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Database: UniProt/TrEMBL
Entry: A0A089XMG1_9LACT
LinkDB: A0A089XMG1_9LACT
Original site: A0A089XMG1_9LACT 
ID   A0A089XMG1_9LACT        Unreviewed;       189 AA.
AC   A0A089XMG1;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-SEP-2017, entry version 15.
DE   RecName: Full=Thymidine kinase {ECO:0000256|HAMAP-Rule:MF_00124, ECO:0000256|RuleBase:RU000544};
DE            EC=2.7.1.21 {ECO:0000256|HAMAP-Rule:MF_00124, ECO:0000256|RuleBase:RU000544};
GN   Name=yfiG {ECO:0000313|EMBL:AIS03157.1};
GN   Synonyms=tdk {ECO:0000256|HAMAP-Rule:MF_00124};
GN   ORFNames=LG36_0557 {ECO:0000313|EMBL:AIS03157.1};
OS   Lactococcus lactis.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Lactococcus.
OX   NCBI_TaxID=1358 {ECO:0000313|EMBL:AIS03157.1, ECO:0000313|Proteomes:UP000029483};
RN   [1] {ECO:0000313|EMBL:AIS03157.1, ECO:0000313|Proteomes:UP000029483}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AI06 {ECO:0000313|EMBL:AIS03157.1,
RC   ECO:0000313|Proteomes:UP000029483};
RA   McCulloch J.A., Oliveira V.M., Pina A.A., Perez-Chaparro P.J.,
RA   Vasconcelos J.M., Almeida L.M., Oliveira L.F., Silva D.A., Rogez H.G.,
RA   Cretenet M., Mamizuka E.M., Nunes M.T.;
RL   Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: ATP + thymidine = ADP + thymidine 5'-
CC       phosphate. {ECO:0000256|HAMAP-Rule:MF_00124,
CC       ECO:0000256|RuleBase:RU000544}.
CC   -!- SUBUNIT: Homotetramer. {ECO:0000256|HAMAP-Rule:MF_00124}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00124}.
CC   -!- SIMILARITY: Belongs to the thymidine kinase family.
CC       {ECO:0000256|HAMAP-Rule:MF_00124, ECO:0000256|RuleBase:RU004165}.
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DR   EMBL; CP009472; AIS03157.1; -; Genomic_DNA.
DR   RefSeq; WP_012897306.1; NZ_CP009472.1.
DR   ProteinModelPortal; A0A089XMG1; -.
DR   EnsemblBacteria; AIS03157; AIS03157; LG36_0557.
DR   KEGG; llj:LG36_0557; -.
DR   eggNOG; ENOG4107104; Bacteria.
DR   eggNOG; COG1435; LUCA.
DR   KO; K00857; -.
DR   Proteomes; UP000029483; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004797; F:thymidine kinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:UniProtKB-KW.
DR   HAMAP; MF_00124; Thymidine_kinase; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001267; Thymidine_kinase.
DR   InterPro; IPR020633; Thymidine_kinase_CS.
DR   PANTHER; PTHR11441; PTHR11441; 1.
DR   Pfam; PF00265; TK; 1.
DR   PIRSF; PIRSF035805; TK_cell; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00603; TK_CELLULAR_TYPE; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00124,
KW   ECO:0000256|RuleBase:RU000544};
KW   Complete proteome {ECO:0000313|Proteomes:UP000029483};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00124};
KW   DNA synthesis {ECO:0000256|HAMAP-Rule:MF_00124,
KW   ECO:0000256|RuleBase:RU000544};
KW   Kinase {ECO:0000256|HAMAP-Rule:MF_00124,
KW   ECO:0000256|RuleBase:RU000544, ECO:0000313|EMBL:AIS03157.1};
KW   Metal-binding {ECO:0000256|HAMAP-Rule:MF_00124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00124,
KW   ECO:0000256|RuleBase:RU000544};
KW   Transferase {ECO:0000256|HAMAP-Rule:MF_00124,
KW   ECO:0000256|RuleBase:RU000544};
KW   Zinc {ECO:0000256|HAMAP-Rule:MF_00124}.
FT   NP_BIND       9     16       ATP. {ECO:0000256|HAMAP-Rule:MF_00124}.
FT   NP_BIND      85     88       ATP. {ECO:0000256|HAMAP-Rule:MF_00124}.
FT   ACT_SITE     86     86       Proton acceptor. {ECO:0000256|HAMAP-Rule:
FT                                MF_00124, ECO:0000256|PIRSR:PIRSR035805-
FT                                1}.
FT   METAL       143    143       Zinc. {ECO:0000256|HAMAP-Rule:MF_00124}.
FT   METAL       146    146       Zinc. {ECO:0000256|HAMAP-Rule:MF_00124}.
FT   METAL       180    180       Zinc. {ECO:0000256|HAMAP-Rule:MF_00124}.
FT   METAL       183    183       Zinc. {ECO:0000256|HAMAP-Rule:MF_00124}.
SQ   SEQUENCE   189 AA;  21413 MW;  FF51FB7110C406CD CRC64;
     MAQLYFKYGT MNSGKSIEIL KVAHNYEEQG KPVLLMTSSL DTRAGVGTVA SRIGMKAEAV
     AIDEEMSVFD YVNSLSAKPF CVLIDEAQFL NKKHVYDFAR VVDELNVPVM AFGLKNDFRN
     ELFEGSKYLL LLADKIEEIK TICWYCSKKA TMVIRTIDGK PVYEGEQLQI GGNETYIPVC
     RKHYFKPEI
//
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