KEGG   Sus scrofa (pig): 396979Help
Entry
396979            CDS       T01009                                 

Gene name
PIK3CG, p120-PI3K
Definition
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma (EC:2.7.11.1 2.7.1.153)
Orthology
K00922  
phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
Organism
ssc  Sus scrofa (pig)
Pathway
Inositol phosphate metabolism
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
Chemokine signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Phosphatidylinositol signaling system
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Apoptosis
Adrenergic signaling in cardiomyocytes
VEGF signaling pathway
Osteoclast differentiation
Focal adhesion
Platelet activation
Toll-like receptor signaling pathway
Jak-STAT signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Cholinergic synapse
Inflammatory mediator regulation of TRP channels
Regulation of actin cytoskeleton
Insulin signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
Carbohydrate digestion and absorption
Bacterial invasion of epithelial cells
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Amoebiasis
Hepatitis C
Hepatitis B
Measles
Influenza A
HTLV-I infection
Epstein-Barr virus infection
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Melanoma
Chronic myeloid leukemia
Acute myeloid leukemia
Small cell lung cancer
Non-small cell lung cancer
Brite
KEGG Orthology (KO) [BR:ssc00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    396979 (PIK3CG)
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    396979 (PIK3CG)
   04015 Rap1 signaling pathway
    396979 (PIK3CG)
   04012 ErbB signaling pathway
    396979 (PIK3CG)
   04370 VEGF signaling pathway
    396979 (PIK3CG)
   04630 Jak-STAT signaling pathway
    396979 (PIK3CG)
   04668 TNF signaling pathway
    396979 (PIK3CG)
   04066 HIF-1 signaling pathway
    396979 (PIK3CG)
   04068 FoxO signaling pathway
    396979 (PIK3CG)
   04070 Phosphatidylinositol signaling system
    396979 (PIK3CG)
   04022 cGMP - PKG signaling pathway
    396979 (PIK3CG)
   04151 PI3K-Akt signaling pathway
    396979 (PIK3CG)
   04152 AMPK signaling pathway
    396979 (PIK3CG)
   04150 mTOR signaling pathway
    396979 (PIK3CG)
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    396979 (PIK3CG)
  Cell growth and death
   04210 Apoptosis
    396979 (PIK3CG)
  Cell communication
   04510 Focal adhesion
    396979 (PIK3CG)
 Organismal Systems
  Immune system
   04611 Platelet activation
    396979 (PIK3CG)
   04620 Toll-like receptor signaling pathway
    396979 (PIK3CG)
   04650 Natural killer cell mediated cytotoxicity
    396979 (PIK3CG)
   04660 T cell receptor signaling pathway
    396979 (PIK3CG)
   04662 B cell receptor signaling pathway
    396979 (PIK3CG)
   04664 Fc epsilon RI signaling pathway
    396979 (PIK3CG)
   04666 Fc gamma R-mediated phagocytosis
    396979 (PIK3CG)
   04670 Leukocyte transendothelial migration
    396979 (PIK3CG)
   04062 Chemokine signaling pathway
    396979 (PIK3CG)
  Endocrine system
   04910 Insulin signaling pathway
    396979 (PIK3CG)
   04915 Estrogen signaling pathway
    396979 (PIK3CG)
   04914 Progesterone-mediated oocyte maturation
    396979 (PIK3CG)
   04917 Prolactin signaling pathway
    396979 (PIK3CG)
   04921 Oxytocin signaling pathway
    396979 (PIK3CG)
   04919 Thyroid hormone signaling pathway
