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Database: UniProt/TrEMBL
Entry: A0A075K385_9GAMM
LinkDB: A0A075K385_9GAMM
Original site: A0A075K385_9GAMM 
ID   A0A075K385_9GAMM        Unreviewed;       328 AA.
AC   A0A075K385;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   07-JUN-2017, entry version 21.
DE   RecName: Full=Malate dehydrogenase {ECO:0000256|HAMAP-Rule:MF_01517, ECO:0000256|SAAS:SAAS00369716};
DE            EC=1.1.1.37 {ECO:0000256|HAMAP-Rule:MF_01517, ECO:0000256|SAAS:SAAS00369716};
GN   Name=mdh {ECO:0000256|HAMAP-Rule:MF_01517};
GN   ORFNames=HY57_16170 {ECO:0000313|EMBL:AIF48664.1};
OS   Dyella japonica A8.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Xanthomonadales;
OC   Rhodanobacteraceae; Dyella.
OX   NCBI_TaxID=1217721 {ECO:0000313|EMBL:AIF48664.1, ECO:0000313|Proteomes:UP000027987};
RN   [1] {ECO:0000313|EMBL:AIF48664.1, ECO:0000313|Proteomes:UP000027987}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=A8 {ECO:0000313|EMBL:AIF48664.1,
RC   ECO:0000313|Proteomes:UP000027987};
RA   Hui R.K.H., Chen J.-W., Chan K.-G., Leung F.C.C.;
RT   "Complete Genome Sequence of Dyella japonica Strain A8 Isolated from
RT   Malaysian Tropical Soil.";
RL   Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the reversible oxidation of malate to
CC       oxaloacetate. {ECO:0000256|HAMAP-Rule:MF_01517,
CC       ECO:0000256|SAAS:SAAS00755561}.
CC   -!- CATALYTIC ACTIVITY: (S)-malate + NAD(+) = oxaloacetate + NADH.
CC       {ECO:0000256|HAMAP-Rule:MF_01517, ECO:0000256|SAAS:SAAS00369698}.
CC   -!- SIMILARITY: Belongs to the LDH/MDH superfamily. MDH type 2 family.
CC       {ECO:0000256|HAMAP-Rule:MF_01517}.
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DR   EMBL; CP008884; AIF48664.1; -; Genomic_DNA.
DR   RefSeq; WP_019464103.1; NZ_CP008884.1.
DR   EnsemblBacteria; AIF48664; AIF48664; HY57_16170.
DR   KEGG; dja:HY57_16170; -.
DR   PATRIC; fig|1217721.7.peg.3317; -.
DR   KO; K00024; -.
DR   Proteomes; UP000027987; Chromosome.
DR   GO; GO:0030060; F:L-malate dehydrogenase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   GO; GO:0006108; P:malate metabolic process; IEA:InterPro.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-HAMAP.
DR   HAMAP; MF_01517; Malate_dehydrog_2; 1.
DR   InterPro; IPR001557; L-lactate/malate_DH.
DR   InterPro; IPR022383; Lactate/malate_DH_C.
DR   InterPro; IPR001236; Lactate/malate_DH_N.
DR   InterPro; IPR015955; Lactate_DH/Glyco_Ohase_4_C.
DR   InterPro; IPR010945; Malate_DH_type2.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   PANTHER; PTHR23382; PTHR23382; 1.
DR   Pfam; PF02866; Ldh_1_C; 1.
DR   Pfam; PF00056; Ldh_1_N; 1.
DR   PIRSF; PIRSF000102; Lac_mal_DH; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF56327; SSF56327; 1.
DR   TIGRFAMs; TIGR01759; MalateDH-SF1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000027987};
KW   NAD {ECO:0000256|HAMAP-Rule:MF_01517};
KW   Oxidoreductase {ECO:0000256|HAMAP-Rule:MF_01517,
KW   ECO:0000256|RuleBase:RU003369, ECO:0000313|EMBL:AIF48664.1};
KW   Tricarboxylic acid cycle {ECO:0000256|HAMAP-Rule:MF_01517}.
FT   DOMAIN        5    149       Ldh_1_N. {ECO:0000259|Pfam:PF00056}.
FT   DOMAIN      157    319       Ldh_1_C. {ECO:0000259|Pfam:PF02866}.
FT   NP_BIND      11     17       NAD. {ECO:0000256|HAMAP-Rule:MF_01517}.
FT   NP_BIND     129    131       NAD. {ECO:0000256|HAMAP-Rule:MF_01517}.
FT   ACT_SITE    187    187       Proton acceptor. {ECO:0000256|HAMAP-Rule:
FT                                MF_01517, ECO:0000256|PIRSR:PIRSR000102-
FT                                1}.
FT   BINDING      92     92       Substrate. {ECO:0000256|HAMAP-Rule:
FT                                MF_01517}.
FT   BINDING      98     98       Substrate. {ECO:0000256|HAMAP-Rule:
FT                                MF_01517}.
FT   BINDING     105    105       NAD. {ECO:0000256|HAMAP-Rule:MF_01517}.
FT   BINDING     112    112       NAD. {ECO:0000256|HAMAP-Rule:MF_01517}.
FT   BINDING     131    131       Substrate. {ECO:0000256|HAMAP-Rule:
FT                                MF_01517}.
FT   BINDING     162    162       Substrate. {ECO:0000256|HAMAP-Rule:
FT                                MF_01517}.
SQ   SEQUENCE   328 AA;  35070 MW;  B36DFDBBED5A98F6 CRC64;
     MKAPVRVAVT GAAGQIGYAL LFRIAAGDML GPDQPVILHL LEITPALPAL QGVVMELNDC
     AFPTLAGVVA TDDLNVAFKD VDYALLVGAR PRGPGMERKD LLEANGAIFG PQGKALNDHA
     KRDVRVLVVG NPANTNALIA QQNAPDLDPK CFTAMVRLDH NRALSQLAEK TGKHSTDIKK
     MTIWGNHSST QYPDLYHATV DGKPALSLVD QAWYESDFIP TVQQRGAAII KARGASSAAS
     AASAAVDHMR TWAQGTAEGD WASMGIPSDG SYGIEPGVIY GYPVTVKDGK YAIVQGLDIN
     DFSRARMDAT NKELREERAG VEHLFAKK
//
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