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Database: UniProt/TrEMBL
Entry: A0A0B8NDN8_9NOCA
LinkDB: A0A0B8NDN8_9NOCA
Original site: A0A0B8NDN8_9NOCA 
ID   A0A0B8NDN8_9NOCA        Unreviewed;       405 AA.
AC   A0A0B8NDN8;
DT   01-APR-2015, integrated into UniProtKB/TrEMBL.
DT   01-APR-2015, sequence version 1.
DT   05-JUL-2017, entry version 19.
DE   RecName: Full=Isocitrate dehydrogenase [NADP] {ECO:0000256|PIRNR:PIRNR000108};
DE            EC=1.1.1.42 {ECO:0000256|PIRNR:PIRNR000108};
GN   Name=idh1 {ECO:0000313|EMBL:APB01416.1};
GN   ORFNames=NS07_v2contig00128-0017 {ECO:0000313|EMBL:GAM49915.1},
GN   NS506_07396 {ECO:0000313|EMBL:APB01416.1};
OS   Nocardia seriolae.
OC   Bacteria; Actinobacteria; Corynebacteriales; Nocardiaceae; Nocardia.
OX   NCBI_TaxID=37332 {ECO:0000313|EMBL:GAM49915.1, ECO:0000313|Proteomes:UP000019401};
RN   [1] {ECO:0000313|EMBL:GAM49915.1, ECO:0000313|Proteomes:UP000019401}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=N-2927 {ECO:0000313|EMBL:GAM49915.1,
RC   ECO:0000313|Proteomes:UP000019401};
RA   Imajoh M., Fukumoto Y., Yamane J., Sukeda M., Shimizu M., Ohnishi K.,
RA   Oshima S.;
RT   "Draft Genome Sequence of Nocardia seriolae Strain N-2927 (NBRC
RT   110360), Isolated as the Causal Agent of Nocardiosis of Yellowtail
RT   (Seriola quinqueradiata) in Kochi Prefecture, Japan.";
RL   Genome Announc. 3:e00082-15(2015).
RN   [2] {ECO:0000313|EMBL:APB01416.1, ECO:0000313|Proteomes:UP000180166}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EM150506 {ECO:0000313|EMBL:APB01416.1,
RC   ECO:0000313|Proteomes:UP000180166};
RA   Han H.-J.;
RT   "Genome sequence of Nocardia seriolae strain EM150506, isolated from
RT   Anguila japonica.";
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: Isocitrate + NADP(+) = 2-oxoglutarate + CO(2)
CC       + NADPH. {ECO:0000256|PIRNR:PIRNR000108}.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRNR:PIRNR000108,
CC         ECO:0000256|PIRSR:PIRSR000108-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRNR:PIRNR000108,
CC         ECO:0000256|PIRSR:PIRSR000108-3};
CC       Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit.
CC       {ECO:0000256|PIRNR:PIRNR000108, ECO:0000256|PIRSR:PIRSR000108-3};
CC   -!- SIMILARITY: Belongs to the isocitrate and isopropylmalate
CC       dehydrogenases family. {ECO:0000256|PIRNR:PIRNR000108}.
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DR   EMBL; CP017839; APB01416.1; -; Genomic_DNA.
DR   EMBL; BAWD02000128; GAM49915.1; -; Genomic_DNA.
DR   RefSeq; WP_033091241.1; NZ_MVAC01000015.1.
DR   EnsemblBacteria; GAM49915; GAM49915; NS07_v2contig00128-0017.
DR   KEGG; nsr:NS506_07396; -.
DR   PATRIC; fig|37332.12.peg.7586; -.
DR   KO; K00031; -.
DR   Proteomes; UP000019401; Unassembled WGS sequence.
DR   Proteomes; UP000180166; Chromosome.
DR   GO; GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0006102; P:isocitrate metabolic process; IEA:InterPro.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
DR   InterPro; IPR019818; IsoCit/isopropylmalate_DH_CS.