    396979 (PIK3CG)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    396979 (PIK3CG)
  Digestive system
   04973 Carbohydrate digestion and absorption
    396979 (PIK3CG)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    396979 (PIK3CG)
  Nervous system
   04725 Cholinergic synapse
    396979 (PIK3CG)
   04722 Neurotrophin signaling pathway
    396979 (PIK3CG)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    396979 (PIK3CG)
  Development
   04380 Osteoclast differentiation
    396979 (PIK3CG)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    396979 (PIK3CG)
   05205 Proteoglycans in cancer
    396979 (PIK3CG)
   05203 Viral carcinogenesis
    396979 (PIK3CG)
   05210 Colorectal cancer
    396979 (PIK3CG)
   05212 Pancreatic cancer
    396979 (PIK3CG)
   05214 Glioma
    396979 (PIK3CG)
   05221 Acute myeloid leukemia
    396979 (PIK3CG)
   05220 Chronic myeloid leukemia
    396979 (PIK3CG)
   05218 Melanoma
    396979 (PIK3CG)
   05211 Renal cell carcinoma
    396979 (PIK3CG)
   05215 Prostate cancer
    396979 (PIK3CG)
   05213 Endometrial cancer
    396979 (PIK3CG)
   05222 Small cell lung cancer
    396979 (PIK3CG)
   05223 Non-small cell lung cancer
    396979 (PIK3CG)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    396979 (PIK3CG)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    396979 (PIK3CG)
  Infectious diseases
   05100 Bacterial invasion of epithelial cells
    396979 (PIK3CG)
   05166 HTLV-I infection
    396979 (PIK3CG)
   05162 Measles
    396979 (PIK3CG)
   05164 Influenza A
    396979 (PIK3CG)
   05161 Hepatitis B
    396979 (PIK3CG)
   05160 Hepatitis C
    396979 (PIK3CG)
   05169 Epstein-Barr virus infection
    396979 (PIK3CG)
   05146 Amoebiasis
    396979 (PIK3CG)
   05145 Toxoplasmosis
    396979 (PIK3CG)
   05142 Chagas disease (American trypanosomiasis)
    396979 (PIK3CG)
Enzymes [BR:ssc01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     396979 (PIK3CG)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
UniProt: 
Structure
PDB: 

Jmol
Position
9
AA seq 1102 aa AA seqDB search
MELENYEQPVVLREDNRRRRRRMKPRSTAASLSSMELIPIEFVLPTSQRNTKTPETALLH
VAGHGNVEQMKAQVWLRALETSVSADFYHRLGPDHFLLLYQKKGQWYEIYDKYQVVQTLD
CLRYWKVLHRSPGQIHVVQRHAPSEETLAFQRQLNALIGYDVTDVSNVHDDELEFTRRRL
VTPRMAEVAGRDPKLYAMHPWVTSKPLPEYLLKKITNNCVFIVIHRSTTSQTIKVSADDT
PGTILQSFFTKMAKKKSLMDIPESQNERDFVLRVCGRDEYLVGETPIKNFQWVRQCLKNG
EEIHLVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRK
FRVKIRGIDIPVLPRTADLTVFVEANIQYGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKI
KDLPKGALLNLQIYCGKAPALSGKTSAEMPSPESKGKAQLLYYVNLLLIDHRFLLRHGEY
VLHMWQLSGKGEDQGSFNADKLTSRTNPDKENSMSISILLDNYCHPIALPKHRPTPDPEG
DRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKDPKAYPKLFSSVKWGQ
QEIVAKTYQLLAKREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYL
LQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAY
LRGCGTAMLHDFTQQVQVIDMLQKVTIDIKSLSAEKYDVSSQVISQLKQKLENLQNLNLP
QSFRVPYDPGLKAGALVIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQ
DMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTG
AFKDEVLSHWLKEKCPIEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMISETGNL
FHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSLHFQKFQDVCVKAYLAL
RHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKSEEDAKKYFLDQIEVCRDKGW
TVQFNWFLHLVLGIKQGEKHSA
NT seq 3309 nt NT seq  +upstreamnt  +downstreamnt
atggagctggagaactatgaacagcccgtggtgctgagagaggacaaccgccgcaggcgt
