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Database: UniProt/TrEMBL
Entry: A0A0B5HTG4_9ACTN
LinkDB: A0A0B5HTG4_9ACTN
Original site: A0A0B5HTG4_9ACTN 
ID   A0A0B5HTG4_9ACTN        Unreviewed;       739 AA.
AC   A0A0B5HTG4;
DT   01-APR-2015, integrated into UniProtKB/TrEMBL.
DT   01-APR-2015, sequence version 1.
DT   22-NOV-2017, entry version 14.
DE   SubName: Full=Isocitrate dehydrogenase {ECO:0000313|EMBL:AJF63746.1};
DE            EC=1.1.1.42 {ECO:0000313|EMBL:AJF63746.1};
GN   ORFNames=SVTN_04075 {ECO:0000313|EMBL:AJF63746.1};
OS   Streptomyces vietnamensis.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=362257 {ECO:0000313|EMBL:AJF63746.1, ECO:0000313|Proteomes:UP000031774};
RN   [1] {ECO:0000313|EMBL:AJF63746.1, ECO:0000313|Proteomes:UP000031774}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GIMV4.0001 {ECO:0000313|Proteomes:UP000031774};
RA   Deng M.R., Guo J., Ma L.Y., Feng G.D., Mo C.Y., Zhu H.H.;
RT   "Complete genome sequence of Streptomyces vietnamensis strain
RT   GIMV4.0001, a genetic manipulable producer of the
RT   benzoisochromanequinone antibiotic granaticin.";
RL   Submitted (DEC-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit.
CC       {ECO:0000256|PIRSR:PIRSR009407-3};
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DR   EMBL; CP010407; AJF63746.1; -; Genomic_DNA.
DR   RefSeq; WP_041127831.1; NZ_CP010407.1.
DR   EnsemblBacteria; AJF63746; AJF63746; SVTN_04075.
DR   GeneID; 34185905; -.
DR   KEGG; svt:SVTN_04075; -.
DR   KO; K00031; -.
DR   Proteomes; UP000031774; Chromosome.
DR   GO; GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   InterPro; IPR004436; Isocitrate_DH_NADP_mono.
DR   PANTHER; PTHR36999; PTHR36999; 1.
DR   Pfam; PF03971; IDH; 1.
DR   PIRSF; PIRSF009407; IDH_monmr; 1.
DR   TIGRFAMs; TIGR00178; monomer_idh; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000031774};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Oxidoreductase {ECO:0000313|EMBL:AJF63746.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000031774}.
FT   REGION      132    139       Substrate binding. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   METAL       348    348       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       546    546       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       550    550       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   BINDING     145    145       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   BINDING     545    545       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   SITE        255    255       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
FT   SITE        418    418       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
SQ   SEQUENCE   739 AA;  79189 MW;  16CF16787AAD58C5 CRC64;
     MTDSTIIYTH TDEAPALATY SFLPVVQAYA SQAGVTVETR DISLAGRIIA VFPEFLEEGQ
     RIADALSELG DLAKTPGANI IKLPNVSASI PQLKAAIAEL QAQGYALPDY PDDPQTDQDK
     DVRARYDKIK GSAVNPVLRE GNSDRRAPGS VKNYAKTHPH RMGAWTPESK TNVATMSEND
     FASTEKSTVI AKDDTLRFEF AAADGTVSEL REPLKVIAGE VVDAAVMRAA ALRTFLGEQV
     SRAKAEGVLF SVHLKATMMK VSDPIVFGHV VRAFFPNTFA KYGEALAAAG LSPNDGLGTV
     LGGLDALPNG AEIKASFEAE LAEGPALAMV DSDKGITNLH VPSDVIVDAS MPAMIRTSGH
     MWGPDGQEAD TLAVLPDHSY SGVYQAVIED CRAHGAFDPS TMGSVPNVGL MAQKAEEYGS
     HDKTFEIAQA GTVRLIDSEG NVVLEQEVAE GDIFRACQTK DLPIQDWVKL AVTRARATGA
     PAVFWLDENR AHDAQLIAKV KQYLPEHDTE GLDIKILSPV EATKFSLERI RRGEDTISVT
     GNVLRDYLTD LFPILELGTS AKMLSVVPLM AGGGLFETGA GGSAPKHVQQ LVKENYLRWD
     SLGEFFALAA SFEHLATSTG NTRAQVLADT LDRATGTFLN EDKSPTRRLG GIDNRGSHFY
     LALYWAQELA AQTEDAELAK AFAPLAETLT ANEQKIVDEL IAVQGSPADI GGYYQPDPAK
     AAAVMRPSAT FNEAIASLA
//
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