KEGG   Sus scrofa (pig): 100157641Help
Entry
100157641         CDS       T01009                                 

Gene name
PLCB2
Definition
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
ssc  Sus scrofa (pig)
Pathway
ssc00562  Inositol phosphate metabolism
ssc01100  Metabolic pathways
ssc04015  Rap1 signaling pathway
ssc04020  Calcium signaling pathway
ssc04022  cGMP-PKG signaling pathway
ssc04062  Chemokine signaling pathway
ssc04070  Phosphatidylinositol signaling system
ssc04071  Sphingolipid signaling pathway
ssc04072  Phospholipase D signaling pathway
ssc04261  Adrenergic signaling in cardiomyocytes
ssc04270  Vascular smooth muscle contraction
ssc04310  Wnt signaling pathway
ssc04371  Apelin signaling pathway
ssc04540  Gap junction
ssc04611  Platelet activation
ssc04621  NOD-like receptor signaling pathway
ssc04713  Circadian entrainment
ssc04720  Long-term potentiation
ssc04723  Retrograde endocannabinoid signaling
ssc04724  Glutamatergic synapse
ssc04725  Cholinergic synapse
ssc04726  Serotonergic synapse
ssc04728  Dopaminergic synapse
ssc04730  Long-term depression
ssc04750  Inflammatory mediator regulation of TRP channels
ssc04911  Insulin secretion
ssc04912  GnRH signaling pathway
ssc04915  Estrogen signaling pathway
ssc04916  Melanogenesis
ssc04918  Thyroid hormone synthesis
ssc04919  Thyroid hormone signaling pathway
ssc04921  Oxytocin signaling pathway
ssc04922  Glucagon signaling pathway
ssc04924  Renin secretion
ssc04925  Aldosterone synthesis and secretion
ssc04926  Relaxin signaling pathway
ssc04927  Cortisol synthesis and secretion
ssc04928  Parathyroid hormone synthesis, secretion and action
ssc04933  AGE-RAGE signaling pathway in diabetic complications
ssc04934  Cushing's syndrome
ssc04961  Endocrine and other factor-regulated calcium reabsorption
ssc04970  Salivary secretion
ssc04971  Gastric acid secretion
ssc04972  Pancreatic secretion
ssc05010  Alzheimer's disease
ssc05016  Huntington's disease
ssc05142  Chagas disease (American trypanosomiasis)
ssc05143  African trypanosomiasis
ssc05146  Amoebiasis
ssc05200  Pathways in cancer
Module
ssc_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:ssc00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100157641 (PLCB2)
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    100157641 (PLCB2)
   04310 Wnt signaling pathway
    100157641 (PLCB2)
   04371 Apelin signaling pathway
    100157641 (PLCB2)
   04020 Calcium signaling pathway
    100157641 (PLCB2)
   04070 Phosphatidylinositol signaling system
    100157641 (PLCB2)
   04072 Phospholipase D signaling pathway
    100157641 (PLCB2)
   04071 Sphingolipid signaling pathway
    100157641 (PLCB2)
   04022 cGMP - PKG signaling pathway
    100157641 (PLCB2)
 Cellular Processes
  Cellular community - eukaryotes
   04540 Gap junction
    100157641 (PLCB2)
 Organismal Systems
  Immune system
   04611 Platelet activation
    100157641 (PLCB2)
   04621 NOD-like receptor signaling pathway
    100157641 (PLCB2)
   04062 Chemokine signaling pathway
    100157641 (PLCB2)
  Endocrine system
   04911 Insulin secretion
    100157641 (PLCB2)
   04922 Glucagon signaling pathway
    100157641 (PLCB2)
   04912 GnRH signaling pathway
    100157641 (PLCB2)
   04915 Estrogen signaling pathway
    100157641 (PLCB2)
   04921 Oxytocin signaling pathway
    100157641 (PLCB2)
   04926 Relaxin signaling pathway
    100157641 (PLCB2)
   04918 Thyroid hormone synthesis
    100157641 (PLCB2)
   04919 Thyroid hormone signaling pathway
    100157641 (PLCB2)
   04928 Parathyroid hormone synthesis, secretion and action
    100157641 (PLCB2)
   04916 Melanogenesis
