KEGG T01009: 100623006

Sus scrofa (pig): 100623006

Entry

100623006 CDS T01009

Gene name

MLL

Definition

myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)

Orthology

K09186

histone-lysine N-methyltransferase MLL1 [EC:2.1.1.43]

Organism

ssc Sus scrofa (pig)

Pathway

ssc00310	Lysine degradation
ssc05202	Transcriptional misregulation in cancer

Class

Metabolism; Amino acid metabolism; Lysine degradation [PATH:ssc00310]
Human Diseases; Cancers; Transcriptional misregulation in cancers [PATH:ssc05202]

SSDB

Motif

Pfam:

FYRC SET PHD FYRN zf-HC5HC2H zf-HC5HC2H_2 PHD_2 Bromodomain

Other DBs

NCBI-GI:

350588548

NCBI-GeneID:

100623006

Position

AA seq 2525 aa
MKFVYCQVCCEPFHKFCLEENERPLEDQLENWCCRRCKFCHVCGRQHQATKQLLECNKCR
NSYHPECLGPNYPTKPTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCAKL
FAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSDEMYEILSNLPESVAYTCV
NCTERHPAEWRLALEKELQISLKQVLTALLNSRTTSHLLRYRQAAKPPDLNPETEESIPS
RSSPEGPDPPVLTEVSKQEDQQPLDLEGVKRKMDQGNYTSVLEFSDDIVKIIQAAINSDG
GQPEIKKANSMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSSNSGMLPNAVLPPSLDHNY
AQWQEREENSHTEQPPLMKKIIPAPKPKGPGEPDSPTPLHPPTPPILSTDRSREDSPELN
PPPGIEDNRQCALCLTYGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLKNVH
MAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFLDDKKVYCQRHRDLIK
GEVVPENGFEVFRRVFVDFEGISLRRKFLNGLEPENIHMMIGSMTIDCLGILNDLSDCED
KLFPIGYQCSRVYWSTTDARKRCVYTCKIVECRPPVVEPDINSTVEHDENRTIAHSPSSF
AEISSKESQNTAEIVSPPSPDRPPHSQTSGSCFYHVISKVPRIRTPSYSPTQRSPGCRPL
PSAGSPTPTTHEIVTVGDPLLSSGLRSIGSRRHSTSSLSPQRSKLRIMSPMRTGGTYSRN
SVSSLSTIGTTTDLESSAKAADHVLGPLNSNTNLGQNTPTSSNLQRTVVTLGTKTSHLDG
PSSSEMKHSSASDSTSKSSSLKGEKTKMPSSKNSEGSAHNVAYPGIPKLAPQVHNTTSGE
LNVSKMGTFAELSSVPFSSKEALPFPPLHLRGQRNDRDQQPDSNQLANPPPDEDTEVKTL
KLSGVSSRASTISEHVGSSSRDRRQKGKKSGKDTFKEKHSSKSFLEPGQVTTGEEGNLKP
EFMDEVLTPEFMGQRPCNNVSSDKIGDKVHSIAGVPKAASMQVEGSAKELQTPRKRTVKV
TLTPLKMESESQSKNTLKESSPVSPLQIEPASPTEPVSASESPGDGPVAQPSPNNTSSQD
SQSNSYQNLPVQDRNLMLPDGPKPQEDGSFKRRYPRRSARARSNMFFGLTPLYGVRSYGE
EDIPFYSSSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVIASGGEERLASHNL
FREEEQCDLPKISQLDGVDDGTESDTSVTATTRKSSQIPKRNSKENGTENLKMDRPEDAG
EKEHVIKSSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQLSSLESGRRVHTSTPSDKNLLD
TYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPESSSSELLNLGEGLG
LDSNREKDMGLFEVFSQQLPTAEPVDSSVSSSISAEEQFELPLELPSDLSVLTTRSPTVP
SQNPSRLAVISDSGEKRVSITEKSVASSESDSALLSPGVDPTPEGHMTPDHFIQGHMDAD
HISSPPCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDSPGPSQISNA
AVQTTPPHLKPATEKLIVVNQNMQPLYVLQTLPNGVTQKIQLTSSVSSAPNVMETNTSVL
GPMGSGLTLTTGLNPSLPTSQSLFPPASKGLLPMPHHQHLHSFPAATQSSFPTNISSPPS
GLLIGVQPPPDPQLLVSEASQRTDLSTTVATPPSGLKKRPISRLQNRKNKKLAPSSTPSN
IAPSDVVSNMTLINFTPSQLPNHPNLLDLGSLNASSHRTVPNIIKRSKSSIMYFEQAPLL
PQSVGGSAAPAAGTSTISQDAGHLTSGPVSGLASGSSVLNVVSMQTTTAPTSSASVPGHV
ALTNPRLLGTPDIGSISNLLIKASQQSLGIQDQSVALPPSSGMFPQLGTSQTPSTAAMTA
ASSICVLPSTQTAGITAASPSGDTDEHYQLQHVNQLLASKTGILSSQRDLDSAPGTQGSN
FTQTVDAPNNMGLEQNKTLSSAMQASSTSPGGSPSSGQQSASPSVPAPTKPKPKSKRIQL
PLDKGSGKKHKVSHLRTSSEAHIPDQEASTTALTSVTGTPGAEAEQQETASVEQSSQKGC
GQPAGQVAVLPEIQTTQNPVNEQENSEPKTAEEEESNFSSPLMLWLQQEQKRKESIAEKK
PKKGLVFEISSDDGFQICAESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGLRMLGILH
DAVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVHLRQSAFDMFNFLASK
HRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLF
CKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARF
INHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKC
RKFLN

