KEGG   Sus scrofa (pig): 100621789Help
Entry
100621789         CDS       T01009                                 

Gene name
PIK3CA
Definition
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
Orthology
K00922  
phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
Organism
ssc  Sus scrofa (pig)
Pathway
Inositol phosphate metabolism
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Phosphatidylinositol signaling system
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Apoptosis
Adrenergic signaling in cardiomyocytes
VEGF signaling pathway
Osteoclast differentiation
Focal adhesion
Signaling pathways regulating pluripotency of stem cells
Platelet activation
Toll-like receptor signaling pathway
Jak-STAT signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Cholinergic synapse
Inflammatory mediator regulation of TRP channels
Regulation of actin cytoskeleton
Insulin signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
Carbohydrate digestion and absorption
Bacterial invasion of epithelial cells
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Amoebiasis
Hepatitis C
Hepatitis B
Measles
Influenza A
HTLV-I infection
Epstein-Barr virus infection
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Melanoma
Chronic myeloid leukemia
Acute myeloid leukemia
Small cell lung cancer
Non-small cell lung cancer
Brite
KEGG Orthology (KO) [BR:ssc00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100621789 (PIK3CA)
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    100621789 (PIK3CA)
   04015 Rap1 signaling pathway
    100621789 (PIK3CA)
   04012 ErbB signaling pathway
    100621789 (PIK3CA)
   04370 VEGF signaling pathway
    100621789 (PIK3CA)
   04630 Jak-STAT signaling pathway
    100621789 (PIK3CA)
   04668 TNF signaling pathway
    100621789 (PIK3CA)
   04066 HIF-1 signaling pathway
    100621789 (PIK3CA)
   04068 FoxO signaling pathway
    100621789 (PIK3CA)
   04070 Phosphatidylinositol signaling system
    100621789 (PIK3CA)
   04024 cAMP signaling pathway
    100621789 (PIK3CA)
   04022 cGMP - PKG signaling pathway
    100621789 (PIK3CA)
   04151 PI3K-Akt signaling pathway
    100621789 (PIK3CA)
   04152 AMPK signaling pathway
    100621789 (PIK3CA)
   04150 mTOR signaling pathway
    100621789 (PIK3CA)
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    100621789 (PIK3CA)
  Cell growth and death
   04210 Apoptosis
    100621789 (PIK3CA)
  Cellular commiunity
   04510 Focal adhesion
    100621789 (PIK3CA)
   04550 Signaling pathways regulating pluripotency of stem cells
    100621789 (PIK3CA)
 Organismal Systems
  Immune system
   04611 Platelet activation
    100621789 (PIK3CA)
   04620 Toll-like receptor signaling pathway
    100621789 (PIK3CA)
   04650 Natural killer cell mediated cytotoxicity
    100621789 (PIK3CA)
   04660 T cell receptor signaling pathway
    100621789 (PIK3CA)
   04662 B cell receptor signaling pathway
    100621789 (PIK3CA)
   04664 Fc epsilon RI signaling pathway
    100621789 (PIK3CA)
   04666 Fc gamma R-mediated phagocytosis
    100621789 (PIK3CA)
   04670 Leukocyte transendothelial migration
    100621789 (PIK3CA)
   04062 Chemokine signaling pathway
    100621789 (PIK3CA)
  Endocrine system
   04910 Insulin signaling pathway
    100621789 (PIK3CA)
   04915 Estrogen signaling pathway
    100621789 (PIK3CA)
   04914 Progesterone-mediated oocyte maturation
    100621789 (PIK3CA)
   04917 Prolactin signaling pathway
    100621789 (PIK3CA)
   04921 Oxytocin signaling pathway
    100621789 (PIK3CA)
   04919 Thyroid hormone signaling pathway
    100621789 (PIK3CA)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    100621789 (PIK3CA)
  Digestive system
   04973 Carbohydrate digestion and absorption
    100621789 (PIK3CA)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    100621789 (PIK3CA)
  Nervous system
   04725 Cholinergic synapse
    100621789 (PIK3CA)
   04722 Neurotrophin signaling pathway
    100621789 (PIK3CA)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100621789 (PIK3CA)
  Development
   04380 Osteoclast differentiation
    100621789 (PIK3CA)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    100621789 (PIK3CA)
   05205 Proteoglycans in cancer
    100621789 (PIK3CA)
   05203 Viral carcinogenesis
    100621789 (PIK3CA)
   05210 Colorectal cancer
    100621789 (PIK3CA)
   05212 Pancreatic cancer
