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Database: UniProt/TrEMBL
Entry: A0A0A8F049_9ACTN
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ID   A0A0A8F049_9ACTN        Unreviewed;       747 AA.
AC   A0A0A8F049;
DT   04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT   04-MAR-2015, sequence version 1.
DT   10-MAY-2017, entry version 11.
DE   SubName: Full=Isocitrate dehydrogenase {ECO:0000313|EMBL:AJC59781.1};
GN   ORFNames=GZL_07229 {ECO:0000313|EMBL:AJC59781.1};
OS   Streptomyces sp. 769.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1262452 {ECO:0000313|EMBL:AJC59781.1, ECO:0000313|Proteomes:UP000031113};
RN   [1] {ECO:0000313|EMBL:AJC59781.1, ECO:0000313|Proteomes:UP000031113}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=769 {ECO:0000313|EMBL:AJC59781.1,
RC   ECO:0000313|Proteomes:UP000031113};
RA   Du Q., Wang Q., Li Q., Wang L., Zhang Z., Ren J., Wang J., Wang M.;
RT   "Complete Genome Sequence of Streptomyces gongzhulingensis.";
RL   Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit.
CC       {ECO:0000256|PIRSR:PIRSR009407-3};
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DR   EMBL; CP003987; AJC59781.1; -; Genomic_DNA.
DR   EnsemblBacteria; AJC59781; AJC59781; GZL_07229.
DR   KEGG; stre:GZL_07229; -.
DR   KO; K00031; -.
DR   Proteomes; UP000031113; Chromosome.
DR   GO; GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   InterPro; IPR004436; Isocitrate_DH_NADP_mono.
DR   Pfam; PF03971; IDH; 1.
DR   PIRSF; PIRSF009407; IDH_monmr; 1.
DR   TIGRFAMs; TIGR00178; monomer_idh; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000031113};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000031113}.
FT   REGION      139    146       Substrate binding. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   METAL       355    355       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       553    553       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       557    557       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   BINDING     152    152       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   BINDING     552    552       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   SITE        262    262       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
FT   SITE        425    425       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
SQ   SEQUENCE   747 AA;  80010 MW;  066A24AD461C3DC7 CRC64;
     MDGAEYPVTD STIIYTHTDE APALATYSFL PVVEAYAAKA GVTLETRDIS LSGRIIASFP
     ERLKEDQRIA DALAELGQLA KTPGANIIKL PNISASIPQL KAAIAELQEQ GYALPDYPDD
     PKTDEERETR ARYDKVKGSA VNPVLREGNS DRRAPASVKN YAKAHPHRMG AWTADSKTNV
     ATMGENDFRA TEKSAVIAED GSLRIELVAE DGTTTVLRES VPVLAGEVVD ASVMRVAQLR
     EFLAAQVVRA KAEGVLFSVH LKATMMKVSD PIVFGHVVRA FFPKTFAQYG EALAAAGLTP
     NDGLGGIFKG LEALSNGAEI KASFDAELAE GPELAMVDSD RGITNLHVPS DVIVDASMPA
     MIRTSGHMWG PDGQEADTLA VLPDSSYAGI YQAVIDDCRA HGAFDPATMG SVPNVGLMAQ
     KAEEYGSHDK TFEVAAAGTV RLVDAHGNVV IEQAVAAGDI FRACQTKDAP IKDWVKLAVS
     RARATGDPAV FWLDETRAHD AQLIAKVNAY LAEHDTEGLE IKILAPVEAT AFSLERIRRG
     ADTISVTGNV LRDYLTDLFP ILELGTSAKM LSVVPLMNGG GLFETGAGGS APKHVQQLVK
     ENYLRWDSLG EFLALAVSFE HLATTTDNTR AKVLADTLDR ATGSFLNENK SPSRKLGGID
     NRGSHFYLAL YWAQELAKQT DDAQLAEAFG PLAKTLTEQE QTIVDELIAV QGSPVDIGGY
     FRPDPAKASA VMRPSKTLNQ ALAALRG
//
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