NT seq 7578 nt +upstreamnt +downstreamnt
atgaagtttgtgtattgccaagtctgttgtgaacccttccacaagttttgtttagaggag
aacgagcgccctctggaggaccagctggaaaattggtgttgtcgtcgctgcaagttctgt
catgtttgtggaaggcagcatcaggctacaaagcagctactggagtgtaataagtgccga
aacagctatcaccctgagtgcctgggaccaaactaccccaccaaacccacaaagaaaaag
aaagtttggatctgtaccaagtgtgttcgctgcaagagctgtggatccacaactccaggc
aaaggatgggatgcacagtggtctcatgatttttcactgtgccatgattgtgccaaactt
tttgctaaaggaaacttctgccctctctgtgataagtgttatgatgatgatgactatgag
agtaagatgatgcagtgtgggaaatgcgatcgctgggtccattccaaatgtgagaatctt
tcagatgaaatgtatgagattctatctaatctgccagaaagtgtggcctacacttgtgtg
aactgtactgagcggcaccctgcggagtggcgactcgcccttgaaaaagagctacagatc
tctctgaagcaagttctgacagccttgttgaactctcggaccaccagccacttgctgcgc
taccgacaggctgccaagcctccagacttaaatccggagacagaggagagtataccttcc
cgcagctctccagaaggacctgatccaccagtgcttactgaggtcagcaaacaggaagat
caacagcctttagatctggaaggagtgaagaggaaaatggaccaagggaactacacatct
gtgctggagttcagtgatgatatcgtgaagatcattcaagcagccatcaactcagatgga
gggcagccagagattaaaaaagccaacagcatggtcaagtccttctttattcggcaaatg
gaacgtgtttttccatggttcagtgtcaaaaagtccaggttttgggagccaaataaagta
tcaagcaacagtgggatgttaccaaacgcagtgcttccaccttcacttgaccataattat
gctcagtggcaggagcgagaggaaaacagccacactgagcagcctcctttaatgaagaaa
atcattccagctcccaaacctaaagggcctggagaaccagactcaccaactcctctgcat
cctcctacaccaccaattttgagtactgatagaagtcgagaagatagtccagaactgaac
ccaccaccaggcatagaagataatagacagtgtgcattgtgtttgacgtatggggacgac
agtgctaatgatgctggccgtttgctctacattggccaaaatgagtggacacatgtaaat
tgcgctttgtggtcagcagaagtgtttgaagatgatgatggatcactaaagaatgtgcat
atggctgtgatcaggggcaagcagctgagatgtgaattctgccaaaagccaggagccacc
gtgggttgctgcctcacatcctgcaccagcaactatcacttcatgtgttcccgggccaag
aactgtgtctttctggatgataaaaaagtatactgccagcggcatcgggatttgatcaaa
ggcgaggtggttcctgagaatggatttgaagtttttagaagagtgtttgtggactttgaa
ggaatcagcttgagaaggaagtttctcaatggcttagaaccagaaaatatccacatgatg
attggctccatgacaatcgactgcttagggatcctgaacgatctctctgactgtgaggat
aagctttttcctattggatatcagtgttcgagggtgtactggagcaccacagatgctcgc
aagcgctgtgtgtacacgtgcaagatagtcgaatgccgtcctccagttgtagagccagac
atcaacagcactgttgaacatgatgaaaatagaaccatcgctcacagtccatcatctttt
gcagaaatttcatctaaggagagtcaaaacacagctgaaattgtaagtcctccatcacca
gaccgacctcctcattcacagacctcgggttcctgtttttatcatgtcatctcaaaggtc
cctaggattcgaacacccagttactctccaacgcagagatcccctggctgtcggccactg
ccttctgcaggaagccctaccccaactacccatgaaatagtcacagtgggtgacccttta
ctctcctctggacttcgaagcattggctccaggcgtcacagtacctcttctttgtcaccc
cagaggtcgaagctccggataatgtctccaatgaggactgggggtacttactccaggaat
agcgtttcctcactctccaccatagggaccactaccgatcttgagtcaagtgccaaagca
gctgatcatgtcttagggccactgaattcaaatactaatttagggcaaaacactcccacc
tcttcaaatttgcaaaggacagtggttactctgggcactaaaaccagtcacttggacggc
ccttcgtcttcagagatgaagcactctagtgcctcagactcgacctccaagagctcctct
