KEGG   Sus scrofa (pig): 100127359Help
Entry
100127359         CDS       T01009                                 

Gene name
MTOR, FRAP1
Definition
mechanistic target of rapamycin (serine/threonine kinase)
Orthology
K07203  
FKBP12-rapamycin complex-associated protein
Organism
ssc  Sus scrofa (pig)
Pathway
ErbB signaling pathway
HIF-1 signaling pathway
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Insulin signaling pathway
Thyroid hormone signaling pathway
Adipocytokine signaling pathway
Type II diabetes mellitus
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Glioma
Prostate cancer
Acute myeloid leukemia
Brite
KEGG Orthology (KO) [BR:ssc00001]
 Environmental Information Processing
  Signal transduction
   04012 ErbB signaling pathway
    100127359 (MTOR)
   04066 HIF-1 signaling pathway
    100127359 (MTOR)
   04151 PI3K-Akt signaling pathway
    100127359 (MTOR)
   04152 AMPK signaling pathway
    100127359 (MTOR)
   04150 mTOR signaling pathway
    100127359 (MTOR)
 Organismal Systems
  Endocrine system
   04910 Insulin signaling pathway
    100127359 (MTOR)
   04920 Adipocytokine signaling pathway
    100127359 (MTOR)
   04919 Thyroid hormone signaling pathway
    100127359 (MTOR)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    100127359 (MTOR)
   05206 MicroRNAs in cancer
    100127359 (MTOR)
   05205 Proteoglycans in cancer
    100127359 (MTOR)
   05214 Glioma
    100127359 (MTOR)
   05221 Acute myeloid leukemia
    100127359 (MTOR)
   05215 Prostate cancer
    100127359 (MTOR)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    100127359 (MTOR)
Protein kinases [BR:ssc01001]
 Serine/threonine protein kinases: Atypical group
  PIKK family [Table]
   100127359 (MTOR)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Ensembl: 
Position
6
AA seq 2548 aa AA seqDB search
MLGTGPAAATTATTTSSNVSVLQQFASGLKSRNEETRAKAAKELQHYVTMELREMSQEES
TRFYDQLNHHIFELVSSSDANERKGGILAIASLIGVEGGNATRIGRFANYLRNLLPSNDP
VVMEMASKAIGRLAMAGDTFTAEYVEFEVKRALEWLGADRNEGRRHAAVLVLRELAVSVP
TFFFQQVQPFFDNIFVAVWDPKQAIREGAVAALRACLILTTQREPKEMQKPQWYRHTFEE
AEKGFDETLAKEKGMNRDDRIHGALLILNELVRISSMEGERLREEMEEITQQQLVHDKYC
KDLMGFGTKPRHITPFTSFQAVQPQQSNALVGLLGYSSHQGLLGFGASPSPAKSTLVESR
CCRDLMEEKFDQVCQWVLKCRNSKNSLIQMTILNLLPRLAAFRPSAFTDTQYLQDTMNHV
LSCVKKEKERTAAFQALGLLSVAVRSEFKVYLPRVLDIIRAALPPKDFAHKRQKAMQVDA
TVFTCISMLARAMGPGIQQDIKELLEPMLAVGLSPALTAVLYDLSRQIPQLKKDIQDGLL
KMLSLVLMHKPLRHPGMPKGLAHQLASPSLTTLPEASDVGSITLALRTLGSFEFEGHSLT
QFVRHCADHFLNSEHKEIRMEAARTCSRLLTPSVHLISGHAHVVSQTAVQVVADVLSKLL
