KEGG   Sus scrofa (pig): 100518663Help
Entry
100518663         CDS       T01009                                 

Gene name
PLCG2
Definition
(RefSeq) phospholipase C, gamma 2 (phosphatidylinositol-specific)
  KO
K05859  
phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
Organism
ssc  Sus scrofa (pig)
Pathway
Inositol phosphate metabolism
Metabolic pathways
EGFR tyrosine kinase inhibitor resistance
ErbB signaling pathway
Ras signaling pathway
Calcium signaling pathway
NF-kappa B signaling pathway
HIF-1 signaling pathway
Phosphatidylinositol signaling system
Phospholipase D signaling pathway
Axon guidance
VEGF signaling pathway
Osteoclast differentiation
Platelet activation
Natural killer cell mediated cytotoxicity
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Inflammatory mediator regulation of TRP channels
Thyroid hormone signaling pathway
AGE-RAGE signaling pathway in diabetic complications
Epstein-Barr virus infection
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Glioma
Non-small cell lung cancer
Module
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:ssc00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100518663 (PLCG2)
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    100518663 (PLCG2)
   04012 ErbB signaling pathway
    100518663 (PLCG2)
   04370 VEGF signaling pathway
    100518663 (PLCG2)
   04064 NF-kappa B signaling pathway
    100518663 (PLCG2)
   04066 HIF-1 signaling pathway
    100518663 (PLCG2)
   04020 Calcium signaling pathway
    100518663 (PLCG2)
   04070 Phosphatidylinositol signaling system
    100518663 (PLCG2)
   04072 Phospholipase D signaling pathway
    100518663 (PLCG2)
 Organismal Systems
  Immune system
   04611 Platelet activation
    100518663 (PLCG2)
   04650 Natural killer cell mediated cytotoxicity
    100518663 (PLCG2)
   04662 B cell receptor signaling pathway
    100518663 (PLCG2)
   04664 Fc epsilon RI signaling pathway
    100518663 (PLCG2)
   04666 Fc gamma R-mediated phagocytosis
    100518663 (PLCG2)
   04670 Leukocyte transendothelial migration
    100518663 (PLCG2)
  Endocrine system
   04919 Thyroid hormone signaling pathway
    100518663 (PLCG2)
  Nervous system
   04722 Neurotrophin signaling pathway
    100518663 (PLCG2)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100518663 (PLCG2)
  Development
   04360 Axon guidance
    100518663 (PLCG2)
   04380 Osteoclast differentiation
    100518663 (PLCG2)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    100518663 (PLCG2)
   05206 MicroRNAs in cancer
    100518663 (PLCG2)
   05205 Proteoglycans in cancer
    100518663 (PLCG2)
   05214 Glioma
    100518663 (PLCG2)
   05223 Non-small cell lung cancer
    100518663 (PLCG2)
  Endocrine and metabolic diseases
   04933 AGE-RAGE signaling pathway in diabetic complications
