Database: SPTrEMBL
Entry: TCBC_PSESQ
LinkDB: TCBC_PSESQ
Original site: TCBC_PSESQ 

ID   TCBC_PSESQ              Reviewed;         251 AA.
AC   P27098;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 1.
DT   19-JAN-2010, entry version 56.
DE   RecName: Full=Chlorocatechol 1,2-dioxygenase;
DE            EC=1.13.11.-;
GN   Name=tcbC;
OS   Pseudomonas sp. (strain P51).
OG   Plasmid pP51.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Comamonadaceae.
OX   NCBI_TaxID=65067;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=91193197; PubMed=2013566;
RA   van der Meer J.R., Eggen R.I., Zehnder A.J., de Vos W.M.;
RT   "Sequence analysis of the Pseudomonas sp. strain P51 tcb gene cluster,
RT   which encodes metabolism of chlorinated catechols: evidence for
RT   specialization of catechol 1,2-dioxygenases for chlorinated
RT   substrates.";
RL   J. Bacteriol. 173:2425-2434(1991).
CC   -!- FUNCTION: Preferentially converts 3,4-dichlorocatechol as opposed
CC       to other chlorinated catechols. Retains diminished activity toward
CC       non-chlorinated substrates.
CC   -!- CATALYTIC ACTIVITY: 3,4-dichlorocatechol + O(2) = 2,3-dichloro
CC       -muconate.
CC   -!- COFACTOR: Binds 1 Fe(3+) ion per subunit.
CC   -!- PATHWAY: Aromatic compound metabolism; 3-chlorocatechol
CC       degradation.
CC   -!- SIMILARITY: Belongs to the intradiol ring-cleavage dioxygenase
CC       family.
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DR   EMBL; M57629; AAD13625.1; -; Genomic_DNA.
DR   PIR; A43673; A43673.
DR   SMR; P27098; 2-245.
DR   BioCyc; MetaCyc:MONOMER-14402; -.
DR   GO; GO:0018576; F:catechol 1,2-dioxygenase activity; IEA:InterPro.
DR   GO; GO:0018575; F:chlorocatechol 1,2-dioxygenase activity; IEA:InterPro.
DR   GO; GO:0008199; F:ferric iron binding; IEA:InterPro.
DR   GO; GO:0019439; P:aromatic compound catabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0009712; P:catechol metabolic process; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR007535; Catechol_dOase_N.
DR   InterPro; IPR012817; Chlorcchol_dOase.
DR   InterPro; IPR000627; Intradiol_dOase_C.
DR   InterPro; IPR015889; Intradiol_dOase_core.
DR   Gene3D; G3DSA:2.60.130.10; Intradiol_dOase_core; 1.
DR   Pfam; PF00775; Dioxygenase_C; 1.
DR   Pfam; PF04444; Dioxygenase_N; 1.
DR   PROSITE; PS00083; INTRADIOL_DIOXYGENAS; 1.
PE   3: Inferred from homology;
KW   Aromatic hydrocarbons catabolism; Dioxygenase; Iron; Metal-binding;
KW   Oxidoreductase; Plasmid.
FT   CHAIN         1    251       Chlorocatechol 1,2-dioxygenase.
FT                                /FTId=PRO_0000085089.
FT   METAL       130    130       Iron (By similarity).
FT   METAL       164    164       Iron (By similarity).
FT   METAL       188    188       Iron (By similarity).
FT   METAL       190    190       Iron (By similarity).
SQ   SEQUENCE   251 AA;  27554 MW;  8867F76282D7C6D7 CRC64;
     MNERVKQVAS ALVDAIQKTL TEQRVTEEEW RAGVGYMMKL AEAKEVAVLL DAFFNHTIVD
     LKAQATRGSR PAMQGPYFLE GAPVVAGALK TYEDDSHHPL VIRGAVRTDD GAPAAGAVID
     VWHSTPDGKY SGIHDQIPTD MYRGKVVADA QGKYAVRTTM PAPYQIPNKG PTGVLLEMMG
     SHTWRPAHVH FKVRKDGFAP LTTQYYFEGG DWVDSDCCKG VAPDLVMPTK TEGGAQVMDI
     DFVIERAREH V
//

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