GenomeNet

Database: UniProt/TrEMBL
Entry: A0A076GSP8_ENTFC
LinkDB: A0A076GSP8_ENTFC
Original site: A0A076GSP8_ENTFC 
ID   A0A076GSP8_ENTFC        Unreviewed;       212 AA.
AC   A0A076GSP8;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   27-SEP-2017, entry version 12.
DE   RecName: Full=Thymidine kinase {ECO:0000256|HAMAP-Rule:MF_00124, ECO:0000256|RuleBase:RU000544};
DE            EC=2.7.1.21 {ECO:0000256|HAMAP-Rule:MF_00124, ECO:0000256|RuleBase:RU000544};
GN   Name=tdk {ECO:0000256|HAMAP-Rule:MF_00124};
GN   ORFNames=M395_10785 {ECO:0000313|EMBL:AII39779.1};
OS   Enterococcus faecium T110.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Enterococcaceae;
OC   Enterococcus.
OX   NCBI_TaxID=1344042 {ECO:0000313|EMBL:AII39779.1, ECO:0000313|Proteomes:UP000028585};
RN   [1] {ECO:0000313|EMBL:AII39779.1, ECO:0000313|Proteomes:UP000028585}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=T110 {ECO:0000313|EMBL:AII39779.1,
RC   ECO:0000313|Proteomes:UP000028585};
RA   Natarajan P., Madasamy P.;
RT   "Complete genome sequencing of Enterococcus faecium T110.";
RL   Submitted (JUN-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: ATP + thymidine = ADP + thymidine 5'-
CC       phosphate. {ECO:0000256|HAMAP-Rule:MF_00124,
CC       ECO:0000256|RuleBase:RU000544}.
CC   -!- SUBUNIT: Homotetramer. {ECO:0000256|HAMAP-Rule:MF_00124}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00124}.
CC   -!- SIMILARITY: Belongs to the thymidine kinase family.
CC       {ECO:0000256|HAMAP-Rule:MF_00124, ECO:0000256|RuleBase:RU004165}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; CP006030; AII39779.1; -; Genomic_DNA.
DR   ProteinModelPortal; A0A076GSP8; -.
DR   EnsemblBacteria; AII39779; AII39779; M395_10785.
DR   KEGG; eft:M395_10785; -.
DR   KO; K00857; -.
DR   Proteomes; UP000028585; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004797; F:thymidine kinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:UniProtKB-KW.
DR   HAMAP; MF_00124; Thymidine_kinase; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001267; Thymidine_kinase.
DR   InterPro; IPR020633; Thymidine_kinase_CS.
DR   PANTHER; PTHR11441; PTHR11441; 1.
DR   Pfam; PF00265; TK; 1.
DR   PIRSF; PIRSF035805; TK_cell; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00603; TK_CELLULAR_TYPE; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00124,
KW   ECO:0000256|RuleBase:RU000544};
KW   Complete proteome {ECO:0000313|Proteomes:UP000028585};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00124};
KW   DNA synthesis {ECO:0000256|HAMAP-Rule:MF_00124,
KW   ECO:0000256|RuleBase:RU000544};
KW   Kinase {ECO:0000256|HAMAP-Rule:MF_00124,
KW   ECO:0000256|RuleBase:RU000544, ECO:0000313|EMBL:AII39779.1};
KW   Metal-binding {ECO:0000256|HAMAP-Rule:MF_00124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00124,
KW   ECO:0000256|RuleBase:RU000544};
KW   Transferase {ECO:0000256|HAMAP-Rule:MF_00124,
KW   ECO:0000256|RuleBase:RU000544};
KW   Zinc {ECO:0000256|HAMAP-Rule:MF_00124}.
FT   NP_BIND      27     34       ATP. {ECO:0000256|HAMAP-Rule:MF_00124}.
FT   NP_BIND     103    106       ATP. {ECO:0000256|HAMAP-Rule:MF_00124}.
FT   ACT_SITE    104    104       Proton acceptor. {ECO:0000256|HAMAP-Rule:
FT                                MF_00124, ECO:0000256|PIRSR:PIRSR035805-
FT                                1}.
FT   METAL       161    161       Zinc. {ECO:0000256|HAMAP-Rule:MF_00124}.
FT   METAL       164    164       Zinc. {ECO:0000256|HAMAP-Rule:MF_00124}.
FT   METAL       198    198       Zinc. {ECO:0000256|HAMAP-Rule:MF_00124}.
FT   METAL       201    201       Zinc. {ECO:0000256|HAMAP-Rule:MF_00124}.
SQ   SEQUENCE   212 AA;  24497 MW;  C772ABAB74568850 CRC64;
     MLKIKYNTIG TNWKVKKSMA QLFFKYGAMN SGKTIEILKV AHNYEEQNKP VVLMTSGIDT
     RDGLGVVSSR IGLKREAMPI FEETDVFDVI QNMESKPYCV LIDEAQFLKK KHVIAFTRIV
     DELDIPVMAF GLKNDFRNEL FEGSKYLLLY ADKIEEMKTI CWFCHKKAIM NLHYIDGKPV
     YEGDQVQIGG NEAYYPVCRK HYFHPSMITE GE
//
DBGET integrated database retrieval system