    100518663 (PLCG2)
  Infectious diseases
   05169 Epstein-Barr virus infection
    100518663 (PLCG2)
  Antineoplastic resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    100518663 (PLCG2)
Enzymes [BR:ssc01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     100518663 (PLCG2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-ProteinID: 
NCBI-GeneID: 
Ensembl: 
Position
6
AA seq 1200 aa AA seqDB search
MSAMISVDALPEYEKSQIKRALELGTVMTVFSFRKSTPERRTVQVIMETRQVAWSKTADK
IEGFLDIMEIKEIRPGKNSKDFERAKAVRQKEDCCFTIFYGTQFVLSTLSLAADSKEDAM
KWLSGLKILHQEVMSASTPTVIESWLRKQIYSVDQTRRNSISLRELKAILPLVNFKASSA
KFLKDKFLEIGAHKDELSFEQFHLFYKKLMFEQQKSILDEFKKDSSVFILGNTDRPDASA
VHLHDFQRFLLHEQQELWAQDLNKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENS
IWDEKYDVVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSTEAYIRCLRMGCRCIELDC
WDGPDGKPIIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSIEEHCCVEQQRHMARV
FKEVFGDLLLTKPTEASADQLPSPSQLREKIIIKHKKLGPRGDVDVNMEDKKDEHKQQGE
LYMWDSIDQKWTRHYCAIADAKLSFSDDIEQTVEEEPPVNTPPTELHFGEKWFHKKVEKR
TSAEKLLQEYCAETGGKDGTFLVRESETYPNDYTLSFWRSGRVQHCRIRSTMEGGVMKYY
LTDNLMFTSIYALIQHYRETHLRCAEFELRLTDPVPNPNPHESKPWYYDGLSRGEAEDML
MRVPRDGAFLIRRREGTDSYAITFRARGKVKHCRINRDGRHFVLGTSAYFESLVELVSYY
EKHALYRKMRLRYPVTPELLERYNMERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDY
RAKQSDELSFCRGALIHNVSKEPGGWWKGDYGTRIQQYFPSNYVEDISAVDVEELEKQII
EDNPLGSLCRGILDLNTYNVVKAPQGKNQKPFVFILEPKKQGDPPVEFATDRVEELFEWF
QSIREITWKIDTKENNMRYWEKNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSFVE
TKADSVTRQKPNDLLKYNQKALTRIYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKY
MQMNHALFSLNGRTGYVLQPESMRAEKYDPMPPESQRKILMTLTVKVLGARHLPKTGRSI
VCPFVEVEICGAEYDNNKFKTTVVNDNGLSPVWAPTQEKVTFEIYDPNLAFLRFVVYEED
IFSDPNFLAHATYPIKGIKSGYRSVPLKNGYSEDIELASLLVFCEMRPVLVSGGTPAGVP
NT seq 3603 nt NT seq  +upstreamnt  +downstreamnt
atgagcgccatgatcagcgtggacgccctccccgagtacgagaagagtcagatcaagagg
gccctggagctgggcacggtcatgaccgttttcagcttccgcaagtccaccccggagcgg
aggaccgtccaggtgatcatggagacgcggcaggtggcctggagcaagacggcggacaag
atcgagggcttcctggatatcatggaaataaaggaaatccgcccggggaagaactccaag
gacttcgagcgtgcgaaagccgtccgccagaaggaagactgctgcttcaccatcttctac
ggcacccagttcgtcctcagcaccctcagcttggcagctgactctaaagaagatgcgatg
aaatggctctctggcttgaaaatcttacaccaggaagtgatgagcgcgtccacacccacc
gtgatcgagagttggctgagaaagcagatttattctgtggatcaaaccagaagaaacagc
atcagcctccgagagctgaaggccatcctgccgctggtcaacttcaaagcgagcagcgcc
aagttcctcaaagacaagtttctggaaattggcgcacacaaagatgaactcagctttgag
cagttccatctcttctataaaaaacttatgtttgaacagcaaaaatcgattctcgacgaa
ttcaaaaaggactcctccgtattcatcttgggcaacactgaccggccggacgcctctgct
gtccacctgcacgacttccagcggtttctcttacatgagcagcaggaactttgggctcag
gatctgaacaaagtccgtgagcggatgaccaagtttatcgacgacaccatgagggaaact
gccgagcctttcttgtttgtggatgagttcctcacgtacctgttttcccgggagaacagc