    100621789 (PIK3CA)
   05214 Glioma
    100621789 (PIK3CA)
   05221 Acute myeloid leukemia
    100621789 (PIK3CA)
   05220 Chronic myeloid leukemia
    100621789 (PIK3CA)
   05218 Melanoma
    100621789 (PIK3CA)
   05211 Renal cell carcinoma
    100621789 (PIK3CA)
   05215 Prostate cancer
    100621789 (PIK3CA)
   05213 Endometrial cancer
    100621789 (PIK3CA)
   05222 Small cell lung cancer
    100621789 (PIK3CA)
   05223 Non-small cell lung cancer
    100621789 (PIK3CA)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    100621789 (PIK3CA)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    100621789 (PIK3CA)
  Infectious diseases
   05100 Bacterial invasion of epithelial cells
    100621789 (PIK3CA)
   05166 HTLV-I infection
    100621789 (PIK3CA)
   05162 Measles
    100621789 (PIK3CA)
   05164 Influenza A
    100621789 (PIK3CA)
   05161 Hepatitis B
    100621789 (PIK3CA)
   05160 Hepatitis C
    100621789 (PIK3CA)
   05169 Epstein-Barr virus infection
    100621789 (PIK3CA)
   05146 Amoebiasis
    100621789 (PIK3CA)
   05145 Toxoplasmosis
    100621789 (PIK3CA)
   05142 Chagas disease (American trypanosomiasis)
    100621789 (PIK3CA)
Enzymes [BR:ssc01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     100621789 (PIK3CA)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Position
13
AA seq 709 aa AA seqDB search
MTVAESDDLYALGIFFFFKIFHRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEH
CPLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDW
FSSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLRAICTRDP
LSEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAM
ELLDCNYPDPMVRGFAVRCLEKYXTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALT
NQRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDIL
KQEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPL
WLNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCL
SIGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTR
SCAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQD
FLIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDI
AYIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 2130 nt NT seq  +upstreamnt  +downstreamnt
atgacggtggcggagtctgatgatttatatgctctggggattttttttttctttaaaatt
tttcataggtggaatgaatggctgaattacgatatatacattcctgatcttcctcgtgct
gctcgactttgcctttccatttgttctgttaaaggccgaaagggtgctaaagaggaacac
tgtccattggcctggggaaatataaacttgtttgattacacagatactctagtatctgga
aaaatggctttgaatctttggcctgtacctcatgggttagaagatttgctgaaccctatt
ggtgttactggatcaaatccaaataaagaaactccatgcttagagttggagtttgactgg
ttcagcagtgtggtgaagtttccagatatgtcagtgattgaagagcatgccaattggtct
gtatcccgagaagcaggatttagttactctcatgcaggactgagtaacagactagctaga
gacaacgaattacgggaaaatgataaagaacagctccgagcaatttgtacacgagatcct
ctatctgaaatcactgagcaagagaaagattttctctggagccacagacactattgtgta
actatccctgaaattctacccaagttgcttctgtctgttaaatggaattctagagatgaa
gtagctcagatgtactgcttggtaaaagattggcctccaatcaaacctgaacaggctatg
gagcttttggactgcaattacccagatcctatggttcgaggttttgctgttcgatgcttg
gaaaaatatntaacagatgacaaactttctcagtacctaattcagctagtacaggtccta
aaatatgaacagtatttggataacctgcttgtgagatttttactcaaaaaagcattgact
aatcaaagaattgggcactttttcttttggcatttaaaatctgagatgcacaataaaact
gttagtcagaggtttggcctacttttggagtcctattgccgtgcatgtgggatgtatttg
aagcacttgaataggcaagttgaggctatggaaaagctcattaacttaactgacattctc
aaacaagagaagaaggatgaaacacaaaaggtacagatgaagtttttagttgaacaaatg
aggcgaccagatttcatggatgctctgcagggctttctatctcctctaaaccctgctcat
cagctgggaaatctcaggcttgaagagtgtcgaattatgtcctctgcaaaaaggccactg
tggttgaattgggagaacccagacatcatgtcagaattactctttcaaaacaatgagatc
atctttaaaaatggggatgatttacggcaagatatgctaacacttcagattattcgcatt
atggaaaatatctggcaaaatcaaggtcttgatcttcgaatgttaccttatggttgtctg
tcaattggtgactgtgtgggacttattgaggtggtgagaaattctcacactattatgcaa
attcagtgcaaaggaggcctgaaaggtgcactgcagttcaacagccacacactacatcag
tggctcaaagacaagaacaagggcgaaatatatgatgcagccattgatctgtttacacgt
tcatgtgctggatattgtgttgccaccttcattttgggaattggagatcgtcacaatagt
aacatcatggttaaagatgatggacaactgtttcatatagattttggacactttttggat
cacaagaagaaaaaatttggttataaacgagagcgtgtgccatttgttttgacacaagat
ttcttaatagtgattagtaaaggagcccaagaatgcacaaagacaagagaatttgagagg
tttcaggagatgtgttacaaggcttatttagctattcggcagcatgccaatctcttcata
aatcttttctcaatgatgcttggctctggaatgccagaactacaatcttttgatgatatt
gcatacattcgaaagaccctagctttagataaaactgagcaagaggctttggaatatttc
atgaaacaaatgaatgatgcacatcatggtggctggacaacaaaaatggattggatcttc
cacacaattaagcagcatgctttgaactga

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