KEGG   Trichechus manatus latirostris (Florida manatee): 101353421
Entry
101353421         CDS       T05135                                 
Name
(RefSeq) serine/threonine-protein kinase B-raf
  KO
K04365  B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
tmu  Trichechus manatus latirostris (Florida manatee)
Pathway
tmu01521  EGFR tyrosine kinase inhibitor resistance
tmu01522  Endocrine resistance
tmu04010  MAPK signaling pathway
tmu04012  ErbB signaling pathway
tmu04015  Rap1 signaling pathway
tmu04024  cAMP signaling pathway
tmu04062  Chemokine signaling pathway
tmu04068  FoxO signaling pathway
tmu04150  mTOR signaling pathway
tmu04270  Vascular smooth muscle contraction
tmu04510  Focal adhesion
tmu04650  Natural killer cell mediated cytotoxicity
tmu04720  Long-term potentiation
tmu04722  Neurotrophin signaling pathway
tmu04726  Serotonergic synapse
tmu04730  Long-term depression
tmu04810  Regulation of actin cytoskeleton
tmu04910  Insulin signaling pathway
tmu04914  Progesterone-mediated oocyte maturation
tmu04928  Parathyroid hormone synthesis, secretion and action
tmu04934  Cushing syndrome
tmu05010  Alzheimer disease
tmu05022  Pathways of neurodegeneration - multiple diseases
tmu05034  Alcoholism
tmu05160  Hepatitis C
tmu05161  Hepatitis B
tmu05200  Pathways in cancer
tmu05205  Proteoglycans in cancer
tmu05208  Chemical carcinogenesis - reactive oxygen species
tmu05210  Colorectal cancer
tmu05211  Renal cell carcinoma
tmu05212  Pancreatic cancer
tmu05213  Endometrial cancer
tmu05214  Glioma
tmu05215  Prostate cancer
tmu05216  Thyroid cancer
tmu05218  Melanoma
tmu05219  Bladder cancer
tmu05220  Chronic myeloid leukemia
tmu05221  Acute myeloid leukemia
tmu05223  Non-small cell lung cancer
tmu05224  Breast cancer
tmu05225  Hepatocellular carcinoma
tmu05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:tmu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    101353421
   04012 ErbB signaling pathway
    101353421
   04015 Rap1 signaling pathway
    101353421
   04068 FoxO signaling pathway
    101353421
   04024 cAMP signaling pathway
    101353421
   04150 mTOR signaling pathway
    101353421
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    101353421
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    101353421
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    101353421
   04062 Chemokine signaling pathway
    101353421
  09152 Endocrine system
   04910 Insulin signaling pathway
    101353421
   04914 Progesterone-mediated oocyte maturation
    101353421
   04928 Parathyroid hormone synthesis, secretion and action
    101353421
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    101353421
  09156 Nervous system
   04726 Serotonergic synapse
    101353421
   04720 Long-term potentiation
    101353421
   04730 Long-term depression
    101353421
   04722 Neurotrophin signaling pathway
    101353421
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101353421
   05205 Proteoglycans in cancer
    101353421
   05208 Chemical carcinogenesis - reactive oxygen species
    101353421
  09162 Cancer: specific types
   05210 Colorectal cancer
    101353421
   05212 Pancreatic cancer
    101353421
   05225 Hepatocellular carcinoma
    101353421
   05226 Gastric cancer
    101353421
   05214 Glioma
    101353421
   05216 Thyroid cancer
    101353421
   05221 Acute myeloid leukemia
    101353421
   05220 Chronic myeloid leukemia
    101353421
   05218 Melanoma
    101353421
   05211 Renal cell carcinoma
    101353421
   05219 Bladder cancer
    101353421
   05215 Prostate cancer
    101353421
   05213 Endometrial cancer
    101353421
   05224 Breast cancer
    101353421
   05223 Non-small cell lung cancer
    101353421
  09172 Infectious disease: viral
   05161 Hepatitis B
    101353421
   05160 Hepatitis C
    101353421
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    101353421
   05022 Pathways of neurodegeneration - multiple diseases
    101353421
  09165 Substance dependence
   05034 Alcoholism
    101353421
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    101353421