    100157641 (PLCB2)
   04924 Renin secretion
    100157641 (PLCB2)
   04925 Aldosterone synthesis and secretion
    100157641 (PLCB2)
   04927 Cortisol synthesis and secretion
    100157641 (PLCB2)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    100157641 (PLCB2)
   04270 Vascular smooth muscle contraction
    100157641 (PLCB2)
  Digestive system
   04970 Salivary secretion
    100157641 (PLCB2)
   04971 Gastric acid secretion
    100157641 (PLCB2)
   04972 Pancreatic secretion
    100157641 (PLCB2)
  Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    100157641 (PLCB2)
  Nervous system
   04724 Glutamatergic synapse
    100157641 (PLCB2)
   04725 Cholinergic synapse
    100157641 (PLCB2)
   04728 Dopaminergic synapse
    100157641 (PLCB2)
   04726 Serotonergic synapse
    100157641 (PLCB2)
   04720 Long-term potentiation
    100157641 (PLCB2)
   04730 Long-term depression
    100157641 (PLCB2)
   04723 Retrograde endocannabinoid signaling
    100157641 (PLCB2)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100157641 (PLCB2)
  Environmental adaptation
   04713 Circadian entrainment
    100157641 (PLCB2)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    100157641 (PLCB2)
  Neurodegenerative diseases
   05010 Alzheimer's disease
    100157641 (PLCB2)
   05016 Huntington's disease
    100157641 (PLCB2)
  Endocrine and metabolic diseases
   04933 AGE-RAGE signaling pathway in diabetic complications
    100157641 (PLCB2)
   04934 Cushing's syndrome
    100157641 (PLCB2)
  Infectious diseases
   05146 Amoebiasis
    100157641 (PLCB2)
   05142 Chagas disease (American trypanosomiasis)
    100157641 (PLCB2)
   05143 African trypanosomiasis
    100157641 (PLCB2)
Enzymes [BR:ssc01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     100157641 (PLCB2)
Membrane trafficking [BR:ssc04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    100157641 (PLCB2)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    100157641 (PLCB2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: PLC-beta_C PI-PLC-X PI-PLC-Y C2 EF-hand_like Gp58 AAA_13 Prominin
Motif
Other DBs
NCBI-GeneID: 100157641
NCBI-ProteinID: XP_020953421
Ensembl: ENSSSCG00000004779
Position
1
AA seq 1194 aa AA seqDB search
MSLLNPVLLPPKVKAYLSQGERFIKWDDETTIASPVILRVDPKGYYLYWTYQSKEMEFLD
ITSIRDTRFGKFAKMPKSQKLREVFNMDFPDNSFLLKTLTVVSGPDMVDLTFHNFVSYKE
NVGKAWAEDVLALAKHPLTANACRSTFLDKILVKLRMQLNPEGKIPVKNFFQMFPADRKR
VEAALSACHLPKGKNDAINPEDFPESVYRSFLMSLCPRPEIDEIFTSYHSKAKPYMTKEH
LTKFINQKQRDSRLNSLLFPPARPDQVQGLIDKYEPSGINVQRGQLSPEGMVWFLCGPEN
SVLVQDKLLLHQDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLAGCRCVELDC
WKGKPPDEEPIITHGFTMTTDIYFKEAIEAIAESAFKTSPYPVILSFENHVDSPRQQAKM
AEYCRTLFGDMLLTEPLEKFPLKPGIPLPSPEDLRGKILIKNKKNQFSGPTDPSKEPGGE
AEGGGPPSAPVGEDTVLMEPCVAAWAGEEGAELEEEVDEEEEEESGNLDEEGIKKMQSDE
GTAGLEVTAYEEMSSLVNYIQPTKFISFEFSAQKNRSYVISSFTELKAYDLLSKASVQFV
DYNKRQMSRIYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMALFEFNGQSG
YLLKHEFMRRLDKQFNPFSVDRIDVVVATTLSITVISGQFLSERSVRTYVEVELFGLPGD
PKRRYRTKLSPSTNSINPVWKEEPFVFEKILMPELASLRVAVMEEGNKFLGHRIIPVNAL
NSGYHHMCLHSESNMPLTMPALFVFLEMKDYVPDTWADLTVALANPIKFFNAHDKKAVKL
KEAMGGLPENPFPLGSPVARQVNGALAPTSNGSAAAGAKASEEVTKEAAEPRTASLEELR
ELKGVVKLQRRHEKELRELERRGARRWEELLQRGAAQLAELAPPGAGGGGGCRGRKVVPG
KGSRKKRTLPGEDTAGLEPAEGPEGADARLRELRERLEQELLQQGEEQCECVLKRKEQHV
AEQMTKMMELAREKQAAELKTLKETLETDTKEMKKKLEAKRLERIQAMIKVTTDKMAQER
LKREINNSHIQEVVQVIKQMTENLERHQEKLEEKQAACLEQIRDMEKQFQQELLAEYEDR
MKGLEAEVKESVRSCLRACFPWEEDKAERPCGVPTELCEQDPLTEKADTQEHHL
NT seq 3585 nt NT seq  +upstreamnt  +downstreamnt
atgtctctgctcaaccccgtcctgctgccccccaaggtgaaggcctatctgagccaaggg
