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Database: UniProt/TrEMBL
Entry: A0A0B5F9R0_STRA4
LinkDB: A0A0B5F9R0_STRA4
Original site: A0A0B5F9R0_STRA4 
ID   A0A0B5F9R0_STRA4        Unreviewed;       739 AA.
AC   A0A0B5F9R0;
DT   01-APR-2015, integrated into UniProtKB/TrEMBL.
DT   01-APR-2015, sequence version 1.
DT   10-MAY-2017, entry version 11.
DE   SubName: Full=Isocitrate dehydrogenase, NADP-dependent {ECO:0000313|EMBL:AJE87207.1};
GN   ORFNames=SLNWT_6831 {ECO:0000313|EMBL:AJE87207.1};
OS   Streptomyces albus (strain ATCC 21838 / DSM 41398 / FERM P-419 / JCM
OS   4703 / NBRC 107858).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1081613 {ECO:0000313|EMBL:AJE87207.1, ECO:0000313|Proteomes:UP000031523};
RN   [1] {ECO:0000313|EMBL:AJE87207.1, ECO:0000313|Proteomes:UP000031523}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 21838 / DSM 41398 / FERM P-419 / JCM 4703 / NBRC 107858
RC   {ECO:0000313|Proteomes:UP000031523};
RA   Lu C.;
RT   "Enhanced salinomycin production by adjusting the supply of polyketide
RT   extender units in Streptomyce albus DSM 41398.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit.
CC       {ECO:0000256|PIRSR:PIRSR009407-3};
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DR   EMBL; CP010519; AJE87207.1; -; Genomic_DNA.
DR   EnsemblBacteria; AJE87207; AJE87207; SLNWT_6831.
DR   KEGG; sals:SLNWT_6831; -.
DR   KO; K00031; -.
DR   Proteomes; UP000031523; Chromosome.
DR   GO; GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   InterPro; IPR004436; Isocitrate_DH_NADP_mono.
DR   Pfam; PF03971; IDH; 1.
DR   PIRSF; PIRSF009407; IDH_monmr; 1.
DR   TIGRFAMs; TIGR00178; monomer_idh; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000031523};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000031523}.
FT   REGION      132    139       Substrate binding. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   METAL       348    348       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       546    546       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       550    550       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   BINDING     145    145       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   BINDING     545    545       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   SITE        255    255       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
FT   SITE        418    418       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
SQ   SEQUENCE   739 AA;  79343 MW;  E0EB1855882E9C4E CRC64;
     MTDSTIIYTH TDEAPALATY SFLPVIEAYA STAGVRVESR DISLAGRIIA SFPERLQESQ
     RIDDALAELG ELAKTPGANI IKLPNISASI PQLKAAVAEL QKQGYALPDY PDDPKTDEER
     DIRARYDKVK GSAVNPVLRE GNSDRRAPAS VKNYAKAHPH RMGAWSPESK TNVTTMGTDD
     FRSTEKSVVI AEDGALRIEL AGDDGSTTVL REAVPVLAGE VVDASVMRVA ALREFLTEQV
     ARAKAEGVLF SVHLKATMMK VSDPIIFGHV VRAFFPKTFA EYGKVLAEAG LTPNDGLGGI
     LKGVESLPEG AAIKASFEAE LAEGPELAMV DSDRGITNLH VPSDVIVDAS MPAMIRTSGH
     MWGPDGEEAD TLAVLPDSSY AGIYQAVIED CRAHGAYDPS TMGSVPNVGL MAQKAEEYGS
     HDKTFEVPVT GTVRVLDGAG KAVLEQTVSA GDIFRMCQTK DAPIKDWVKL AVTRARATGD
     PAVFWLDEGR AHDANLIAKV RQYLPEHDTA GLQIEIKSPV DAITFSLDRI RRGENTISVT
     GNVLRDYLTD LFPILELGTS AKMLSVVPLM NGGGLFETGA GGSAPKHVQQ LVKENYLRWD
     SLGEFLALAV SFEHLAQTTG NARAQVLADT LDRATATFLN EDKSPSRKLG GIDNRGSHFY
     LALYWAQELA KQTEDAKLAE AFAPLAKTLA EQEQTIVDEL LAVQGSPADI GGYYQPETAK
     AAAVMRPSAT LNQALATLA
//
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