KEGG   Sus scrofa (pig): 100152497Help
Entry
100152497         CDS       T01009                                 

Gene name
PLCG1
Definition
(RefSeq) phospholipase C, gamma 1
  KO
K01116  
phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
Organism
ssc  Sus scrofa (pig)
Pathway
Inositol phosphate metabolism
Metabolic pathways
EGFR tyrosine kinase inhibitor resistance
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
Calcium signaling pathway
NF-kappa B signaling pathway
HIF-1 signaling pathway
Phosphatidylinositol signaling system
Phospholipase D signaling pathway
Axon guidance
VEGF signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Inflammatory mediator regulation of TRP channels
Thyroid hormone signaling pathway
AGE-RAGE signaling pathway in diabetic complications
Epstein-Barr virus infection
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Glioma
Non-small cell lung cancer
Choline metabolism in cancer
Module
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:ssc00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100152497 (PLCG1)
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    100152497 (PLCG1)
   04015 Rap1 signaling pathway
    100152497 (PLCG1)
   04012 ErbB signaling pathway
    100152497 (PLCG1)
   04370 VEGF signaling pathway
    100152497 (PLCG1)
   04064 NF-kappa B signaling pathway
    100152497 (PLCG1)
   04066 HIF-1 signaling pathway
    100152497 (PLCG1)
   04020 Calcium signaling pathway
    100152497 (PLCG1)
   04070 Phosphatidylinositol signaling system
    100152497 (PLCG1)
   04072 Phospholipase D signaling pathway
    100152497 (PLCG1)
 Organismal Systems
  Immune system
   04650 Natural killer cell mediated cytotoxicity
    100152497 (PLCG1)
   04660 T cell receptor signaling pathway
    100152497 (PLCG1)
   04664 Fc epsilon RI signaling pathway
    100152497 (PLCG1)
   04666 Fc gamma R-mediated phagocytosis
    100152497 (PLCG1)
   04670 Leukocyte transendothelial migration
    100152497 (PLCG1)
  Endocrine system
   04919 Thyroid hormone signaling pathway
    100152497 (PLCG1)
  Nervous system
   04722 Neurotrophin signaling pathway
    100152497 (PLCG1)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100152497 (PLCG1)
  Development
   04360 Axon guidance
    100152497 (PLCG1)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    100152497 (PLCG1)
   05231 Choline metabolism in cancer
    100152497 (PLCG1)
   05206 MicroRNAs in cancer
    100152497 (PLCG1)
   05205 Proteoglycans in cancer
    100152497 (PLCG1)
   05214 Glioma
    100152497 (PLCG1)
   05223 Non-small cell lung cancer
    100152497 (PLCG1)
  Endocrine and metabolic diseases
   04933 AGE-RAGE signaling pathway in diabetic complications
    100152497 (PLCG1)
  Infectious diseases
   05169 Epstein-Barr virus infection
    100152497 (PLCG1)
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    100152497 (PLCG1)
Enzymes [BR:ssc01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     100152497 (PLCG1)