ttgaagggagaaaagaccaaaatgccgagttccaagaactcggaggggtctgcacataac
gtggcttaccctggcattccgaaactggccccacaggttcataatacaacatctggagaa
ttgaacgttagtaaaatgggcactttcgctgaactctcttcagtgccattttcttctaaa
gaggccctcccgttcccaccactccatttgagagggcaaaggaacgatcgagaccaacag
ccagattctaaccagttggcaaaccctcctcccgatgaagatactgaagtcaaaactttg
aagttgtctggagtgagcagcagagcgtccactatcagtgaacacgtgggatctagttcc
agagacaggagacagaaagggaaaaaatctggtaaagacactttcaaagaaaagcattcc
agtaaatcttttttggaacctggtcaggtgacaactggtgaggaaggaaacctaaagcca
gagttcatggatgaagttttgactcctgagttcatggggcaacgaccatgtaataatgtt
tcttctgataagattggggacaaagtccattctattgcaggagtccccaaagctgcatcc
atgcaagtagaagggtctgccaaggaattacagacaccccggaaacgcacagtcaaagta
acactgacacctctaaaaatggagagcgagagtcagtccaagaataccctgaaagaaagt
agtcctgtttcccctctgcagatagagccagcatctccgacagaaccagtctcagcctct
gaaagtccaggagatggtccagtagcccagccaagccccaataatacctcctcccaggat
tctcaaagtaacagctatcagaatcttccagtacaggacagaaacctaatgcttccagat
ggccccaaacctcaggaggatggctctttcaagaggaggtatcctcgtcgcagtgcccgg
gcgcgttctaacatgttctttgggctcaccccgctctatggagtacgatcctatggggaa
gaagacattccattttacagcagctcgactgggaagaagcgtggcaagaggtccgccgaa
ggccaggtggacggggctgatgacttgagcacgtcagatgaagacgatttatactattac
aatttcaccagaacagtgattgcctcagggggagaggaacggctggcatcccataattta
tttcgggaagaggaacagtgtgatcttccaaaaatctcacagctagatggcgtcgatgac
gggacagagagtgatactagcgtcacagccacaacaaggaaaagcagccagattccaaaa
agaaacagtaaagaaaacggaacggagaacttgaagatggatcggcccgaagatgctggt
gaaaaagaacatgtcattaaaagctctgttggccacaaaaatgagccaaagatggataac
tgccactctgtgagccgagtgaaaacacagggacaggattccttggaagctcagctcagc
tccttggagtcaggccgcagggtccacaccagcaccccctcagacaaaaacttactggac
acctataacactgagctcctgaaatcagattcagataataacaacagcgatgactgtggc
aacatcctgccctcagacattatggactttgtactaaagaatactccatccatgcaggct
ttgggtgagagcccagagtcctcgtcatcagaactcctgaatctcggtgaaggtttgggt
cttgacagtaatcgggaaaaagacatgggtctctttgaagtgttttctcagcagctgcca
acagcagaacctgtggacagtagtgtctcttcctccatctcggccgaggagcagtttgag
ttgccgctagagctgccatcggatctctctgtcctgaccacccgcagccccaccgtccct
agccagaaccccagtaggctagctgtcatctcagactcaggagagaagagagtaagcatc
acagaaaagtccgtggcatcctctgaaagtgactctgcactgctgagtccaggggtggat
ccaactcctgaaggccacatgactcctgaccactttatccaaggacacatggatgcagac
cacatctccagccctccttgtggttcagtggagcaaggtcatggcaacaatcaggattta
actagaaatagtagcacccctggccttcaggtacctgtttcccctactgttcccatccag
aaccagaaatacgtgcccaactccaccgatagtcctggcccatctcagatttctaacgcc
gctgtccagaccactccaccccacctgaaaccagccactgagaaactcattgttgttaac
cagaacatgcagccactctatgttctccagactcttccaaatggagtgacccaaaaaatc
cagttgacctcttctgttagttctgcacccaatgtgatggagacaaatacttcagtattg
gggcccatgggcagtggtctcaccctaaccacaggactaaatccaagcttgccaacttct
cagtctttgttccctcctgctagcaaaggactgctccccatgcctcatcaccagcactta
cattccttccctgcggctactcagagtagcttcccgactaacatcagcagccctccttca
