KEGG   Sus scrofa (pig): 100621789Help
Entry
100621789         CDS       T01009                                 

Gene name
PIK3CA
Definition
(RefSeq) phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
  KO
K00922  
phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
Organism
ssc  Sus scrofa (pig)
Pathway
Inositol phosphate metabolism
EGFR tyrosine kinase inhibitor resistance
Endocrine resistance
Platinum drug resistance
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Phosphatidylinositol signaling system
Sphingolipid signaling pathway
Phospholipase D signaling pathway
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Apoptosis
Longevity regulating pathway
Longevity regulating pathway - multiple species
Adrenergic signaling in cardiomyocytes
Axon guidance
VEGF signaling pathway
Osteoclast differentiation
Focal adhesion
Signaling pathways regulating pluripotency of stem cells
Platelet activation
Toll-like receptor signaling pathway
Jak-STAT signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Cholinergic synapse
Inflammatory mediator regulation of TRP channels
Regulation of actin cytoskeleton
Insulin signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Regulation of lipolysis in adipocytes
Type II diabetes mellitus
Insulin resistance
Non-alcoholic fatty liver disease (NAFLD)
AGE-RAGE signaling pathway in diabetic complications
Aldosterone-regulated sodium reabsorption
Carbohydrate digestion and absorption
Bacterial invasion of epithelial cells
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Amoebiasis
Hepatitis C
Hepatitis B
Measles
Influenza A
HTLV-I infection
Epstein-Barr virus infection
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Melanoma
Chronic myeloid leukemia
Acute myeloid leukemia
Small cell lung cancer
Non-small cell lung cancer
Breast cancer
Central carbon metabolism in cancer
Choline metabolism in cancer
Module
PI3K-Akt signaling
Brite
KEGG Orthology (KO) [BR:ssc00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100621789 (PIK3CA)
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    100621789 (PIK3CA)
   04015 Rap1 signaling pathway
    100621789 (PIK3CA)
   04012 ErbB signaling pathway
    100621789 (PIK3CA)
   04370 VEGF signaling pathway
    100621789 (PIK3CA)
   04630 Jak-STAT signaling pathway
    100621789 (PIK3CA)
   04668 TNF signaling pathway
    100621789 (PIK3CA)
   04066 HIF-1 signaling pathway
    100621789 (PIK3CA)
   04068 FoxO signaling pathway
    100621789 (PIK3CA)
   04070 Phosphatidylinositol signaling system
    100621789 (PIK3CA)
   04072 Phospholipase D signaling pathway
    100621789 (PIK3CA)
   04071 Sphingolipid signaling pathway
    100621789 (PIK3CA)
   04024 cAMP signaling pathway
    100621789 (PIK3CA)
   04022 cGMP - PKG signaling pathway
    100621789 (PIK3CA)
   04151 PI3K-Akt signaling pathway
    100621789 (PIK3CA)
   04152 AMPK signaling pathway
    100621789 (PIK3CA)
   04150 mTOR signaling pathway
    100621789 (PIK3CA)
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    100621789 (PIK3CA)
  Cell growth and death
   04210 Apoptosis
    100621789 (PIK3CA)
  Cellular community
   04510 Focal adhesion
    100621789 (PIK3CA)
   04550 Signaling pathways regulating pluripotency of stem cells
    100621789 (PIK3CA)
 Organismal Systems
  Immune system
   04611 Platelet activation
    100621789 (PIK3CA)
   04620 Toll-like receptor signaling pathway
    100621789 (PIK3CA)
   04650 Natural killer cell mediated cytotoxicity
    100621789 (PIK3CA)
   04660 T cell receptor signaling pathway
    100621789 (PIK3CA)
   04662 B cell receptor signaling pathway
    100621789 (PIK3CA)
   04664 Fc epsilon RI signaling pathway
    100621789 (PIK3CA)
   04666 Fc gamma R-mediated phagocytosis
    100621789 (PIK3CA)
   04670 Leukocyte transendothelial migration
