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Database: UniProt/TrEMBL
Entry: A0A023WRV6_PSEST
LinkDB: A0A023WRV6_PSEST
Original site: A0A023WRV6_PSEST 
ID   A0A023WRV6_PSEST        Unreviewed;       742 AA.
AC   A0A023WRV6;
DT   09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT   09-JUL-2014, sequence version 1.
DT   05-JUL-2017, entry version 15.
DE   SubName: Full=Isocitrate dehydrogenase {ECO:0000313|EMBL:AHY42868.1};
DE            EC=1.1.1.42 {ECO:0000313|EMBL:AHY42868.1};
GN   ORFNames=UIB01_10470 {ECO:0000313|EMBL:AHY42868.1};
OS   Pseudomonas stutzeri (Pseudomonas perfectomarina).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=316 {ECO:0000313|EMBL:AHY42868.1, ECO:0000313|Proteomes:UP000025238};
RN   [1] {ECO:0000313|EMBL:AHY42868.1, ECO:0000313|Proteomes:UP000025238}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=19SMN4 {ECO:0000313|EMBL:AHY42868.1,
RC   ECO:0000313|Proteomes:UP000025238};
RA   Brunet-Galmes I., Nogales B., Busquets A., Pena A., Gomila M.,
RA   Garcia-Valdes E., Lalucat J., Bennasar A., Bosch R.;
RT   "Complete genome sequence of Pseudomonas stutzeri 19SMN4.";
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit.
CC       {ECO:0000256|PIRSR:PIRSR009407-3};
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DR   EMBL; CP007509; AHY42868.1; -; Genomic_DNA.
DR   RefSeq; WP_038659747.1; NZ_CP007509.1.
DR   EnsemblBacteria; AHY42868; AHY42868; UIB01_10470.
DR   KEGG; pstu:UIB01_10470; -.
DR   PATRIC; fig|316.97.peg.2092; -.
DR   eggNOG; ENOG4105E9K; Bacteria.
DR   eggNOG; COG2838; LUCA.
DR   KO; K00031; -.
DR   Proteomes; UP000025238; Chromosome.
DR   GO; GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   InterPro; IPR004436; Isocitrate_DH_NADP_mono.
DR   Pfam; PF03971; IDH; 1.
DR   PIRSF; PIRSF009407; IDH_monmr; 1.
DR   TIGRFAMs; TIGR00178; monomer_idh; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000025238};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Oxidoreductase {ECO:0000313|EMBL:AHY42868.1}.
FT   REGION      133    140       Substrate binding. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   METAL       350    350       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       548    548       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       552    552       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   BINDING     146    146       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   BINDING     547    547       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   SITE        255    255       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
FT   SITE        420    420       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
SQ   SEQUENCE   742 AA;  81746 MW;  0BF84BCBC6D27CC8 CRC64;
     MSTPSKIIYT FTDEAPALAT YSLLPIVEAF AASADIAVET RDISLAGRIL ASFADQLDAD
     KKVDDDLAKL AELTNQPDAN IIKLPNISAS VPQLKAAIAE LQALGYNIPN FPEDPQTDAE
     KDVRARYSKV LGSAVNPVLR EGNSDRRAPA AVKAYARKHP HSMGKWSKAS QSHADYMRGG
     DFFSSEQSIT MDKAGDVRIE FVGKDGKVEV KKQLALLEGE VLDGMFMSCN KLRAFFEETL
     QDCKETGVMW SLHVKATMMK ISHPIVFGHA VSVYYKDVFD KYGELFKELG VNPNNGISSV
     YDKIKSLPAS QQEEILHDIH EVYAHRPEMA MVDSVKGITN LHIPSDVIVD ASMPAMIRNS
     GQMWGKDGKQ KDTKAVMPES TYARIYQEMI NFCKTNGAFD PVTMGSVPNV GLMAQKAEEY
     GSHDKTFEMQ ADGTMRVVLA DGTVLMQHEV EKGDIWRACQ TKDAPIRDWV KLAVTRARQS
     NTPAVFWLDP ERAHDMQLQK KVETYLQEHD LSGLDIRIMG YNEAIRLSME RMIRGKDTIS
     VTGNVLRDYL TDLFPIMELG TSAKMLSIVP LMAGGGMYET GAGGSAPKHV QQLVEENYLR
     WDSLGEFLAL AVSLEETGIK TGNTKAKILG KTLDQATGKL LDNNKSPARK VGQIDNRGSH
     FYLALYWSQA LAAQDDDAEL KAHFTPLAKQ LSEQEAAIVA ELAAVQGKPV DIGGYYRSNP
     ELTSKVMRPS TTFNSALAAL NA
//
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