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Database: UniProt/TrEMBL
Entry: A0A0C5FYC4_9ACTN
LinkDB: A0A0C5FYC4_9ACTN
Original site: A0A0C5FYC4_9ACTN 
ID   A0A0C5FYC4_9ACTN        Unreviewed;       739 AA.
AC   A0A0C5FYC4;
DT   29-APR-2015, integrated into UniProtKB/TrEMBL.
DT   29-APR-2015, sequence version 1.
DT   07-JUN-2017, entry version 9.
DE   SubName: Full=Isocitrate dehydrogenase {ECO:0000313|EMBL:AJP05022.1};
DE            EC=1.1.1.42 {ECO:0000313|EMBL:AJP05022.1};
GN   ORFNames=TU94_29890 {ECO:0000313|EMBL:AJP05022.1};
OS   Streptomyces cyaneogriseus subsp. noncyanogenus.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=477245 {ECO:0000313|EMBL:AJP05022.1, ECO:0000313|Proteomes:UP000032234};
RN   [1] {ECO:0000313|EMBL:AJP05022.1, ECO:0000313|Proteomes:UP000032234}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NMWT 1 {ECO:0000313|EMBL:AJP05022.1,
RC   ECO:0000313|Proteomes:UP000032234};
RA   Wang H., Li C., Xiang W., Wang X.;
RT   "Genome sequence of thermotolerant Streptomyces cyaneogriseus subsp.
RT   Noncyanogenus NMWT1, the producer of nematocidal antibiotics
RT   nemadectin.";
RL   Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit.
CC       {ECO:0000256|PIRSR:PIRSR009407-3};
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DR   EMBL; CP010849; AJP05022.1; -; Genomic_DNA.
DR   RefSeq; WP_044386357.1; NZ_CP010849.1.
DR   EnsemblBacteria; AJP05022; AJP05022; TU94_29890.
DR   KEGG; scw:TU94_29890; -.
DR   PATRIC; fig|477245.3.peg.6361; -.
DR   KO; K00031; -.
DR   Proteomes; UP000032234; Chromosome.
DR   GO; GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   InterPro; IPR004436; Isocitrate_DH_NADP_mono.
DR   Pfam; PF03971; IDH; 1.
DR   PIRSF; PIRSF009407; IDH_monmr; 1.
DR   TIGRFAMs; TIGR00178; monomer_idh; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000032234};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Oxidoreductase {ECO:0000313|EMBL:AJP05022.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000032234}.
FT   REGION      132    139       Substrate binding. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   METAL       348    348       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       546    546       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       550    550       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   BINDING     145    145       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   BINDING     545    545       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   SITE        255    255       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
FT   SITE        418    418       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
SQ   SEQUENCE   739 AA;  79651 MW;  452D84439E08CC0E CRC64;
     MTDSTIIYTH TDEAPALATY SFLPVVQAYA SQAGVAVETR DISLAGRIIA VFPEYLTEDQ
     RIPDALAELG ELAKTPAANI IKLPNISASI PQLKAAIAEL QGQGYALPDY PDDPKTDEER
     EIRARYDKIK GSAVNPVLRE GNSDRRAPAS VKNYAKTHPH RMGAWTSESK TNVATMGEND
     FRSTEKSVII AEDGTLRIEL VGDDGSTTVL RESVPVQKGE VVDASVMRVA ALREFLAAQV
     ARAKQEGVLF SVHLKATMMK VSDPIIFGHV VRAFFPKTFA KYGATLAAAG LTPNDGLGGI
     YKGLEALPEG AEIKASFDAE LAEGPELAMV DSDKGITNLH VPSDVIIDAS MPAMIRTSGH
     MWGPDGQEHD ALAVIPDSSY AGVYQAVIDD CRVNGAYDPA TMGSVPNVGL MAQKAEEYGS
     HDKTFEIAVT GTVRLVDQNG DAVIEQPVSA GDIFRACQTK DAPIKDWVKL AVTRARATGD
     PAVFWLDATR AHDANLIKKV EQYLPEHDTE GLDIKILSPV EATKLSVERI RRGENTISVT
     GNVLRDYLTD LFPILELGTS AKMLSVVPLM AGGGLFETGA GGSAPKHVQQ LVKENYLRWD
     SLGEFFALVP SLEQYAEATG NARAKVLADT LDRATATFLN EDKSPTRRVG GIDNRGSHFY
     LSLYWAQELA RQTDDADLAK AFAPLAETLA ANEQKIVEEL NAVQGKPVDI GGYYQPDPAK
     AAEVMRPSAT WNEALASLS
//
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