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Database: UniProt/TrEMBL
Entry: A0A0D4DWP1_9ACTN
LinkDB: A0A0D4DWP1_9ACTN
Original site: A0A0D4DWP1_9ACTN 
ID   A0A0D4DWP1_9ACTN        Unreviewed;       739 AA.
AC   A0A0D4DWP1;
DT   27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2017, sequence version 2.
DT   05-JUL-2017, entry version 10.
DE   SubName: Full=Isocitrate dehydrogenase, NADP-dependent {ECO:0000313|EMBL:AJT68389.2};
GN   ORFNames=T261_6787 {ECO:0000313|EMBL:AJT68389.2};
OS   Streptomyces lydicus.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=47763 {ECO:0000313|EMBL:AJT68389.2, ECO:0000313|Proteomes:UP000032413};
RN   [1] {ECO:0000313|Proteomes:UP000032413}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=A02 {ECO:0000313|Proteomes:UP000032413};
RA   Wu H., Yan J., Liu W., Liu T., Dong D., Li J., Liu H., Lu C.,
RA   Zhang D., Zhang T., Tian Z.;
RT   "Complete genome sequence of the natamycin-producing actinomycete
RT   Streptomyces lydicus A02.";
RL   Submitted (MAY-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit.
CC       {ECO:0000256|PIRSR:PIRSR009407-3};
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DR   EMBL; CP007699; AJT68389.2; -; Genomic_DNA.
DR   RefSeq; WP_046929046.1; NZ_CP007699.2.
DR   EnsemblBacteria; AJT68389; AJT68389; T261_6787.
DR   KEGG; sld:T261_6787; -.
DR   PATRIC; fig|1403539.3.peg.6949; -.
DR   KO; K00031; -.
DR   Proteomes; UP000032413; Chromosome.
DR   GO; GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   InterPro; IPR004436; Isocitrate_DH_NADP_mono.
DR   Pfam; PF03971; IDH; 1.
DR   PIRSF; PIRSF009407; IDH_monmr; 1.
DR   TIGRFAMs; TIGR00178; monomer_idh; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000032413};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   REGION      132    139       Substrate binding. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   METAL       348    348       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       546    546       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       550    550       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   BINDING     145    145       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   BINDING     545    545       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   SITE        255    255       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
FT   SITE        418    418       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
SQ   SEQUENCE   739 AA;  79088 MW;  A85CDD4FA26E40B4 CRC64;
     MTDSTIIYTH TDEAPALATH SFLPVIQAYA STAGVTVETR DISLAGRIIA SFPERLEEGQ
     RIDDALAELG ELAKTPGANI IKLPNISASI PQLKAAIAEL QQQGYALPDY PDDPKTDEEK
     DVRARYDKVK GSAVNPVLRE GNSDRRAAAA VKNYAKAHPH RMGAWTSESK TNVATMGADD
     FRSTEKSAVI GEAGTLRIEL HGDDGSTTVL RESVPVLAGE VVDASVMRVA ALREFLTAQV
     ARAKADGVLF SVHLKATMMK VSDPIIFGHV VRAFFPDTFA TYGETFAKAG LTPNDGLGGI
     LKGVESLPEG AAIKASFEAE LAEGPALAMV DSDRGITNLH VPSDVIVDAS MPAMIRTSGH
     MWGPDGEEAD TLAVIPDSSY AGIYQVVIDD CRAHGAYDPS TMGSVPNVGL MAQKAEEYGS
     HDKTFEIPVT GTVRVVDEAG NAVLEQVVSA GDVFRMCQTK DLPIQDWVKL AVTRARATGD
     PAVFWLDEGR AHDASLIAKV KQYLPEHDTE GLQIDIMSPV DAIGFSLERI RRGENTISVT
     GNVLRDYLTD LFPILELGTS AKMLSVVPLM NGGGLFETGA GGSAPKHVQQ LVKENYLRWD
     SLGEFLALGV SFEHLAQTTG NARAQVLADT LDRATGTFLE NDKSPSRRVG GIDNRGSHFY
     LALYWAQELA KQTDDAQLAE AFGPLAKTLT EQEQTIVDEL IAVQGSPADI GGYYQPDVTK
     ASAVMRPSAT LNQALATLA
//
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