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Database: UniProt/TrEMBL
Entry: A0A023NRX9_9GAMM
LinkDB: A0A023NRX9_9GAMM
Original site: A0A023NRX9_9GAMM 
ID   A0A023NRX9_9GAMM        Unreviewed;       328 AA.
AC   A0A023NRX9;
DT   09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT   09-JUL-2014, sequence version 1.
DT   07-JUN-2017, entry version 21.
DE   RecName: Full=Malate dehydrogenase {ECO:0000256|HAMAP-Rule:MF_01517, ECO:0000256|SAAS:SAAS00369716};
DE            EC=1.1.1.37 {ECO:0000256|HAMAP-Rule:MF_01517, ECO:0000256|SAAS:SAAS00369716};
GN   Name=mdh {ECO:0000256|HAMAP-Rule:MF_01517};
GN   ORFNames=CH75_12480 {ECO:0000313|EMBL:AHX13922.1};
OS   Dyella jiangningensis.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Xanthomonadales;
OC   Rhodanobacteraceae; Dyella.
OX   NCBI_TaxID=1379159 {ECO:0000313|EMBL:AHX13922.1, ECO:0000313|Proteomes:UP000024387};
RN   [1] {ECO:0000313|EMBL:AHX13922.1, ECO:0000313|Proteomes:UP000024387}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SBZ 3-12 {ECO:0000313|EMBL:AHX13922.1,
RC   ECO:0000313|Proteomes:UP000024387};
RA   Bao Y., Kwok A., Huang Z., Jiang J., He L., Xu Z., Sheng X., Leung F.;
RT   "Dyella jiangningensis sp. nov., a mineral-weathering bacterium
RT   isolated from the surface of potassium-bearing rock.";
RL   Submitted (FEB-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the reversible oxidation of malate to
CC       oxaloacetate. {ECO:0000256|HAMAP-Rule:MF_01517,
CC       ECO:0000256|SAAS:SAAS00755561}.
CC   -!- CATALYTIC ACTIVITY: (S)-malate + NAD(+) = oxaloacetate + NADH.
CC       {ECO:0000256|HAMAP-Rule:MF_01517, ECO:0000256|SAAS:SAAS00369698}.
CC   -!- SIMILARITY: Belongs to the LDH/MDH superfamily. MDH type 2 family.
CC       {ECO:0000256|HAMAP-Rule:MF_01517}.
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DR   EMBL; CP007444; AHX13922.1; -; Genomic_DNA.
DR   RefSeq; WP_038619602.1; NZ_CP007444.1.
DR   EnsemblBacteria; AHX13922; AHX13922; CH75_12480.
DR   KEGG; dji:CH75_12480; -.
DR   KO; K00024; -.
DR   Proteomes; UP000024387; Chromosome.
DR   GO; GO:0030060; F:L-malate dehydrogenase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   GO; GO:0006108; P:malate metabolic process; IEA:InterPro.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-HAMAP.
DR   HAMAP; MF_01517; Malate_dehydrog_2; 1.
DR   InterPro; IPR001557; L-lactate/malate_DH.
DR   InterPro; IPR022383; Lactate/malate_DH_C.
DR   InterPro; IPR001236; Lactate/malate_DH_N.
DR   InterPro; IPR015955; Lactate_DH/Glyco_Ohase_4_C.
DR   InterPro; IPR010945; Malate_DH_type2.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   PANTHER; PTHR23382; PTHR23382; 1.
DR   Pfam; PF02866; Ldh_1_C; 1.
DR   Pfam; PF00056; Ldh_1_N; 1.
DR   PIRSF; PIRSF000102; Lac_mal_DH; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF56327; SSF56327; 1.
DR   TIGRFAMs; TIGR01759; MalateDH-SF1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000024387};
KW   NAD {ECO:0000256|HAMAP-Rule:MF_01517};
KW   Oxidoreductase {ECO:0000256|HAMAP-Rule:MF_01517,
KW   ECO:0000256|RuleBase:RU003369, ECO:0000313|EMBL:AHX13922.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000024387};
KW   Tricarboxylic acid cycle {ECO:0000256|HAMAP-Rule:MF_01517}.
FT   DOMAIN        5    149       Ldh_1_N. {ECO:0000259|Pfam:PF00056}.
FT   DOMAIN      157    319       Ldh_1_C. {ECO:0000259|Pfam:PF02866}.
FT   NP_BIND      11     17       NAD. {ECO:0000256|HAMAP-Rule:MF_01517}.
FT   NP_BIND     129    131       NAD. {ECO:0000256|HAMAP-Rule:MF_01517}.
FT   ACT_SITE    187    187       Proton acceptor. {ECO:0000256|HAMAP-Rule:
FT                                MF_01517, ECO:0000256|PIRSR:PIRSR000102-
FT                                1}.
FT   BINDING      92     92       Substrate. {ECO:0000256|HAMAP-Rule:
FT                                MF_01517}.
FT   BINDING      98     98       Substrate. {ECO:0000256|HAMAP-Rule:
FT                                MF_01517}.
FT   BINDING     105    105       NAD. {ECO:0000256|HAMAP-Rule:MF_01517}.
FT   BINDING     112    112       NAD. {ECO:0000256|HAMAP-Rule:MF_01517}.
FT   BINDING     131    131       Substrate. {ECO:0000256|HAMAP-Rule:
FT                                MF_01517}.
FT   BINDING     162    162       Substrate. {ECO:0000256|HAMAP-Rule:
FT                                MF_01517}.
SQ   SEQUENCE   328 AA;  35026 MW;  54FC3DAFFC80EF30 CRC64;
     MKAPVRVAVT GAAGQIGYAL LFRIAAGDML GPDQPVILHL LEITPALPAL QGVVMELNDC
     AFPTLAGVVA TDDLNVAFKD VDYALLVGAR PRGPGMERKD LLEANGAIFG PQGKALNDHA
     KRDVRVLVVG NPANTNALIA QQNAPDLDPK CFTAMVRLDH NRALSQLAEK TGKHNTDIKK
     MTIWGNHSST QYPDLHHATV GGKPALSLVD QAWYESDFIP TVQQRGAAII KARGASSAAS
     AASAAVDHMR TWALGTAEGD WVSMGIPSDG SYGIAPGVIY GYPVTVKNGK YEIVQGLEVN
     DFSRARMDAT DKELREERAG VEHLFAKK
//
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