VVGITDPDPDIRYCVLASLDERFDAHLAQAENLQALFVALNDQVFEIRELAICTVGRLSS
MNPAFVMPFLRKMLIQILTELEHSGIGRIKEQSARMLGHLVSNAPRLIRPYMEPILKALI
LKLKDPDPDPNPGVINNVLATIGELAQVSGLEMRKWVDELFIIIMDMLQDSSLLAKRQVA
LWTLGQLVASTGYVVEPYRKYPTLLEVLLNFLKTEQNQGTRREAIRVLGLLGALDPYKHK
VNIGMIDQSRDASAVSLSESKSSQDSSDYSTSEMLVNMGNLPLDEFYPAVSMVALMRIFR
DQSLSHHHTMVVQAITFIFKSLGLKCVQFLPQVMPTFLNVIRVCDGAIREFLFQQLGMLV
SFVKSHIRPYMDEIVTLMREFWVMNTSIQSTIILLIEQIVVALGGEFKLYLPQLIPHMLR
VFMHDNSPGRIVSIKLLAAIQLFGANLDDYLHLLLPPIVKLFDAPEVPLPSRKAALETVD
RLTESLDFTDYASRIIHPIVRTLDQSPELRPTAMDTLSSLVFQLGKKYQIFIPMVNKVLV
RHRINHQRYDILICRIVKGYTLADEEEDPLIYQHRMLRSGQGDALASGPVETGPMKKLHV
STINLQKAWGAARRVSKDDWLEWLRRLSLELLKDSSSPSLRSCWALAQAYNPMARDLFNA
AFVSCWSELNEDQQDELIRSIELALTSQDIAEVTQTLLNLAEFMEHSDKGPLPLRDDNGI
VLLGERAAKCRAYAKALHYKELEFQKGPTPAILESLISINNKLQQPEAAAGVLEYAMKHF
GELEIQATWYEKLHEWEDALVAYDKKMDTNKDDPELMLGRMRCLEALGEWGQLHQQCCEK
WTLVNDETQAKMARMAAAAAWGLGQWDSMEEYTCMIPRDTHDGAFYRAVLALHQDLFSLA
QQCIDKARDLLDAELTAMAGESYSRAYGAMVSCHMLSELEEVIQYKLVPERREIIRQIWW
ERLQGCQRIVEDWQRILMVRSLVVSPHEDMRTWLKYASLCGKSGRLALAHKTLVLLLGVD
PSRQLDHPLPTGHPQVTYAYMKNMWKSARKIDAFQHMQHFVQTMQQQAQRAIATEDQQHK
QELHKLMARCFLKLGEWQLNLQGINESTIPKVLQYYSAATEHDRSWYKAWHAWAVMNFEA
VLHYKHQNQARDEKKKLRHASGANITNAATAATTAATATATSTEGSNSESEAESTENSPT
PSPLQKKVTEDLSKTLLMYTVPAVQGFFRSISLSRGNNLQDTLRVLTLWFDYGHWPDVNE
ALVEGVKAIQIDTWLQVIPQLIARIDTPRPLVGRLIHQLLTDIGRYHPQALIYPLTVASK
STTTARHNAANKILKNMCEHSNTLVQQAMMVSEELIRVAILWHEMWHEGLEEASRLYFGE
RNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQAW
DLYYHVFRRISKQLPQLTSLELQYVSPKLLMCRDLELAVPGTYDPNQPIIRIQSIAPSLQ
VITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRKNLS
IQRYAVIPLSTNSGLIGWVPHCDTLHALIRDYREKKKILLNIEHRIMLRMAPDYDHLTLM
QKVEVFEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRTNYTRSLAVMSMVGYILGLGDRHP
SNLMLDRLSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLTNAMEVTGLDGNYRITCH
TVMEVLREHKDSVMAVLEAFVYDPLLNWRLMDTNTKGNKRSRTRTDSYSAGQSVEILDGV
ELGEPAHKKTGTTVPESIHSFIGDGLVKPEALNKKAIQIINRVRDKLTGRDFSHDETLDV
PTQVELLIKQATSHENLCQCYIGWCPFW
NT seq 7647 nt NT seq  +upstreamnt  +downstreamnt
atgcttggaaccggacctgccgccgccaccacagcgaccaccacttccagcaacgtgagc
gtcctgcagcagtttgccagtggcctgaagagccggaatgaggagaccagggccaaagct
gccaaggaactccagcactatgtcaccatggagctccgagagatgagtcaagaggagtct
actcgtttctatgatcagctgaaccatcacatttttgaactggtttccagctcagatgcc
aatgagaggaaaggcggcatcttggccatagccagcctcataggagtggaaggcgggaat
gccacccgaatcggaagatttgccaactatcttcggaacctcctcccctccaatgacccc
gttgtcatggaaatggcatccaaggccattggtcgcctcgccatggcaggagacactttt
