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Database: UniProt/TrEMBL
Entry: A0A0A1D1X4_9MICC
LinkDB: A0A0A1D1X4_9MICC
Original site: A0A0A1D1X4_9MICC 
ID   A0A0A1D1X4_9MICC        Unreviewed;       739 AA.
AC   A0A0A1D1X4;
DT   04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT   04-FEB-2015, sequence version 1.
DT   07-JUN-2017, entry version 11.
DE   SubName: Full=Isocitrate dehydrogenase {ECO:0000313|EMBL:AIY03465.1};
DE            EC=1.1.1.42 {ECO:0000313|EMBL:AIY03465.1};
GN   ORFNames=ART_3866 {ECO:0000313|EMBL:AIY03465.1};
OS   Arthrobacter sp. PAMC 25486.
OC   Bacteria; Actinobacteria; Micrococcales; Micrococcaceae; Arthrobacter.
OX   NCBI_TaxID=1494608 {ECO:0000313|EMBL:AIY03465.1, ECO:0000313|Proteomes:UP000030301};
RN   [1] {ECO:0000313|EMBL:AIY03465.1, ECO:0000313|Proteomes:UP000030301}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PAMC25486 {ECO:0000313|EMBL:AIY03465.1,
RC   ECO:0000313|Proteomes:UP000030301};
RA   Jung J.-H., Joe M.-H., Cho Y.-J., Lee S.G., Han S.J., Lim S.,
RA   Choi J.-I.;
RT   "Complete genome sequence of Arthrobacter sp. PAMC25486 isolated from
RT   the Arctic.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit.
CC       {ECO:0000256|PIRSR:PIRSR009407-3};
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DR   EMBL; CP007595; AIY03465.1; -; Genomic_DNA.
DR   RefSeq; WP_038467226.1; NZ_CP007595.1.
DR   EnsemblBacteria; AIY03465; AIY03465; ART_3866.
DR   KEGG; arm:ART_3866; -.
DR   KO; K00031; -.
DR   Proteomes; UP000030301; Chromosome.
DR   GO; GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   InterPro; IPR004436; Isocitrate_DH_NADP_mono.
DR   Pfam; PF03971; IDH; 1.
DR   PIRSF; PIRSF009407; IDH_monmr; 1.
DR   TIGRFAMs; TIGR00178; monomer_idh; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000030301};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Oxidoreductase {ECO:0000313|EMBL:AIY03465.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030301}.
FT   REGION      130    137       Substrate binding. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   METAL       348    348       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       546    546       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       550    550       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   BINDING     143    143       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   BINDING     545    545       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   SITE        253    253       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
FT   SITE        418    418       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
SQ   SEQUENCE   739 AA;  78951 MW;  5A0034F4D3327E83 CRC64;
     MAKIIYTLTD EAPMLATYSL LPIVEAFAST AGVDVETRDI SVSARIIAVF GDYLTEDQRI
     DDALAELGAL AKSPDANIIK LPNISASIPQ LKAAIAELQG QGFALPDYPD DPSTDEEKDV
     RARYDKIKGS AVNPVLREGN SDRRAPLSVK NYAKANPHSM GAWSVDSKTN VATMSEGDFR
     HNEKSVVIAA DDKIKIQFVA ADGTTTVLKD SFAVLADEIV DGTVMRAAAL DTFLAAQVAR
     AKEEGILLSA HLKATMMKVS DPIIFGHVVK AYFPELFANY GDALAAAGLS PANGLASIIN
     GLGELPADVR AGVEAAIKKG YEDGPALAMV DSSKGITNLH VPSDVIVDAS MPAMIRTSGH
     MWGADDQEHD TLAVLPDSSY AGVYQATIED CRAHGAFDPT TMGTVPNVGL MAQAAEEYGS
     HDKTFELSEA GTVQIVNAAG TVLIEHDVAA GDIWRACQVK DIPVRDWVKL AVTRARASAT
     PAIFWLDPTR AHDANIITKV NEYLKDHDTE GLDIRIMSPE DATKFTLERI RRGEDTISVT
     GNVLRDYLTD LFPILELGTS AKMLSVVPLI AGGGLFETGA GGSAPKHVQQ LIKENHLRWD
     SLGEFLAIAV SFEHLAVTEG NARAQILADT LDRATGTFLL ENKSPKRKVG EIDNRGSHFH
     LAKFWAQELA AQTVDADLAA AFKAVAADLT TNEDAIIAEL ADVQGSPVDL GGYYRPDAAK
     VAAIMRPSAL LNKAIDTLS
//
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