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Database: UniProt/TrEMBL
Entry: A0A076FB58_9PROT
LinkDB: A0A076FB58_9PROT
Original site: A0A076FB58_9PROT 
ID   A0A076FB58_9PROT        Unreviewed;       344 AA.
AC   A0A076FB58;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2016, sequence version 2.
DT   07-JUN-2017, entry version 20.
DE   RecName: Full=D-alanine--D-alanine ligase {ECO:0000256|SAAS:SAAS00754435};
DE            EC=6.3.2.4 {ECO:0000256|SAAS:SAAS00754435};
GN   Name=ddlA {ECO:0000313|EMBL:AII14903.2};
GN   ORFNames=CIG1485E_1067 {ECO:0000313|EMBL:AII14903.2};
OS   Campylobacter iguaniorum.
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Campylobacteraceae; Campylobacter.
OX   NCBI_TaxID=1244531 {ECO:0000313|EMBL:AII14903.2, ECO:0000313|Proteomes:UP000028486};
RN   [1] {ECO:0000313|Proteomes:UP000028486}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=25146144;
RA   Gilbert M.J., Miller W.G., Yee E., Kik M., Wagenaar J.A., Duim B.;
RT   "Complete Genome Sequence of Campylobacter iguaniorum Strain 1485ET,
RT   Isolated from a Bearded Dragon (Pogona vitticeps).";
RL   Genome Announc. 2:0-0(2014).
CC   -!- FUNCTION: Cell wall formation. {ECO:0000256|SAAS:SAAS00754456}.
CC   -!- CATALYTIC ACTIVITY: ATP + 2 D-alanine = ADP + phosphate + D-
CC       alanyl-D-alanine. {ECO:0000256|SAAS:SAAS00754451}.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|SAAS:SAAS00754472};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|SAAS:SAAS00754454};
CC   -!- PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis.
CC       {ECO:0000256|SAAS:SAAS00754475}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|SAAS:SAAS00644680}.
CC   -!- SIMILARITY: Belongs to the D-alanine--D-alanine ligase family.
CC       {ECO:0000256|SAAS:SAAS00644812}.
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DR   EMBL; CP009043; AII14903.2; -; Genomic_DNA.
DR   RefSeq; WP_038454488.1; NZ_CP009043.1.
DR   EnsemblBacteria; AII14903; AII14903; CIG1485E_1067.
DR   KEGG; caj:CIG1485E_1067; -.
DR   KO; K01921; -.
DR   UniPathway; UPA00219; -.
DR   Proteomes; UP000028486; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0008716; F:D-alanine-D-alanine ligase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR   GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.1490.20; -; 1.
DR   InterPro; IPR011761; ATP-grasp.
DR   InterPro; IPR013815; ATP_grasp_subdomain_1.
DR   InterPro; IPR000291; D-Ala_lig_Van_CS.
DR   InterPro; IPR005905; D_ala_D_ala.
DR   InterPro; IPR011095; Dala_Dala_lig_C.
DR   InterPro; IPR011127; Dala_Dala_lig_N.
DR   InterPro; IPR016185; PreATP-grasp_dom.
DR   Pfam; PF07478; Dala_Dala_lig_C; 1.
DR   Pfam; PF01820; Dala_Dala_lig_N; 1.
DR   SUPFAM; SSF52440; SSF52440; 1.
DR   TIGRFAMs; TIGR01205; D_ala_D_alaTIGR; 1.
DR   PROSITE; PS50975; ATP_GRASP; 1.
DR   PROSITE; PS00843; DALA_DALA_LIGASE_1; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00409,
KW   ECO:0000256|SAAS:SAAS00644673};
KW   Cell shape {ECO:0000256|SAAS:SAAS00644718};
KW   Cell wall biogenesis/degradation {ECO:0000256|SAAS:SAAS00644792};
KW   Complete proteome {ECO:0000313|Proteomes:UP000028486};
KW   Cytoplasm {ECO:0000256|SAAS:SAAS00754427};
KW   Ligase {ECO:0000256|SAAS:SAAS00644741, ECO:0000313|EMBL:AII14903.2};
KW   Magnesium {ECO:0000256|SAAS:SAAS00754439};
KW   Manganese {ECO:0000256|SAAS:SAAS00754447};
KW   Metal-binding {ECO:0000256|SAAS:SAAS00754442};
KW   Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00409,
KW   ECO:0000256|SAAS:SAAS00644705};
KW   Peptidoglycan synthesis {ECO:0000256|SAAS:SAAS00644714}.
FT   DOMAIN      133    325       ATP-grasp. {ECO:0000259|PROSITE:PS50975}.
SQ   SEQUENCE   344 AA;  38785 MW;  65C724A8B98A49F4 CRC64;
     MKFGIVFGGN SFEHEISIVS AIAVKKVLKA DLSFIFVDAF RDFYLIDPSD MRANFFSSGK
     YKNSKKLHLK KGGFATHGLF GTTLLDVECY INLIHGSDGE DGKIAGMFEF FGLNFIGPRL
     ESSVMSFNKE LTKLLAVKCD VQMLPYETIK RGEKPQTNLP FILKPARLGS SIGVSVVREE
     KELDYALDVA FEFDSDVLVE PFMEGIREFN LAGFKAGDEF EFSIIEEPQK KDFLDFEQKY
     MSFSARSSEE AKIDESIKTE LKNAFMAIYN GGAFDGALIR CDFFVLDNKV YLNEINPNPG
     SMANYLFKDF TSSITRLANS LKMPRNIKID YKFINSITSN KGKI
//
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