DR   InterPro; IPR004790; Isocitrate_DH_NADP.
DR   InterPro; IPR024084; IsoPropMal-DH-like_dom.
DR   PANTHER; PTHR11822; PTHR11822; 1.
DR   Pfam; PF00180; Iso_dh; 1.
DR   PIRSF; PIRSF000108; IDH_NADP; 1.
DR   SMART; SM01329; Iso_dh; 1.
DR   TIGRFAMs; TIGR00127; nadp_idh_euk; 1.
DR   PROSITE; PS00470; IDH_IMDH; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000019401,
KW   ECO:0000313|Proteomes:UP000180166};
KW   Magnesium {ECO:0000256|PIRNR:PIRNR000108,
KW   ECO:0000256|PIRSR:PIRSR000108-3};
KW   Manganese {ECO:0000256|PIRNR:PIRNR000108,
KW   ECO:0000256|PIRSR:PIRSR000108-3};
KW   Metal-binding {ECO:0000256|PIRNR:PIRNR000108,
KW   ECO:0000256|PIRSR:PIRSR000108-3};
KW   NADP {ECO:0000256|PIRNR:PIRNR000108, ECO:0000256|PIRSR:PIRSR000108-4};
KW   Oxidoreductase {ECO:0000256|PIRNR:PIRNR000108,
KW   ECO:0000313|EMBL:APB01416.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000019401};
KW   Tricarboxylic acid cycle {ECO:0000256|PIRNR:PIRNR000108}.
FT   DOMAIN        9    396       Iso_dh. {ECO:0000259|SMART:SM01329}.
FT   NP_BIND      75     77       NADP. {ECO:0000256|PIRSR:PIRSR000108-4}.
FT   NP_BIND     310    315       NADP. {ECO:0000256|PIRSR:PIRSR000108-4}.
FT   REGION       94    100       Substrate binding. {ECO:0000256|PIRSR:
FT                                PIRSR000108-2}.
FT   METAL       252    252       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR000108-3}.
FT   METAL       275    275       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR000108-3}.
FT   BINDING      77     77       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR000108-2}.
FT   BINDING      82     82       NADP. {ECO:0000256|PIRSR:PIRSR000108-4}.
FT   BINDING     109    109       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR000108-2}.
FT   BINDING     132    132       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR000108-2}.
FT   BINDING     260    260       NADP. {ECO:0000256|PIRSR:PIRSR000108-4}.
FT   BINDING     328    328       NADP; via amide nitrogen and carbonyl
FT                                oxygen. {ECO:0000256|PIRSR:PIRSR000108-
FT                                4}.
FT   SITE        139    139       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR000108-1}.
FT   SITE        212    212       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR000108-1}.
SQ   SEQUENCE   405 AA;  45098 MW;  D1351F59524ECAF4 CRC64;
     MSKIKVEGTV VELDGDEMTR IIWQFIKDKL IVPYLDVNLE YYDLGIEARD KTDDQITIDA
     ANAIKKHGVG VKCATITPDE ARVEEFGLKK MWRSPNGTIR NILGGTIFRA PIIISNVPRL
     VPGWTKPIII GRHAFGDQYR ATDFKVHQAG TVTLTFTPED GSEPIVQEVV KMPEDGGVVM
     GMYNFQDSIR DFARASLNYG LQQNYPVYMS TKNTILKAYD GMFKDTFEEV YQTEFKDEFD
     AAGLTYEHRL IDDMVASALK WEGGYVWACK NYDGDVQSDT VAQGFGSLGL MTSVLLTPDG
     RTCEAEAAHG TVTRHYRQHQ QGKPTSTNPI ASIFAWTRGL AHRGKLDNTP EVIGFAQTLE
     DVVIKTVESG QMTKDLALLV GGDQGYLTTE EFLGVLDANL AREIR
//
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