actgcagagtatgtggagtttgaggtgaagcgagccctggagtggctgggtgctgaccga
aacgagggccggagacacgcagctgtcctggtccttcgtgagctggccgtcagcgtcccc
accttcttcttccagcaagtgcagcccttctttgacaacatttttgtggctgtgtgggac
cccaaacaggccatccgggagggagctgtcgccgcgctccgtgcctgtctgatcctcacc
acccagcgagagccaaaggagatgcagaagccgcagtggtacaggcacacgttcgaagaa
gcagagaaagggtttgacgagaccttggccaaggagaagggcatgaaccgggacgaccgg
atccacggagccttgctgatcctcaacgagctggtccgcatcagcagcatggagggagag
cgcctgagagaagaaatggaagaaatcacacagcagcagttggtacatgacaagtactgc
aaggacctcatgggcttcgggacgaaacctcgtcacatcacccccttcaccagtttccag
gccgtgcagccccagcagtcaaacgccttggtgggactgctggggtacagctctcaccaa
ggcctcctggggtttggggcttcccccagcccagccaagtccacgctggtggagagtcgc
tgttgcagagacttgatggaggagaaattcgaccaggtgtgccagtgggtgctgaaatgc
aggaatagcaagaactcactgatccaaatgacaatccttaatttgctgccccgcttggct
gccttccgaccctctgccttcacagatacgcagtacctccaggacaccatgaaccatgtt
ctaagctgcgtcaagaaggagaaggaacggacagcagccttccaagccctagggctgctt
tctgtggctgtgaggtctgagttcaaggtctatttacctcgtgtgctggacatcatccga
gcagccttgcctcctaaggactttgctcataagagacagaaggccatgcaggtggacgcc
acagtgttcacctgcatcagcatgctggcccgggccatggggccaggcatccagcaggat
atcaaggagctgctggagcccatgctggcggtgggactgagccctgccctcacagctgtg
ctctacgacctgagccgtcagattccacagctgaaaaaggacatccaggatgggctcctg
aagatgctgtccctggtccttatgcacaaacccctgcggcacccgggcatgcccaagggc
ctggcccatcagctggcttcccccagcctcacgaccctccccgaggccagtgacgtgggc
agcattactcttgccctccgaactctcggcagttttgaattcgaaggccactctctgacc
cagttcgtccgccactgtgcggatcacttcctgaacagcgagcacaaggagatccgcatg
gaagccgcccgcacctgctcccgcctgcttacgccctccgtccacctcatcagcggccac
gctcacgtggtcagccagaccgcagtgcaggtggtggcggatgtgctcagcaagctgctc
gtggttgggataaccgatcctgaccccgacatccgctactgcgtcttggcgtccctggat
gagcgctttgacgcgcacctggcccaggcagagaatctgcaggccctgtttgtggccctg
aatgaccaggtgtttgagatccgggagctggccatctgcaccgtgggccggctcagcagc
atgaacccagccttcgtcatgcccttcctgcgcaagatgctcatccagattttgacggag
ctggagcacagtggcatcggaagaatcaaggagcagagtgcccgcatgctgggccacctg
gtctccaacgccccccgactcatccgcccctacatggagcccattctcaaggccttaatt
ttgaaactgaaagatccagaccctgatccaaaccccggagtgatcaacaacgtcttggct
acaatcggagagctggctcaggtcagtggcctagaaatgaggaagtgggtggatgaactt
tttattatcatcatggacatgctccaggactcctctctgttggccaaaaggcaggtggcc
ctgtggactctgggacagctggtggccagcactggctatgtggtggagccctacaggaag
taccccacattgctggaggtgctgctgaatttcctgaagactgagcagaaccagggtaca
cggcgagaggctatccgcgtgttagggctcttgggggccttggacccctacaagcacaaa
gtgaacattggcatgatcgaccagtcccgggacgcttctgccgtcagcctgtcagaatcc
aagtcaagtcaggactcctccgactacagcaccagtgagatgctggtcaacatggggaac