Membrane trafficking [BR:ssc04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    100152497 (PLCG1)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    100152497 (PLCG1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-ProteinID: 
NCBI-GeneID: 
Ensembl: 
Position
17
AA seq 1389 aa AA seqDB search
RPSRSEAAVHDGAGRGRKAVSGAAKGSSAGRRDRLVDRERHERPRCLCSQCPYSGPVRGS
RGAGAAXAGVLPTGARAPLFPARGPGRGLQGRPAPYSGSAPSPSPCPNGCGPGAPSDAEV
LHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQITWSRGADKIEGAIDIREIKEIR
PGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTLSLQATSEDEVNMWIKGLTWLME
DTLQAATPLQIERWLRKQFYSVDRNREDRISAKDLKNMLSQVNYRVPNMRFLRERLTELE
QRSSDITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRAGERPELCRVSLPEFQQFLLEYQ
GELWAVDRLQVQEFMLSFLRDPLREIEETYFFLDEFVTFLFSKENSVWNSQLDAVCPDTM
NNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWDGPDGMPVIYHGH
TLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIAQQRNMAQYFKKVLGDTLLTKPV
DIAADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSVMYSENDISNSIKNGILYLEDPVN
HEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEASSSTELHSNEKWFHGKLGAGRDGR
HIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFWRNGKVQHCRIHSRQDAGTPKFF
LTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQTNAHESKEWYHASLTRAQAEHML
MRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQEGQTVMLGNSEFDSLVDLVSYYE
KHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNPGFYVEANPMPTFKCAVKALFDY
KAQRDDELTFTKSAIIQNVEKQEGGWWRGDYGGKKQLWFPSNYVEEMVSPAALEPEREHL
DENSPLGDLLRGVLDVPACQIAIRPEGKNNRLFVFSISMASVAHWSLDVAADSQEELQDW
VKKIREVAQTADARLTEGKMMERRKKIALELSELVVYCRPVPFDEEKIGTERACYRDMSS
FPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDSSNYDPLPMWICGSQLVALNFQT
PDKPMQMNQALFMAGGHCGYVLQPSTMRDEAFDPFDKSSLRGLEPCAICVEVLGARHLPK
NGRGIVCPFVEIEVAGAEYDSIKQKTEFVVDNGLNPVWPAKLFHFQISNPEFAFLRFVVY
EEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDLELASLLIKLDIFPVKQENSDLS
PFGGTSLRERGYDISGQPAHGRAREGSFEARYQQPFEDFRISQEHLADHFDSRERRAPRR
TRVNGDNRL
NT seq 4170 nt NT seq  +upstreamnt  +downstreamnt
cggccgagccggagcgaggctgccgtgcatgacggggccggccgtggccgcaaggctgtg
tccggggccgcgaaaggaagctctgcgggacggagggaccggctggttgaccgcgagcgg
cacgagcgtccgcgctgcctttgctcccagtgcccctactcggggcctgtccgggggtcg
cggggcgcaggcgcagcannagcgggggtcctccccacgggcgcgcgggcgcctttgttc
ccggcgcgcgggccggggcggggcctgcagggccgccccgccccctactcaggctccgcc
ccgtctccgtccccctgccccaatggatgcgggccgggcgcaccctcggacgccgaggtg
ttgcacctctgccgcagcctcgaggtgggcaccgtcatgactttgttttactccaagaag
tcgcagcggcccgaacggaagaccttccaggtcaagctggagacgcggcagatcacgtgg
agccgtggcgccgacaagatcgagggggccattgacattcgcgaaatcaaggagatccgc
ccagggaagacctcccgggactttgatcgataccaagaggatcctgcttttcgaccagac
cagtcacactgctttgtcatcctgtatggaatggaattccgcttgaagaccctgagtctg
caggctacctctgaggacgaagtgaacatgtggatcaagggcttgacttggctgatggag
gacacgctgcaggcggccacgcctctgcagattgagaggtggctgcggaagcagttctac
tcagtggaccggaatcgtgaggatcgtatatcagccaaggatctgaagaacatgctgtcc
caggtcaactaccgggtccccaacatgcgcttcctccgagagcggctgacggagctggag
cagcgcagcagcgacatcacctacggacagtttgcacaactgtaccgcagcctcatgtac
agcgcccagaagacgatggacctccccttcctggaagccagtaccctaagggcaggggag
cggccagagctctgccgggtgtcccttcctgagttccagcagttcctcctcgagtaccag
ggggagctgtgggctgtcgaccggctccaggtgcaggagttcatgctcagcttcctccga
gaccccttgcgagagatagaggagacttacttcttcctggacgagtttgtcaccttcctg
