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Database: UniProt/TrEMBL
Entry: A0A0D2Y5C5_FUSO4
LinkDB: A0A0D2Y5C5_FUSO4
Original site: A0A0D2Y5C5_FUSO4 
ID   A0A0D2Y5C5_FUSO4        Unreviewed;       984 AA.
AC   A0A0D2Y5C5;
DT   29-APR-2015, integrated into UniProtKB/TrEMBL.
DT   29-APR-2015, sequence version 1.
DT   25-OCT-2017, entry version 21.
DE   RecName: Full=DNA ligase {ECO:0000256|RuleBase:RU000617};
DE            EC=6.5.1.1 {ECO:0000256|RuleBase:RU000617};
GN   ORFNames=FOXG_11480 {ECO:0000313|EMBL:KNB11651.1};
OS   Fusarium oxysporum f. sp. lycopersici (strain 4287 / CBS 123668 / FGSC
OS   9935 / NRRL 34936) (Fusarium vascular wilt of tomato).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
OC   Sordariomycetes; Hypocreomycetidae; Hypocreales; Nectriaceae;
OC   Fusarium; Fusarium oxysporum species complex.
OX   NCBI_TaxID=426428 {ECO:0000313|EnsemblFungi:FOXG_11480P0, ECO:0000313|Proteomes:UP000009097};
RN   [1] {ECO:0000313|EMBL:KNB11651.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=4287 {ECO:0000313|EMBL:KNB11651.1};
RG   The Broad Institute Genome Sequencing Platform;
RA   Birren B., Lander E., Galagan J., Nusbaum C., Devon K., Ma L.-J.,
RA   Jaffe D., Butler J., Alvarez P., Gnerre S., Grabherr M., Kleber M.,
RA   Mauceli E., Brockman W., MacCallum I.A., Young S., LaButti K.,
RA   DeCaprio D., Crawford M., Koehrsen M., Engels R., Montgomery P.,
RA   Pearson M., Howarth C., Larson L., White J., O'Leary S., Kodira C.,
RA   Zeng Q., Yandava C., Alvarado L., Kistler C., Shim W.-B., Kang S.,
RA   Woloshuk C.;
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:KNB11651.1, ECO:0000313|EnsemblFungi:FOXG_11480P0, ECO:0000313|Proteomes:UP000009097}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=4287 {ECO:0000313|EMBL:KNB11651.1}, and 4287 / CBS 123668 /
RC   FGSC 9935 / NRRL 34936 {ECO:0000313|EnsemblFungi:FOXG_11480P0,
RC   ECO:0000313|Proteomes:UP000009097};
RX   PubMed=20237561; DOI=10.1038/nature08850;
RA   Ma L.-J., van der Does H.C., Borkovich K.A., Coleman J.J.,
RA   Daboussi M.-J., Di Pietro A., Dufresne M., Freitag M., Grabherr M.,
RA   Henrissat B., Houterman P.M., Kang S., Shim W.-B., Woloshuk C.,
RA   Xie X., Xu J.-R., Antoniw J., Baker S.E., Bluhm B.H., Breakspear A.,
RA   Brown D.W., Butchko R.A.E., Chapman S., Coulson R., Coutinho P.M.,
RA   Danchin E.G.J., Diener A., Gale L.R., Gardiner D.M., Goff S.,
RA   Hammond-Kosack K.E., Hilburn K., Hua-Van A., Jonkers W., Kazan K.,
RA   Kodira C.D., Koehrsen M., Kumar L., Lee Y.-H., Li L., Manners J.M.,
RA   Miranda-Saavedra D., Mukherjee M., Park G., Park J., Park S.-Y.,
RA   Proctor R.H., Regev A., Ruiz-Roldan M.C., Sain D., Sakthikumar S.,
RA   Sykes S., Schwartz D.C., Turgeon B.G., Wapinski I., Yoder O.,
RA   Young S., Zeng Q., Zhou S., Galagan J., Cuomo C.A., Kistler H.C.,
RA   Rep M.;
RT   "Comparative genomics reveals mobile pathogenicity chromosomes in
RT   Fusarium.";
RL   Nature 464:367-373(2010).
RN   [3] {ECO:0000313|EnsemblFungi:FOXG_11480P0}
RP   IDENTIFICATION.
RC   STRAIN=4287 / CBS 123668 / FGSC 9935 / NRRL 34936
RC   {ECO:0000313|EnsemblFungi:FOXG_11480P0};
RG   EnsemblFungi;
RL   Submitted (MAR-2015) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY: ATP + (deoxyribonucleotide)(n)-3'-hydroxyl +
CC       5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) +
CC       AMP + diphosphate. {ECO:0000256|RuleBase:RU000617}.
CC   -!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
CC       {ECO:0000256|RuleBase:RU004196}.
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DR   EMBL; DS231710; KNB11651.1; -; Genomic_DNA.
DR   EMBL; DS231710; KNB11652.1; -; Genomic_DNA.
DR   RefSeq; XP_018249696.1; XM_018391109.1.
DR   RefSeq; XP_018249697.1; XM_018391110.1.
DR   STRING; 5507.FOXG_11480P0; -.
