KEGG   Sus scrofa (pig): 100152497Help
Entry
100152497         CDS       T01009                                 

Gene name
PLCG1
Definition
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1
  KO
K01116  
phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
Organism
ssc  Sus scrofa (pig)
Pathway
Inositol phosphate metabolism
Metabolic pathways
EGFR tyrosine kinase inhibitor resistance
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
Calcium signaling pathway
NF-kappa B signaling pathway
HIF-1 signaling pathway
Phosphatidylinositol signaling system
Phospholipase D signaling pathway
Axon guidance
VEGF signaling pathway
Natural killer cell mediated cytotoxicity
Th1 and Th2 cell differentiation
Th17 cell differentiation
T cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Inflammatory mediator regulation of TRP channels
Thyroid hormone signaling pathway
AGE-RAGE signaling pathway in diabetic complications
Kaposi's sarcoma-associated herpesvirus infection
Epstein-Barr virus infection
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Glioma
Non-small cell lung cancer
Hepatocellular carcinoma
Choline metabolism in cancer
Module
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:ssc00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100152497 (PLCG1)
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    100152497 (PLCG1)
   04015 Rap1 signaling pathway
    100152497 (PLCG1)
   04012 ErbB signaling pathway
    100152497 (PLCG1)
   04370 VEGF signaling pathway
    100152497 (PLCG1)
   04064 NF-kappa B signaling pathway
    100152497 (PLCG1)
   04066 HIF-1 signaling pathway
    100152497 (PLCG1)
   04020 Calcium signaling pathway
    100152497 (PLCG1)
   04070 Phosphatidylinositol signaling system
    100152497 (PLCG1)
   04072 Phospholipase D signaling pathway
    100152497 (PLCG1)
 Organismal Systems
  Immune system
   04650 Natural killer cell mediated cytotoxicity
    100152497 (PLCG1)
   04660 T cell receptor signaling pathway
    100152497 (PLCG1)
   04658 Th1 and Th2 cell differentiation
    100152497 (PLCG1)
   04659 Th17 cell differentiation
    100152497 (PLCG1)
   04664 Fc epsilon RI signaling pathway
    100152497 (PLCG1)
   04666 Fc gamma R-mediated phagocytosis
    100152497 (PLCG1)
   04670 Leukocyte transendothelial migration
    100152497 (PLCG1)
  Endocrine system
   04919 Thyroid hormone signaling pathway
    100152497 (PLCG1)
  Nervous system
   04722 Neurotrophin signaling pathway
    100152497 (PLCG1)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100152497 (PLCG1)
  Development
   04360 Axon guidance
    100152497 (PLCG1)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    100152497 (PLCG1)
   05231 Choline metabolism in cancer
    100152497 (PLCG1)
   05206 MicroRNAs in cancer
    100152497 (PLCG1)
   05205 Proteoglycans in cancer
    100152497 (PLCG1)
   05225 Hepatocellular carcinoma
    100152497 (PLCG1)
   05214 Glioma
    100152497 (PLCG1)
   05223 Non-small cell lung cancer
    100152497 (PLCG1)
  Endocrine and metabolic diseases
   04933 AGE-RAGE signaling pathway in diabetic complications
