KEGG   Sus scrofa (pig): 100153927Help
Entry
100153927         CDS       T01009                                 

Gene name
MAPK1
Definition
(RefSeq) mitogen-activated protein kinase 1
  KO
K04371  mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
Organism
ssc  Sus scrofa (pig)
Pathway
ssc01521  EGFR tyrosine kinase inhibitor resistance
ssc01522  Endocrine resistance
ssc01524  Platinum drug resistance
ssc04010  MAPK signaling pathway
ssc04012  ErbB signaling pathway
ssc04014  Ras signaling pathway
ssc04015  Rap1 signaling pathway
ssc04022  cGMP-PKG signaling pathway
ssc04024  cAMP signaling pathway
ssc04062  Chemokine signaling pathway
ssc04066  HIF-1 signaling pathway
ssc04068  FoxO signaling pathway
ssc04071  Sphingolipid signaling pathway
ssc04072  Phospholipase D signaling pathway
ssc04114  Oocyte meiosis
ssc04140  Autophagy - animal
ssc04150  mTOR signaling pathway
ssc04151  PI3K-Akt signaling pathway
ssc04210  Apoptosis
ssc04218  Cellular senescence
ssc04261  Adrenergic signaling in cardiomyocytes
ssc04270  Vascular smooth muscle contraction
ssc04350  TGF-beta signaling pathway
ssc04360  Axon guidance
ssc04370  VEGF signaling pathway
ssc04371  Apelin signaling pathway
ssc04380  Osteoclast differentiation
ssc04510  Focal adhesion
ssc04520  Adherens junction
ssc04540  Gap junction
ssc04550  Signaling pathways regulating pluripotency of stem cells
ssc04611  Platelet activation
ssc04620  Toll-like receptor signaling pathway
ssc04621  NOD-like receptor signaling pathway
ssc04625  C-type lectin receptor signaling pathway
ssc04650  Natural killer cell mediated cytotoxicity
ssc04657  IL-17 signaling pathway
ssc04658  Th1 and Th2 cell differentiation
ssc04659  Th17 cell differentiation
ssc04660  T cell receptor signaling pathway
ssc04662  B cell receptor signaling pathway
ssc04664  Fc epsilon RI signaling pathway
ssc04666  Fc gamma R-mediated phagocytosis
ssc04668  TNF signaling pathway
ssc04713  Circadian entrainment
ssc04720  Long-term potentiation
ssc04722  Neurotrophin signaling pathway
ssc04723  Retrograde endocannabinoid signaling
ssc04724  Glutamatergic synapse
ssc04725  Cholinergic synapse
ssc04726  Serotonergic synapse
ssc04730  Long-term depression
ssc04810  Regulation of actin cytoskeleton
ssc04910  Insulin signaling pathway
ssc04912  GnRH signaling pathway
ssc04914  Progesterone-mediated oocyte maturation
ssc04915  Estrogen signaling pathway
ssc04916  Melanogenesis
ssc04917  Prolactin signaling pathway
ssc04919  Thyroid hormone signaling pathway
ssc04921  Oxytocin signaling pathway
ssc04926  Relaxin signaling pathway
ssc04928  Parathyroid hormone synthesis, secretion and action
ssc04930  Type II diabetes mellitus
ssc04933  AGE-RAGE signaling pathway in diabetic complications
ssc04934  Cushing's syndrome
ssc04960  Aldosterone-regulated sodium reabsorption
ssc05010  Alzheimer's disease
ssc05020  Prion diseases
ssc05034  Alcoholism
ssc05132  Salmonella infection
ssc05133  Pertussis
ssc05140  Leishmaniasis
ssc05142  Chagas disease (American trypanosomiasis)
ssc05145  Toxoplasmosis
ssc05152  Tuberculosis
ssc05160  Hepatitis C
ssc05161  Hepatitis B
ssc05164  Influenza A
ssc05165  Human papillomavirus infection
ssc05167  Kaposi's sarcoma-associated herpesvirus infection
ssc05200  Pathways in cancer
ssc05203  Viral carcinogenesis
ssc05205  Proteoglycans in cancer
ssc05210  Colorectal cancer
ssc05211  Renal cell carcinoma
ssc05212  Pancreatic cancer
ssc05213  Endometrial cancer
ssc05214  Glioma
ssc05215  Prostate cancer
ssc05216  Thyroid cancer
ssc05218  Melanoma
ssc05219  Bladder cancer
ssc05220  Chronic myeloid leukemia
ssc05221  Acute myeloid leukemia
ssc05223  Non-small cell lung cancer
ssc05224  Breast cancer
ssc05225  Hepatocellular carcinoma
ssc05226  Gastric cancer
ssc05230  Central carbon metabolism in cancer
ssc05231  Choline metabolism in cancer
Module
ssc_M00687  MAPK (ERK1/2) signaling
Brite
KEGG Orthology (KO) [BR:ssc00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    100153927 (MAPK1)
   04015 Rap1 signaling pathway
    100153927 (MAPK1)
   04010 MAPK signaling pathway
    100153927 (MAPK1)