DR   EnsemblFungi; FOXG_11480T0; FOXG_11480P0; FOXG_11480.
DR   GeneID; 28952883; -.
DR   KEGG; fox:FOXG_11480; -.
DR   KO; K10777; -.
DR   OMA; HMCPSTK; -.
DR   Proteomes; UP000009097; Chromosome 10.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:InterPro.
DR   GO; GO:0051103; P:DNA ligation involved in DNA repair; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   CDD; cd00027; BRCT; 2.
DR   Gene3D; 1.10.3260.10; -; 1.
DR   Gene3D; 3.40.50.10190; -; 2.
DR   InterPro; IPR001357; BRCT_dom.
DR   InterPro; IPR036420; BRCT_dom_sf.
DR   InterPro; IPR000977; DNA_ligase_ATP-dep.
DR   InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR   InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR   InterPro; IPR016059; DNA_ligase_ATP-dep_CS.
DR   InterPro; IPR012308; DNA_ligase_ATP-dep_N.
DR   InterPro; IPR036599; DNA_ligase_N_sf.
DR   InterPro; IPR029710; LIG4.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   PANTHER; PTHR10459:SF7; PTHR10459:SF7; 1.
DR   Pfam; PF16589; BRCT_2; 2.
DR   Pfam; PF04679; DNA_ligase_A_C; 1.
DR   Pfam; PF01068; DNA_ligase_A_M; 1.
DR   Pfam; PF04675; DNA_ligase_A_N; 1.
DR   SMART; SM00292; BRCT; 2.
DR   SUPFAM; SSF117018; SSF117018; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   SUPFAM; SSF52113; SSF52113; 2.
DR   TIGRFAMs; TIGR00574; dnl1; 1.
DR   PROSITE; PS50172; BRCT; 2.
DR   PROSITE; PS00697; DNA_LIGASE_A1; 1.
DR   PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU000617};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000009097};
KW   DNA damage {ECO:0000256|RuleBase:RU000617};
KW   DNA recombination {ECO:0000256|RuleBase:RU000617};
KW   DNA repair {ECO:0000256|RuleBase:RU000617};
KW   DNA replication {ECO:0000256|RuleBase:RU000617};
KW   Ligase {ECO:0000256|RuleBase:RU000617, ECO:0000313|EMBL:KNB11651.1};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU000617};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009097}.
FT   DOMAIN      427    552       DNA_LIGASE_A3. {ECO:0000259|PROSITE:
FT                                PS50160}.
FT   DOMAIN      720    802       BRCT. {ECO:0000259|PROSITE:PS50172}.
FT   DOMAIN      882    983       BRCT. {ECO:0000259|PROSITE:PS50172}.
FT   COILED      669    692       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   984 AA;  112917 MW;  86E6A083A561D8FA CRC64;
     MSQTDEAQHE DEIQYGIVGM TREELEEKFP NRPKNHSKTL IFSELFREVF NPLNENKKQN
     AIGAGPRKGF RGVNKLSPHE QRRHIIERFI TRWRKEVGPD FYPALRLILP DKDRDRGVYG
     LKENTIGKLL VKLMKIDKNS EDGYNLLHWK LPGQTTASRL AGDFAGRCFE VISKRPMRTD
     VGNMTIAEVN EQLDKLAAST GESENLRVFE TFYNRMNSEE LMWLIRIVLK QMKVGATEKT
     FLDLWHPDGD ALFSVSSSLR RVCWELHDPE TRLEQEETGV ALMQCFQPQL AQFQMPASFQ
     KMIELLRPTE EDPEFWIEEK LDGERMQVHM VQDKSHPGGK RFCFWSRKAK DYTYLYGDGL
     QDENSSLTRH LKNAFASGVK NLILDGEMIT WDMGVDKIVP FGTLKTAALS EQKNKSDTDS
     AGHRPLFRVF DILYLNNKPL TQYTLRDRHR ALEKAIKPVH RRLEIHSYDK ATSADAIEPL
     LREVVANASE GLVLKNPRSM YRLNSRNDDW LKVKPEYMSE FGESLDCVII GGYYGSGKRG
     GMLSSFLCGL RVTQNHIQAG ANPEKCFSFF KVGGGFRAED YAEIRHRTEG KWIEWDQKNP
     PSKYIELGGG ELRQYERPDV WIRPKDSVVV SVKAASVGPS DQFARGFTLR FPRFRRLRLD
     RTWDTALSLE EFQELKERVE EESKEKAMTV EDRKRRNPKR VKRELTIAGE DATVAEFKGE
     MTNLFEGLDF CVLSEALRPY KKTKAQLEAI IKENGGTVLQ RAVPGTNMVL IADKKVVKVA
     SLIKGGAVDI ICPKWIRDCL EQELGAFLLP FEPSHLFHAT DALHRAAEDN TDQFGDSYAR
     DLSIEELREL MQDMPKIEDG TQFDKNEFLQ QLEEHGKDLG RLRSFTFRRC VVLFHAVEAG
     DNKISRLKHL VKYGGGNVTD DTDDLSVTHV VIEGDDPMQV GEAADMVRKE LSSRRLQPRL
     VTGKWIDECW NESTLLDEEQ FVIP
//
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