ctgcccctggacgagttctacccggccgtgtccatggtggccctgatgcggatcttccga
gaccagtccctctcccaccaccacaccatggtcgtccaggccatcaccttcatcttcaag
tccctggggctcaagtgtgtgcagttcctgccccaggtcatgcccacgttcctgaacgtc
attcgggtttgcgacggggccatccgggaatttctgttccagcaactggggatgctggtg
tcctttgtgaagagccacatcagaccttatatggatgagattgtcaccctcatgagagaa
ttctgggtcatgaacacctccatccagagcaccatcattcttctcattgagcagattgtg
gtagctcttgggggcgagtttaagctctacctgccccagctgatcccacacatgctccga
gtcttcatgcatgacaacagcccaggccgcatcgtctccatcaagttgctggccgcaatc
cagctgtttggcgccaacctggatgactatctgcatttgttgttgccccctattgtgaag
ttgtttgatgcccctgaagttccattgccatctcgaaaggcagcgctagagacagtggac
cgcctgacggagtccctggatttcactgactatgcctctcggatcatccacccgattgtg
cgaaccctggaccagagcccagaactccgtcccacggccatggacacgctctcttcgctc
gttttccagctggggaagaagtaccaaattttcattcccatggtgaacaaagttctggtg
cgacatcgcatcaaccatcagcgctacgatattctcatctgcaggattgtcaagggctac
acccttgccgacgaagaagaggaccctttgatttaccagcatcggatgctaagaagtggc
caaggggacgcactggctagtggaccagtagagacgggacccatgaagaaattgcacgtc
agcaccatcaacctccaaaaggcctggggagctgccagaagggtctccaaagatgactgg
ttggaatggctgaggcggctgagcctggagctgctgaaggactcctcgtccccatccctg
cgctcgtgctgggccctggctcaggcctacaacccgatggccagggatctcttcaacgcg
gcctttgtgtcctgctggtctgagctgaacgaagaccagcaggatgagctcatcagaagc
atcgagctggccctcacctcccaggacatcgctgaagtcacacaaacgctcttaaacttg
gccgaattcatggaacacagtgacaagggccccctgccgttgagagatgacaatggcatt
gttctgctgggcgagagggccgccaagtgtcgagcatacgccaaggcgctgcactacaaa
gaactggagttccagaagggccccacccccgccatcctggagtctctcatcagcatcaat
aataagctacaacagccagaggcagctgccggggtcttggagtatgccatgaagcacttt
ggagagctggagatccaggctacctggtacgagaaactgcatgagtgggaggatgccctg
gtggcctacgacaagaagatggacaccaacaaggacgacccggagctgatgctgggccgc
atgcgctgcctcgaggccttgggggaatgggggcagctgcaccagcagtgctgtgagaag
tggaccctggtgaatgacgaaacccaagccaagatggcccggatggctgctgcggctgcc
tggggtctcggtcagtgggacagcatggaggagtacacctgtatgatccctcgggacacc
cacgatggggcgttttatagagccgtgctggccctgcatcaggacctcttctccttggcc
caacagtgcatcgacaaagcccgggacctgctggacgccgagctgactgcgatggcagga
gagagctacagccgggcctacggggccatggtctcctgccacatgctctccgagctggag
gaggttatccagtacaaacttgtccccgagcgacgagagatcatccgccagatctggtgg
gagagactacagggctgccagcggatcgtggaggactggcagaggatcctcatggtgcgc
tcgctcgtggtcagccctcacgaggacatgaggacatggctcaagtacgcgagcctgtgc
ggcaagagcggcaggctggctcttgctcacaagaccttggtgctgctcctgggagtggat
ccgtctcggcagctcgaccaccctctgcccacaggccacccccaggtgacctacgcctac
atgaagaacatgtggaagagcgcccgcaagatcgatgccttccagcacatgcagcacttt
gttcagaccatgcagcagcaagcccaacgcgccatcgccactgaggaccagcagcacaag
caggagctgcacaagctcatggcccgatgtttcctgaaacttggagagtggcagctgaac