    100152497 (PLCG1)
  Infectious diseases
   05167 Kaposi's sarcoma-associated herpesvirus infection
    100152497 (PLCG1)
   05169 Epstein-Barr virus infection
    100152497 (PLCG1)
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    100152497 (PLCG1)
Enzymes [BR:ssc01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     100152497 (PLCG1)
Membrane trafficking [BR:ssc04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    100152497 (PLCG1)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    100152497 (PLCG1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GeneID: 
NCBI-ProteinID: 
Ensembl: 
Position
17
AA seq 1291 aa AA seqDB search
MAGAASPCANGCGPGAPSDAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQI
TWSRGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTL
SLQATSEDEVNMWIKGLTWLMEDTLQAATPLQIERWLRKQFYSVDRNREDRISAKDLKNM
LSQVNYRVPNMRFLRERLTELEQRSSDITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRA
GERPELCRVSLPEFQQFLLEYQGELWAVDRLQVQEFMLSFLRDPLREIEETYFFLDEFVT
FLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMG
CRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIA
QQRNMAQYFKKVLGDTLLTKPVDIAADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSVM
YSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEASS
STELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFW
RNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQT
NAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQE
GQTVMLGNSEFDSLVDLVSYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNP
GFYVEANPMPTFKCAVKALFDYKAQRDDELTFTKSAIIQNVEKQEGGWWRGDYGGKKQLW
FPSNYVEEMVSPAALEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRLFVFSIS
MASVAHWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKMMERRKKIALELSELVVYC
RPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDS
SNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMAGGHCGYVLQPSTMRDEAFDPFDKS
SLRGLEPCAICVEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSIKQKTEFVVDNGLNPVW
PAKLFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDL
ELASLLIKLDIFPVKQENSDLSPFGGTSLRERGYDISGQPAHGRAREGSFEARYQQPFED
FRISQEHLADHFDSRERRAPRRTRVNGDNRL
NT seq 3876 nt NT seq  +upstreamnt  +downstreamnt
atggcgggcgccgcgtccccctgcgccaatggctgcgggccgggcgcaccctcggacgcc
gaggtgttgcacctctgccgcagcctcgaggtgggcaccgtcatgactttgttctactcc
aagaagtcgcagcggcccgaacggaagaccttccaggtcaagctggagacgcggcagatc
acgtggagccgtggcgccgacaagatcgagggggccattgacattcgcgaaatcaaggag
atccgcccagggaagacctcccgggactttgatcgataccaagaggatcctgcttttcga
ccagaccagtcacactgctttgtcatcctgtatggaatggaattccgcctgaagaccctg
agtctgcaggctacctctgaggacgaagtgaacatgtggatcaagggcttgacttggctg
atggaggacacgctgcaggcggccacgcctctgcagattgagaggtggctgcggaagcag
ttctactcagtggaccggaatcgtgaggatcgtatatcagccaaggatctgaagaacatg
ctgtcccaggtcaactaccgggtccccaacatgcgcttcctccgagagcggctgacggag
ctggagcagcgcagcagcgacatcacctacggacagtttgcacaactgtaccgcagcctc
atgtacagcgcccagaagacgatggacctccccttcctggaagccagtaccctaagggca
ggggagcggccagagctctgccgggtgtcccttcctgagttccagcagttcctcctcgag
taccagggggagctgtgggctgtcgaccggctccaggtgcaggagttcatgctcagcttc
ctccgagaccccttgcgagagatagaggagacttacttcttcctggacgagtttgtcacc
