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Database: UniProt/TrEMBL
Entry: A0A0A0NCD9_9ACTN
LinkDB: A0A0A0NCD9_9ACTN
Original site: A0A0A0NCD9_9ACTN 
ID   A0A0A0NCD9_9ACTN        Unreviewed;       739 AA.
AC   A0A0A0NCD9;
DT   04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT   04-FEB-2015, sequence version 1.
DT   22-NOV-2017, entry version 12.
DE   SubName: Full=Isocitrate dehydrogenase {ECO:0000313|EMBL:AGP53763.1};
DE            EC=1.1.1.42 {ECO:0000313|EMBL:AGP53763.1};
GN   ORFNames=M271_10810 {ECO:0000313|EMBL:AGP53763.1};
OS   Streptomyces rapamycinicus NRRL 5491.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1343740 {ECO:0000313|EMBL:AGP53763.1, ECO:0000313|Proteomes:UP000030183};
RN   [1] {ECO:0000313|EMBL:AGP53763.1, ECO:0000313|Proteomes:UP000030183}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NRRL 5491 {ECO:0000313|EMBL:AGP53763.1};
RX   PubMed=23929477;
RA   Baranasic D., Gacesa R., Starcevic A., Zucko J., Blazic M., Horvat M.,
RA   Gjuracic K., Fujs S., Hranueli D., Kosec G., Cullum J., Petkovic H.;
RT   "Draft Genome Sequence of Streptomyces rapamycinicus Strain NRRL 5491,
RT   the Producer of the Immunosuppressant Rapamycin.";
RL   Genome Announc. 1:0-0(2013).
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit.
CC       {ECO:0000256|PIRSR:PIRSR009407-3};
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DR   EMBL; CP006567; AGP53763.1; -; Genomic_DNA.
DR   EnsemblBacteria; AGP53763; AGP53763; M271_10810.
DR   KEGG; src:M271_10810; -.
DR   PATRIC; fig|1343740.8.peg.9728; -.
DR   KO; K00031; -.
DR   BioCyc; SRAP1343740:G13G7-2140-MONOMER; -.
DR   Proteomes; UP000030183; Chromosome.
DR   GO; GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   InterPro; IPR004436; Isocitrate_DH_NADP_mono.
DR   PANTHER; PTHR36999; PTHR36999; 1.
DR   Pfam; PF03971; IDH; 1.
DR   PIRSF; PIRSF009407; IDH_monmr; 1.
DR   TIGRFAMs; TIGR00178; monomer_idh; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000030183};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Oxidoreductase {ECO:0000313|EMBL:AGP53763.1}.
FT   REGION      132    139       Substrate binding. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   METAL       348    348       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       546    546       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       550    550       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   BINDING     145    145       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   BINDING     545    545       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   SITE        255    255       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
FT   SITE        418    418       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
SQ   SEQUENCE   739 AA;  79192 MW;  A87565149E490C2F CRC64;
     MTDSTIIYTH TDEAPALATY SFLPVIEAYA STAGVGVESR DISLAGRIIA QFPEHLEEGQ
     RIPDALAELG DLAKTPEANI IKLPNISASI PQLKAAVAEL QQQGYALPDY PDDPKTDEER
     KIRARYDKVK GSAVNPVLRE GNSDRRAPAS VKNYARANPH RMGAWTADSK TNVSHMDTDD
     FRSTEKSVVI PEDGSLRIEL AGDDGSTTVL RESVPVLAGE VVDASVMRVA ALREFLSAQV
     ARAKAEGVLF SLHLKATMMK VSDPIVFGHG VRAFFPKTFA EHGETLAAAG LTPNDGLGGI
     LKGLEALPEG AAIKASFDAE LAEGPELAMV DSDRGITNLH VPSDVIVDAS MPAMIRTSGH
     MWGPDGEEHD TLAVIPDSSY AGIYQAVIDD CRAHGAFDPA TMGSVPNVGL MAQKAEEYGS
     HDKTFEIPTT GTVRVLDGAG NAVIEQVVGA GDIFRMCQTK DVPIQDWVKL AVTRARATGD
     PAVFWLDEGR AHDANLIEKV KAYLPEHDTE GLDIRILAPV EAIKLSLERI RRGEDTISVT
     GNVLRDYLTD LFPILELGTS AKMLSVVPLI NGGGLFETGA GGSAPKHVQQ LVKENYLRWD
     SLGEFLALAV SFEHLAQKTG NARAQVLADT LDRATGTFLA ENKSPSRRVG GIDNRGSHFY
     LALYWAQELA KQTDDADLAK AFAQLADTLS TQEQTIVDEL LAVQGSPADI GGYYRPDTAK
     AAAVMRPSAT LNQALATLG
//
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