cttcaggggatcaacgagagcacgatccctaaagtcctgcagtactacagcgccgccacg
gagcacgaccgtagctggtacaaggcctggcacgcgtgggcagtgatgaacttcgaagct
gtgctccattacaaacatcagaaccaagcccgcgacgagaagaagaagctgcgccacgcc
agcggggccaacatcactaacgcagccaccgcagccaccacagcggccaccgccacggcc
accagcactgagggcagcaacagcgagagcgaggccgagagcactgagaacagccccacc
ccgtctcctctgcagaagaaggtcactgaggatttgtccaaaaccctcttgatgtacacc
gtccctgctgtccagggtttcttccgttccatctctttgtcacgaggcaacaacctccag
gacacactcagagtcctcaccttatggtttgattatgggcactggccggatgtaaacgaa
gccttagtggaaggggtgaaagcgatccagattgatacctggttacaggtcatacctcag
ctcattgcaagaatcgatacgcccaggcccttggtggggcgtctcattcaccagcttctc
acagacatcggtcggtaccacccccaggccctcatctaccccctgacggtggcgtctaag
tccaccaccaccgcccggcacaacgcggccaacaagatcctgaagaacatgtgtgagcac
agcaacaccctggtgcagcaggccatgatggtgagcgaggagctgatccgagtggccatc
ctctggcacgagatgtggcacgaaggcctggaagaggcgtctcgcttgtacttcggggag
aggaacgtgaaaggcatgttcgaggtgctggagcccctgcacgccatgatggagcgggga
ccccagaccctgaaggagacctcctttaaccaggcatacggtcgagacttaatggaggcc
caggagtggtgcaggaagtacatgaaatccgggaacgtcaaggacctcacccaggcctgg
gacctctattaccacgtgttcaggcgcatctcgaagcagctgccgcagctcacatcccta
gagctgcagtatgtttcccccaaactcctgatgtgccgggaccttgaattggctgtgcca
ggaacctatgaccccaaccagcccatcattcgcattcagtccatagcgccgtctctgcag
gtcatcacgtccaagcagaggccccggaagctgacacttatgggcagcaacggccacgag
ttcgtcttcctcctgaagggccacgaagacctgcggcaggacgagcgcgtcatgcagctc
ttcggcctggtcaacacccttttggccaacgacccaacgtctctccgcaagaacctcagc
atccagaggtacgccgtcatccccttatccaccaactcgggcctcatcggctgggtcccc
cactgtgacacactgcacgccctcatccgggactacagggagaagaagaagatccttctc
aacatcgagcatcgcatcatgctgcggatggctccagactacgaccacctgaccctgatg
cagaaggttgaggtgttcgagcacgccgtcaacaacaccgccggcgatgacctggccaag
ctgctgtggctgaaaagccccagctccgaggtgtggtttgatcgaagaaccaactacact
cgctctttagcagtcatgtccatggttgggtatattttgggcctgggcgatagacaccca
tctaacctgatgctggaccggctgagcgggaagatcctgcacattgactttggggactgc
tttgaggttgctatgaccagagagaagttcccagagaagattccatttagactaacgaga
atgttgaccaatgctatggaggtcactggtctggatggcaactacaggatcacgtgccac
acggtcatggaagtgcttcgggaacacaaggacagcgtcatggccgtgctggaagccttc
gtctatgaccccttactgaactggaggctgatggacacaaacaccaaaggtaacaagcga
tcgcgcacaaggacggattcctactctgccggccagtcagtagaaattttggatggtgtg
gaacttggggaaccagcccataagaaaacggggaccacagtgccagaatctattcattcg
ttcattggagatggtttggtgaaaccggaggccctaaataagaaagctattcagattatt
aacagggttcgagataagctcactggtcgggacttttctcatgatgaaaccttggatgtc
ccaacgcaagtggagctgctcatcaaacaagccacatcccatgaaaacctctgccagtgc
tacatcggctggtgtcctttctggtaa

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