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    101353421
   01522 Endocrine resistance
    101353421
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:tmu01001]
    101353421
Enzymes [BR:tmu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     101353421
Protein kinases [BR:tmu01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   101353421
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase RBD C1_1 Kinase-like zf-RING-like ABC1 C1_2 Pkinase_fungal Kdo
Other DBs
NCBI-GeneID: 101353421
NCBI-ProteinID: XP_012412755
UniProt: A0A2Y9FYY4
Position
Unknown
AA seq 743 aa
MDPEAGPGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEE
YTSKLDSLQQREQQLLESLGDGAEFSVSSSASTDTVTSSSSSSLSVLPSSLSVFQNPTDV
SRTNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGE
KKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTC
GYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEETSFAETALAPGSSPPAPPSD
SPGPPILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIR
NQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRR
DSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGV
LRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGM
DYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEV
IRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSN
CPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFS
LYACASPKTPIQAGGYGEFAAFK
NT seq 2232 nt   +upstreamnt  +downstreamnt
atggatcccgaggccggccccggcgccgcggcctcgtcggccgcggaccctgctatcccc
gaggaggtgtggaatatcaaacagatgatcaagttgacacaggaacacatagaggcccta
ttggacaagtttggtggggagcacaatccaccgtcaatatacctggaggcctatgaagag
tacaccagcaagctggattccctccaacaaagagaacaacagttattggagtccctgggg
gatggagctgagttttctgtttctagctctgcatcaacggacaccgttacatcttcttcc
tcttctagcctttcagtgctgccttcatctctttcagtttttcaaaatcccacagatgtc
tcacggaccaaccccaagtcaccgcaaaaacctattgttagagtcttcctgcccaacaaa
cagagaacagtggtgcctgcaagatgtggtgtcaccgtccgggacagtctgaagaaagca
cttatgatgagaggtctgatcccagagtgctgtgctgtttacagaattcaggatggagag
aagaaaccaattggctgggacactgatatttcctggctcactggcgaggagttacatgta
gaagtgttggagaatgttccactcacaacacacaactttgtacggaaaacttttttcacc
ttggcattttgtgacttttgtcgaaagctccttttccaaggtttccgctgtcaaacatgt
ggttacaaatttcaccagcgctgtagtacagaggttccactgatgtgcgttaattatgac
caactggatttgctgtttgtctccaagttctttgaacaccacccaatcccgcaggaggag
acgtcctttgccgagactgcccttgctccgggatcgtcccctcccgcgcccccctcagac
tctcctgggcccccaattctcaccagtccgtctccttcaaaatccattccaattccacag
cccttccgaccagcagatgaagatcatcgaaatcaatttgggcagcgagaccggtcctca
tcagcccccaatgtgcatataaacacaatagagcctgtcaatattgatgacttgattaga
aaccaggggtttcgtggtgatggaggatcaaccacaggtttgtcggccacccctcccgca
tcgctccctggctccctcactaacgtgaaagccttacagaaatctcctggacctcagcgg
gaaaggaaatcctcgtcatcctcagaagacaggaatcgaatgaaaacacttggtcggcga
gattcaagtgacgactgggagattcccgatggacagatcacagttggacagagaatcgga
tccgggtcgtttggaaccgtctacaagggcaagtggcatggtgatgtggcagtgaaaatg
ttgaatgtgacagcacccacacctcagcagttacaggccttcaaaaatgaagtaggagta
ctcaggaaaacacgacacgtgaatatcctactctttatgggctattcaacaaagccacag
ctggctattgtcacccagtggtgtgagggctccagcttatatcaccatctccacatcatt
gagaccaaatttgagatgatcaaactcatagacattgcacggcagactgcacagggcatg
gattacttacacgccaagtccatcatccacagagacctcaagagtaataatatatttctt
catgaagacctcacagtaaaaataggtgattttggtctagcgacagtgaaatctcgatgg
agtgggtcccatcagtttgaacagttgtctggatccattttgtggatggcaccagaagta
atcagaatgcaagataaaaacccctatagctttcagtcagatgtgtatgcatttgggatt
gttctgtatgaattaatgactggacagttaccttattcaaacatcaacaacagagaccag
ataatttttatggtgggacgaggatacctgtctccagatctcagtaaggtacggagtaac
tgtccaaaagccatgaagagattaatggcagagtgcctgaagaagaaacgagacgagaga
ccactctttccccaaattctcgcctccattgagctgctggcccgctcattgccaaaaatt
caccgcagtgcatccgaaccctccttgaatcgggccggcttccagacagaggattttagt
ctgtatgcttgtgcttctccaaaaacgcccatccaggcagggggctatggagaatttgca
gccttcaagtag

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (44)   
   KEGG PATHWAY (44)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (15)   
   KEGG ORTHOLOGY (1)   
   RefGene (11)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
Protein sequence (2)   
   UniProt (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (10)   
   Pfam (10)   
All databases (77)   

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