   04012 ErbB signaling pathway
    100153927 (MAPK1)
   04350 TGF-beta signaling pathway
    100153927 (MAPK1)
   04370 VEGF signaling pathway
    100153927 (MAPK1)
   04371 Apelin signaling pathway
    100153927 (MAPK1)
   04668 TNF signaling pathway
    100153927 (MAPK1)
   04066 HIF-1 signaling pathway
    100153927 (MAPK1)
   04068 FoxO signaling pathway
    100153927 (MAPK1)
   04072 Phospholipase D signaling pathway
    100153927 (MAPK1)
   04071 Sphingolipid signaling pathway
    100153927 (MAPK1)
   04024 cAMP signaling pathway
    100153927 (MAPK1)
   04022 cGMP - PKG signaling pathway
    100153927 (MAPK1)
   04151 PI3K-Akt signaling pathway
    100153927 (MAPK1)
   04150 mTOR signaling pathway
    100153927 (MAPK1)
 Cellular Processes
  Transport and catabolism
   04140 Autophagy - animal
    100153927 (MAPK1)
  Cell growth and death
   04114 Oocyte meiosis
    100153927 (MAPK1)
   04210 Apoptosis
    100153927 (MAPK1)
   04218 Cellular senescence
    100153927 (MAPK1)
  Cellular community - eukaryotes
   04510 Focal adhesion
    100153927 (MAPK1)
   04520 Adherens junction
    100153927 (MAPK1)
   04540 Gap junction
    100153927 (MAPK1)
   04550 Signaling pathways regulating pluripotency of stem cells
    100153927 (MAPK1)
  Cell motility
   04810 Regulation of actin cytoskeleton
    100153927 (MAPK1)
 Organismal Systems
  Immune system
   04611 Platelet activation
    100153927 (MAPK1)
   04620 Toll-like receptor signaling pathway
    100153927 (MAPK1)
   04621 NOD-like receptor signaling pathway
    100153927 (MAPK1)
   04625 C-type lectin receptor signaling pathway
    100153927 (MAPK1)
   04650 Natural killer cell mediated cytotoxicity
    100153927 (MAPK1)
   04660 T cell receptor signaling pathway
    100153927 (MAPK1)
   04658 Th1 and Th2 cell differentiation
    100153927 (MAPK1)
   04659 Th17 cell differentiation
    100153927 (MAPK1)
   04657 IL-17 signaling pathway
    100153927 (MAPK1)
   04662 B cell receptor signaling pathway
    100153927 (MAPK1)
   04664 Fc epsilon RI signaling pathway
    100153927 (MAPK1)
   04666 Fc gamma R-mediated phagocytosis
    100153927 (MAPK1)
   04062 Chemokine signaling pathway
    100153927 (MAPK1)
  Endocrine system
   04910 Insulin signaling pathway
    100153927 (MAPK1)
   04912 GnRH signaling pathway
    100153927 (MAPK1)
   04915 Estrogen signaling pathway
    100153927 (MAPK1)
   04914 Progesterone-mediated oocyte maturation
    100153927 (MAPK1)
   04917 Prolactin signaling pathway
    100153927 (MAPK1)
   04921 Oxytocin signaling pathway
    100153927 (MAPK1)
   04926 Relaxin signaling pathway
    100153927 (MAPK1)
   04919 Thyroid hormone signaling pathway
    100153927 (MAPK1)
   04928 Parathyroid hormone synthesis, secretion and action
    100153927 (MAPK1)
   04916 Melanogenesis
    100153927 (MAPK1)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    100153927 (MAPK1)
   04270 Vascular smooth muscle contraction
    100153927 (MAPK1)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    100153927 (MAPK1)
  Nervous system
   04724 Glutamatergic synapse
    100153927 (MAPK1)
   04725 Cholinergic synapse
    100153927 (MAPK1)
   04726 Serotonergic synapse
    100153927 (MAPK1)
   04720 Long-term potentiation
    100153927 (MAPK1)
   04730 Long-term depression
    100153927 (MAPK1)
   04723 Retrograde endocannabinoid signaling
    100153927 (MAPK1)
   04722 Neurotrophin signaling pathway
    100153927 (MAPK1)
  Development
   04360 Axon guidance
    100153927 (MAPK1)
   04380 Osteoclast differentiation
    100153927 (MAPK1)
  Environmental adaptation
   04713 Circadian entrainment
    100153927 (MAPK1)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    100153927 (MAPK1)
   05230 Central carbon metabolism in cancer
    100153927 (MAPK1)
   05231 Choline metabolism in cancer
    100153927 (MAPK1)
   05205 Proteoglycans in cancer
    100153927 (MAPK1)
   05203 Viral carcinogenesis
    100153927 (MAPK1)
   05210 Colorectal cancer
    100153927 (MAPK1)
   05212 Pancreatic cancer
    100153927 (MAPK1)
   05225 Hepatocellular carcinoma
    100153927 (MAPK1)