atttgggacgagaagtacgacgtggtggacatgcaggacatgaacaaccccttgtctcat
tactggatctcctcgtcccacaacacgtacctcacaggtgaccagctgcggagcgagtcg
tccacagaggcgtacatccgctgtctgcggatgggctgccgctgcatcgagctggactgc
tgggacgggcccgacgggaagcccatcatctaccacggctggacgcggaccaccaagatc
aagtttgacgatgtggtgcaggccatcaaagaccatgccttcgtcacctccagcttcccc
gtgatcctgtccatcgaggagcactgctgcgtggagcagcagcgccacatggccagggtg
ttcaaggaggtgtttggggacctgctgctgacgaagcccacggaggccagtgccgaccag
ctgccctcgcccagccagctgcgggagaagatcatcatcaagcataagaagctgggcccc
cgaggcgacgtggatgtcaacatggaggacaagaaagatgagcacaagcagcagggcgag
ctgtacatgtgggattccatcgaccagaaatggacccggcactactgcgccattgctgat
gccaagctgtccttcagcgatgacattgaacagactgtggaggaggaaccgcccgtgaac
acgccccccacggagctgcattttggggagaagtggttccacaagaaggtggagaagagg
acaagtgccgagaagctgctgcaggagtactgtgccgagacagggggcaaggatgggacc
ttcttggtgcgggagagcgagacctaccccaacgactacaccctgtccttctggcggtca
ggccgagtgcagcactgccgcatccgctccaccatggagggcggggtcatgaagtactac
ctgactgacaacctcatgttcaccagcatctacgccctcatccagcactaccgcgagacg
cacctgcgctgtgccgagttcgagctccggctgaccgaccccgtgcccaaccccaacccg
cacgagtcgaagccgtggtactatgacgggctgagccgcggagaagcggaggacatgctg
atgagggttccccgggatggggccttcctcatccggaggcgggaaggtaccgactcctac
gccatcaccttcagggccaggggcaaggtgaagcactgccgaatcaaccgggatggccgg
cacttcgtgctgggcacctccgcctactttgagagcctcgtggagctggtcagctactac
gagaagcacgcgctctaccggaagatgagactgcgctaccctgtgacccccgagctcctg
gagcgctacaatatggaaagagatatcaactccctctatgacgtcagcagaatgtatgtg
gatcccagtgaaatcaacccttccatgcctcagagaaccgtgaaagcgctgtatgactac
agagccaagcaaagcgatgagctgagcttctgccgtggcgccctcatccataatgtctcc
aaggagccggggggctggtggaaaggagactacggaaccagaatccagcagtacttcccg
tccaattacgtcgaggacatttcagccgttgatgtggaggagctggagaagcagattatt
gaagacaatcccttagggtctctttgcagaggaatcctggatctcaacacctataatgtg
gtgaaagccccccaggggaaaaaccagaagcctttcgtctttatcttggagcccaagaag
cagggcgacccgccggtggagtttgccacggacagggtggaggagctctttgagtggttt
cagagcatccgggagatcacctggaagatagacaccaaggagaacaacatgaggtactgg
gagaagaaccagtccatcgccatcgagctctcggacctggtcgtctactgcaaacccacc
agcaagaccaaggacaacttagaaaaccccgacttccgagaaatccgctcctttgtggaa
acgaaggctgacagcgtcaccagacagaaacccaatgacctcctcaaatacaatcaaaag
gctctgacccgcatctaccccaagggacagcgggttgactcctccaactacgaccccttc
cgcctctggctgtgtggctcccagatggtggcactcaatttccagaccgcagataagtac
atgcagatgaaccacgctctgttttccctcaacggacggacgggttacgtcctgcagccc
gagagcatgagggccgagaagtacgaccccatgccgcccgagtcgcagaggaagatcctg
atgactctgacggtcaaggtcctcggggctcgccatctccccaaaactggccgaagtatt
gtgtgtccctttgtggaggtggaaatatgcggagccgagtatgacaacaacaaattcaaa
acaacagttgtgaatgacaatggcctaagccctgtttgggctccaacgcaggagaaggtg
acatttgaaatttatgaccccaacctcgcatttctgcgcttcgtggtttatgaggaagat
attttcagcgatcccaactttctcgctcacgccacttaccccattaaaggcatcaaatca
ggataccgatctgttcctctgaagaatgggtacagtgaagacatcgagctggcgtccctc
ctggttttctgtgagatgcggccagtcctggtgagtggaggcacaccagcgggggttccc
tga

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