KEGG   Sus scrofa (pig): 100518663Help
Entry
100518663         CDS       T01009                                 

Gene name
PLCG2
Definition
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1
  KO
K05859  phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
Organism
ssc  Sus scrofa (pig)
Pathway
ssc00562  Inositol phosphate metabolism
ssc01100  Metabolic pathways
ssc01521  EGFR tyrosine kinase inhibitor resistance
ssc04012  ErbB signaling pathway
ssc04014  Ras signaling pathway
ssc04020  Calcium signaling pathway
ssc04064  NF-kappa B signaling pathway
ssc04066  HIF-1 signaling pathway
ssc04070  Phosphatidylinositol signaling system
ssc04072  Phospholipase D signaling pathway
ssc04360  Axon guidance
ssc04370  VEGF signaling pathway
ssc04380  Osteoclast differentiation
ssc04611  Platelet activation
ssc04625  C-type lectin receptor signaling pathway
ssc04650  Natural killer cell mediated cytotoxicity
ssc04662  B cell receptor signaling pathway
ssc04664  Fc epsilon RI signaling pathway
ssc04666  Fc gamma R-mediated phagocytosis
ssc04670  Leukocyte transendothelial migration
ssc04722  Neurotrophin signaling pathway
ssc04750  Inflammatory mediator regulation of TRP channels
ssc04919  Thyroid hormone signaling pathway
ssc04933  AGE-RAGE signaling pathway in diabetic complications
ssc05167  Kaposi's sarcoma-associated herpesvirus infection
ssc05169  Epstein-Barr virus infection
ssc05200  Pathways in cancer
ssc05205  Proteoglycans in cancer
ssc05206  MicroRNAs in cancer
ssc05214  Glioma
ssc05223  Non-small cell lung cancer
ssc05225  Hepatocellular carcinoma
Module
ssc_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:ssc00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100518663 (PLCG2)
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    100518663 (PLCG2)
   04012 ErbB signaling pathway
    100518663 (PLCG2)
   04370 VEGF signaling pathway
    100518663 (PLCG2)
   04064 NF-kappa B signaling pathway
    100518663 (PLCG2)
   04066 HIF-1 signaling pathway
    100518663 (PLCG2)
   04020 Calcium signaling pathway
    100518663 (PLCG2)
   04070 Phosphatidylinositol signaling system
    100518663 (PLCG2)
   04072 Phospholipase D signaling pathway
    100518663 (PLCG2)
 Organismal Systems
  Immune system
   04611 Platelet activation
    100518663 (PLCG2)
   04625 C-type lectin receptor signaling pathway
    100518663 (PLCG2)
   04650 Natural killer cell mediated cytotoxicity
    100518663 (PLCG2)
   04662 B cell receptor signaling pathway
    100518663 (PLCG2)
   04664 Fc epsilon RI signaling pathway
    100518663 (PLCG2)
   04666 Fc gamma R-mediated phagocytosis
    100518663 (PLCG2)
   04670 Leukocyte transendothelial migration
    100518663 (PLCG2)
  Endocrine system
   04919 Thyroid hormone signaling pathway
    100518663 (PLCG2)
  Nervous system
   04722 Neurotrophin signaling pathway
    100518663 (PLCG2)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100518663 (PLCG2)
  Development
   04360 Axon guidance
    100518663 (PLCG2)
   04380 Osteoclast differentiation
    100518663 (PLCG2)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    100518663 (PLCG2)
   05206 MicroRNAs in cancer
    100518663 (PLCG2)
   05205 Proteoglycans in cancer
