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Database: UniProt/TrEMBL
Entry: A0A089XCG3_STRGA
LinkDB: A0A089XCG3_STRGA
Original site: A0A089XCG3_STRGA 
ID   A0A089XCG3_STRGA        Unreviewed;       739 AA.
AC   A0A089XCG3;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   30-AUG-2017, entry version 14.
DE   SubName: Full=Putative Isocitrate dehydrogenase [NADP] {ECO:0000313|EMBL:AIS01683.1};
DE            EC=1.1.1.42 {ECO:0000313|EMBL:AIS01683.1};
GN   ORFNames=SGLAU_28745 {ECO:0000313|EMBL:AIS01683.1};
OS   Streptomyces glaucescens.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1907 {ECO:0000313|EMBL:AIS01683.1, ECO:0000313|Proteomes:UP000029482};
RN   [1] {ECO:0000313|Proteomes:UP000029482}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GLA.O {ECO:0000313|Proteomes:UP000029482};
RX   PubMed=25499805; DOI=10.1016/j.jbiotec.2014.11.036;
RA   Ortseifen V., Winkler A., Albersmeier A., Wendler S., Puhler A.,
RA   Kalinowski J., Ruckert C.;
RT   "Complete genome sequence of the actinobacterium Streptomyces
RT   glaucescens GLA.O (DSM 40922) consisting of a linear chromosome and
RT   one linear plasmid.";
RL   J. Biotechnol. 194:81-83(2015).
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit.
CC       {ECO:0000256|PIRSR:PIRSR009407-3};
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DR   EMBL; CP009438; AIS01683.1; -; Genomic_DNA.
DR   RefSeq; WP_043505380.1; NZ_CP009438.1.
DR   EnsemblBacteria; AIS01683; AIS01683; SGLAU_28745.
DR   KEGG; sgu:SGLAU_28745; -.
DR   KO; K00031; -.
DR   Proteomes; UP000029482; Chromosome.
DR   GO; GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   InterPro; IPR004436; Isocitrate_DH_NADP_mono.
DR   Pfam; PF03971; IDH; 1.
DR   PIRSF; PIRSF009407; IDH_monmr; 1.
DR   TIGRFAMs; TIGR00178; monomer_idh; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000029482};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Oxidoreductase {ECO:0000313|EMBL:AIS01683.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000029482}.
FT   REGION      132    139       Substrate binding. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   METAL       348    348       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       546    546       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       550    550       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   BINDING     145    145       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   BINDING     545    545       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   SITE        255    255       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
FT   SITE        418    418       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
SQ   SEQUENCE   739 AA;  79770 MW;  94A79848CF227F61 CRC64;
     MTDSTIIYTH TDEAPALATY SFLPVVKAYA SQAGVAVETR DISLAGRIIA VFPEYLTEDQ
     RIPDALAELG ELAKTPEANI IKLPNISASI PQLKAAVAEL QAQGYALPDY PDDPKTDEER
     EIKARYDKVK GSAVNPVLRE GNSDRRAPAS VKNYAKTHPH RMGAWTGESK TNVATMGEND
     FRSTEKSVVI AEDGALRIEL VAEDGTTTVL RDSVPVLAGE VVDASVMRVA HLREFLASQV
     ARAKAEGVLF SVHLKATMMK VSDPIIFGHV VRAFFPKTFE RYGETLAAAG LSPNDGLGGI
     FKGLESLPEG AEIKASFDAE LAEGPALAMV DSDKGITNLH VPSDVIVDAS MPAMIRTSGH
     MWGPDGQEAD TIAVIPDSSY AGVYQAVIED CKANGAYDPS TMGSVPNVGL MAQKAEEYGS
     HDKTFEIPAA GTVRLVDRSG DVLIEQPVSQ GDIFRACQTK DAPIRDWVKL AVTRARATGD
     PAVFWLDETR AHDANLIAKV EQYLPEHDTE GLDIRILSPV EATNLSVERI RRGENTISVT
     GNVLRDYLTD LFPILELGTS AKMLSVVPLM AGGGLFETGA GGSAPKHVQQ LVKENYLRWD
     SLGEFFALVP SLEQYAAFTG NNRAKVLADT LDRATATFLN EDKSPTRRVG GIDNRGSHFY
     LSLYWAQELA RQTDDAELAK AFAPLAETLA ANEQKIVEEL NAVQGKPADI GGYYQPDPAK
     AAEIMRPSAT WNEVLASLS
//
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