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Database: UniProt/TrEMBL
Entry: A0A089S0U6_MYCTU L7N699_MYCTU
LinkDB: A0A089S0U6_MYCTU L7N699_MYCTU
Original site: A0A089S0U6_MYCTU L7N699_MYCTU 
ID   A0A089S0U6_MYCTU        Unreviewed;       562 AA.
AC   A0A089S0U6;
DT   10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2017, sequence version 1.
DT   28-MAR-2018, entry version 4.
DE   SubName: Full=Fatty acyl-AMP ligase {ECO:0000313|EMBL:AIR12754.1};
GN   ORFNames=LH57_00210 {ECO:0000313|EMBL:AIR12754.1};
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332 {ECO:0000313|EMBL:AIR12754.1, ECO:0000313|Proteomes:UP000031768};
RN   [1] {ECO:0000213|PubMed:21969609}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21969609; DOI=10.1074/mcp.M111.011445;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B.,
RA   Yadav A.K., Shrivastava P., Marimuthu A., Anand S., Sundaram H.,
RA   Kingsbury R., Harsha H.C., Nair B., Prasad T.S., Chauhan D.S.,
RA   Katoch K., Katoch V.M., Kumar P., Chaerkady R., Ramachandran S.,
RA   Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high
RT   resolution mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
RN   [2] {ECO:0000313|EMBL:AIR12754.1, ECO:0000313|Proteomes:UP000031768}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27294 / TMC 102 / H37Rv
RC   {ECO:0000313|Proteomes:UP000031768};
RA   Hazbon M.H., Riojas M.A., Damon A.M., Alalade R.O., Cantwell B.J.,
RA   Monaco A., King S., Sohrabi A.;
RT   "Phylogenetic analysis of Mycobacterial species using whole genome
RT   sequences.";
RL   Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CP009480; AIR12754.1; -; Genomic_DNA.
DR   RefSeq; WP_003400425.1; NZ_KK339370.1.
DR   RefSeq; YP_177686.1; NC_000962.3.
DR   SMR; A0A089S0U6; -.
DR   GeneID; 887048; -.
DR   KEGG; mtu:Rv0035; -.
DR   KEGG; mtv:RVBD_0035; -.
DR   eggNOG; COG0318; LUCA.
DR   OMA; NGAVYIT; -.
DR   Proteomes; UP000031768; Chromosome.
DR   GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008152; P:metabolic process; IEA:InterPro.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig.
DR   Pfam; PF00501; AMP-binding; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000031768};
KW   Ligase {ECO:0000313|EMBL:AIR12754.1}.
FT   DOMAIN       17    436       AMP-binding. {ECO:0000259|Pfam:PF00501}.
SQ   SEQUENCE   562 AA;  60962 MW;  412D1F4D7A3757D3 CRC64;
     MTAALLSPAI AWQQISACTD RTLTITCEDS EVISYQDLIA RAAACIPPLR RLDLKRGEPV
     LITAHTNLEF LSCFLGLMLH GAVPVPIPPR EALKTTERFM TRLGPLLRHH RVLICTPAEH
     DEIRAAASTD CQISRFTALA EAGDEQFGRA TAQQLADTAT ADWPLCTLDD DAYVQYTSGS
     TAAPRGVVIT YRNLLSNMRA MAVGSQFQHG DVMGSWLPLH HDMGLVGSLF AALFNSVSAV
     FTTPHRFLYD PLGFLRLLTS SGATHTFMPN FALEWLINAY HRRGADIEGI DLHKMRRLII
     ASEPVHAEGM RRFAATFAGV GLAPTALGSG YGLAEATVAV SMSAPNTGFR TETHAAAEVV
     TGGRVLPGYE VRIDAAPGAR AGTIKLRGDS VAAKAYVGGK KLDALDEEGF CDTHDLGFLV
     DDEIVILGRQ DEVFIVHGEN RFPYDIEFII RGESEQHRTK VACFGVNERV VVVLESPLDS
     IIDKAEADRL RCQVVAATGL QLDELITVRR GAIPTTTSGK LKRRAVAQAY RDGTLPRLAT
     HAWTADPDSA PKTTRSSLEG AH
//
ID   L7N699_MYCTU            Unreviewed;       562 AA.
AC   L7N699; I6XU87;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   31-JAN-2018, entry version 40.
