ID   A0A088EVT8_9SPHI        Unreviewed;       912 AA.
AC   A0A088EVT8;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   RecName: Full=oxoglutarate dehydrogenase (succinyl-transferring) {ECO:0000256|ARBA:ARBA00012280};
DE            EC=1.2.4.2 {ECO:0000256|ARBA:ARBA00012280};
GN   ORFNames=KO02_05935 {ECO:0000313|EMBL:AIM36288.1};
OS   Sphingobacterium sp. ML3W.
OC   Bacteria; Bacteroidota; Sphingobacteriia; Sphingobacteriales;
OC   Sphingobacteriaceae; Sphingobacterium.
OX   NCBI_TaxID=1538644 {ECO:0000313|EMBL:AIM36288.1, ECO:0000313|Proteomes:UP000028992};
RN   [1] {ECO:0000313|EMBL:AIM36288.1, ECO:0000313|Proteomes:UP000028992}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ML3W {ECO:0000313|EMBL:AIM36288.1};
RX   PubMed=25614576;
RA   Smith S.A., Krasucki S.P., McDowell J.V., Balke V.L.;
RT   "Complete Genome Sequence of Sphingobacterium sp. Strain ML3W, Isolated
RT   from Wings of Myotis lucifugus Infected with White Nose Syndrome.";
RL   Genome Announc. 3:0-0(2015).
CC   -!- COFACTOR:
CC       Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC         Evidence={ECO:0000256|ARBA:ARBA00001964};
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DR   EMBL; CP009278; AIM36288.1; -; Genomic_DNA.
DR   RefSeq; WP_038696619.1; NZ_CP009278.1.
DR   AlphaFoldDB; A0A088EVT8; -.
DR   STRING; 1538644.KO02_05935; -.
DR   KEGG; sht:KO02_05935; -.
DR   eggNOG; COG0567; Bacteria.
DR   HOGENOM; CLU_004709_1_0_10; -.
DR   OrthoDB; 9759785at2; -.
DR   Proteomes; UP000028992; Chromosome.
DR   GO; GO:0004591; F:oxoglutarate dehydrogenase (succinyl-transferring) activity; IEA:UniProtKB-EC.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   CDD; cd02016; TPP_E1_OGDC_like; 1.
DR   Gene3D; 3.40.50.12470; -; 1.
DR   Gene3D; 3.40.50.970; -; 1.
DR   Gene3D; 3.40.50.11610; Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain; 1.
DR   Gene3D; 1.10.287.1150; TPP helical domain; 1.
DR   InterPro; IPR032106; 2-oxogl_dehyd_N.
DR   InterPro; IPR011603; 2oxoglutarate_DH_E1.
DR   InterPro; IPR001017; DH_E1.
DR   InterPro; IPR031717; KGD_C.
DR   InterPro; IPR042179; KGD_C_sf.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR   NCBIfam; TIGR00239; 2oxo_dh_E1; 1.
DR   PANTHER; PTHR23152:SF4; 2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1; 1.
DR   PANTHER; PTHR23152; 2-OXOGLUTARATE DEHYDROGENASE; 1.
DR   Pfam; PF16078; 2-oxogl_dehyd_N; 1.
DR   Pfam; PF00676; E1_dh; 1.
DR   Pfam; PF16870; OxoGdeHyase_C; 1.
DR   Pfam; PF02779; Transket_pyr; 1.
DR   PIRSF; PIRSF000157; Oxoglu_dh_E1; 1.
DR   SMART; SM00861; Transket_pyr; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028992};
KW   Thiamine pyrophosphate {ECO:0000256|ARBA:ARBA00023052}.
FT   DOMAIN          576..768
FT                   /note="Transketolase-like pyrimidine-binding"
FT                   /evidence="ECO:0000259|SMART:SM00861"
SQ   SEQUENCE   912 AA;  103389 MW;  CE242006755E2D06 CRC64;
     MDKLTYLSNA DSSYIDGLYQ AYTQDPESVD FGWQKFFEGF DFGQNAGESV GATADATPDH
     VLKEINVLNM INGYRDRGHL FTQTNPVRER RKYYPGKELE TFGLSEADMN TIFNAGVEVG
     LGPAKLKDIR QLIEDTYCRS IGAEFKYIRN PEKIKWLQDR MEADRNKPTY SLDIKKRILD
     KLNHAVAFES FLGTKFLGQK RFSLEGAESL IPALDAVIEK GSELGIQEFV IGMAHRGRLN
     VLTNIMGKPY KTVFSEFEGK TYAEDPEVNF GGDVKYHLGY STDVKTDDGK TIHLSLAPNP
     SHLETVDPIV EGLVRSKIDM KYEGDSSKIA PIAIHGDAAI AGQGVVYEVT QMSKLDGYKT
     GGTIHIVINN QIGFTTNYKD ARSGTYCTDV AKITSSPVFH VNGDDAEALV YAIKLAVEYR
     QKYKTDVFID LLCYRRFGHN EADEPKFTQP LLYKLIEKHP NPKEVYAKKL IEEGSIDESY
     AKKIEKDFKA ILQEKLEESK EVVNLTEETP MFSGAWKGLR PAKKGESFET VKTNVSDKTF
     VQLAKEITTL PTNKSFFRKI SRLFEDRAKM IEKDSYDWAM GELMAYATLL NEGSRVRISG
     QDVQRGTFSH RHAVLTLENS EETYTPLANI NGGDKFSIYN SLLSEYAVLG FEYGYASANP
     HALTIWEAQF GDFYNGAQII VDQYLSSAET KWKRSNGLVM LLPHGMEGQG PEHSSGRIER
     FLELCADENL ILANCTTPAN YFHLLRRQQV REFRKPLVVF TPKSLLRHPK VVSPLKDFTS
     NTFQEVIDDV NVTAKDVKRV LFCSGKIYYD LLEKQEVDKR KDVAIVRLEQ LFPIPEEQLK
     AIRKKYNKAS EFVWVQEENE NMGAWSYYCR KLMNTEIAFT GFVARKESGS TATGYMKQHI
     AQQAKILNKS FE
//