    100621789 (PIK3CA)
   04062 Chemokine signaling pathway
    100621789 (PIK3CA)
  Endocrine system
   04910 Insulin signaling pathway
    100621789 (PIK3CA)
   04923 Regulation of lipolysis in adipocyte
    100621789 (PIK3CA)
   04915 Estrogen signaling pathway
    100621789 (PIK3CA)
   04914 Progesterone-mediated oocyte maturation
    100621789 (PIK3CA)
   04917 Prolactin signaling pathway
    100621789 (PIK3CA)
   04921 Oxytocin signaling pathway
    100621789 (PIK3CA)
   04919 Thyroid hormone signaling pathway
    100621789 (PIK3CA)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    100621789 (PIK3CA)
  Digestive system
   04973 Carbohydrate digestion and absorption
    100621789 (PIK3CA)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    100621789 (PIK3CA)
  Nervous system
   04725 Cholinergic synapse
    100621789 (PIK3CA)
   04722 Neurotrophin signaling pathway
    100621789 (PIK3CA)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100621789 (PIK3CA)
  Development
   04360 Axon guidance
    100621789 (PIK3CA)
   04380 Osteoclast differentiation
    100621789 (PIK3CA)
  Aging
   04211 Longevity regulating pathway - mammal
    100621789 (PIK3CA)
   04213 Longevity regulating pathway - multiple species
    100621789 (PIK3CA)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    100621789 (PIK3CA)
   05230 Central carbon metabolism in cancer
    100621789 (PIK3CA)
   05231 Choline metabolism in cancer
    100621789 (PIK3CA)
   05205 Proteoglycans in cancer
    100621789 (PIK3CA)
   05203 Viral carcinogenesis
    100621789 (PIK3CA)
   05210 Colorectal cancer
    100621789 (PIK3CA)
   05212 Pancreatic cancer
    100621789 (PIK3CA)
   05214 Glioma
    100621789 (PIK3CA)
   05221 Acute myeloid leukemia
    100621789 (PIK3CA)
   05220 Chronic myeloid leukemia
    100621789 (PIK3CA)
   05218 Melanoma
    100621789 (PIK3CA)
   05211 Renal cell carcinoma
    100621789 (PIK3CA)
   05215 Prostate cancer
    100621789 (PIK3CA)
   05213 Endometrial cancer
    100621789 (PIK3CA)
   05224 Breast cancer
    100621789 (PIK3CA)
   05222 Small cell lung cancer
    100621789 (PIK3CA)
   05223 Non-small cell lung cancer
    100621789 (PIK3CA)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    100621789 (PIK3CA)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    100621789 (PIK3CA)
   04931 Insulin resistance
    100621789 (PIK3CA)
   04933 AGE-RAGE signaling pathway in diabetic complications
    100621789 (PIK3CA)
  Infectious diseases
   05100 Bacterial invasion of epithelial cells
    100621789 (PIK3CA)
   05166 HTLV-I infection
    100621789 (PIK3CA)
   05162 Measles
    100621789 (PIK3CA)
   05164 Influenza A
    100621789 (PIK3CA)
   05161 Hepatitis B
    100621789 (PIK3CA)
   05160 Hepatitis C
    100621789 (PIK3CA)
   05169 Epstein-Barr virus infection
    100621789 (PIK3CA)
   05146 Amoebiasis
    100621789 (PIK3CA)
   05145 Toxoplasmosis
    100621789 (PIK3CA)
   05142 Chagas disease (American trypanosomiasis)
    100621789 (PIK3CA)
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    100621789 (PIK3CA)
   01522 Endocrine resistance
    100621789 (PIK3CA)
   01524 Platinum drug resistance
    100621789 (PIK3CA)
Enzymes [BR:ssc01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     100621789 (PIK3CA)
Membrane trafficking [BR:ssc04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    100621789 (PIK3CA)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-ProteinID: 
NCBI-GeneID: 
Ensembl: 
Position
13
AA seq 1067 aa AA seqDB search
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLVTIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
CFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLRAICTRDPL
SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRGFAVRCLEKLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTNQ
RIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILKQ
EKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLWL
NWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSI
GDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRSC
AGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDFL
IVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIAY
IRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3204 nt NT seq  +upstreamnt  +downstreamnt
atgcctccaagaccatcatcaggtgaactgtggggcatccacttgatgcccccaagaatc
ctagtggaatgtttactaccaaatggaatgatagtgactttagaatgcctccgtgaggct
acattagtaactataaagcatgaactatttaaagaagcaagaaaataccctctccatcaa
cttcttcaagatgaatcttcttacattttcgtaagtgttacccaagaagcagaaagggaa
gaattttttgatgaaacaagacgactttgtgatcttcggctttttcaaccatttttaaaa
gtaattgaaccagtaggcaaccgtgaagaaaagatcctcaatcgagaaattggttttgct
atcggcatgccagtgtgcgaatttgatatggttaaagatcctgaagtacaggacttccga
agaaatattcttaatgtttgtaaagaagctgtggatcttagggatcttaattcacctcat
agtagagcaatgtatgtctatcctccaaatgtagaatcttcaccagaactgccaaagcac
atatataataaattggataaagggcaaataatagtggtgatttgggtaatagtttctcca
aataatgacaagcagaagtatactctgaaaatcaaccatgactgtgtgccagaacaagta
attgctgaagcaatcaggaaaaaaactagaagtatgttgctatcatctgaacaattaaaa
ctctgtgttttagaatatcagggcaagtacattttaaaagtgtgtggatgtgatgaatac
ttcctagaaaaatatcctctgagtcagtataagtatataagaagctgtataatgcttggg
aggatgcccaatttgatgctgatggctaaagaaagcctttactctcaactgccaatggac
tgtttcacaatgccatcttattccagacgcatctccacagctactccatatatgaatgga
gaaacatctacaaaatccctttgggttataaacagcgcactcagaataaaaatactttgt
gcaacctatgtgaatgtaaatattcgagacattgacaagatctatgttcgaacaggtatc
taccatggaggagaaccattatgtgataatgtgaacactcaacgagtaccttgttccaat
cccaggtggaatgaatggctgaattacgatatatacattcctgatcttcctcgtgctgct
cgactttgcctttccatttgttctgttaaaggccgaaagggtgctaaagaggaacactgt
ccattggcctggggaaatataaacttgtttgattacacagatactctagtatctggaaaa
atggctttgaatctttggcctgtacctcatgggttagaagatttgctgaaccctattggt
gttactggatcaaatccaaataaagaaactccatgcttagagttggagtttgactggttc
agcagtgtggtgaagtttccagatatgtcagtgattgaagagcatgccaattggtctgta
tcccgagaagcaggatttagttactctcatgcaggactgagtaacagactagctagagac
aacgaattacgggaaaatgataaagaacagctccgagcaatttgtacacgagatcctcta
tctgaaatcactgagcaagagaaagattttctctggagccacagacactattgtgtaact
atccctgaaattctacccaagttgcttctgtctgttaaatggaattctagagatgaagta
gctcagatgtactgcttggtaaaagattggcctccaatcaaacctgaacaggctatggag
cttttggactgcaattacccagatcctatggttcgaggttttgctgttcgatgcttggaa
aaattaacagatgacaaactttctcagtacctaattcagctagtacaggtcctaaaatat
gaacagtatttggataacctgcttgtgagatttttactcaaaaaagcattgactaatcaa
agaattgggcactttttcttttggcatttaaaatctgagatgcacaataaaactgttagt
cagaggtttggcctacttttggagtcctattgccgtgcatgtgggatgtatttgaagcac
ttgaataggcaagttgaggctatggaaaagctcattaacttaactgacattctcaaacaa
gagaagaaggatgaaacacaaaaggtacagatgaagtttttagttgaacaaatgaggcga
ccagatttcatggatgctctgcagggctttctatctcctctaaaccctgctcatcagctg
ggaaatctcaggcttgaagagtgtcgaattatgtcctctgcaaaaaggccactgtggttg
aattgggagaacccagacatcatgtcagaattactctttcaaaacaatgagatcatcttt
aaaaatggggatgatttacggcaagatatgctaacacttcagattattcgcattatggaa
aatatctggcaaaatcaaggtcttgatcttcgaatgttaccttatggttgtctgtcaatt
ggtgactgtgtgggacttattgaggtggtgagaaattctcacactattatgcaaattcag
tgcaaaggaggcctgaaaggtgcactgcagttcaacagccacacactacatcagtggctc
aaagacaagaacaagggcgaaatatatgatgcagccattgatctgtttacacgttcatgt
gctggatattgtgttgccaccttcattttgggaattggagatcgtcacaatagtaacatc
atggttaaagatgatggacaactgtttcatatagattttggacactttttggatcacaag
aagaaaaaatttggttataaacgagagcgtgtgccatttgttttgacacaagatttctta
atagtgattagtaaaggagcccaagaatgcacaaagacaagagaatttgagaggtttcag
gagatgtgttacaaggcttatttagctattcggcagcatgccaatctcttcataaatctt
ttctcaatgatgcttggctctggaatgccagaactacaatcttttgatgatattgcatac
attcgaaagaccctagctttagataaaactgagcaagaggctttggaatatttcatgaaa
caaatgaatgatgcacatcatggtggctggacaacaaaaatggattggatcttccacaca
attaagcagcatgctttgaactga

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