   05226 Gastric cancer
    100153927 (MAPK1)
   05214 Glioma
    100153927 (MAPK1)
   05216 Thyroid cancer
    100153927 (MAPK1)
   05221 Acute myeloid leukemia
    100153927 (MAPK1)
   05220 Chronic myeloid leukemia
    100153927 (MAPK1)
   05218 Melanoma
    100153927 (MAPK1)
   05211 Renal cell carcinoma
    100153927 (MAPK1)
   05219 Bladder cancer
    100153927 (MAPK1)
   05215 Prostate cancer
    100153927 (MAPK1)
   05213 Endometrial cancer
    100153927 (MAPK1)
   05224 Breast cancer
    100153927 (MAPK1)
   05223 Non-small cell lung cancer
    100153927 (MAPK1)
  Neurodegenerative diseases
   05010 Alzheimer's disease
    100153927 (MAPK1)
   05020 Prion diseases
    100153927 (MAPK1)
  Substance dependence
   05034 Alcoholism
    100153927 (MAPK1)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    100153927 (MAPK1)
   04933 AGE-RAGE signaling pathway in diabetic complications
    100153927 (MAPK1)
   04934 Cushing's syndrome
    100153927 (MAPK1)
  Infectious diseases
   05132 Salmonella infection
    100153927 (MAPK1)
   05133 Pertussis
    100153927 (MAPK1)
   05152 Tuberculosis
    100153927 (MAPK1)
   05164 Influenza A
    100153927 (MAPK1)
   05161 Hepatitis B
    100153927 (MAPK1)
   05160 Hepatitis C
    100153927 (MAPK1)
   05167 Kaposi's sarcoma-associated herpesvirus infection
    100153927 (MAPK1)
   05165 Human papillomavirus infection
    100153927 (MAPK1)
   05145 Toxoplasmosis
    100153927 (MAPK1)
   05140 Leishmaniasis
    100153927 (MAPK1)
   05142 Chagas disease (American trypanosomiasis)
    100153927 (MAPK1)
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    100153927 (MAPK1)
   01524 Platinum drug resistance
    100153927 (MAPK1)
   01522 Endocrine resistance
    100153927 (MAPK1)
Enzymes [BR:ssc01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     100153927 (MAPK1)
Protein kinases [BR:ssc01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   100153927 (MAPK1)
Chromosome and associated proteins [BR:ssc03036]
 Eukaryotic Type
  Centromeric chromatin formation proteins
   SAC (spindle assembly checkpoint) factors
    Protein kinases
     100153927 (MAPK1)
Exosome [BR:ssc04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   100153927 (MAPK1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Pkinase Pkinase_Tyr APH Haspin_kinase FTA2 Choline_kinase Kinase-like Kdo
Motif
Other DBs
NCBI-GeneID: 100153927
NCBI-ProteinID: NP_001185851
Ensembl: ENSSSCG00000010081
Vega: OTTSUSG00000001605
UniProt: E3UV40
Position
14
AA seq 359 aa AA seqDB search
MAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEH
QTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHL
SNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHT
GFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILADMLSNRPIFPGKHYLDQLNHIL
GILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKR
IEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
NT seq 1080 nt NT seq  +upstreamnt  +downstreamnt
atggcggcggcggcggcgggcgcgggccccgagatggtccgcgggcaggtgttcgacgtg
gggccgcgctacaccaacctctcctacatcggcgagggcgcctacggcatggtgtgctct
gcttatgataatgtcaacaaagttcgagtagctatcaagaaaatcagtccatttgagcat
cagacctactgccagagaaccctgagggagataaaaatcttactgcgctttagacacgag
aacatcattggaatcaatgatatcattcgagcaccaaccatcgagcagatgaaagatgta
tacatagtacaggacctcatggaaacagatctctacaagctcttgaagacgcagcacctc
agcaacgaccatatctgctattttctttaccagatcctcagagggttaaaatatatccat
tcagctaacgtactgcaccgtgacctcaaaccttccaacctgctgctcaacaccacctgc
gatctcaagatctgtgactttgggttggcccgtgttgcagatccagaccatgatcacaca
gggttcctgacggagtatgtcgccacacgttggtacagggctccagaaattatgttaaat
tccaagggctacaccaagtccatcgacatctggtctgtcggctgcatcttggcagatatg
ctctccaacaggcccatcttcccggggaagcattatctcgaccagctgaaccacattctg
ggtattcttggatccccatcacaggaagacctgaattgtataataaatttaaaagctaga
aactatttgctttctcttccacacaaaaataaggtgccatggaacaggctgttcccaaat
gctgactccaaagctctggatttactggacaaaatgttgacattcaaccctcacaagagg
attgaagtagagcaggctcttgcccacccatacctggagcagtattatgacccaagtgat
gagcccatcgctgaagcaccattcaagtttgacatggaattggatgacttgcccaaggaa
aagctcaaagagctcatttttgaagagaccgctcgattccagccaggatacagatcttaa

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