ttctccaaggagaacagcgtgtggaactcgcagctggatgccgtgtgcccagacaccatg
aacaaccccctttcccactactggatctcctcctctcacaacacgtacctgaccggggac
cagttctccagcgagtcctccctggaagcctacgcccgctgcctgcggatgggctgccgc
tgcattgagttggactgctgggacggcccagacgggatgccggtcatttaccatggacac
actctgaccaccaagatcaagttctcagacgtcctgcacaccatcaaggagcacgccttt
gtggcctcagagtacccggtcatcctgtccatcgaggaccactgcagcattgcccagcag
aggaacatggcccagtatttcaagaaggtgctcggggacacgctcctcaccaagcccgtg
gacatcgcggccgacgggctcccctcacccaatcagctcaagaggaagatcctcatcaag
cacaagaagctggctgagggcagtgcgtatgaggaggtgcctacgtctgtgatgtactct
gagaacgacatcagcaactccatcaagaacggcatcctctacctggaggaccctgtgaac
cacgagtggtatccccactactttgttctgaccagcagcaagatctactactcagaggag
accagcagtgaccagggcaacgaggatgaggaggagcccaaggaggcgagcagcagcaca
gagctgcattccaatgagaagtggttccacgggaagctcggggcggggcgggacggccgg
cacatcgccgagcgcctgctcacagagtactgcatcgagaccggagccccggacggctcc
ttcctcgtgcgcgagagtgagaccttcgtgggtgactacaccctctccttctggcggaac
gggaaagtccagcactgccggatccactcccggcaggacgctgggacccccaagttcttc
ctgacagacaacctcgtcttcgactcactctacgacctcatcacacactaccagcaggtg
cccctgcgctgcaacgagtttgagatgcgcctctctgagccggtcccgcagaccaacgcc
cacgagagcaaagagtggtaccacgcgagcctgaccagagcgcaggccgagcacatgctg
atgcgcgtgccccgggacggggccttcctggtgcggaaacgcaatgagcccaactcctac
gccatctccttccgggctgagggcaagatcaagcattgccgtgtccagcaggagggccag
actgtgatgctgggcaactcggagtttgacagcctcgtggatcttgtcagctactatgag
aagcacccgctgtaccgcaagatgaagctgcgctatcccatcaacgaggaggcattggag
aagatcggcacagctgagcctgactacggggccctgtatgagggccgcaaccctggcttc
tacgtggaggccaaccctatgccgactttcaagtgtgccgtcaaagcgctcttcgactac
aaggcccagagagatgacgagctgaccttcaccaagagcgccatcatccagaacgtggag
aagcaggagggaggctggtggcggggggactatggtgggaagaagcagctgtggtttccg
tccaactacgtggaagagatggtcagccctgcggccctggagcccgagagggagcacttg
gacgagaacagccccctgggggacttgctgcggggggtcttggatgtgccagcctgtcag
atagccatccgtcctgagggcaagaacaacaggctcttcgtcttctccatcagcatggcg
tcggtggcacattggtccttggatgtggctgctgactcacaggaggagctgcaggactgg
gtgaaaaagatccgagaggtggcccagaccgcggatgccaggctcacagaggggaagatg
atggagcggaggaagaaaatcgccttggagctttctgagctcgtcgtctactgccggcct
gttcccttcgatgaagagaagatcggcacagaacgcgcctgctaccgggacatgtcgtcc
ttcccggaaaccaaggctgagaagtatgtgaacaaggccaaaggcaagaagttcctccag
tacaaccggctgcagctgtcgcgcatctaccccaagggccagcggctggactcctccaat
tatgaccccttgcccatgtggatctgtggcagtcagctggtggccctcaacttccagacc
ccagacaagccgatgcagatgaaccaggctctcttcatggccggcgggcactgcggctac
gtgctgcagccaagcaccatgagggacgaggccttcgaccccttcgacaagagcagcctc
cgcgggctggagccgtgcgccatctgtgttgaggtgctgggggcccggcatctgccgaag
aatggccgaggcattgtgtgtccttttgtggagattgaggtggccggagcagagtatgac
agcatcaagcagaagacagagtttgtggtggacaacggactgaaccccgtgtggccggcc
aagctcttccacttccagatcagtaaccccgaatttgccttcctgcgctttgtggtgtat
gaagaagacatgtttagcgaccagaacttcctggctcaggccaccttcccggtgaaggga
ctgaagacgggatacagagcggtgcctttgaagaacaactacagcgaggacctggagttg
gcctccctgctcatcaagctcgacattttccccgtcaagcaggagaacagcgacctcagt
ccctttggggggacgtccctgcgggagcggggctacgacatctctggccagccggcacac
ggccgggcccgggagggctccttcgaagcccgctaccagcagccgtttgaggacttccgc
atctcccaggagcatctcgcagaccattttgacagtcgggagcgaagggccccacgaagg
actcgggtcaatggagacaaccgcctctag

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