DE   SubName: Full=Probable fatty-acid-CoA ligase FadD34 (Fatty-acid-CoA synthetase) (Fatty-acid-CoA synthase) {ECO:0000313|EMBL:CCP42757.1};
GN   Name=fadD34 {ECO:0000313|EMBL:CCP42757.1};
GN   OrderedLocusNames=Rv0035 {ECO:0000313|EMBL:CCP42757.1};
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332 {ECO:0000313|EMBL:CCP42757.1, ECO:0000313|Proteomes:UP000001584};
RN   [1] {ECO:0000313|EMBL:CCP42757.1, ECO:0000313|Proteomes:UP000001584}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv {ECO:0000313|Proteomes:UP000001584};
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C., Harris D.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E.III., Tekaia F.,
RA   Badcock K., Basham D., Brown D., Chillingworth T., Connor R.,
RA   Davies R., Devlin K., Feltwell T., Gentles S., Hamlin N., Holroyd S.,
RA   Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L.,
RA   Oliver K., Osborne J., Quail M.A., Rajandream M.A., Rogers J.,
RA   Rutter S., Seeger K., Skelton J., Squares R., Squares S.,
RA   Sulston J.E., Taylor K., Whitehead S., Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the
RT   complete genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2] {ECO:0000213|PubMed:21969609}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21969609; DOI=10.1074/mcp.M111.011445;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B.,
RA   Yadav A.K., Shrivastava P., Marimuthu A., Anand S., Sundaram H.,
RA   Kingsbury R., Harsha H.C., Nair B., Prasad T.S., Chauhan D.S.,
RA   Katoch K., Katoch V.M., Kumar P., Chaerkady R., Ramachandran S.,
RA   Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high
RT   resolution mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AL123456; CCP42757.1; -; Genomic_DNA.
DR   RefSeq; WP_003400425.1; NZ_KK339370.1.
DR   RefSeq; YP_177686.1; NC_000962.3.
DR   SMR; L7N699; -.
DR   STRING; 83332.Rv0035; -.
DR   PaxDb; L7N699; -.
DR   EnsemblBacteria; AIR12754; AIR12754; LH57_00210.
DR   EnsemblBacteria; CCP42757; CCP42757; Rv0035.
DR   GeneID; 887048; -.
DR   KEGG; mtu:Rv0035; -.
DR   KEGG; mtv:RVBD_0035; -.
DR   PATRIC; fig|83332.111.peg.40; -.
DR   TubercuList; Rv0035; -.
DR   eggNOG; COG0318; LUCA.
DR   OMA; NGAVYIT; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0070566; F:adenylyltransferase activity; IBA:GO_Central.
DR   GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IBA:GO_Central.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig.
DR   Pfam; PF00501; AMP-binding; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001584};
KW   Ligase {ECO:0000313|EMBL:CCP42757.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001584}.
FT   DOMAIN       17    436       AMP-binding. {ECO:0000259|Pfam:PF00501}.
SQ   SEQUENCE   562 AA;  60962 MW;  412D1F4D7A3757D3 CRC64;
     MTAALLSPAI AWQQISACTD RTLTITCEDS EVISYQDLIA RAAACIPPLR RLDLKRGEPV
     LITAHTNLEF LSCFLGLMLH GAVPVPIPPR EALKTTERFM TRLGPLLRHH RVLICTPAEH
     DEIRAAASTD CQISRFTALA EAGDEQFGRA TAQQLADTAT ADWPLCTLDD DAYVQYTSGS
     TAAPRGVVIT YRNLLSNMRA MAVGSQFQHG DVMGSWLPLH HDMGLVGSLF AALFNSVSAV
     FTTPHRFLYD PLGFLRLLTS SGATHTFMPN FALEWLINAY HRRGADIEGI DLHKMRRLII
     ASEPVHAEGM RRFAATFAGV GLAPTALGSG YGLAEATVAV SMSAPNTGFR TETHAAAEVV
     TGGRVLPGYE VRIDAAPGAR AGTIKLRGDS VAAKAYVGGK KLDALDEEGF CDTHDLGFLV
     DDEIVILGRQ DEVFIVHGEN RFPYDIEFII RGESEQHRTK VACFGVNERV VVVLESPLDS
     IIDKAEADRL RCQVVAATGL QLDELITVRR GAIPTTTSGK LKRRAVAQAY RDGTLPRLAT
     HAWTADPDSA PKTTRSSLEG AH
//
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