-CoA, another important precursor metabolite, is produced by oxidative decarboxylation of pyruvate [MD:M00307]. When the enzyme genes of this pathway are examined in completely sequenced genomes, the reaction steps of three-carbon compounds from glycerone-P to pyruvate form a conserved core module [MD:M00002], which is found in almost all organisms and which sometimes contains operon structures in bacterial genomes. Gluconeogenesis is a synthesis pathway of glucose from noncarbohydrate precursors. It is essentially a reversal of glycolysis with minor variations of alternative paths [MD:M00003].
Class
Metabolism; Carbohydrate metabolism
BRITE hierarchy
Pathway map
Glycolysis / Gluconeogenesis
spt00010

All organismsOrtholog table
Module
Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate [PATH:spt00010]
Glycolysis, core module involving three-carbon compounds [PATH:spt00010]
Gluconeogenesis, oxaloacetate => fructose-6P [PATH:spt00010]
PTS system, glucose-specific II component [PATH:spt00010]
Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:spt00010]
Other DBs
BSID: 
GO: 
Organism
Salmonella enterica subsp. enterica serovar Paratyphi A ATCC9150 [GN:spt]
Gene
glk; glucokinase [KO:K00845] [EC:2.7.1.2]
pgi; glucose-6-phosphate isomerase [KO:K01810] [EC:5.3.1.9]
pfkA; 6-phosphofructokinase [KO:K00850] [EC:2.7.1.11]
pfkB; 6-phosphofructokinase [KO:K16370] [EC:2.7.1.11]
carbohydrate kinase; K16370 6-phosphofructokinase 2 [EC:2.7.1.11] [KO:K16370] [EC:2.7.1.11]
fbp; fructose-1,6-bisphosphatase [KO:K03841] [EC:3.1.3.11]
glpX; glycerol metabolic protein [KO:K02446] [EC:3.1.3.11]
fbaB; fructose-bisphosphate aldolase [KO:K11645] [EC:4.1.2.13]
fba; fructose 1,6-bisphosphate aldolase [KO:K01624] [EC:4.1.2.13]
tpiA; triosephosphate isomerase [KO:K01803] [EC:5.3.1.1]
gapA; glyceraldehyde 3-phosphate dehydrogenase A [KO:K00134] [EC:1.2.1.12]
pgk; phosphoglycerate kinase [KO:K00927] [EC:2.7.2.3]
gpmA; phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
pmgI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
gpmB; phosphoglycerate mutase [KO:K15634] [EC:5.4.2.12]
eno; enolase [KO:K01689] [EC:4.2.1.11]
pykA; pyruvate kinase A [KO:K00873] [EC:2.7.1.40]
pykF; pyruvate kinase [KO:K00873] [EC:2.7.1.40]
aceE; pyruvate dehydrogenase E1 component [KO:K00163] [EC:1.2.4.1]
aceF; dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase [KO:K00627] [EC:2.3.1.12]
lpdA; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
adh; alcohol dehydrogenase [KO:K04072] [EC:1.1.1.1 1.2.1.10]
adhP; alcohol dehydrogenase [KO:K13953] [EC:1.1.1.1]
alcohol dehydrogenase; K00001 alcohol dehydrogenase [EC:1.1.1.1] [KO:K00001] [EC:1.1.1.1]
eutG; alchohol dehydrogenase [KO:K04022]
aldB; aldehyde dehydrogenase B [KO:K00138] [EC:1.2.1.-]
acs; acetyl-coenzyme A synthetase [KO:K01895] [EC:6.2.1.1]
galM; aldose 1-epimerase (mutarotase) [KO:K01785] [EC:5.1.3.3]
agp; glucose-1-phosphatase precursor (G1Pase), secreted [KO:K01085] [EC:3.1.3.10]
pgm; phosphoglucomutase [KO:K01835] [EC:5.4.2.2]
yeaD; aldose 1-epimerase [KO:K01792] [EC:5.1.3.15]
pckA; phosphoenolpyruvate carboxykinase [KO:K01610] [EC:4.1.1.49]
celF; phospho-beta-glucosidase B [KO:K01222] [EC:3.2.1.86]
bglA; 6-phospho-beta-glucosidase [KO:K01223] [EC:3.2.1.86]
glycosyl hydrolase; K01223 6-phospho-beta-glucosidase [EC:3.2.1.86] [KO:K01223] [EC:3.2.1.86]
crr; pts system, glucose-specific IIA component [KO:K02777] [EC:2.7.1.69]
ptsG; PTS system glucose-specific transporter subunit IIBC [KO:K02778 K02779] [EC:2.7.1.69]
Compound
C00022  
Pyruvate
C00024  
Acetyl-CoA
C00031  
D-Glucose
C00033  
Acetate
C00036  
Oxaloacetate
C00068  
Thiamin diphosphate
C00074  
Phosphoenolpyruvate
C00084  
Acetaldehyde
C00103  
D-Glucose 1-phosphate
C00111  
Glycerone phosphate
C00118  
D-Glyceraldehyde 3-phosphate
C00186  
(S)-Lactate
C00197  
3-Phospho-D-glycerate
C00221  
beta-D-Glucose
C00236  
3-Phospho-D-glyceroyl phosphate
C00267  
alpha-D-Glucose
C00469  
Ethanol
C00631  
2-Phospho-D-glycerate
C00668  
alpha-D-Glucose 6-phosphate
C01159  
2,3-Bisphospho-D-glycerate
C01172  
beta-D-Glucose 6-phosphate
C01451  
Salicin
C05125  
2-(alpha-Hydroxyethyl)thiamine diphosphate
C05345  
beta-D-Fructose 6-phosphate
C05378  
beta-D-Fructose 1,6-bisphosphate
C06186  
Arbutin
C06187  
Arbutin 6-phosphate
C06188  
Salicin 6-phosphate
C15972  
Enzyme N6-(lipoyl)lysine
C15973  
Enzyme N6-(dihydrolipoyl)lysine
C16255  
[Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
(map 1)
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
(map 1)
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
KO pathway
 

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