ttcctgttctccaaggagaacagcgtgtggaactcgcagctggatgccgtgtgcccagac
accatgaacaaccccctttcccactactggatctcctcctctcacaacacgtacctgacc
ggggaccagttctccagcgagtcctccctggaagcctacgcccgctgcctgcggatgggc
tgccgctgcattgagttggactgctgggacggcccagacgggatgccggtcatttaccat
ggacacactctgaccaccaagatcaagttctcagacgtcctgcacaccatcaaggagcac
gcctttgtggcctcagagtacccggtcatcctgtccatcgaggaccactgcagcattgcc
cagcagaggaacatggcccagtatttcaagaaggtgctcggggacacgctcctcaccaag
cccgtggacatcgcggccgacgggctcccctcacccaatcagctcaagaggaagatcctc
atcaagcacaagaagctggctgagggcagtgcgtatgaggaggtgcctacgtctgtgatg
tactctgagaacgacatcagcaactccatcaagaacggcatcctctacctggaggaccct
gtgaaccacgagtggtatccccactactttgttctgaccagcagcaagatctactactca
gaggagaccagcagtgaccagggcaacgaggatgaggaggagcccaaggaggcgagcagc
agcacagagctgcattccaatgagaagtggttccacgggaagctcggggcggggcgggac
ggccggcacatcgccgagcgcctgctcacagagtactgcatcgagaccggagccccggac
ggctccttcctcgtgcgcgagagtgagaccttcgtgggtgactacaccctctccttctgg
cggaacgggaaagtccagcactgccggatccactcccggcaggacgctgggacccccaag
ttcttcctgacagacaacctcgtcttcgactcactctacgacctcatcacacactaccag
caggtgcccctgcgctgcaacgagtttgagatgcgcctctctgagccggtcccgcagacc
aacgcccacgagagcaaagagtggtaccacgcgagcctgaccagagcgcaggccgagcac
atgctgatgcgcgtgccccgggacggggccttcctggtgcggaaacgcaatgagcccaac
tcctacgccatctccttccgggctgagggcaagatcaagcattgccgtgtccagcaggag
ggccagactgtgatgctgggcaactcggagtttgacagcctcgtggatcttgtcagctac
tatgagaagcacccgctgtaccgcaagatgaagctgcgctatcccatcaacgaggaggca
ttggagaagatcggcacagctgagcctgactacggggccctgtatgagggccgcaaccct
ggcttctacgtggaggccaaccctatgccgactttcaagtgtgccgtcaaagcgctcttc
gactacaaggcccagagagatgacgagctgaccttcaccaagagcgccatcatccagaac
gtggagaagcaggagggaggctggtggcggggggactatggtgggaagaagcagctgtgg
tttccgtccaactacgtggaagagatggtcagccctgcggccctggagcccgagagggag
cacttggacgagaacagccccctgggggacttgctgcggggggtcttggatgtgccagcc
tgtcagatagccatccgtcctgagggcaagaacaacaggctcttcgtcttctccatcagc
atggcgtcggtggcacattggtccttggatgtggctgctgactcacaggaggagctgcag
gactgggtgaaaaagatccgagaggtggcccagaccgcggatgccaggctcacagagggg
aagatgatggagcggaggaagaaaatcgccttggagctttctgagctcgtcgtctactgc
cggcctgttcccttcgatgaagagaagatcggcacagaacgcgcctgctaccgggacatg
tcgtccttcccggaaaccaaggctgagaagtatgtgaacaaggccaaaggcaagaagttc
ctccagtacaaccggctgcagctgtcgcgcatctaccccaagggccagcggctggactcc
tccaattatgaccccttgcccatgtggatctgtggcagtcagctggtggccctcaacttc
cagaccccagacaagccgatgcagatgaaccaggctctcttcatggccggcgggcactgc
ggctacgtgctgcagccaagcaccatgagggacgaggccttcgaccccttcgacaagagc
agcctccgcgggctggagccgtgcgccatctgtgttgaggtgctgggggcccggcatctg
ccgaagaatggccgaggcattgtgtgtccttttgtggagattgaggtggccggagcagag
tatgacagcatcaagcagaagacagagtttgtggtggacaacggactgaaccccgtgtgg
ccggccaagctcttccacttccagatcagtaaccccgaatttgccttcctgcgctttgtg
gtgtatgaagaagacatgtttagcgaccagaacttcctggctcaggccaccttcccggtg
aagggactgaagacgggatacagagcggtgcctttgaagaacaactacagcgaggacctg
gagttggcctccctgctcatcaagctcgacattttccccgtcaagcaggagaacagcgac
ctcagtccctttggggggacgtccctgcgggagcggggctacgacatctctggccagccg
gcacacggccgggcccgggagggctccttcgaagcccgctaccagcagccgtttgaggac
ttccgcatctcccaggagcatctcgcagaccattttgacagtcgggagcgaagggcccca
cgaaggactcgggtcaatggagacaaccgcctctag

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