ggcctacttatcggggtccagcctcctccagatccccagcttttggtttcagaagccagc
cagaggacagacctcagtaccacagtagccactccaccctctggactcaagaaaagaccc
atatctcgtctgcagaaccgaaagaataaaaaactcgccccctctagtaccccttccaac
attgccccttccgatgtggtttctaacatgaccttgattaacttcacaccctcccagctt
ccaaatcatcccaacctgttagatttggggtcacttaatgcttcatctcaccgaactgtc
cccaacatcataaaaaggtctaaatctagcatcatgtattttgaacaggcacccctgtta
ccacagagtgtgggaggaagtgctgccccggcggcgggcacatccaccataagccaggat
gctggccacctcacgtcagggcctgtttctggcttggcctctggttcctctgtcttgaac
gttgtatccatgcaaactacaaccgcccccacaagtagtgcatccgttccaggacatgtc
gctttaaccaacccaaggttgctcggtaccccagatattggctccataagcaatctttta
atcaaagccagccagcagagcctagggattcaggaccagtctgtggctttgcctccaagt
tctggaatgtttccgcaactggggacatcacagactccctctactgctgcgatgacagca
gcctctagcatctgtgtccttccctccactcagactgcgggcataacggcggcttcgcct
tctggggacacagatgagcactatcagcttcagcatgtgaaccagctcctcgccagcaaa
actgggattctctcttcccagcgggatcttgattctgctccagggacccagggatccaac
tttacccagacagtagatgctcccaataacatggggctagagcagaataagactttatcc
tcagctatgcaagccagctccacctctcctgggggctctccatcctctggacagcagtca
gcaagtccctcagtgccggctcccactaaacccaaaccaaaaagcaagcggattcagctg
cctttggacaaagggagtggcaagaagcacaaagtttcccacttgcggaccagttctgaa
gcacacattccagaccaagaagccagcacgacagccctgacctccgtcacagggactcca
ggagcagaggctgagcagcaagaaacagctagtgtggagcagtcatcacagaagggatgt
gggcagcctgcagggcaagtggctgttcttcctgagattcagacaacacagaatccagtg
aatgaacaggaaaattcagaacctaaaacagcagaagaagaagaaagtaatttcagctct
ccactgatgctttggctccagcaagaacagaagcggaaggaaagcattgctgagaaaaag
cccaagaaaggtcttgtttttgaaatttcaagtgatgatggctttcagatctgtgcggaa
agtattgaagatgcctggaaatcattgacagataaagtccaggaagctcggtcaaatgcc
cgcctaaagcagctttcatttgcaggtgtgaatggtttgaggatgctggggattctccat
gatgcggttgtgttcctgattgagcagctgtctggtgccaagcactgtaggaattacaaa
ttccgtttccacaagccagaggaggccaatgaaccccccctgaaccctcatggctcagcc
agggctgaggtccacctgaggcaatcagcatttgacatgtttaacttcctggcttctaaa
catcggcagcctcctgaatacaaccccaatgatgaggaggaggaagaggtacagctgaag
tcagctcggagggcaactagtatggatctgccaatgcccatgcgtttccggcacttaaaa
aagacttctaaggaggcagttggtgtctacaggtctcccatccacggccggggtcttttt
tgtaaaagaaacattgacgcgggtgagatggtgattgagtacgccggcaatgtcatccgt
tccatccaaaccgacaagcgagagaagtattatgacagcaagggcatcggttgctacatg
ttccgaatcgatgactctgaggtcgtggatgccaccatgcacggaaatgccgcccgcttc
atcaatcactcctgtgagcctaactgttactcccgagtcatcaatatcgacgggcagaag
cacattgtcatctttgccatgcgcaagatctaccgaggggaggaactcacttacgactat
aagttccccattgaggatgccagcaacaagttaccctgcaactgtggtgccaagaaatgc
cggaagttcctaaactaa

All links

Pathway (2)   
   KEGG PATHWAY (2)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (4)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (1)   
   OC (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (8)   
   Pfam (8)   
All databases (27)   

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