KEGG   Sus scrofa (pig): 100525148Help
Entry
100525148         CDS       T01009                                 

Gene name
PLCB3
Definition
phospholipase C, beta 3 (phosphatidylinositol-specific)
Orthology
K05858  
phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
ssc  Sus scrofa (pig)
Pathway
Inositol phosphate metabolism
Metabolic pathways
Rap1 signaling pathway
Calcium signaling pathway
cGMP-PKG signaling pathway
Chemokine signaling pathway
Phosphatidylinositol signaling system
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Wnt signaling pathway
Gap junction
Platelet activation
Circadian entrainment
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
Dopaminergic synapse
Long-term depression
Inflammatory mediator regulation of TRP channels
Insulin secretion
GnRH signaling pathway
Estrogen signaling pathway
Melanogenesis
Thyroid hormone synthesis
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Endocrine and other factor-regulated calcium reabsorption
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Alzheimer's disease
Huntington's disease
Chagas disease (American trypanosomiasis)
African trypanosomiasis
Amoebiasis
Pathways in cancer
Module
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:ssc00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100525148 (PLCB3)
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    100525148 (PLCB3)
   04310 Wnt signaling pathway
    100525148 (PLCB3)
   04020 Calcium signaling pathway
    100525148 (PLCB3)
   04070 Phosphatidylinositol signaling system
    100525148 (PLCB3)
   04022 cGMP - PKG signaling pathway
    100525148 (PLCB3)
 Cellular Processes
  Cellular commiunity
   04540 Gap junction
    100525148 (PLCB3)
 Organismal Systems
  Immune system
   04611 Platelet activation
    100525148 (PLCB3)
   04062 Chemokine signaling pathway
    100525148 (PLCB3)
  Endocrine system
   04911 Insulin secretion
    100525148 (PLCB3)
   04912 GnRH signaling pathway
    100525148 (PLCB3)
   04915 Estrogen signaling pathway
    100525148 (PLCB3)
   04921 Oxytocin signaling pathway
    100525148 (PLCB3)
   04918 Thyroid hormone synthesis
    100525148 (PLCB3)
   04919 Thyroid hormone signaling pathway
    100525148 (PLCB3)
   04916 Melanogenesis
    100525148 (PLCB3)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    100525148 (PLCB3)
   04270 Vascular smooth muscle contraction
    100525148 (PLCB3)
  Digestive system
   04970 Salivary secretion
    100525148 (PLCB3)
   04971 Gastric acid secretion
    100525148 (PLCB3)
   04972 Pancreatic secretion
    100525148 (PLCB3)
  Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    100525148 (PLCB3)
  Nervous system
   04724 Glutamatergic synapse
    100525148 (PLCB3)
   04725 Cholinergic synapse
    100525148 (PLCB3)
   04728 Dopaminergic synapse
    100525148 (PLCB3)
   04726 Serotonergic synapse
    100525148 (PLCB3)