cggaggatgaagccgcgcagcacggcagccagcctgtcctccatggagctcatccccatc
gagtttgttttgcccaccagccagcgcaacaccaagacccccgaaacggcactgctgcac
gtggccggccacggcaatgtggagcagatgaaggcccaggtgtggctgcgcgcgctggag
acgagcgtgtctgcggacttctaccaccggctcggccccgaccacttcctcctgctctac
cagaagaaggggcagtggtacgagatctatgacaagtaccaggtggtgcagaccctggac
tgcctgcgctactggaaggtgttgcaccgcagccccgggcagatccacgtggtccagcgg
cacgcgccctcggaggagacattggccttccagcgccagctcaacgccctcatcggctac
gacgtcaccgacgtcagcaacgtgcatgacgatgagctggagttcacgcggcgccgcctg
gtcaccccgcgcatggccgaggtggccggccgcgaccccaagctttacgccatgcacccc
tgggtgacatccaagcccctccctgagtaccttctgaagaagatcactaacaactgcgtc
ttcatcgtcattcaccgcagcaccaccagccagaccatcaaggtctcggccgatgacacc
ccaggcaccatcctccagagcttctttaccaagatggccaagaagaaatctctgatggat
atccctgaaagccagaacgaacgggactttgtgctgcgcgtctgcggccgggatgagtac
ctggtgggtgagacgcccatcaaaaatttccagtgggtgaggcagtgcctcaagaatggg
gaggagattcaccttgtgctggacactcctccagacccagccctggacgaggtgaggaag
gaagagtggccgctggtggatgactgcacgggagtcactggctaccacgagcagctgacc
atccacggcaaggaccatgaaagtgtgttcaccgtgtccctgtgggactgtgaccgcaag
ttcagggtcaaaatcagaggcattgatatccctgtcctgccccggaccgctgacctcacg
gtgtttgtggaggcaaacatccagtatgggcagcaagtcctttgccaaaggagaaccagc
cccaaacccttcacggaggaggtgctctggaacgtgtggcttgagttcagtattaaaatc
aaagacttacccaaaggggctctgctgaacctccagatctactgcggcaaagctccagca
ctgtctggcaagacctctgcagagatgcccagtcccgagtccaaaggcaaagctcagctt
ctgtactatgtcaacctattgctgatagaccaccgcttcctcctgcgccatggcgagtat
gtgctccacatgtggcagttatccgggaagggggaagaccaagggagcttcaatgccgac
aagctcacgtcgcgaaccaacccggacaaggagaactcaatgtctatctccattcttctg
gacaattactgccaccccatagccttgcctaagcatcggcctacccctgacccagaaggg
gaccgggttcgggcagaaatgcccaatcagcttcggaagcaactggaggcaatcatagcc
acggatccgcttaacccactcacagctgaagacaaagaactgctctggcatttcagatat
gaaagcctgaaggatcccaaagcgtatcctaagctctttagctcggtgaaatggggacag
caagaaattgtggccaaaacataccaattattagccaaaagggaggtctgggatcagagt
gctttggatgtggggttaaccatgcagctcctggactgcaacttctcggatgaaaacgtg
agagccattgcagtccagaaactggagagcttggaggatgatgacgtgctccattacctg
ctccagctggtccaggctgtgaaatttgaaccataccatgacagtgccctagccagattt
ctgctgaagcgtggtttaagaaacaagagaattggtcacttcttgttttggttcttgaga
agtgagattgcccagtctaggcactatcagcagaggtttgcagtgatcctggaagcctac
ctgaggggctgtggcacagccatgctgcacgacttcacccagcaagtccaagtaattgac
atgttacaaaaagtcaccattgacattaaatcgctctctgctgaaaagtatgacgtcagt
tcccaagttatttcccaacttaagcaaaagcttgaaaacctacagaatttgaatctcccc
caaagctttagagttccctatgatcctggactgaaagccggggcactggtgatcgaaaaa
tgtaaagtgatggcctccaagaagaagcccctgtggcttgagtttaaatgtgccgatcct
acggctctatcaaatgaaacaattggaattatctttaaacacggtgacgatctgcgccaa
gacatgcttattttacagattctacgaatcatggagtccatttgggagaccgaatctttg
gatctgtgcctcctgccatatggctgcatttcaactggtgacaaaataggaatgatcgag
atcgtgaaggacgccacgacaatcgccaaaattcagcaaagcacagtgggcaacacgggt
gcctttaaagatgaagtcctgagtcactggctcaaagaaaaatgccctattgaagaaaag
tttcaggcagctgtggagagatttgtttattcctgtgccggctactgtgtggcaaccttt
gttctcggaataggcgacagacacaatgacaatattatgatctcagaaacaggaaatcta
tttcatattgatttcggacacattcttgggaattacaaaagtttcctgggcattaataaa
gagagggtgccatttgtgctaaccccagacttcctgtttgtgatggggacttctggaaag
aagacaagtctacacttccagaaatttcaggatgtctgcgtcaaggcttacctagccctt
cgtcatcacacaaacctactgatcatcctcttctccatgatgctgatgacaggaatgccc
cagttaaccagcaaagaagacattgaatacattcgggatgccctcacagtgggcaaaagt
gaggaggatgctaaaaagtattttctggatcagattgaagtttgcagagacaaaggatgg
accgtgcagtttaactggttcttacatcttgttcttggcatcaaacaaggggagaagcat
tccgcataa

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