gagcgcttcatcaaatgggatgatgaaacaacaatagcctccccggttatcctccgtgtg
gaccccaagggctactacttatactggacgtatcagagtaaggagatggagtttctggat
atcaccagcatccgggacacccgctttgggaagtttgccaagatgcccaagagccagaag
ctccgagaagtcttcaacatggactttcccgacaacagcttcctgctgaagacactgact
gtggtgtccggcccagacatggtggacctcaccttccataacttcgtctcctacaaggag
aatgtgggcaaggcctgggctgaagatgtcctggctctggccaagcatccgctcacagcc
aacgcctgccgtagcaccttcctggacaagatcctggtgaagctcaggatgcagctcaac
cctgaagggaagattcctgtgaagaattttttccagatgtttcctgctgaccgcaagcgg
gtggaagctgctctcagcgcctgccacctccccaaaggcaagaatgatgccatcaatccc
gaggacttcccagaatccgtctataggagtttcctcatgagcctctgtcctcggcctgaa
atagacgagatcttcacttcctaccactccaaggccaaaccctacatgaccaaggaacac
ctgaccaaattcatcaaccagaaacagcgcgactccaggctgaactccctactgtttccg
ccagcgcggcctgaccaggtgcagggcctcatcgacaagtacgaacccagcggcatcaac
gtgcagaggggccagctgtcccccgagggcatggtgtggtttctctgtgggccagagaac
agcgtgctggtccaggacaagctgctgctgcatcaggacatgacgcagccactcaaccat
tacttcatcaactcgtcacacaacacctacctgacagctggccagttctcaggcctttcc
tcggccgagatgtaccgccaggtgctgctggctggctgccgctgcgtggagctggactgt
tggaagggaaagccccctgatgaggagcccattatcactcacggcttcaccatgaccaca
gacatctatttcaaggaagcaatcgaagctattgcagagagtgcctttaagacctcccct
tatccggtcatcctgtcatttgaaaaccacgtggactcaccccgccaacaggcgaagatg
gccgagtactgccggacgctatttggggatatgctgctcacagagcccctggaaaagttc
ccactgaaaccaggtatccccctgcccagccctgaggatctccggggtaagatcctcatc
aagaacaagaagaaccagttctctggccccacggaccccagcaaggagccgggtggggag
gctgagggtggcggtccacccagtgcccctgtgggtgaggacacggtgctgatggagccc
tgtgtggcagcgtgggctggtgaggaaggggctgagctggaggaggaggtggacgaggaa
gaggaggaggagtcgggaaacctggatgaggaagggataaagaagatgcagtcagatgag
ggcacagcgggcctggaagtgacggcttatgaggagatgtccagccttgtcaattacatc
cagcccaccaagttcatctcctttgagttctctgcccagaagaaccgaagttatgtcatc
tcctccttcacagagctcaaggcctacgacctgctctccaaggcctcagtgcagttcgtg
gactacaacaagcgccaaatgagccgcatctaccccaagggcacccgcatggactcctcc
aactacatgccccagatgttctggaatgctggttgccagatggttgccctcaacttccag
acgatggacctgcccatgcagcagaacatggcgctctttgagttcaacgggcagagcggc
tacctcctcaagcatgagttcatgcgtcggctggacaagcagttcaaccccttctcggtg
gaccgcatcgatgtggtggtggccaccaccctttctattacggtgatatctgggcagttc
ctgtcagaacgcagtgtgcgcacctatgtggaagtggagctgtttggcctgcctggggac
cccaagaggcgctatcgcaccaagctgtcacccagtaccaactccatcaatcccgtctgg
aaggaggagccctttgtctttgagaagatcttgatgcccgagctggcttccctcagggtg
gctgtgatggaggaaggcaacaagtttcttggacatcgcatcattcctgtcaatgccttg
aattctggataccaccacatgtgcctgcacagcgaaagcaacatgcccctcaccatgcct
gcactctttgtcttcctggagatgaaggactatgtacctgacacctgggcagatctcacg
gtggccctcgccaatcccatcaagttcttcaatgcccatgataagaaggctgtgaaactc
aaggaagccatgggaggtctacctgagaatcccttccctctcgggagtccggttgcccgc
caggtcaatggggcattggccccaacgagcaacgggtcagcagcagctggggccaaggcc
agcgaagaggtcaccaaagaagctgcggagccgcggaccgccagcctggaggagctgcgg
gagctgaagggcgtcgtgaagctgcagcggcggcacgagaaggagcttcgggagctggag
cggcgcggcgcgcggcgctgggaggagctgctgcagcggggcgcggcacagctggccgag
ctcgcgccgccaggtgcggggggcggcggcgggtgccgtggccgcaaagtcgttccgggc
aagggctcccgcaagaaaaggaccctgccgggcgaggacaccgccgggttggagccggct
gagggcccggagggcgcggacgcgcgcctgagagagctgagagagaggctggagcaggag
ctgctacagcaaggagaggagcagtgcgagtgcgtcctgaagcgcaaggagcagcacgtg
gccgagcaaatgaccaagatgatggagctggccagagagaaacaggctgcagagctgaag
accctcaaggagaccctggagactgacaccaaagagatgaagaaaaagctggaggccaaa
aggctagagaggatccaggccatgatcaaggtcactacagacaaaatggctcaggagagg
ttgaaaagagagatcaacaactcccacatccaggaggtggtgcaggtcatcaagcagatg
acagagaatctggagaggcatcaggagaagctagaagagaagcaggcagcctgcctggaa
cagatccgagatatggaaaagcagttccagcaggagttgctggcagagtacgaggacagg
atgaagggtctggaggcggaagtgaaggagtcagtgaggtcctgcctcagggcctgcttc
ccctgggaggaggacaaggctgagaggccctgtggggttcccacagagctgtgtgagcag
gacccactcacggagaaggcagacacccaggagcaccacctctga

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