   04720 Long-term potentiation
    100525148 (PLCB3)
   04730 Long-term depression
    100525148 (PLCB3)
   04723 Retrograde endocannabinoid signaling
    100525148 (PLCB3)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100525148 (PLCB3)
  Environmental adaptation
   04713 Circadian entrainment
    100525148 (PLCB3)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    100525148 (PLCB3)
  Neurodegenerative diseases
   05010 Alzheimer's disease
    100525148 (PLCB3)
   05016 Huntington's disease
    100525148 (PLCB3)
  Infectious diseases
   05146 Amoebiasis
    100525148 (PLCB3)
   05142 Chagas disease (American trypanosomiasis)
    100525148 (PLCB3)
   05143 African trypanosomiasis
    100525148 (PLCB3)
Enzymes [BR:ssc01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     100525148 (PLCB3)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Ensembl: 
UniProt: 
Position
2
AA seq 1160 aa AA seqDB search
MAGARPGVHALQLEPPTVVETLRRGSKFIKWDEEKLMTVVAGPDPVNTTFLNFMAVQDDT
AKVWSEELFKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNILKMFSADKKRVE
TALESCGLNFNRSESIRPDEFSLEIFERFLNKLCLRPDIDKILLEIGAKGKPYLTLEQLM
DFINQKQRDPRLNEVLYPPLRPSQARQLIEKYEPNKQFLERDQMSMEGFSRYLGGEENSI
LPLEALDLSADMTQPLSSYFINSSHNTYLTAGQLAGASSVEMYRQALLWGCRCVELDVWK
GRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVILSFENHVDSAKQQAKMAE
YCRSIFGDALLIDPLDKYPLAPGVPLPSPQDLMGRILVKNKKRHRPSTGGVPDSSIRKRP
LEQSNSALSESSAATEPSSPQLGSPSSDSCPGLSNGEEAGLEKPSLEPQKSLGEEGLPRG
SDAYREEEEEDEEEEEQSDPKKPTTDEGTASSEVNATEEMSTLVNYIEPVKFKSFEAARK
RNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNYMPQLFWNVGCQ
LVALNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVIVDGIVANALRV
KVISGQFLSDRKVGIYVEVDMFGLPVDTRRKYRTRTSQGNSFNPVWDEEPFDFPKVVLPT
LASLRIAAFEEGGKFVGHRILPVSAIRSGYHYICLRNEANQPLCLPALLIYTEASDYIPD
DHQDYAEALINPIKHVSLMDQRAKQLAALIGESEAQAGPETSQETQSQQPGSQLTPNPTP
SPLDASPRRPPGPTTSPTSTSLSSPGQRDDLVASILSEVAPAPLDDLRGHKALVKLRSRQ
ERDLRELRKKHQRKAVALTRRLLDSLAQARAEGRCRPRPGVLGGEDEKEEEEEVKRYQEF
QKKQVQCLLELREAQADIETERRLEHLKQAQQRLREVVMEAHTTQFKRLKEMNDREKKEL
QKILDRKRHNSISEAKTREKHKKEAELTEINRRHITESVNSIRRLEEAQKQRHERLVAGQ
QQILQQLAEEEPKLLAQLAQECQEQRERLPQEIRWSLLGETPEGLGDGHLVACASNGHAP
GSGGHLSGADSESQEENTKL
NT seq 3483 nt NT seq  +upstreamnt  +downstreamnt
atggcgggcgccaggcccggcgtccacgcgctgcagctggagccgcccaccgtcgtggag
accctgcggcgcgggagtaagttcatcaaatgggacgaggagaagctgatgacggtggtg
gccgggccagacccagtgaacaccacattcttgaacttcatggccgtgcaggatgacaca
gccaaggtctggtctgaggagctgttcaagctggctatgaacatcctggctcagaacgcc
tcccggaacaccttcttgcgcaaagcgtacacgaagctgaagctgcaggtgaaccaggac
gggcggatcccggtcaagaacatcctgaagatgttctcagcagacaagaagcgggtagag
actgcactggaatcctgtggcctcaatttcaaccggagcgagtccatccggcctgacgag
ttctccttggaaatcttcgagcggttcctgaacaagctgtgtctgcggccggacattgac
aagatcctgctggagataggcgccaagggcaagccgtacctgacgctggagcagctcatg
gacttcatcaaccagaagcaacgggacccaagactcaatgaagtgctgtacccgcctctg
cggccctcccaggcccggcagctcatcgagaagtatgagcccaacaagcagttcttggag