    100518663 (PLCG2)
   05225 Hepatocellular carcinoma
    100518663 (PLCG2)
   05214 Glioma
    100518663 (PLCG2)
   05223 Non-small cell lung cancer
    100518663 (PLCG2)
  Endocrine and metabolic diseases
   04933 AGE-RAGE signaling pathway in diabetic complications
    100518663 (PLCG2)
  Infectious diseases
   05167 Kaposi's sarcoma-associated herpesvirus infection
    100518663 (PLCG2)
   05169 Epstein-Barr virus infection
    100518663 (PLCG2)
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    100518663 (PLCG2)
Enzymes [BR:ssc01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     100518663 (PLCG2)
Membrane trafficking [BR:ssc04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    100518663 (PLCG2)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    100518663 (PLCG2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: PI-PLC-X SH2 PI-PLC-Y C2 SH3_1 SH3_9 PH SH3_2 PH_12 GDPD
Motif
Other DBs
NCBI-GeneID: 100518663
NCBI-ProteinID: XP_020949402
Ensembl: ENSSSCG00000002688
Position
6
AA seq 1265 aa AA seqDB search
MSAMISVDALPEYEKSQIKRALELGTVMTVFSFRKSTPERRTVQVIMETRQVAWSKTADK
IEGFLDIMEIKEIRPGKNSKDFERAKAVRQKEDCCFTIFYGTQFVLSTLSLAADSKEDAM
KWLSGLKILHQEVMSASTPTVIESWLRKQIYSVDQTRRNSISLRELKAILPLVNFKASSA
KFLKDKFLEIGAHKDELSFEQFHLFYKKLMFEQQKSILDEFKKDSSVFILGNTDRPDASA
VHLHDFQRFLLHEQQELWAQDLNKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENS
IWDEKYDVVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSTEAYIRCLRMGCRCIELDC
WDGPDGKPIIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSIEEHCCVEQQRHMARV
FKEVFGDLLLTKPTEASADQLPSPSQLREKIIIKHKKLGPRGDVDVNMEDKKDEHKQQGE
LYMWDSIDQKWTRHYCAIADAKLSFSDDIEQTVEEEPPVNTPPTELHFGEKWFHKKVEKR
TSAEKLLQEYCAETGGKDGTFLVRESETYPNDYTLSFWRSGRVQHCRIRSTMEGGVMKYY
LTDNLMFTSIYALIQHYRETHLRCAEFELRLTDPVPNPNPHESKPWYYDGLSRGEAEDML
MRVPRDGAFLIRRREGTDSYAITFRARGKVKHCRINRDGRHFVLGTSAYFESLVELVSYY
EKHALYRKMRLRYPVTPELLERYNMERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDY
RAKQSDELSFCRGALIHNVSKEPGGWWKGDYGTRIQQYFPSNYVEDISAVDVEELEKQII
EDNPLGSLCRGILDLNTYNVVKAPQGKNQKPFVFILEPKKQGDPPVEFATDRVEELFEWF
QSIREITWKIDTKENNMRYWEKNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSFVE
TKADSVTRQKPNDLLKYNQKALTRIYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKY
MQMNHALFSLNGRTGYVLQPESMRAEKYDPMPPESQRKILMTLTVKVLGARHLPKTGRSI
VCPFVEVEICGAEYDNNKFKTTVVNDNGLSPVWAPTQEKVTFEIYDPNLAFLRFVVYEED
IFSDPNFLAHATYPIKGIKSGYRSVPLKNGYSEDIELASLLVFCEMRPVLESEEELYASC
RQLRRRQEELNNQLFLYDTHQNLRNANRDALVREFNVNENQLQLYQEKCNRRLREKRVSN
SKFYS
NT seq 3798 nt NT seq  +upstreamnt  +downstreamnt
atgagcgccatgatcagcgtggacgccctccccgagtacgagaagagtcagatcaagagg
gccctggagctgggcacggtcatgaccgttttcagcttccgcaagtccaccccggagcgg
aggaccgtccaggtgatcatggagacgcggcaggtggcctggagcaagacggcggacaag
atcgagggcttcctggatatcatggaaataaaggaaatccgcccggggaagaactccaag
gacttcgagcgtgcgaaagccgtccgccagaaggaagactgctgcttcaccatcttctac
ggcacccagttcgtcctcagcaccctcagcttggcagctgactctaaagaagatgcgatg
aaatggctctctggcttgaaaatcttacaccaggaagtgatgagcgcgtccacacccacc
gtgatcgagagttggctgagaaagcagatttattctgtggatcaaaccagaagaaacagc
atcagcctccgagagctgaaggccatcctgccgctggtcaacttcaaagcgagcagcgcc
aagttcctcaaagacaagtttctggaaattggcgcacacaaagatgaactcagctttgag
cagttccatctcttctataaaaaacttatgtttgaacagcaaaaatcgattctcgacgaa
ttcaaaaaggactcctccgtattcatcttgggcaacactgaccggccggacgcctctgct