agagaccagatgtccatggagggcttcagccgctacctgggaggtgaggagaacagcatc
ctgcccctagaggccttggatctgagcgcggacatgacccagccgctgagctcctacttc
atcaactcctcacacaacacgtatctcaccgcggggcagctggccggggcctcgtcggtg
gagatgtaccgccaggcgctgctgtggggctgccgctgcgtggagctggacgtgtggaag
gggcggccgcccgaggaggagcccttcatcacgcacggcttcaccatgaccacggaggtg
ccgctgcgcgacgtgctcgaggccatcgcggagaccgccttcaagacctcgccctacccc
gtcatcctctccttcgagaaccacgtggactcagcaaagcagcaggccaagatggccgag
tactgccgctccatctttggggacgcactgctcattgacccactggacaagtacccgctg
gccccgggcgtccccctgcccagcccccaggacctgatgggccgcatccttgtgaagaac
aagaagcggcaccggccgagcacgggcggcgtcccggacagctccatacgcaagcggccg
ctcgagcagagcaactcggccttgagcgagagctctgccgccaccgagccctcctcgccc
cagctcgggtcgcccagctctgacagctgcccaggcctgagcaatggggaggaggcgggc
cttgagaagcccagcctggagcctcagaagtctctgggtgaggagggtttgccgcggggc
tctgatgcctaccgcgaggaggaggaggaggacgaggaagaggaggaacagtcggacccc
aaaaagccgaccacagatgagggcactgccagcagtgaagtcaatgccactgaggaaatg
tcaacactggtcaactacatcgagcctgtgaagttcaagtccttcgaggctgcgcgaaaa
aggaacaagtgcttcgagatgtcctccttcgtggagaccaaggccatggagcaactgacc
aagagccccatggagtttgtggaatacaacaagcagcagctcagccgcatctaccccaag
ggcacccgcgtggactcgtccaactacatgccccagctcttctggaacgtgggctgccag
ctcgttgcactgaacttccagaccctggatgtggcgatgcagctcaatgcgggcgtgttc
gagtacaacgggcgcagcggctacctcctcaaacccgagttcatgcggcggccggacaag
tcctttgaccccttcaccgaggtcatcgtggacggcattgtggccaatgccttgcgggtc
aaggtgatctcggggcagttcctgtccgacaggaaggtgggcatctacgtggaggtggat
atgttcggcctccccgttgacacccggcgcaagtaccgcacgcggacttctcaggggaac
tcgttcaaccccgtgtgggacgaggagcccttcgatttccccaaggtggtgctacccaca
ctggcttctctgcgcatcgcggcctttgaggagggcggcaagttcgtgggccaccggatc
ctgcctgtctctgccattcgctcagggtaccactacatctgcctgcggaacgaggccaac
cagccactgtgcctgccagccctgctcatctacactgaggcctccgactacatccccgac
gaccaccaggactacgcagaggccctgatcaaccccatcaagcacgtcagcctgatggac
cagagggccaagcagctggctgccctcattggggagagcgaggctcaggctggcccggag
acaagccaggagacccagtctcagcagccaggatcccagctgaccccaaaccccacaccc
agccccctggacgcctccccccgccggcccccgggccccaccacctcccctaccagcacc
tccctcagcagcccaggtcagcgcgatgacctcgttgccagcatcctctcagaggtggcc
ccggccccgctggacgatctccgaggccacaaggccctggtgaagctccggagccggcaa
gagcgagacctgcgggagctgcgcaagaagcatcagcggaaggctgtggccctcactcgc
cgattgctcgacagcctggcccaggcccgggccgagggcaggtgccggccccggccaggt
gtcctaggcggggaggacgagaaggaggaggaggaggaggtgaagaggtatcaggagttc
caaaagaaacaggtgcagtgtctgctggagctgagggaagcccaggctgacatagagacc
gagcggaggctggaacacctgaaacaggctcagcagcggctcagggaggttgtcatggag
gctcacacaactcagttcaagagactgaaggagatgaatgacagggagaagaaggaactg
cagaagatcctggacaggaagcgccacaacagcatctcggaggccaagaccagggagaaa
cataagaaggaggcggaactgacagagattaaccgtcggcacatcactgagtcggtcaac
tccatccgtcggctggaggaggcccagaagcagcggcatgaacgccttgtggctgggcag
cagcagatcctacaacagctggcagaagaagagcccaagctgctggcccagctggcccag
gagtgtcaggagcagcgggagaggctgccccaggagatccgctggagcctgctgggcgag
acaccggagggactgggggacgggcatctggtggcctgtgccagcaatggtcacgcgcct
gggagcggcgggcacctgtcgggcgctgactcggagagccaagaggagaatacgaagctc
tga

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