gtccacctgcacgacttccagcggtttctcttacatgagcagcaggaactttgggctcag
gatctgaacaaagtccgtgagcggatgaccaagtttatcgacgacaccatgagggaaact
gccgagcctttcttgtttgtggatgagttcctcacgtacctgttttcccgggagaacagc
atttgggacgagaagtacgacgtggtggacatgcaggacatgaacaaccccttgtctcat
tactggatctcctcgtcccacaacacgtacctcacaggtgaccagctgcggagcgagtcg
tccacagaggcgtacatccgctgtctgcggatgggctgccgctgcatcgagctggactgc
tgggacgggcccgacgggaagcccatcatctaccacggctggacgcggaccaccaagatc
aagtttgacgatgtggtgcaggccatcaaagaccatgccttcgtcacctccagcttcccc
gtgatcctgtccatcgaggagcactgctgcgtggagcagcagcgccacatggccagggtg
ttcaaggaggtgtttggggacctgctgctgacgaagcccacggaggccagtgccgaccag
ctgccctcgcccagccagctgcgggagaagatcatcatcaagcataagaagctgggcccc
cgaggcgacgtggatgtcaacatggaggacaagaaagatgagcacaagcagcagggcgag
ctgtacatgtgggattccatcgaccagaaatggacccggcactactgcgccattgctgat
gccaagctgtccttcagcgatgacattgaacagactgtggaggaggaaccgcccgtgaac
acgccccccacggagctgcattttggggagaagtggttccacaagaaggtggagaagagg
acaagtgccgagaagctgctgcaggagtactgtgccgagacagggggcaaggatgggacc
ttcttggtgcgggagagcgagacctaccccaacgactacaccctgtccttctggcggtca
ggccgagtgcagcactgccgcatccgctccaccatggagggcggggtcatgaagtactac
ctgactgacaacctcatgttcaccagcatctacgccctcatccagcactaccgcgagacg
cacctgcgctgtgccgagttcgagctccggctgaccgaccccgtgcccaaccccaacccg
cacgagtcgaagccgtggtactatgacgggctgagccgcggagaagcggaggacatgctg
atgagggttccccgggatggggccttcctcatccggaggcgggaaggtaccgactcctac
gccatcaccttcagggccaggggcaaggtgaagcactgccgaatcaaccgggatggccgg
cacttcgtgctgggcacctccgcctactttgagagcctcgtggagctggtcagctactac
gagaagcacgcgctctaccggaagatgagactgcgctaccctgtgacccccgagctcctg
gagcgctacaatatggaaagagatatcaactccctctatgacgtcagcagaatgtatgtg
gatcccagtgaaatcaacccttccatgcctcagagaaccgtgaaagcgctgtatgactac
agagccaagcaaagcgatgagctgagcttctgccgtggcgccctcatccataatgtctcc
aaggagccggggggctggtggaaaggagactacggaaccagaatccagcagtacttcccg
tccaattacgtcgaggacatttcagccgttgatgtggaggagctggagaagcagattatt
gaagacaatcccttagggtctctttgcagaggaatcctggatctcaacacctataatgtg
gtgaaagccccccaggggaaaaaccagaagcctttcgtctttatcttggagcccaagaag
cagggcgacccgccggtggagtttgccacggacagggtggaggagctctttgagtggttt
cagagcatccgggagatcacctggaagatagacaccaaggagaacaacatgaggtactgg
gagaagaaccagtccatcgccatcgagctctcggacctggtcgtctactgcaaacccacc
agcaagaccaaggacaacttagaaaaccccgacttccgagaaatccgctcctttgtggaa
acgaaggctgacagcgtcaccagacagaaacccaatgacctcctcaaatacaatcaaaag
gctctgacccgcatctaccccaagggacagcgggttgactcctccaactacgaccccttc
cgcctctggctgtgtggctcccagatggtggcactcaatttccagaccgcagataagtac
atgcagatgaaccacgctctgttttccctcaacggacggacgggttacgtcctgcagccc
gagagcatgagggccgagaagtacgaccccatgccgcccgagtcgcagaggaagatcctg
atgactctgacggtcaaggtcctcggggctcgccatctccccaaaactggccgaagtatt
gtgtgtccctttgtggaggtggaaatatgcggagccgagtatgacaacaacaaattcaaa
acaacagttgtgaatgacaatggcctaagccctgtttgggctccaacgcaggagaaggtg
acatttgaaatttatgaccccaacctcgcatttctgcgcttcgtggtttatgaggaagat
attttcagcgatcccaactttctcgctcacgccacttaccccattaaaggcatcaaatca
ggataccgatctgttcctctgaagaatgggtacagtgaagacatcgagctggcgtccctc
ctggttttctgtgagatgcggccagtcctggagagtgaggaggagctctacgcctcctgc
cgccagctgcggaggcgccaggaggagctcaacaaccagctctttctgtacgacacacac
cagaacttgcgcaacgccaaccgggatgccctcgtccgagagttcaacgtcaacgagaac
cagctgcagctctaccaggagaagtgcaaccgcaggttgagagagaagagggtcagcaac
agcaagttttactcctag

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